Fundamentals of SARS-CoV-2 Biosensors

COVID-19 diagnostic strategies based on advanced techniques are currently essential topics of interest, with crucial roles in scientific research. This book integrates fundamental concepts and critical analyses that explore the progress of modern methods for the detection of SARS-CoV-2

Developing the MAR databases – Augmenting Genomic Versatility of Sequenced Marine Microbiota

This thesis introduces the MAR databases as marine-specific resources in the genomic landscape. Paper 1 describes the curation effort and development leading to the MAR databases being created. It results in the highly valued reference database MarRef, the broader MarDB, and the marine gene catalog MarCat. Definition of a marine environment, the curation process, and the Marine Metagenomics Portal as a public web-service are described. It facilitates scientists to find marine sequence data for prokaryotes and to explore rich contextual information, secondary metabolites, updated taxonomy, and helps in evaluating genome quality. Many of these database advancements are covered in Paper 2. This includes new entries and development of specific databases on marine fungi (MarFun) and salmon related prokaryotes (SalDB). With the implementation of metagenome assembled and single amplified genomes it leads up to the database quality evaluation discussed in Paper 3. The lack of quality control in primary databases is here discussed based on estimated completeness and contamination in the genomes of the MAR databases. Paper 4 explores the microbiota of skin and gut mucosa of Atlantic salmon. By using a database dependent amplicon analysis, the full-length 16 rRNA gene proved accurate, but not a game-changer in taxonomic classification for this environmental niche. The proportion of dataset sequences lacking clear taxonomic classification suggests lack of diversity in current-day databases and inadequate phylogenetic resolution. Advancing phylogenetic resolution was the subject of Paper 5. Here the highly similar species of genus Aliivibrio became delineated using six genes in a multilocus sequence analysis. Five potentially novel species could in this way be delineated, which coincided with recent genome-wide taxonomy listings. Thus, Paper 4 and 5 parallel those of the MAR databases by providing insight into the inter-relational framework of bioinformatic analysis and marine database sources

Safe and Sound: Proceedings of the 27th Annual International Conference on Auditory Display

Complete proceedings of the 27th International Conference on Auditory Display (ICAD2022), June 24-27. Online virtual conference

Models and Analysis of Vocal Emissions for Biomedical Applications

The International Workshop on Models and Analysis of Vocal Emissions for Biomedical Applications (MAVEBA) came into being in 1999 from the particularly felt need of sharing know-how, objectives and results between areas that until then seemed quite distinct such as bioengineering, medicine and singing. MAVEBA deals with all aspects concerning the study of the human voice with applications ranging from the newborn to the adult and elderly. Over the years the initial issues have grown and spread also in other fields of research such as occupational voice disorders, neurology, rehabilitation, image and video analysis. MAVEBA takes place every two years in Firenze, Italy. This edition celebrates twenty-two years of uninterrupted and successful research in the field of voice analysis

pHealth 2021. Proc. of the 18th Internat. Conf. on Wearable Micro and Nano Technologies for Personalised Health, 8-10 November 2021, Genoa, Italy

Smart mobile systems – microsystems, smart textiles, smart implants, sensor-controlled medical devices – together with related body, local and wide-area networks up to cloud services, have become important enablers for telemedicine and the next generation of healthcare services. The multilateral benefits of pHealth technologies offer enormous potential for all stakeholder communities, not only in terms of improvements in medical quality and industrial competitiveness, but also for the management of healthcare costs and, last but not least, the improvement of patient experience. This book presents the proceedings of pHealth 2021, the 18th in a series of conferences on wearable micro and nano technologies for personalized health with personal health management systems, hosted by the University of Genoa, Italy, and held as an online event from 8 – 10 November 2021. The conference focused on digital health ecosystems in the transformation of healthcare towards personalized, participative, preventive, predictive precision medicine (5P medicine). The book contains 46 peer-reviewed papers (1 keynote, 5 invited papers, 33 full papers, and 7 poster papers). Subjects covered include the deployment of mobile technologies, micro-nano-bio smart systems, bio-data management and analytics, autonomous and intelligent systems, the Health Internet of Things (HIoT), as well as potential risks for security and privacy, and the motivation and empowerment of patients in care processes. Providing an overview of current advances in personalized health and health management, the book will be of interest to all those working in the field of healthcare today

Biosensors

A biosensor is defined as a detecting device that combines a transducer with a biologically sensitive and selective component. When a specific target molecule interacts with the biological component, a signal is produced, at transducer level, proportional to the concentration of the substance. Therefore biosensors can measure compounds present in the environment, chemical processes, food and human body at low cost if compared with traditional analytical techniques. This book covers a wide range of aspects and issues related to biosensor technology, bringing together researchers from 11 different countries. The book consists of 16 chapters written by 53 authors. The first four chapters describe several aspects of nanotechnology applied to biosensors. The subsequent section, including three chapters, is devoted to biosensor applications in the fields of drug discovery, diagnostics and bacteria detection. The principles behind optical biosensors and some of their application are discussed in chapters from 8 to 11. The last five chapters treat of microelectronics, interfacing circuits, signal transmission, biotelemetry and algorithms applied to biosensing

Aggregation of biological knowledge for immunological and virological applications

Ph.DDOCTOR OF PHILOSOPH