12,705 research outputs found
Symbolic Reachability Analysis of B through ProB and LTSmin
We present a symbolic reachability analysis approach for B that can provide a
significant speedup over traditional explicit state model checking. The
symbolic analysis is implemented by linking ProB to LTSmin, a high-performance
language independent model checker. The link is achieved via LTSmin's PINS
interface, allowing ProB to benefit from LTSmin's analysis algorithms, while
only writing a few hundred lines of glue-code, along with a bridge between ProB
and C using ZeroMQ. ProB supports model checking of several formal
specification languages such as B, Event-B, Z and TLA. Our experiments are
based on a wide variety of B-Method and Event-B models to demonstrate the
efficiency of the new link. Among the tested categories are state space
generation and deadlock detection; but action detection and invariant checking
are also feasible in principle. In many cases we observe speedups of several
orders of magnitude. We also compare the results with other approaches for
improving model checking, such as partial order reduction or symmetry
reduction. We thus provide a new scalable, symbolic analysis algorithm for the
B-Method and Event-B, along with a platform to integrate other model checking
improvements via LTSmin in the future
MOLNs: A cloud platform for interactive, reproducible and scalable spatial stochastic computational experiments in systems biology using PyURDME
Computational experiments using spatial stochastic simulations have led to
important new biological insights, but they require specialized tools, a
complex software stack, as well as large and scalable compute and data analysis
resources due to the large computational cost associated with Monte Carlo
computational workflows. The complexity of setting up and managing a
large-scale distributed computation environment to support productive and
reproducible modeling can be prohibitive for practitioners in systems biology.
This results in a barrier to the adoption of spatial stochastic simulation
tools, effectively limiting the type of biological questions addressed by
quantitative modeling. In this paper, we present PyURDME, a new, user-friendly
spatial modeling and simulation package, and MOLNs, a cloud computing appliance
for distributed simulation of stochastic reaction-diffusion models. MOLNs is
based on IPython and provides an interactive programming platform for
development of sharable and reproducible distributed parallel computational
experiments
Dialogue Act Modeling for Automatic Tagging and Recognition of Conversational Speech
We describe a statistical approach for modeling dialogue acts in
conversational speech, i.e., speech-act-like units such as Statement, Question,
Backchannel, Agreement, Disagreement, and Apology. Our model detects and
predicts dialogue acts based on lexical, collocational, and prosodic cues, as
well as on the discourse coherence of the dialogue act sequence. The dialogue
model is based on treating the discourse structure of a conversation as a
hidden Markov model and the individual dialogue acts as observations emanating
from the model states. Constraints on the likely sequence of dialogue acts are
modeled via a dialogue act n-gram. The statistical dialogue grammar is combined
with word n-grams, decision trees, and neural networks modeling the
idiosyncratic lexical and prosodic manifestations of each dialogue act. We
develop a probabilistic integration of speech recognition with dialogue
modeling, to improve both speech recognition and dialogue act classification
accuracy. Models are trained and evaluated using a large hand-labeled database
of 1,155 conversations from the Switchboard corpus of spontaneous
human-to-human telephone speech. We achieved good dialogue act labeling
accuracy (65% based on errorful, automatically recognized words and prosody,
and 71% based on word transcripts, compared to a chance baseline accuracy of
35% and human accuracy of 84%) and a small reduction in word recognition error.Comment: 35 pages, 5 figures. Changes in copy editing (note title spelling
changed
Model-free reconstruction of neuronal network connectivity from calcium imaging signals
A systematic assessment of global neural network connectivity through direct
electrophysiological assays has remained technically unfeasible even in
dissociated neuronal cultures. We introduce an improved algorithmic approach
based on Transfer Entropy to reconstruct approximations to network structural
connectivities from network activity monitored through calcium fluorescence
imaging. Based on information theory, our method requires no prior assumptions
on the statistics of neuronal firing and neuronal connections. The performance
of our algorithm is benchmarked on surrogate time-series of calcium
fluorescence generated by the simulated dynamics of a network with known
ground-truth topology. We find that the effective network topology revealed by
Transfer Entropy depends qualitatively on the time-dependent dynamic state of
the network (e.g., bursting or non-bursting). We thus demonstrate how
conditioning with respect to the global mean activity improves the performance
of our method. [...] Compared to other reconstruction strategies such as
cross-correlation or Granger Causality methods, our method based on improved
Transfer Entropy is remarkably more accurate. In particular, it provides a good
reconstruction of the network clustering coefficient, allowing to discriminate
between weakly or strongly clustered topologies, whereas on the other hand an
approach based on cross-correlations would invariantly detect artificially high
levels of clustering. Finally, we present the applicability of our method to
real recordings of in vitro cortical cultures. We demonstrate that these
networks are characterized by an elevated level of clustering compared to a
random graph (although not extreme) and by a markedly non-local connectivity.Comment: 54 pages, 8 figures (+9 supplementary figures), 1 table; submitted
for publicatio
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