AUTOMATIC IDENTIFICATION OF DYSPHONIAS USING MACHINE LEARNING ALGORITHMS

Dysphonia is a prevalent symptom of some respiratory diseases that affects voice quality, even for prolonged periods. For its diagnosis, speech-language pathologists make use of different acoustic parameters to perform objective evaluations on patients and determine the type of dysphonia that affects them, such as hyperfunctional and hypofunctional dysphonia, which is important because each type requires a different treatment. In the field of artificial intelligence this problem has been addressed through the use of acoustic parameters that are used as input data to train machine learning and deep learning models. However, its purpose is usually to identify whether a patient is ill or not, making binary classifications between healthy voices and voices with dysphonia, but not between dysphonias. In this paper, harmonic-to-noise ratio, cepstral peak prominence-smoothed, zero crossing rate and the means of the Mel frequency cepstral coefficients (2-19) are used to make multiclass classification of voices with euphony, hyperfunction and hypofunction by means of six machine learning algorithms, which are: Random Forest, K nearest neighbors, Logistic regression, Decision trees, Support vector machines and Naive Bayes. In order to evaluate which of them presents a better performance to identify the three voice classes, bootstrap.632 was used. It is concluded that the best confidence interval ranges from 87% to 92%, in terms of accuracy for the K Nearest Neighbors model. Results can be implemented in the development of a complementary application for the clinical diagnosis or monitoring of a patient under the supervision of a specialist

Improving automatic detection of obstructive sleep apnea through nonlinear analysis of sustained speech

We present a novel approach for the detection of severe obstructive sleep apnea (OSA) based on patients' voices introducing nonlinear measures to describe sustained speech dynamics. Nonlinear features were combined with state-of-the-art speech recognition systems using statistical modeling techniques (Gaussian mixture models, GMMs) over cepstral parameterization (MFCC) for both continuous and sustained speech. Tests were performed on a database including speech records from both severe OSA and control speakers. A 10 % relative reduction in classification error was obtained for sustained speech when combining MFCC-GMM and nonlinear features, and 33 % when fusing nonlinear features with both sustained and continuous MFCC-GMM. Accuracy reached 88.5 % allowing the system to be used in OSA early detection. Tests showed that nonlinear features and MFCCs are lightly correlated on sustained speech, but uncorrelated on continuous speech. Results also suggest the existence of nonlinear effects in OSA patients' voices, which should be found in continuous speech

An algorithm for Parkinson's disease speech classification based on isolated words analysis

Introduction Automatic assessment of speech impairment is a cutting edge topic in Parkinson's disease (PD). Language disorders are known to occur several years earlier than typical motor symptoms, thus speech analysis may contribute to the early diagnosis of the disease. Moreover, the remote monitoring of dysphonia could allow achieving an effective follow-up of PD clinical condition, possibly performed in the home environment. Methods In this work, we performed a multi-level analysis, progressively combining features extracted from the entire signal, the voiced segments, and the on-set/off-set regions, leading to a total number of 126 features. Furthermore, we compared the performance of early and late feature fusion schemes, aiming to identify the best model configuration and taking advantage of having 25 isolated words pronounced by each subject. We employed data from the PC-GITA database (50 healthy controls and 50 PD patients) for validation and testing. Results We implemented an optimized k-Nearest Neighbours model for the binary classification of PD patients versus healthy controls. We achieved an accuracy of 99.4% in 10-fold cross-validation and 94.3% in testing on the PC-GITA database (average value of male and female subjects). Conclusion The promising performance yielded by our model confirms the feasibility of automatic assessment of PD using voice recordings. Moreover, a post-hoc analysis of the most relevant features discloses the option of voice processing using a simple smartphone application

Novel speech signal processing algorithms for high-accuracy classification of Parkinson's disease

There has been considerable recent research into the connection between Parkinson's disease (PD) and speech impairment. Recently, a wide range of speech signal processing algorithms (dysphonia measures) aiming to predict PD symptom severity using speech signals have been introduced. In this paper, we test how accurately these novel algorithms can be used to discriminate PD subjects from healthy controls. In total, we compute 132 dysphonia measures from sustained vowels. Then, we select four parsimonious subsets of these dysphonia measures using four feature selection algorithms, and map these feature subsets to a binary classification response using two statistical classifiers: random forests and support vector machines. We use an existing database consisting of 263 samples from 43 subjects, and demonstrate that these new dysphonia measures can outperform state-of-the-art results, reaching almost 99% overall classification accuracy using only ten dysphonia features. We find that some of the recently proposed dysphonia measures complement existing algorithms in maximizing the ability of the classifiers to discriminate healthy controls from PD subjects. We see these results as an important step toward noninvasive diagnostic decision support in PD

Assessing Parkinson’s Disease at Scale Using Telephone-Recorded Speech:Insights from the Parkinson’s Voice Initiative

Numerous studies have reported on the high accuracy of using voice tasks for the remote detection and monitoring of Parkinson’s Disease (PD). Most of these studies, however, report findings on a small number of voice recordings, often collected under acoustically controlled conditions, and therefore cannot scale at large without specialized equipment. In this study, we aimed to evaluate the potential of using voice as a population-based PD screening tool in resource-constrained settings. Using the standard telephone network, we processed 11,942 sustained vowel /a/ phonations from a US-English cohort comprising 1078 PD and 5453 control participants. We characterized each phonation using 304 dysphonia measures to quantify a range of vocal impairments. Given that this is a highly unbalanced problem, we used the following strategy: we selected a balanced subset (n = 3000 samples) for training and testing using 10-fold cross-validation (CV), and the remaining (unbalanced held-out dataset, n = 8942) samples for further model validation. Using robust feature selection methods we selected 27 dysphonia measures to present into a radial-basis-function support vector machine and demonstrated differentiation of PD participants from controls with 67.43% sensitivity and 67.25% specificity. These findings could help pave the way forward toward the development of an inexpensive, remote, and reliable diagnostic support tool for PD using voice as a digital biomarker

Automatic voice disorder recognition using acoustic amplitude modulation features

Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2004.Includes bibliographical references (p. 114-117).An automatic dysphonia recognition system is designed that exploits amplitude modulations (AM) in voice using biologically-inspired models. This system recognizes general dysphonia and four subclasses: hyperfunction, A-P squeezing, paralysis, and vocal fold lesions. The models developed represent processing in the auditory system at the level of the cochlea, auditory nerve, and inferior colliculus. Recognition experiments using dysphonic sentence data obtained from the Kay Elemetrics Disordered Voice Database suggest that our system provides complementary information to state-of-the-art mel-cepstral features. A model for analyzing AM in dysphonic speech is also developed from a traditional communications engineering perspective. Through a case study of seven disordered voices, we show that different AM patterns occur in different frequency bands. This perspective challenges current dysphonia analysis methods that analyze AM in the time-domain signal.by Nicolas Malyska.S.M