A review of arthritis diagnosis techniques in artificial intelligence era: Current trends and research challenges

Deep learning, a branch of artificial intelligence, has achieved unprecedented performance in several domains including medicine to assist with efficient diagnosis of diseases, prediction of disease progression and pre-screening step for physicians. Due to its significant breakthroughs, deep learning is now being used for the diagnosis of arthritis, which is a chronic disease affecting young to aged population. This paper provides a survey of recent and the most representative deep learning techniques (published between 2018 to 2020) for the diagnosis of osteoarthritis and rheumatoid arthritis. The paper also reviews traditional machine learning methods (published 2015 onward) and their application for the diagnosis of these diseases. The paper identifies open problems and research gaps. We believe that deep learning can assist general practitioners and consultants to predict the course of the disease, make treatment propositions and appraise their potential benefits

Machine Learning in Chronic Pain Research: A Scoping Review

Given the high prevalence and associated cost of chronic pain, it has a significant impact on individuals and society. Improvements in the treatment and management of chronic pain may increase patients’ quality of life and reduce societal costs. In this paper, we evaluate state-of-the-art machine learning approaches in chronic pain research. A literature search was conducted using the PubMed, IEEE Xplore, and the Association of Computing Machinery (ACM) Digital Library databases. Relevant studies were identified by screening titles and abstracts for keywords related to chronic pain and machine learning, followed by analysing full texts. Two hundred and eighty-seven publications were identified in the literature search. In total, fifty-three papers on chronic pain research and machine learning were reviewed. The review showed that while many studies have emphasised machine learning-based classification for the diagnosis of chronic pain, far less attention has been paid to the treatment and management of chronic pain. More research is needed on machine learning approaches to the treatment, rehabilitation, and self-management of chronic pain. As with other chronic conditions, patient involvement and self-management are crucial. In order to achieve this, patients with chronic pain need digital tools that can help them make decisions about their own treatment and care

Extracting clinical knowledge from electronic medical records

As the adoption of Electronic Medical Records (EMRs) rises in the healthcare institutions, these resources’ importance increases due to all clinical information they contain about patients. However, the unstructured information in the form of clinical narratives present in these records makes it hard to extract and structure useful clinical knowledge. This unstructured information limits the potential of the EMRs because the clinical information these records contain can be used to perform essential tasks inside healthcare institutions such as searching, summarization, decision support and statistical analysis, as well as be used to support management decisions or serve for research. These tasks can only be done if the unstructured clinical information from the narratives is appropriately extracted, structured and processed in clinical knowledge. Usually, this information extraction and structuration in clinical knowledge is performed manually by healthcare practitioners, which is not efficient and is error-prone. This research aims to propose a solution to this problem, by using Machine Translation (MT) from the Portuguese language to the English language, Natural Language Processing (NLP) and Information Extraction (IE) techniques. With the help of these techniques, the goal is to develop a prototype pipeline modular system that can extract clinical knowledge from unstructured clinical information contained in Portuguese EMRs, in an automated way, in order to help EMRs to fulfil their potential and consequently help the Portuguese hospital involved in this research. This research also intends to show that this generic prototype system and approach can potentially be applied to other hospitals, even if they don’t use the Portuguese language.Com a adopção cada vez maior das instituições de saúde face aos Processos Clínicos Electrónicos (PCE), estes documentos ganham cada vez mais importância em contexto clínico, devido a toda a informação clínica que contêm relativamente aos pacientes. No entanto, a informação não estruturada na forma de narrativas clínicas presente nestes documentos electrónicos, faz com que seja difícil extrair e estruturar deles conhecimento clínico. Esta informação não estruturada limita o potencial dos PCE, uma vez que essa mesma informação, caso seja extraída e estruturada devidamente, pode servir para que as instituições de saúde possam efectuar actividades importantes com maior eficiência e sucesso, como por exemplo actividades de pesquisa, sumarização, apoio à decisão, análises estatísticas, suporte a decisões de gestão e de investigação. Este tipo de actividades apenas podem ser feitas com sucesso caso a informação clínica não estruturada presente nos PCE seja devidamente extraída, estruturada e processada em conhecimento clínico. Habitualmente, esta extração é realizada manualmente pelos profissionais médicos, o que não é eficiente e é susceptível a erros. Esta dissertação pretende então propôr uma solução para este problema, ao utilizar técnicas de Tradução Automática (TA) da língua portuguesa para a língua inglesa, Processamento de Linguagem Natural (PLN) e Extração de Informação (EI). O objectivo é desenvolver um sistema protótipo de módulos em série que utilize estas técnicas, possibilitando a extração de conhecimento clínico, de uma forma automática, de informação clínica não estruturada presente nos PCE de um hospital português. O principal objetivo é ajudar os PCE a atingirem todo o seu potencial em termos de conhecimento clínico que contêm e consequentemente ajudar o hospital português em questão envolvido nesta dissertação, demonstrando também que este sistema protótipo e esta abordagem podem potencialmente ser aplicados a outros hospitais, mesmo que não sejam de língua portuguesa

Artificial intelligence-based preventive, personalized and precision medicine for cardiovascular disease/stroke risk assessment in rheumatoid arthritis patients: a narrative review

The challenges associated with diagnosing and treating cardiovascular disease (CVD)/Stroke in Rheumatoid arthritis (RA) arise from the delayed onset of symptoms. Existing clinical risk scores are inadequate in predicting cardiac events, and conventional risk factors alone do not accurately classify many individuals at risk. Several CVD biomarkers consider the multiple pathways involved in the development of atherosclerosis, which is the primary cause of CVD/Stroke in RA. To enhance the accuracy of CVD/Stroke risk assessment in the RA framework, a proposed approach involves combining genomic-based biomarkers (GBBM) derived from plasma and/or serum samples with innovative non-invasive radiomic-based biomarkers (RBBM), such as measurements of synovial fluid, plaque area, and plaque burden. This review presents two hypotheses: (i) RBBM and GBBM biomarkers exhibit a significant correlation and can precisely detect the severity of CVD/Stroke in RA patients. (ii) Artificial Intelligence (AI)-based preventive, precision, and personalized (aiP3) CVD/Stroke risk AtheroEdge™ model (AtheroPoint™, CA, USA) that utilizes deep learning (DL) to accurately classify the risk of CVD/stroke in RA framework. The authors conducted a comprehensive search using the PRISMA technique, identifying 153 studies that assessed the features/biomarkers of RBBM and GBBM for CVD/Stroke. The study demonstrates how DL models can be integrated into the AtheroEdge™–aiP3 framework to determine the risk of CVD/Stroke in RA patients. The findings of this review suggest that the combination of RBBM with GBBM introduces a new dimension to the assessment of CVD/Stroke risk in the RA framework. Synovial fluid levels that are higher than normal lead to an increase in the plaque burden. Additionally, the review provides recommendations for novel, unbiased, and pruned DL algorithms that can predict CVD/Stroke risk within a RA framework that is preventive, precise, and personalized. © 2023, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature