Abstract Pattern Image Generation using Generative Adversarial Networks

Abstract pattern is very commonly used in the textile and fashion industry. Pattern design is an area where designers need to come up with new and attractive patterns every day. It is very difficult to find employees with a sufficient creative mindset and the necessary skills to come up with new unseen attractive designs. Therefore, it would be ideal to identify a process that would allow for these patterns to be generated on their own with little to no human interaction. This can be achieved using deep learning models and techniques. One of the most recent and promising tools to solve this type of problem is Generative Adversarial Networks (GANs). In this paper, we investigate the suitability of GAN in producing abstract patterns. We achieve this by generating abstract design patterns using the two most popular GANs, namely Deep Convolutional GAN and Wasserstein GAN. By identifying the best-performing model after training using hyperparameter optimization and generating some output patterns we show that Wasserstein GAN is superior to Deep Convolutional GAN

Realistic adversarial machine learning to improve network intrusion detection

Modern organizations can significantly benefit from the use of Artificial Intelligence (AI), and more specifically Machine Learning (ML), to tackle the growing number and increasing sophistication of cyber-attacks targeting their business processes. However, there are several technological and ethical challenges that undermine the trustworthiness of AI. One of the main challenges is the lack of robustness, which is an essential property to ensure that ML is used in a secure way. Improving robustness is no easy task because ML is inherently susceptible to adversarial examples: data samples with subtle perturbations that cause unexpected behaviors in ML models. ML engineers and security practitioners still lack the knowledge and tools to prevent such disruptions, so adversarial examples pose a major threat to ML and to the intelligent Network Intrusion Detection (NID) systems that rely on it. This thesis presents a methodology for a trustworthy adversarial robustness analysis of multiple ML models, and an intelligent method for the generation of realistic adversarial examples in complex tabular data domains like the NID domain: Adaptative Perturbation Pattern Method (A2PM). It is demonstrated that a successful adversarial attack is not guaranteed to be a successful cyber-attack, and that adversarial data perturbations can only be realistic if they are simultaneously valid and coherent, complying with the domain constraints of a real communication network and the class-specific constraints of a certain cyber-attack class. A2PM can be used for adversarial attacks, to iteratively cause misclassifications, and adversarial training, to perform data augmentation with slightly perturbed data samples. Two case studies were conducted to evaluate its suitability for the NID domain. The first verified that the generated perturbations preserved both validity and coherence in Enterprise and Internet-of Things (IoT) network scenarios, achieving realism. The second verified that adversarial training with simple perturbations enables the models to retain a good generalization to regular IoT network traffic flows, in addition to being more robust to adversarial examples. The key takeaway of this thesis is: ML models can be incredibly valuable to improve a cybersecurity system, but their own vulnerabilities must not be disregarded. It is essential to continue the research efforts to improve the security and trustworthiness of ML and of the intelligent systems that rely on it.Organizações modernas podem beneficiar significativamente do uso de Inteligência Artificial (AI), e mais especificamente Aprendizagem Automática (ML), para enfrentar a crescente quantidade e sofisticação de ciberataques direcionados aos seus processos de negócio. No entanto, há vários desafios tecnológicos e éticos que comprometem a confiabilidade da AI. Um dos maiores desafios é a falta de robustez, que é uma propriedade essencial para garantir que se usa ML de forma segura. Melhorar a robustez não é uma tarefa fácil porque ML é inerentemente suscetível a exemplos adversos: amostras de dados com perturbações subtis que causam comportamentos inesperados em modelos ML. Engenheiros de ML e profissionais de segurança ainda não têm o conhecimento nem asferramentas necessárias para prevenir tais disrupções, por isso os exemplos adversos representam uma grande ameaça a ML e aos sistemas de Deteção de Intrusões de Rede (NID) que dependem de ML. Esta tese apresenta uma metodologia para uma análise da robustez de múltiplos modelos ML, e um método inteligente para a geração de exemplos adversos realistas em domínios de dados tabulares complexos como o domínio NID: Método de Perturbação com Padrões Adaptativos (A2PM). É demonstrado que um ataque adverso bem-sucedido não é garantidamente um ciberataque bem-sucedido, e que as perturbações adversas só são realistas se forem simultaneamente válidas e coerentes, cumprindo as restrições de domínio de uma rede de computadores real e as restrições específicas de uma certa classe de ciberataque. A2PM pode ser usado para ataques adversos, para iterativamente causar erros de classificação, e para treino adverso, para realizar aumento de dados com amostras ligeiramente perturbadas. Foram efetuados dois casos de estudo para avaliar a sua adequação ao domínio NID. O primeiro verificou que as perturbações preservaram tanto a validade como a coerência em cenários de redes Empresariais e Internet-das-Coisas (IoT), alcançando o realismo. O segundo verificou que o treino adverso com perturbações simples permitiu aos modelos reter uma boa generalização a fluxos de tráfego de rede IoT, para além de serem mais robustos contra exemplos adversos. A principal conclusão desta tese é: os modelos ML podem ser incrivelmente valiosos para melhorar um sistema de cibersegurança, mas as suas próprias vulnerabilidades não devem ser negligenciadas. É essencial continuar os esforços de investigação para melhorar a segurança e a confiabilidade de ML e dos sistemas inteligentes que dependem de ML

Semi-automated Ontology Generation for Biocuration and Semantic Search

Background: In the life sciences, the amount of literature and experimental data grows at a tremendous rate. In order to effectively access and integrate these data, biomedical ontologies – controlled, hierarchical vocabularies – are being developed. Creating and maintaining such ontologies is a difficult, labour-intensive, manual process. Many computational methods which can support ontology construction have been proposed in the past. However, good, validated systems are largely missing. Motivation: The biocuration community plays a central role in the development of ontologies. Any method that can support their efforts has the potential to have a huge impact in the life sciences. Recently, a number of semantic search engines were created that make use of biomedical ontologies for document retrieval. To transfer the technology to other knowledge domains, suitable ontologies need to be created. One area where ontologies may prove particularly useful is the search for alternative methods to animal testing, an area where comprehensive search is of special interest to determine the availability or unavailability of alternative methods. Results: The Dresden Ontology Generator for Directed Acyclic Graphs (DOG4DAG) developed in this thesis is a system which supports the creation and extension of ontologies by semi-automatically generating terms, definitions, and parent-child relations from text in PubMed, the web, and PDF repositories. The system is seamlessly integrated into OBO-Edit and Protégé, two widely used ontology editors in the life sciences. DOG4DAG generates terms by identifying statistically significant noun-phrases in text. For definitions and parent-child relations it employs pattern-based web searches. Each generation step has been systematically evaluated using manually validated benchmarks. The term generation leads to high quality terms also found in manually created ontologies. Definitions can be retrieved for up to 78% of terms, child ancestor relations for up to 54%. No other validated system exists that achieves comparable results. To improve the search for information on alternative methods to animal testing an ontology has been developed that contains 17,151 terms of which 10% were newly created and 90% were re-used from existing resources. This ontology is the core of Go3R, the first semantic search engine in this field. When a user performs a search query with Go3R, the search engine expands this request using the structure and terminology of the ontology. The machine classification employed in Go3R is capable of distinguishing documents related to alternative methods from those which are not with an F-measure of 90% on a manual benchmark. Approximately 200,000 of the 19 million documents listed in PubMed were identified as relevant, either because a specific term was contained or due to the automatic classification. The Go3R search engine is available on-line under www.Go3R.org

Semi-automated Ontology Generation for Biocuration and Semantic Search

Background: In the life sciences, the amount of literature and experimental data grows at a tremendous rate. In order to effectively access and integrate these data, biomedical ontologies – controlled, hierarchical vocabularies – are being developed. Creating and maintaining such ontologies is a difficult, labour-intensive, manual process. Many computational methods which can support ontology construction have been proposed in the past. However, good, validated systems are largely missing. Motivation: The biocuration community plays a central role in the development of ontologies. Any method that can support their efforts has the potential to have a huge impact in the life sciences. Recently, a number of semantic search engines were created that make use of biomedical ontologies for document retrieval. To transfer the technology to other knowledge domains, suitable ontologies need to be created. One area where ontologies may prove particularly useful is the search for alternative methods to animal testing, an area where comprehensive search is of special interest to determine the availability or unavailability of alternative methods. Results: The Dresden Ontology Generator for Directed Acyclic Graphs (DOG4DAG) developed in this thesis is a system which supports the creation and extension of ontologies by semi-automatically generating terms, definitions, and parent-child relations from text in PubMed, the web, and PDF repositories. The system is seamlessly integrated into OBO-Edit and Protégé, two widely used ontology editors in the life sciences. DOG4DAG generates terms by identifying statistically significant noun-phrases in text. For definitions and parent-child relations it employs pattern-based web searches. Each generation step has been systematically evaluated using manually validated benchmarks. The term generation leads to high quality terms also found in manually created ontologies. Definitions can be retrieved for up to 78% of terms, child ancestor relations for up to 54%. No other validated system exists that achieves comparable results. To improve the search for information on alternative methods to animal testing an ontology has been developed that contains 17,151 terms of which 10% were newly created and 90% were re-used from existing resources. This ontology is the core of Go3R, the first semantic search engine in this field. When a user performs a search query with Go3R, the search engine expands this request using the structure and terminology of the ontology. The machine classification employed in Go3R is capable of distinguishing documents related to alternative methods from those which are not with an F-measure of 90% on a manual benchmark. Approximately 200,000 of the 19 million documents listed in PubMed were identified as relevant, either because a specific term was contained or due to the automatic classification. The Go3R search engine is available on-line under www.Go3R.org

Smoking and Second Hand Smoking in Adolescents with Chronic Kidney Disease: A Report from the Chronic Kidney Disease in Children (CKiD) Cohort Study

The goal of this study was to determine the prevalence of smoking and second hand smoking [SHS] in adolescents with CKD and their relationship to baseline parameters at enrollment in the CKiD, observational cohort study of 600 children (aged 1-16 yrs) with Schwartz estimated GFR of 30-90 ml/min/1.73m2. 239 adolescents had self-report survey data on smoking and SHS exposure: 21 [9%] subjects had “ever” smoked a cigarette. Among them, 4 were current and 17 were former smokers. Hypertension was more prevalent in those that had “ever” smoked a cigarette (42%) compared to non-smokers (9%), p\u3c0.01. Among 218 non-smokers, 130 (59%) were male, 142 (65%) were Caucasian; 60 (28%) reported SHS exposure compared to 158 (72%) with no exposure. Non-smoker adolescents with SHS exposure were compared to those without SHS exposure. There was no racial, age, or gender differences between both groups. Baseline creatinine, diastolic hypertension, C reactive protein, lipid profile, GFR and hemoglobin were not statistically different. Significantly higher protein to creatinine ratio (0.90 vs. 0.53, p\u3c0.01) was observed in those exposed to SHS compared to those not exposed. Exposed adolescents were heavier than non-exposed adolescents (85th percentile vs. 55th percentile for BMI, p\u3c 0.01). Uncontrolled casual systolic hypertension was twice as prevalent among those exposed to SHS (16%) compared to those not exposed to SHS (7%), though the difference was not statistically significant (p= 0.07). Adjusted multivariate regression analysis [OR (95% CI)] showed that increased protein to creatinine ratio [1.34 (1.03, 1.75)] and higher BMI [1.14 (1.02, 1.29)] were independently associated with exposure to SHS among non-smoker adolescents. These results reveal that among adolescents with CKD, cigarette use is low and SHS is highly prevalent. The association of smoking with hypertension and SHS with increased proteinuria suggests a possible role of these factors in CKD progression and cardiovascular outcomes

Antioxidant and DPPH-Scavenging Activities of Compounds and Ethanolic Extract of the Leaf and Twigs of Caesalpinia bonduc L. Roxb.

Antioxidant effects of ethanolic extract of Caesalpinia bonduc and its isolated bioactive compounds were evaluated in vitro. The compounds included two new cassanediterpenes, 1α,7α-diacetoxy-5α,6β-dihydroxyl-cass-14(15)-epoxy-16,12-olide (1)and 12α-ethoxyl-1α,14β-diacetoxy-2α,5α-dihydroxyl cass-13(15)-en-16,12-olide(2); and others, bonducellin (3), 7,4’-dihydroxy-3,11-dehydrohomoisoflavanone (4), daucosterol (5), luteolin (6), quercetin-3-methyl ether (7) and kaempferol-3-O-α-L-rhamnopyranosyl-(1Ç2)-β-D-xylopyranoside (8). The antioxidant properties of the extract and compounds were assessed by the measurement of the total phenolic content, ascorbic acid content, total antioxidant capacity and 1-1-diphenyl-2-picryl hydrazyl (DPPH) and hydrogen peroxide radicals scavenging activities.Compounds 3, 6, 7 and ethanolic extract had DPPH scavenging activities with IC50 values of 186, 75, 17 and 102 μg/ml respectively when compared to vitamin C with 15 μg/ml. On the other hand, no significant results were obtained for hydrogen peroxide radical. In addition, compound 7 has the highest phenolic content of 0.81±0.01 mg/ml of gallic acid equivalent while compound 8 showed the highest total antioxidant capacity with 254.31±3.54 and 199.82±2.78 μg/ml gallic and ascorbic acid equivalent respectively. Compound 4 and ethanolic extract showed a high ascorbic acid content of 2.26±0.01 and 6.78±0.03 mg/ml respectively.The results obtained showed the antioxidant activity of the ethanolic extract of C. bonduc and deduced that this activity was mediated by its isolated bioactive compounds

Food, Nutrition, Physical Activity, and the Prevention of Cancer: a Global Perspective

This Report has a number of inter-related general purposes. One is to explore the extent to which food, nutrition, physical activity, and body composition modify the risk of cancer, and to specify which factors are most important. To the extent that environmental factors such as food, nutrition, and physical activity influence the risk of cancer, it is a preventable disease. The Report specifies recommendations based on solid evidence which, when followed, will be expected to reduce the incidence of cancer