Automatic Estimation of Self-Reported Pain by Interpretable Representations of Motion Dynamics

We propose an automatic method for pain intensity measurement from video. For each video, pain intensity was measured using the dynamics of facial movement using 66 facial points. Gram matrices formulation was used for facial points trajectory representations on the Riemannian manifold of symmetric positive semi-definite matrices of fixed rank. Curve fitting and temporal alignment were then used to smooth the extracted trajectories. A Support Vector Regression model was then trained to encode the extracted trajectories into ten pain intensity levels consistent with the Visual Analogue Scale for pain intensity measurement. The proposed approach was evaluated using the UNBC McMaster Shoulder Pain Archive and was compared to the state-of-the-art on the same data. Using both 5-fold cross-validation and leave-one-subject-out cross-validation, our results are competitive with respect to state-of-the-art methods.Comment: accepted at ICPR 2020 Conferenc

Deep Interpretability Methods for Neuroimaging

Brain dynamics are highly complex and yet hold the key to understanding brain function and dysfunction. The dynamics captured by resting-state functional magnetic resonance imaging data are noisy, high-dimensional, and not readily interpretable. The typical approach of reducing this data to low-dimensional features and focusing on the most predictive features comes with strong assumptions and can miss essential aspects of the underlying dynamics. In contrast, introspection of discriminatively trained deep learning models may uncover disorder-relevant elements of the signal at the level of individual time points and spatial locations. Nevertheless, the difficulty of reliable training on high-dimensional but small-sample datasets and the unclear relevance of the resulting predictive markers prevent the widespread use of deep learning in functional neuroimaging. In this dissertation, we address these challenges by proposing a deep learning framework to learn from high-dimensional dynamical data while maintaining stable, ecologically valid interpretations. The developed model is pre-trainable and alleviates the need to collect an enormous amount of neuroimaging samples to achieve optimal training. We also provide a quantitative validation module, Retain and Retrain (RAR), that can objectively verify the higher predictability of the dynamics learned by the model. Results successfully demonstrate that the proposed framework enables learning the fMRI dynamics directly from small data and capturing compact, stable interpretations of features predictive of function and dysfunction. We also comprehensively reviewed deep interpretability literature in the neuroimaging domain. Our analysis reveals the ongoing trend of interpretability practices in neuroimaging studies and identifies the gaps that should be addressed for effective human-machine collaboration in this domain. This dissertation also proposed a post hoc interpretability method, Geometrically Guided Integrated Gradients (GGIG), that leverages geometric properties of the functional space as learned by a deep learning model. With extensive experiments and quantitative validation on MNIST and ImageNet datasets, we demonstrate that GGIG outperforms integrated gradients (IG), which is considered to be a popular interpretability method in the literature. As GGIG is able to identify the contours of the discriminative regions in the input space, GGIG may be useful in various medical imaging tasks where fine-grained localization as an explanation is beneficial

Discriminatively Trained Latent Ordinal Model for Video Classification

We study the problem of video classification for facial analysis and human action recognition. We propose a novel weakly supervised learning method that models the video as a sequence of automatically mined, discriminative sub-events (eg. onset and offset phase for "smile", running and jumping for "highjump"). The proposed model is inspired by the recent works on Multiple Instance Learning and latent SVM/HCRF -- it extends such frameworks to model the ordinal aspect in the videos, approximately. We obtain consistent improvements over relevant competitive baselines on four challenging and publicly available video based facial analysis datasets for prediction of expression, clinical pain and intent in dyadic conversations and on three challenging human action datasets. We also validate the method with qualitative results and show that they largely support the intuitions behind the method.Comment: Paper accepted in IEEE TPAMI. arXiv admin note: substantial text overlap with arXiv:1604.0150

Gamma Band Oscillation Response to Somatosensory Feedback Stimulation Schemes Constructed on Basis of Biphasic Neural Touch Representation

abstract: Prosthetic users abandon devices due to difficulties performing tasks without proper graded or interpretable feedback. The inability to adequately detect and correct error of the device leads to failure and frustration. In advanced prostheses, peripheral nerve stimulation can be used to deliver sensations, but standard schemes used in sensorized prosthetic systems induce percepts inconsistent with natural sensations, providing limited benefit. Recent uses of time varying stimulation strategies appear to produce more practical sensations, but without a clear path to pursue improvements. This dissertation examines the use of physiologically based stimulation strategies to elicit sensations that are more readily interpretable. A psychophysical experiment designed to investigate sensitivities to the discrimination of perturbation direction within precision grip suggests that perception is biomechanically referenced: increased sensitivities along the ulnar-radial axis align with potential anisotropic deformation of the finger pad, indicating somatosensation uses internal information rather than environmental. Contact-site and direction dependent deformation of the finger pad activates complimentary fast adapting and slow adapting mechanoreceptors, exhibiting parallel activity of the two associate temporal patterns: static and dynamic. The spectrum of temporal activity seen in somatosensory cortex can be explained by a combined representation of these distinct response dynamics, a phenomenon referred in this dissertation to “biphasic representation.” In a reach-to-precision-grasp task, neurons in somatosensory cortex were found to possess biphasic firing patterns in their responses to texture, orientation, and movement. Sensitivities seem to align with variable deformation and mechanoreceptor activity: movement and smooth texture responses align with potential fast adapting activation, non-movement and coarse texture responses align with potential increased slow adapting activation, and responses to orientation are conceptually consistent with coding of tangential load. Using evidence of biphasic representations’ association with perceptual priorities, gamma band phase locking is used to compare responses to peripheral nerve stimulation patterns and mechanical stimulation. Vibrotactile and punctate mechanical stimuli are used to represent the practical and impractical percepts commonly observed in peripheral nerve stimulation feedback. Standard patterns of constant parameters closely mimic impractical vibrotactile stimulation while biphasic patterns better mimic punctate stimulation and provide a platform to investigate intragrip dynamics representing contextual activation.Dissertation/ThesisDoctoral Dissertation Biomedical Engineering 201

Robust subspace learning for static and dynamic affect and behaviour modelling

Machine analysis of human affect and behavior in naturalistic contexts has witnessed a growing attention in the last decade from various disciplines ranging from social and cognitive sciences to machine learning and computer vision. Endowing machines with the ability to seamlessly detect, analyze, model, predict as well as simulate and synthesize manifestations of internal emotional and behavioral states in real-world data is deemed essential for the deployment of next-generation, emotionally- and socially-competent human-centered interfaces. In this thesis, we are primarily motivated by the problem of modeling, recognizing and predicting spontaneous expressions of non-verbal human affect and behavior manifested through either low-level facial attributes in static images or high-level semantic events in image sequences. Both visual data and annotations of naturalistic affect and behavior naturally contain noisy measurements of unbounded magnitude at random locations, commonly referred to as ‘outliers’. We present here machine learning methods that are robust to such gross, sparse noise. First, we deal with static analysis of face images, viewing the latter as a superposition of mutually-incoherent, low-complexity components corresponding to facial attributes, such as facial identity, expressions and activation of atomic facial muscle actions. We develop a robust, discriminant dictionary learning framework to extract these components from grossly corrupted training data and combine it with sparse representation to recognize the associated attributes. We demonstrate that our framework can jointly address interrelated classification tasks such as face and facial expression recognition. Inspired by the well-documented importance of the temporal aspect in perceiving affect and behavior, we direct the bulk of our research efforts into continuous-time modeling of dimensional affect and social behavior. Having identified a gap in the literature which is the lack of data containing annotations of social attitudes in continuous time and scale, we first curate a new audio-visual database of multi-party conversations from political debates annotated frame-by-frame in terms of real-valued conflict intensity and use it to conduct the first study on continuous-time conflict intensity estimation. Our experimental findings corroborate previous evidence indicating the inability of existing classifiers in capturing the hidden temporal structures of affective and behavioral displays. We present here a novel dynamic behavior analysis framework which models temporal dynamics in an explicit way, based on the natural assumption that continuous- time annotations of smoothly-varying affect or behavior can be viewed as outputs of a low-complexity linear dynamical system when behavioral cues (features) act as system inputs. A novel robust structured rank minimization framework is proposed to estimate the system parameters in the presence of gross corruptions and partially missing data. Experiments on prediction of dimensional conflict and affect as well as multi-object tracking from detection validate the effectiveness of our predictive framework and demonstrate that for the first time that complex human behavior and affect can be learned and predicted based on small training sets of person(s)-specific observations.Open Acces

Personalized face and gesture analysis using hierarchical neural networks

The video-based computational analyses of human face and gesture signals encompass a myriad of challenging research problems involving computer vision, machine learning and human computer interaction. In this thesis, we focus on the following challenges: a) the classification of hand and body gestures along with the temporal localization of their occurrence in a continuous stream, b) the recognition of facial expressivity levels in people with Parkinson's Disease using multimodal feature representations, c) the prediction of student learning outcomes in intelligent tutoring systems using affect signals, and d) the personalization of machine learning models, which can adapt to subject and group-specific nuances in facial and gestural behavior. Specifically, we first conduct a quantitative comparison of two approaches to the problem of segmenting and classifying gestures on two benchmark gesture datasets: a method that simultaneously segments and classifies gestures versus a cascaded method that performs the tasks sequentially. Second, we introduce a framework that computationally predicts an accurate score for facial expressivity and validate it on a dataset of interview videos of people with Parkinson's disease. Third, based on a unique dataset of videos of students interacting with MathSpring, an intelligent tutoring system, collected by our collaborative research team, we build models to predict learning outcomes from their facial affect signals. Finally, we propose a novel solution to a relatively unexplored area in automatic face and gesture analysis research: personalization of models to individuals and groups. We develop hierarchical Bayesian neural networks to overcome the challenges posed by group or subject-specific variations in face and gesture signals. We successfully validate our formulation on the problems of personalized subject-specific gesture classification, context-specific facial expressivity recognition and student-specific learning outcome prediction. We demonstrate the flexibility of our hierarchical framework by validating the utility of both fully connected and recurrent neural architectures