5,750 research outputs found
Computerized Analysis of Magnetic Resonance Images to Study Cerebral Anatomy in Developing Neonates
The study of cerebral anatomy in developing neonates is of great importance for
the understanding of brain development during the early period of life. This
dissertation therefore focuses on three challenges in the modelling of cerebral
anatomy in neonates during brain development. The methods that have been
developed all use Magnetic Resonance Images (MRI) as source data.
To facilitate study of vascular development in the neonatal period, a set of image
analysis algorithms are developed to automatically extract and model cerebral
vessel trees. The whole process consists of cerebral vessel tracking from
automatically placed seed points, vessel tree generation, and vasculature
registration and matching. These algorithms have been tested on clinical Time-of-
Flight (TOF) MR angiographic datasets.
To facilitate study of the neonatal cortex a complete cerebral cortex segmentation
and reconstruction pipeline has been developed. Segmentation of the neonatal
cortex is not effectively done by existing algorithms designed for the adult brain
because the contrast between grey and white matter is reversed. This causes pixels
containing tissue mixtures to be incorrectly labelled by conventional methods. The
neonatal cortical segmentation method that has been developed is based on a novel
expectation-maximization (EM) method with explicit correction for mislabelled
partial volume voxels. Based on the resulting cortical segmentation, an implicit
surface evolution technique is adopted for the reconstruction of the cortex in
neonates. The performance of the method is investigated by performing a detailed
landmark study.
To facilitate study of cortical development, a cortical surface registration algorithm
for aligning the cortical surface is developed. The method first inflates extracted
cortical surfaces and then performs a non-rigid surface registration using free-form
deformations (FFDs) to remove residual alignment. Validation experiments using
data labelled by an expert observer demonstrate that the method can capture local
changes and follow the growth of specific sulcus
Mesh-to-raster based non-rigid registration of multi-modal images
Region of interest (ROI) alignment in medical images plays a crucial role in
diagnostics, procedure planning, treatment, and follow-up. Frequently, a model
is represented as triangulated mesh while the patient data is provided from CAT
scanners as pixel or voxel data. Previously, we presented a 2D method for
curve-to-pixel registration. This paper contributes (i) a general
mesh-to-raster (M2R) framework to register ROIs in multi-modal images; (ii) a
3D surface-to-voxel application, and (iii) a comprehensive quantitative
evaluation in 2D using ground truth provided by the simultaneous truth and
performance level estimation (STAPLE) method. The registration is formulated as
a minimization problem where the objective consists of a data term, which
involves the signed distance function of the ROI from the reference image, and
a higher order elastic regularizer for the deformation. The evaluation is based
on quantitative light-induced fluoroscopy (QLF) and digital photography (DP) of
decalcified teeth. STAPLE is computed on 150 image pairs from 32 subjects, each
showing one corresponding tooth in both modalities. The ROI in each image is
manually marked by three experts (900 curves in total). In the QLF-DP setting,
our approach significantly outperforms the mutual information-based
registration algorithm implemented with the Insight Segmentation and
Registration Toolkit (ITK) and Elastix
Tex2Shape: Detailed Full Human Body Geometry From a Single Image
We present a simple yet effective method to infer detailed full human body shape from only a single photograph. Our model can infer full-body shape including face, hair, and clothing including wrinkles at interactive frame-rates. Results feature details even on parts that are occluded in the input image. Our main idea is to turn shape regression into an aligned image-to-image translation problem. The input to our method is a partial texture map of the visible region obtained from off-the-shelf methods. From a partial texture, we estimate detailed normal and vector displacement maps, which can be applied to a low-resolution smooth body model to add detail and clothing. Despite being trained purely with synthetic data, our model generalizes well to real-world photographs. Numerous results demonstrate the versatility and robustness of our method
Tex2Shape: Detailed Full Human Body Geometry From a Single Image
We present a simple yet effective method to infer detailed full human body
shape from only a single photograph. Our model can infer full-body shape
including face, hair, and clothing including wrinkles at interactive
frame-rates. Results feature details even on parts that are occluded in the
input image. Our main idea is to turn shape regression into an aligned
image-to-image translation problem. The input to our method is a partial
texture map of the visible region obtained from off-the-shelf methods. From a
partial texture, we estimate detailed normal and vector displacement maps,
which can be applied to a low-resolution smooth body model to add detail and
clothing. Despite being trained purely with synthetic data, our model
generalizes well to real-world photographs. Numerous results demonstrate the
versatility and robustness of our method
A statistical method (cross-validation) for bone loss region detection after spaceflight.
Astronauts experience bone loss after the long spaceflight missions. Identifying specific regions that undergo the greatest losses (e.g. the proximal femur) could reveal information about the processes of bone loss in disuse and disease. Methods for detecting such regions, however, remains an open problem. This paper focuses on statistical methods to detect such regions. We perform statistical parametric mapping to get t-maps of changes in images, and propose a new cross-validation method to select an optimum suprathreshold for forming clusters of pixels. Once these candidate clusters are formed, we use permutation testing of longitudinal labels to derive significant changes
- …