21,422 research outputs found
Segmentation of the left ventricle of the heart in 3-D+t MRI data using an optimized nonrigid temporal model
Modern medical imaging modalities provide large amounts of information in both the spatial and temporal domains and the incorporation of this information in a coherent algorithmic framework is a significant challenge. In this paper, we present a novel and intuitive approach to combine 3-D spatial and temporal (3-D + time) magnetic resonance imaging (MRI) data in an integrated segmentation algorithm to extract the myocardium of the left ventricle. A novel level-set segmentation process is developed that simultaneously delineates and tracks the boundaries of the left ventricle muscle. By encoding prior knowledge about cardiac temporal evolution in a parametric framework, an expectation-maximization algorithm optimally tracks the myocardial deformation over the cardiac cycle. The expectation step deforms the level-set function while the maximization step updates the prior temporal model parameters to perform the segmentation in a nonrigid sense
Locally Adaptive Bayesian P-Splines with a Normal-Exponential-Gamma Prior
The necessity to replace smoothing approaches with a global amount of smoothing arises in a variety of situations such as effects with highly varying curvature or effects with discontinuities. We present an implementation of locally adaptive spline smoothing using a class of heavy-tailed shrinkage priors. These priors utilize scale mixtures of normals with locally varying exponential-gamma distributed variances for the differences of the P-spline coefficients. A fully Bayesian hierarchical structure is derived with inference about the posterior being based on Markov Chain Monte Carlo techniques. Three increasingly flexible and automatic approaches are introduced to estimate the spatially varying structure of the variances. In an extensive simulation study, the performance of our approach on a number of benchmark functions is shown to be at least equivalent, but mostly better than previous approaches and fits both functions of smoothly varying complexity and discontinuous functions well. Results from two applications also reflecting these two situations support the simulation results
A statistical shape model for deformable surface
This short paper presents a deformable surface registration scheme which is based on the statistical shape
modelling technique. The method consists of two major processing stages, model building and model
fitting. A statistical shape model is first built using a set of training data. Then the model is deformed and
matched to the new data by a modified iterative closest point (ICP) registration process. The proposed
method is tested on real 3-D facial data from BU-3DFE database. It is shown that proposed method can
achieve a reasonable result on surface registration, and can be used for patient position monitoring in
radiation therapy and potentially can be used for monitoring of the radiation therapy progress for head and
neck patients by analysis of facial articulation
Approximating Data with weighted smoothing Splines
Given a data set (t_i, y_i), i=1,..., n with the t_i in [0,1] non-parametric
regression is concerned with the problem of specifying a suitable function
f_n:[0,1] -> R such that the data can be reasonably approximated by the points
(t_i, f_n(t_i)), i=1,..., n. If a data set exhibits large variations in local
behaviour, for example large peaks as in spectroscopy data, then the method
must be able to adapt to the local changes in smoothness. Whilst many methods
are able to accomplish this they are less successful at adapting derivatives.
In this paper we show how the goal of local adaptivity of the function and its
first and second derivatives can be attained in a simple manner using weighted
smoothing splines. A residual based concept of approximation is used which
forces local adaptivity of the regression function together with a global
regularization which makes the function as smooth as possible subject to the
approximation constraints
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