39 research outputs found

    Biomarkers in Neurodegenerative Diseases

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    This book focuses on the recent advancements in both fundamental and clinical research, focusing on identifying, developing, and applying new and improved biological markers for specific neurologic disorders in the future. The original research work and review articles published here highlight some unique mechanisms underlying the most prevalent pathophysiological conditions affecting human health. Other areas covered in the book include emerging treatment options and correct diagnoses using different biochemical and imaging techniques

    LIPIcs, Volume 277, GIScience 2023, Complete Volume

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    LIPIcs, Volume 277, GIScience 2023, Complete Volum

    12th International Conference on Geographic Information Science: GIScience 2023, September 12–15, 2023, Leeds, UK

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    Understanding Cognitive Variability in Alzheimer’s Disease

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    Alzheimer’s Disease (AD) is highly heterogenous, both clinically and biologically. This variability is exacerbated by the ways within which, the clinical presentation is assessed with cognitive measures. This inhibits clinical trial success and earlier diagnosis of individuals. Marrying the clinical presentation to the pathology of the disease has so far proved troublesome. This thesis will look at how cognitive measures can best capture the clinical presentation of AD and how these measures can link to the underlying pathology using machine learning methods. This thesis studied this problem across four analyses and two cohorts. Each study looked at a different aspect of cognitive testing within AD. This was done with the overarching aim to interrogate the cognitive variability across the spectrum of AD. Study 1 showed a novel discrepancy score is different to memory measures at screening for AD. It also showed it tracks with AD severity, in the same way memory recall does. Studies 2 & 3 uncovered broad psychometric variance within amnestic measurement of impairment due to AD. This was done in two different populations across two different constructs of amnestic measurement, story recall and verbal list learning. These tests are frequently used interchangeably. These two studies show they should not be. Finally, Study 4 built models from cognitive measures to predict AD pathology. The performance of these models was moderate showing that even with novel cognitive measures, further work is needed to link the clinical and amyloid related biological presentations of AD. Bridging the gap between clinical presentation and pathology of AD using clinical and cognitive markers alone is not possible. Even when using a novel measure of discrepancy score. The discrepancy measure shows promise but was limited due to the inability of the MMSE to measure verbal ability. Conceptually a discrepancy score remains a promising avenue of research for screening, but broader language measures, as well as other AD biomarkers are needed to further test the construct validity of this measure

    Automatic MRI volumetry in asymptomatic cases at risk for normal pressure hydrocephalus

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    The occurrence of significant Alzheimer’s disease (AD) pathology was described in approximately 30% of normal pressure hydrocephalus (NPH) cases, leading to the distinction between neurodegenerative and idiopathic forms of this disorder. Whether or not there is a specific MRI signature of NPH remains a matter of debate. The present study focuses on asymptomatic cases at risk for NPH as defined with automatic machine learning tools and combines automatic MRI assessment of cortical and white matter volumetry, risk of AD (AD-RAI), and brain age gap estimation (BrainAge). Our hypothesis was that brain aging and AD process-independent volumetric changes occur in asymptomatic NPH-positive cases. We explored the volumetric changes in normal aging-sensitive (entorhinal cortex and parahippocampal gyrus/PHG) and AD-signature areas (hippocampus), four control cortical areas (frontal, parietal, occipital, and temporal), and cerebral and cerebellar white matter in 30 asymptomatic cases at risk for NPH (NPH probability >30) compared to 30 NPH-negative cases (NPH probability <5) with preserved cognition. In univariate regression models, NPH positivity was associated with decreased volumes in the hippocampus, parahippocampal gyrus (PHG), and entorhinal cortex bilaterally. The strongest negative association was found in the left hippocampus that persisted when adjusting for AD-RAI and Brain Age values. A combined model including the three parameters explained 36.5% of the variance, left hippocampal volumes, and BrainAge values, which remained independent predictors of the NPH status. Bilateral PHG and entorhinal cortex volumes were negatively associated with NPH-positive status in univariate models but this relationship did not persist when adjusting for BrainAge, the latter remaining the only predictor of the NPH status. We also found a negative association between bilateral cerebral and cerebellar white matter volumes and NPH status that persisted after controlling for AD-RAI or Brain Age values, explaining between 50 and 65% of its variance. These observations support the idea that in cases at risk for NPH, as defined by support vector machine assessment of NPH-related MRI markers, brain aging-related and brain aging and AD-independent volumetric changes coexist. The latter concerns volume loss in restricted hippocampal and white matter areas that could be considered as the MRI signature of idiopathic forms of NPH

    Collected Papers (on Neutrosophics, Plithogenics, Hypersoft Set, Hypergraphs, and other topics), Volume X

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    This tenth volume of Collected Papers includes 86 papers in English and Spanish languages comprising 972 pages, written between 2014-2022 by the author alone or in collaboration with the following 105 co-authors (alphabetically ordered) from 26 countries: Abu Sufian, Ali Hassan, Ali Safaa Sadiq, Anirudha Ghosh, Assia Bakali, Atiqe Ur Rahman, Laura Bogdan, Willem K.M. Brauers, Erick González Caballero, Fausto Cavallaro, Gavrilă Calefariu, T. Chalapathi, Victor Christianto, Mihaela Colhon, Sergiu Boris Cononovici, Mamoni Dhar, Irfan Deli, Rebeca Escobar-Jara, Alexandru Gal, N. Gandotra, Sudipta Gayen, Vassilis C. Gerogiannis, Noel Batista Hernández, Hongnian Yu, Hongbo Wang, Mihaiela Iliescu, F. Nirmala Irudayam, Sripati Jha, Darjan Karabašević, T. Katican, Bakhtawar Ali Khan, Hina Khan, Volodymyr Krasnoholovets, R. Kiran Kumar, Manoranjan Kumar Singh, Ranjan Kumar, M. Lathamaheswari, Yasar Mahmood, Nivetha Martin, Adrian Mărgean, Octavian Melinte, Mingcong Deng, Marcel Migdalovici, Monika Moga, Sana Moin, Mohamed Abdel-Basset, Mohamed Elhoseny, Rehab Mohamed, Mohamed Talea, Kalyan Mondal, Muhammad Aslam, Muhammad Aslam Malik, Muhammad Ihsan, Muhammad Naveed Jafar, Muhammad Rayees Ahmad, Muhammad Saeed, Muhammad Saqlain, Muhammad Shabir, Mujahid Abbas, Mumtaz Ali, Radu I. Munteanu, Ghulam Murtaza, Munazza Naz, Tahsin Oner, ‪Gabrijela Popović‬‬‬‬‬, Surapati Pramanik, R. Priya, S.P. Priyadharshini, Midha Qayyum, Quang-Thinh Bui, Shazia Rana, Akbara Rezaei, Jesús Estupiñán Ricardo, Rıdvan Sahin, Saeeda Mirvakili, Said Broumi, A. A. Salama, Flavius Aurelian Sârbu, Ganeshsree Selvachandran, Javid Shabbir, Shio Gai Quek, Son Hoang Le, Florentin Smarandache, Dragiša Stanujkić, S. Sudha, Taha Yasin Ozturk, Zaigham Tahir, The Houw Iong, Ayse Topal, Alptekin Ulutaș, Maikel Yelandi Leyva Vázquez, Rizha Vitania, Luige Vlădăreanu, Victor Vlădăreanu, Ștefan Vlăduțescu, J. Vimala, Dan Valeriu Voinea, Adem Yolcu, Yongfei Feng, Abd El-Nasser H. Zaied, Edmundas Kazimieras Zavadskas.‬

    Serious Games and Mixed Reality Applications for Healthcare

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    Virtual reality (VR) and augmented reality (AR) have long histories in the healthcare sector, offering the opportunity to develop a wide range of tools and applications aimed at improving the quality of care and efficiency of services for professionals and patients alike. The best-known examples of VR–AR applications in the healthcare domain include surgical planning and medical training by means of simulation technologies. Techniques used in surgical simulation have also been applied to cognitive and motor rehabilitation, pain management, and patient and professional education. Serious games are ones in which the main goal is not entertainment, but a crucial purpose, ranging from the acquisition of knowledge to interactive training.These games are attracting growing attention in healthcare because of their several benefits: motivation, interactivity, adaptation to user competence level, flexibility in time, repeatability, and continuous feedback. Recently, healthcare has also become one of the biggest adopters of mixed reality (MR), which merges real and virtual content to generate novel environments, where physical and digital objects not only coexist, but are also capable of interacting with each other in real time, encompassing both VR and AR applications.This Special Issue aims to gather and publish original scientific contributions exploring opportunities and addressing challenges in both the theoretical and applied aspects of VR–AR and MR applications in healthcare

    A framework for AI-driven neurorehabilitation training: the profiling challenge

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    Cognitive decline is a common sign that a person is ageing. However, abnormal cases can lead to dementia, affecting daily living activities and independent functioning. It is a leading cause of disability and death. Its prevention is a global health priority. One way to address cognitive decline is to undergo cognitive rehabilitation. Cognitive rehabilitation aims to restore or mitigate the symptoms of a cognitive disability, increasing the quality of life for the patient. However, cognitive rehabilitation is stuck to clinical environments and logistics, leading to a suboptimal set of expansive tools that is hard to accommodate every patient’s needs. The BRaNT project aims to create a tool that mitigates this problem. The NeuroAIreh@b is a rehabilitation tool developed within a framework that combines neuropsychological assessments, neurorehabilitation procedures, artificial intelligence and game design, composing a tool that is easy to set up in a clinical environment and accessible to adapt to every patient’s needs. Among all the challenges within NeuroAlreh@b, one focuses on representing a cognitive profile through the aggregation of multiple neuropsychological assessments. To test this possibility, we will need data from patients currently unavailable. In the first part of this master’s project, study the possibility of aggregating neuropsychological assessments for the case of Alzheimer’s disease using the Alzheimer’s Disease Neuroimaging Initiative database. This database contains a vast collection of images and neuropsychological assessments that will serve as a baseline for the NeuroAlreh@b when the time comes. In the second part of this project, we set up a computational system to run all the artificial intelligence models and simulations required for the BRaNT project. The system allocates a database and a webserver to serve all the required pages for the project.O declínio cognitivo é um sinal comum de que uma pessoa está a envelhecer. No entanto, casos anormais podem levar à demência, afetando as atividades diárias e funcionamento independente. Demência é uma das principais causas de incapacidade e morte. Fazendo da sua prevenção uma prioridade para a saúde global. Uma forma de lidar com o declínio cognitivo é submeter-se à reabilitação cognitiva. A reabilitação cognitiva visa restaurar ou mitigar os sintomas de uma deficiência cognitiva, aumentando a qualidade de vida do paciente. No entanto, a reabilitação cognitiva está presa a ambientes clínicos e logística, levando a um conjunto sub-ideal de ferramentas com custos elevados e complicadas de acomodar as necessidades de cada paciente. O projeto BRaNT visa criar uma ferramenta que atenue este problema. O NeuroAIreh@b é uma ferramenta de reabilitação desenvolvida num quadro que combina avaliações neuropsicológicas, reabilitação, inteligência artificial e design de jogos, compondo uma ferramenta fácil de adaptar a um ambiente clínico e acessível para se adaptar às necessidades de cada paciente. Entre todos os desafios dentro de NeuroAlreh@b, foca-se em representar um perfil cognitivo através da agregação de múltiplas avaliações neuropsicológicas. Para testar esta possibilidade, precisaremos de dados de pacientes, que atualmente não temos. Na primeira parte do projeto deste mestrado, vamos testar a possibilidade de agregar avaliações neuropsicológicas para o caso da doença de Alzheimer utilizando a base de dados da Iniciativa de Neuroimagem da Doença de Alzheimer. Esta base de dados contém uma vasta coleção de imagens e avaliações neuropsicológicas que servirão de base para o NeuroAlreh@b quando chegar a hora. Na segunda parte deste projeto, vamos criar um sistema informático para executar todos os modelos e simulações de inteligência artificial necessários para o projeto BRaNT. O sistema também irá alocar uma base de dados e um webserver para servir todas as páginas necessárias para o projeto
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