A Survey on Service Composition Middleware in Pervasive Environments

The development of pervasive computing has put the light on a challenging problem: how to dynamically compose services in heterogeneous and highly changing environments? We propose a survey that defines the service composition as a sequence of four steps: the translation, the generation, the evaluation, and finally the execution. With this powerful and simple model we describe the major service composition middleware. Then, a classification of these service composition middleware according to pervasive requirements - interoperability, discoverability, adaptability, context awareness, QoS management, security, spontaneous management, and autonomous management - is given. The classification highlights what has been done and what remains to do to develop the service composition in pervasive environments

Prosper: image and robot-guided prostate brachytherapy

Brachytherapy for localized prostate cancer consists in destroying cancer by introducing iodine radioactive seeds into the gland through hollow needles. The planning of the position of the seeds and their introduction into the prostate is based on intra-operative ultrasound (US) imaging. We propose to optimize the global quality of the procedure by: i) using 3D US; ii) enhancing US data with MRI registration; iii) using a specially designed needle-insertion robot, connected to the imaging data. The imaging methods have been successfully tested on patient data while the robot accuracy has been evaluated on a realistic deformable phantom

A retrospective view on the promise on machine translation for Bahasa Melayu-English

Research and development activities for machine translation systems from English language to others are more progressive than vice versa. It has been more than 30 years since the machine translation was introduced and yet a Malay language or Bahasa Melayu (BM) to English machine translation engine is not available. Consequently, many translation systems have been developed for the world's top 10 languages in terms of native speakers, but none for BM, although the language is used by more than 200 million speakers around the world. This paper attempts to seek possible reasons as why such situation occurs. A summative overview to show progress, challenges as well as future works on MT is presented. Issues faced by researchers and system developers in modeling and developing a machine translation engine are also discussed. The study of the previous translation systems (from other languages to English) reveals that the accuracy level can be achieved up to 85 %. The figure suggests that the translation system is not reliable if it is to be utilized in a serious translation activity. The most prominent difficulties are the complexity of grammar rules and ambiguity problems of the source language. Thus, we hypothesize that the inclusion of ‘semantic’ property in the translation rules may produce a better quality BM-English MT engine

Intelligent agent simulator in massive crowd

Crowd simulations have many benefits over real-life research such as in computer games, architecture and entertainment. One of the key elements in this study is to include elements of decision-making into the crowd. The aim of this simulator is to simulate the features of an intelligent agent to escape from crowded environments especially in one-way corridor, two-way corridor and four-way intersection. The addition of the graphical user interface enables intuitive and fast handling in all settings and features of the Intelligent Agent Simulator and allows convenient research in the field of intelligent behaviour in massive crowd. This paper describes the development of a simulator by using the Open Graphics Library (OpenGL), starting from the production of training data, the simulation process, until the simulation results. The Social Force Model (SFM) is used to generate the motion of agents and the Support Vector Machine (SVM) is used to predict the next step for intelligent agent

An Ontology-Based Method for Semantic Integration of Business Components

Building new business information systems from reusable components is today an approach widely adopted and used. Using this approach in analysis and design phases presents a great interest and requires the use of a particular class of components called Business Components (BC). Business Components are today developed by several manufacturers and are available in many repositories. However, reusing and integrating them in a new Information System requires detection and resolution of semantic conflicts. Moreover, most of integration and semantic conflict resolution systems rely on ontology alignment methods based on domain ontology. This work is positioned at the intersection of two research areas: Integration of reusable Business Components and alignment of ontologies for semantic conflict resolution. Our contribution concerns both the proposal of a BC integration solution based on ontologies alignment and a method for enriching the domain ontology used as a support for alignment.Comment: IEEE New Technologies of Distributed Systems (NOTERE), 2011 11th Annual International Conference; ISSN: 2162-1896 Print ISBN: 978-1-4577-0729-2 INSPEC Accession Number: 12122775 201

Overcoming the false-minima problem in direct methods: Structure determination of the packaging enzyme P4 from bacteriophage φ13

The problems encountered during the phasing and structure determination of the packaging enzyme P4 from bacteriophage φ13 using the anomalous signal from selenium in a single-wavelength anomalous dispersion experiment (SAD) are described. The oligomeric state of P4 in the virus is a hexamer (with sixfold rotational symmetry) and it crystallizes in space group C2, with four hexamers in the crystallographic asymmetric unit. Current state-of-the-art ab initio phasing software yielded solutions consisting of 96 atoms arranged as sixfold symmetric clusters of Se atoms. However, although these solutions showed high correlation coefficients indicative that the substructure had been solved, the resulting phases produced uninterpretable electron-density maps. Only after further analysis were correct solutions found (also of 96 atoms), leading to the eventual identification of the positions of 120 Se atoms. Here, it is demonstrated how the difficulties in finding a correct phase solution arise from an intricate false-minima problem. © 2005 International Union of Crystallography - all rights reserved

Ribosomal oxygenases are structurally conserved from prokaryotes to humans

2-Oxoglutarate (2OG)-dependent oxygenases have important roles in the regulation of gene expression via demethylation of N-methylated chromatin components1,2 and in the hydroxylation of transcription factors3 and splicing factor proteins4. Recently, 2OG-dependent oxygenases that catalyse hydroxylation of transfer RNA5,6,7 and ribosomal proteins8 have been shown to be important in translation relating to cellular growth, TH17-cell differentiation and translational accuracy9,10,11,12. The finding that ribosomal oxygenases (ROXs) occur in organisms ranging from prokaryotes to humans8 raises questions as to their structural and evolutionary relationships. In Escherichia coli, YcfD catalyses arginine hydroxylation in the ribosomal protein L16; in humans, MYC-induced nuclear antigen (MINA53; also known as MINA) and nucleolar protein 66 (NO66) catalyse histidine hydroxylation in the ribosomal proteins RPL27A and RPL8, respectively. The functional assignments of ROXs open therapeutic possibilities via either ROX inhibition or targeting of differentially modified ribosomes. Despite differences in the residue and protein selectivities of prokaryotic and eukaryotic ROXs, comparison of the crystal structures of E. coli YcfD and Rhodothermus marinus YcfD with those of human MINA53 and NO66 reveals highly conserved folds and novel dimerization modes defining a new structural subfamily of 2OG-dependent oxygenases. ROX structures with and without their substrates support their functional assignments as hydroxylases but not demethylases, and reveal how the subfamily has evolved to catalyse the hydroxylation of different residue side chains of ribosomal proteins. Comparison of ROX crystal structures with those of other JmjC-domain-containing hydroxylases, including the hypoxia-inducible factor asparaginyl hydroxylase FIH and histone Nε-methyl lysine demethylases, identifies branch points in 2OG-dependent oxygenase evolution and distinguishes between JmjC-containing hydroxylases and demethylases catalysing modifications of translational and transcriptional machinery. The structures reveal that new protein hydroxylation activities can evolve by changing the coordination position from which the iron-bound substrate-oxidizing species reacts. This coordination flexibility has probably contributed to the evolution of the wide range of reactions catalysed by oxygenases