An Automated System for Epilepsy Detection using EEG Brain Signals based on Deep Learning Approach

Epilepsy is a neurological disorder and for its detection, encephalography (EEG) is a commonly used clinical approach. Manual inspection of EEG brain signals is a time-consuming and laborious process, which puts heavy burden on neurologists and affects their performance. Several automatic techniques have been proposed using traditional approaches to assist neurologists in detecting binary epilepsy scenarios e.g. seizure vs. non-seizure or normal vs. ictal. These methods do not perform well when classifying ternary case e.g. ictal vs. normal vs. inter-ictal; the maximum accuracy for this case by the state-of-the-art-methods is 97+-1%. To overcome this problem, we propose a system based on deep learning, which is an ensemble of pyramidal one-dimensional convolutional neural network (P-1D-CNN) models. In a CNN model, the bottleneck is the large number of learnable parameters. P-1D-CNN works on the concept of refinement approach and it results in 60% fewer parameters compared to traditional CNN models. Further to overcome the limitations of small amount of data, we proposed augmentation schemes for learning P-1D-CNN model. In almost all the cases concerning epilepsy detection, the proposed system gives an accuracy of 99.1+-0.9% on the University of Bonn dataset.Comment: 18 page

High-performance detection of epilepsy in seizure-free EEG recordings: A novel machine learning approach using very specific epileptic EEG sub-bands

We applied machine learning to diagnose epilepsy based on the fine-graded spectral analysis of seizure-free (resting state) EEG recordings. Despite using unspecific agglomerated EEG spectra, our fine-graded spectral analysis specifically identified the two EEG resting state sub-bands differentiating healthy people from epileptics (1.5-2 Hz and 11-12.5 Hz). The rigorous evaluation of completely unseen data of 100 EEG recordings (50 belonging to epileptics and the other 50 to healthy people) shows that the approach works successfully, achieving an outstanding accuracy of 99 percent, which significantly outperforms the current benchmark of 70% to 95% by a panel of up to three experienced neurologists. Our epilepsy diagnosis classifier can be implemented in modern EEG analysis devices, especially in intensive care units where early diagnosis and appropriate treatment are decisive in life and death scenarios and where physicians’ error rates are particularly high. Our approach is accurate, robust, fast, and cost-efficient and substantially contributes to Information Systems research in healthcare. The approach is also of high practical and theoretical relevance

Towards developing a reliable medical device for automated epileptic seizure detection in the ICU

Abstract. Epilepsy is a prevalent neurological disorder that affects millions of people globally, and its diagnosis typically involves laborious manual inspection of electroencephalography (EEG) data. Automated detection of epileptic seizures in EEG signals could potentially improve diagnostic accuracy and reduce diagnosis time, but there should be special attention to the number of false alarms to reduce unnecessary treatments and costs. This research presents a study on the use of machine learning techniques for EEG seizure detection with the aim of investigating the effectiveness of different algorithms in terms of high sensitivity and low false alarm rates for feature extraction, selection, pre-processing, classification, and post-processing in designing a medical device for detecting seizure activity in EEG data. The current state-of-the-art methods which are validated clinically using large amounts of data are introduced. The study focuses on finding potential machine learning methods, considering KNN, SVM, decision trees and, Random forests, and compares their performance on the task of seizure detection using features introduced in the literature. Also using ensemble methods namely, bootstrapping and majority voting techniques we achieved a sensitivity of 0.80 and FAR/h of 2.10, accuracy of 97.1% and specificity of 98.2%. Overall, the findings of this study can be useful for developing more accurate and efficient algorithms for EEG seizure detection medical device, which can contribute to the early diagnosis and treatment of epilepsy in the intensive care unit for critically ill patients

An EEG Signal Recognition Algorithm During Epileptic Seizure Based on Distributed Edge Computing

Epilepsy is one kind of brain diseases, and its sudden unpredictability is the main cause of disability and even death. Thus, it is of great significance to identify electroencephalogram (EEG) during the seizure quickly and accurately. With the rise of cloud computing and edge computing, the interface between local detection and cloud recognition is established, which promotes the development of portable EEG detection and diagnosis. Thus, we construct a framework for identifying EEG signals in epileptic seizure based on cloud-edge computing. The EEG signals are obtained in real time locally, and the horizontal viewable model is established at the edge to enhance the internal correlation of the signals. The Takagi-Sugeno-Kang (TSK) fuzzy system is established to analyze the epileptic signals. In the cloud, the fusion of clinical features and signal features is established to establish a deep learning framework. Through local signal acquisition, edge signal processing and cloud signal recognition, the diagnosis of epilepsy is realized, which can provide a new idea for the real-time diagnosis and feedback of EEG during epileptic seizure

Klasifikasi Epileptiform dan Wicket Spikes Menggunakan Metode Key-Point Based Local Binary Pattern

Epilepsi adalah gangguan kronis otak disebabkan oleh adanya lepasan muatan listrik abnormal yang berlebihan di neuron-neuron otak secara berlebihan di neuron-neuron otak secara paroksismal dan disebabkan oleh berbagai etiologi, bukan disebabkan oleh penyakit otak akut. Sampai saat ini jumlah penderita Epilepsi mencapai 50 juta di seluruh dunia. Di Indonesia diperkirakan kesalahan diagnosis epilepsi mencapai 20-30%. Salah satu metode yang lazim digunakan untuk pemeriksaan epilepsi adalah dengan melakukan perekaman Electroencephalogram (EEG) kemudian dilanjutkan dengan melakukan diagnosis berdasarkan hasil rekaman sinyal EEG yang dihasilkan. Proses pemeriksaan secara manual oleh dokter ini merupakan proses yang panjang dan melelahkan sehingga tidak jarang menyebabkan terjadinya kesalahan dan over-diagnosis. Salah satu jenis sinyal EEG yang cukup sering salah dianggap sebagai sinyal tanda epilepsi adalah Wicket spikes. Wicket spikes merupakan sinyal wicket yang muncul saat pasien mengalami tidur ringan pada saat pemeriksaan EEG, bentuknya yang mirip sering disalah-artikan sebagai epileptiform sharp wave. Pada penelitian ini, diajukan metode Key-Point Local Binary Pattern dan Support Vector Machine untuk melakukan klasifikasi antara Epileptiform dan Wicket spikes. Metode yang diajukan termasuk pendeteksian Key-Point pada sinyal yang sebelumnya telah melalui proses konvolusi dengan filter gaussian. Local Binary Pattern kemudian akan dihasilkan berdasarkan lokasi Key-Point. Kemudian hasil histogram tersebut akan dimasukkan ke dalam Support Vector Machine untuk diklasifikasikan. Hasil proses klasifikasi berupa hyperplane yang mengklasifikasikan tiga kelas yaitu normal, epileptiform dan wicket spikes. Didapatkan metode yang diajukan memiliki tingkat keberhasilan sebesar 96% persen untuk klasifikasi pada Epileptiform dan Wicket spikes dan lebih besar dari yang ada pada saat ini

Deep learning approach for epileptic seizure detection

Abstract. Epilepsy is the most common brain disorder that affects approximately fifty million people worldwide, according to the World Health Organization. The diagnosis of epilepsy relies on manual inspection of EEG, which is error-prone and time-consuming. Automated epileptic seizure detection of EEG signal can reduce the diagnosis time and facilitate targeting of treatment for patients. Current detection approaches mainly rely on the features that are designed manually by domain experts. The features are inflexible for the detection of a variety of complex patterns in a large amount of EEG data. Moreover, the EEG is non-stationary signal and seizure patterns vary across patients and recording sessions. EEG data always contain numerous noise types that negatively affect the detection accuracy of epileptic seizures. To address these challenges deep learning approaches are examined in this paper. Deep learning methods were applied to a large publicly available dataset, the Children’s Hospital of Boston-Massachusetts Institute of Technology dataset (CHB-MIT). The present study includes three experimental groups that are grouped based on the pre-processing steps. The experimental groups contain 3–4 experiments that differ between their objectives. The time-series EEG data is first pre-processed by certain filters and normalization techniques, and then the pre-processed signal was segmented into a sequence of non-overlapping epochs. Second, time series data were transformed into different representations of input signals. In this study time-series EEG signal, magnitude spectrograms, 1D-FFT, 2D-FFT, 2D-FFT magnitude spectrum and 2D-FFT phase spectrum were investigated and compared with each other. Third, time-domain or frequency-domain signals were used separately as a representation of input data of VGG or DenseNet 1D. The best result was achieved with magnitude spectrograms used as representation of input data in VGG model: accuracy of 0.98, sensitivity of 0.71 and specificity of 0.998 with subject dependent data. VGG along with magnitude spectrograms produced promising results for building personalized epileptic seizure detector. There was not enough data for VGG and DenseNet 1D to build subject-dependent classifier.Epileptisten kohtausten havaitseminen syväoppimisella lähestymistavalla. Tiivistelmä. Epilepsia on yleisin aivosairaus, joka Maailman terveysjärjestön mukaan vaikuttaa noin viiteenkymmeneen miljoonaan ihmiseen maailmanlaajuisesti. Epilepsian diagnosointi perustuu EEG:n manuaaliseen tarkastamiseen, mikä on virhealtista ja aikaa vievää. Automaattinen epileptisten kohtausten havaitseminen EEG-signaalista voi potentiaalisesti vähentää diagnoosiaikaa ja helpottaa potilaan hoidon kohdentamista. Nykyiset tunnistusmenetelmät tukeutuvat pääasiassa piirteisiin, jotka asiantuntijat ovat määritelleet manuaalisesti, mutta ne ovat joustamattomia monimutkaisten ilmiöiden havaitsemiseksi suuresta määrästä EEG-dataa. Lisäksi, EEG on epästationäärinen signaali ja kohtauspiirteet vaihtelevat potilaiden ja tallennusten välillä ja EEG-data sisältää aina useita kohinatyyppejä, jotka huonontavat epilepsiakohtauksen havaitsemisen tarkkuutta. Näihin haasteisiin vastaamiseksi tässä diplomityössä tarkastellaan soveltuvatko syväoppivat menetelmät epilepsian havaitsemiseen EEG-tallenteista. Aineistona käytettiin suurta julkisesti saatavilla olevaa Bostonin Massachusetts Institute of Technology lastenklinikan tietoaineistoa (CHB-MIT). Tämän työn tutkimus sisältää kolme koeryhmää, jotka eroavat toisistaan esikäsittelyvaiheiden osalta: aikasarja-EEG-data esikäsiteltiin perinteisten suodattimien ja normalisointitekniikoiden avulla, ja näin esikäsitelty signaali segmentoitiin epookkeihin. Kukin koeryhmä sisältää 3–4 koetta, jotka eroavat menetelmiltään ja tavoitteiltaan. Kussakin niistä epookkeihin jaettu aikasarjadata muutettiin syötesignaalien erilaisiksi esitysmuodoiksi. Tässä tutkimuksessa tutkittiin ja verrattiin keskenään EEG-signaalia sellaisenaan, EEG-signaalin amplitudi-spektrogrammeja, 1D-FFT-, 2D-FFT-, 2D-FFT-amplitudi- ja 2D-FFT -vaihespektriä. Näin saatuja aika- ja taajuusalueen signaaleja käytettiin erikseen VGG- tai DenseNet 1D -mallien syötetietoina. Paras tulos saatiin VGG-mallilla kun syötetietona oli amplitudi-spektrogrammi ja tällöin tarkkuus oli 0,98, herkkyys 0,71 ja spesifisyys 0,99 henkilöstä riippuvaisella EEG-datalla. VGG yhdessä amplitudi-spektrogrammien kanssa tuottivat lupaavia tuloksia henkilökohtaisen epilepsiakohtausdetektorin rakentamiselle. VGG- ja DenseNet 1D -malleille ei ollut tarpeeksi EEG-dataa henkilöstä riippumattoman luokittelijan opettamiseksi

Is EEG a Useful Examination Tool for Diagnosis of Epilepsy and Comorbid Psychiatric Disorders?

Diagnosis of epilepsy usually involves interviewing the patients and the individuals who witnessed the seizure. An electroencephalogram (EEG) adds useful information for the diagnosis of epilepsy when epileptic abnormalities emerge. EEG exhibits nonlinearity and weak stationarity. Thus, nonlinear EEG analysis may be useful for clinical application. We examined only about English language studies of nonlinear EEG analysis that compared normal EEG and interictal EEG and reported the accuracy. We identified 60 studies from the public data of Andrzejak 2001 and two studies that did not use the data of Andrzejak 2001. Comorbid psychiatric disorders in patients with epilepsy were not reported in nonlinear EEG analysis except for one case series of comorbid psychotic disorders. Using a variety of feature extraction methods and classifier methods, we concluded that the studies that used the data of Andrzejak 2001 played a valuable role in EEG diagnosis of epilepsy. In the future, according to the evolution of artificial intelligence, deep learning, new nonlinear analysis methods, and the EEG association with the rating scale of the quality of life and psychiatric symptoms, we anticipate that EEG diagnosis of epilepsy, seizures, and comorbid psychiatric disorders in patients with epilepsy will be possible

Advanced framework for epilepsy detection through image-based EEG signal analysis

BackgroundRecurrent and unpredictable seizures characterize epilepsy, a neurological disorder affecting millions worldwide. Epilepsy diagnosis is crucial for timely treatment and better outcomes. Electroencephalography (EEG) time-series data analysis is essential for epilepsy diagnosis and surveillance. Complex signal processing methods used in traditional EEG analysis are computationally demanding and difficult to generalize across patients. Researchers are using machine learning to improve epilepsy detection, particularly visual feature extraction from EEG time-series data.ObjectiveThis study examines the application of a Gramian Angular Summation Field (GASF) approach for the analysis of EEG signals. Additionally, it explores the utilization of image features, specifically the Scale-Invariant Feature Transform (SIFT) and Oriented FAST and Rotated BRIEF (ORB) techniques, for the purpose of epilepsy detection in EEG data.MethodsThe proposed methodology encompasses the transformation of EEG signals into images based on GASF, followed by the extraction of features utilizing SIFT and ORB techniques, and ultimately, the selection of relevant features. A state-of-the-art machine learning classifier is employed to classify GASF images into two categories: normal EEG patterns and focal EEG patterns. Bern-Barcelona EEG recordings were used to test the proposed method.ResultsThis method classifies EEG signals with 96% accuracy using SIFT features and 94% using ORB features. The Random Forest (RF) classifier surpasses state-of-the-art approaches in precision, recall, F1-score, specificity, and Area Under Curve (AUC). The Receiver Operating Characteristic (ROC) curve shows that Random Forest outperforms Support Vector Machine (SVM) and k-Nearest Neighbors (k-NN) classifiers.SignificanceThe suggested method has many advantages over time-series EEG data analysis and machine learning classifiers used in epilepsy detection studies. A novel image-based preprocessing pipeline using GASF for robust image synthesis and SIFT and ORB for feature extraction is presented here. The study found that the suggested method can accurately discriminate between normal and focal EEG signals, improving patient outcomes through early and accurate epilepsy diagnosis