Multimodal Signal Processing for Diagnosis of Cardiorespiratory Disorders

This thesis addresses the use of multimodal signal processing to develop algorithms for the automated processing of two cardiorespiratory disorders. The aim of the first application of this thesis was to reduce false alarm rate in an intensive care unit. The goal was to detect five critical arrhythmias using processing of multimodal signals including photoplethysmography, arterial blood pressure, Lead II and augmented right arm electrocardiogram (ECG). A hierarchical approach was used to process the signals as well as a custom signal processing technique for each arrhythmia type. Sleep disorders are a prevalent health issue, currently costly and inconvenient to diagnose, as they normally require an overnight hospital stay by the patient. In the second application of this project, we designed automated signal processing algorithms for the diagnosis of sleep apnoea with a main focus on the ECG signal processing. We estimated the ECG-derived respiratory (EDR) signal using different methods: QRS-complex area, principal component analysis (PCA) and kernel PCA. We proposed two algorithms (segmented PCA and approximated PCA) for EDR estimation to enable applying the PCA method to overnight recordings and rectify the computational issues and memory requirement. We compared the EDR information against the chest respiratory effort signals. The performance was evaluated using three automated machine learning algorithms of linear discriminant analysis (LDA), extreme learning machine (ELM) and support vector machine (SVM) on two databases: the MIT PhysioNet database and the St. Vincent’s database. The results showed that the QRS area method for EDR estimation combined with the LDA classifier was the highest performing method and the EDR signals contain respiratory information useful for discriminating sleep apnoea. As a final step, heart rate variability (HRV) and cardiopulmonary coupling (CPC) features were extracted and combined with the EDR features and temporal optimisation techniques were applied. The cross-validation results of the minute-by-minute apnoea classification achieved an accuracy of 89%, a sensitivity of 90%, a specificity of 88%, and an AUC of 0.95 which is comparable to the best results reported in the literature

A review of automated sleep disorder detection

Automated sleep disorder detection is challenging because physiological symptoms can vary widely. These variations make it difficult to create effective sleep disorder detection models which support hu-man experts during diagnosis and treatment monitoring. From 2010 to 2021, authors of 95 scientific papers have taken up the challenge of automating sleep disorder detection. This paper provides an expert review of this work. We investigated whether digital technology and Artificial Intelligence (AI) can provide automated diagnosis support for sleep disorders. We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines during the content discovery phase. We compared the performance of proposed sleep disorder detection methods, involving differ-ent datasets or signals. During the review, we found eight sleep disorders, of which sleep apnea and insomnia were the most studied. These disorders can be diagnosed using several kinds of biomedical signals, such as Electrocardiogram (ECG), Polysomnography (PSG), Electroencephalogram (EEG), Electromyogram (EMG), and snore sound. Subsequently, we established areas of commonality and distinctiveness. Common to all reviewed papers was that AI models were trained and tested with labelled physiological signals. Looking deeper, we discovered that 24 distinct algorithms were used for the detection task. The nature of these algorithms evolved, before 2017 only traditional Machine Learning (ML) was used. From 2018 onward, both ML and Deep Learning (DL) methods were used for sleep disorder detection. The strong emergence of DL algorithms has considerable implications for future detection systems because these algorithms demand significantly more data for training and testing when compared with ML. Based on our review results, we suggest that both type and amount of labelled data is crucial for the design of future sleep disorder detection systems because this will steer the choice of AI algorithm which establishes the desired decision support. As a guiding principle, more labelled data will help to represent the variations in symptoms. DL algorithms can extract information from these larger data quantities more effectively, therefore; we predict that the role of these algorithms will continue to expand

Detection of Obstructive Sleep Apnea from ECG Signal using SVM based Grid Search

Obstructive Sleep Apnea is one common form of sleep apnea and is now tested by means of a process called Polysomnography which is time-consuming, expensive and also requires a human observer throughout the study of the subject which makes it inconvenient and new detection techniques are now being developed to overcome these difficulties. Heart rate variability has proven to be related to sleep apnea episodes and thus the features from the ECG signal can be used in the detection of sleep apnea. The proposed detection technique uses Support Vector Machines using Grid search algorithm and the classifier is trained using features based on heart rate variability derived from the ECG signal. The developed system is tested using the dataset and the results show that this classification system can recognize the disorder with an accuracy rate of 89%. Further, the use of the grid search algorithm has made this system a reliable and an accurate means for the classification of sleep apnea and can serve as a basis for the future development of its screening

Towards an accurate sleep apnea detection based on ECG signal: The quintessential of a wise feature selection

A wise feature selection from minute-to-minute Electrocardiogram (ECG) signal is a challenging task for many reasons, but mostly because of the promise of the accurate detection of clinical disorders, such as the sleep apnea. In this study, the ECG signal was modeled in order to obtain the Heart Rate Variability (HRV) and the ECG-Derived Respiration (EDR). Selected features techniques were used for benchmark with different classifiers such as Artificial Neural Networks (ANN) and Support Vector Machine(SVM), among others. The results evidence that the best accuracy was 82.12%, with a sensitivity and specificity of 88.41% and 72.29%, respectively. In addition, experiments revealed that a wise feature selection may improve the system accuracy. Therefore, the proposed model revealed to be reliable and simpler alternative to classical solutions for the sleep apnea detection, for example the ones based on the Polysomnography.info:eu-repo/semantics/publishedVersio

Detection of Obstructive Sleep Apnoea Using Features Extracted From Segmented Time-Series ECG Signals With a One Dimensional Convolutional Neural Network

This paper reports on ongoing research, which aims to prove that features of Obstructed Sleep Apnoea (OSA) can be automatically identified from single-lead electrocardiogram (ECG) signals using a One-Dimensional Convolutional Neural Network (1DCNN) model. The 1DCNN is also compared against other machine learning (ML) classifier models, namely Support Vector Machine (SVM) and Random Forest Classifier (RFC). The 1DCNN architecture consists of 4 major parts, a Convolutional Layer, a Flattened Dense Layer, a Max Pooling Layer and a Fully Connected Multilayer Perceptron (MLP), with 1 Hidden Layer and a SoftMax output. The model repeatedly learns how to better extract prominent features from one-dimensional data and map it to the MLP for increased prediction. Training and validation are achieved using pre-processed time-series ECG signals captured from 35 ECG recordings. Using our unique windowing strategy, the data is shaped into 5 datasets of different window sizes. A total of 15 models (5 for each group, 1DCNNs, RFCs, SVMs) were evaluated using various metrics, with each being run over numerous experiments. Results show the 1DCNN-500 model delivered the greatest degree of accuracy and rapidity in comparison to the best producing RFC and SVM classifiers. 1DCNN-500 (Sensitivity 0.9743, Specificity 0.9708, Accuracy 0.9699); RFC-500 (Sensitivity/Recall (0) 0.90 / (1) 0.94, Precision (0) 0.94 / (1) 0.90, Accuracy 0.91); SVM-500 (Sensitivity (0) 0.94 / (1) 0.50, Precision (0) 0.65 / (1) 0.90, Accuracy 0.72). The model presents a novel approach that could provide support mechanisms in clinical practice to promptly diagnose patients suffering from OSA

Review on biomedical sensors, technologies, and algorithms for diagnosis of sleep-disordered breathing: Comprehensive survey

This paper provides a comprehensive review of available technologies for measurements of vital physiology related parameters that cause sleep disordered breathing (SDB). SDB is a chronic disease that may lead to several health problems and increase the risk of high blood pressure and even heart attack. Therefore, the diagnosis of SDB at an early stage is very important. The essential primary step before diagnosis is measurement. Vital health parameters related to SBD might be measured through invasive or non-invasive methods. Nowadays, with respect to increase in aging population, improvement in home health management systems is needed more than even a decade ago. Moreover, traditional health parameter measurement techniques such as polysomnography are not comfortable and introduce additional costs to the consumers. Therefore, in modern advanced self-health management devices, electronics and communication science are combined to provide appliances that can be used for SDB diagnosis, by monitoring a patient's physiological parameters with more comfort and accuracy. Additionally, development in machine learning algorithms provides accurate methods of analysing measured signals. This paper provides a comprehensive review of measurement approaches, data transmission, and communication networks, alongside machine learning algorithms for sleep stage classification, to diagnose SDB

Algoritmos avanzados para detección del síndrome de apnea-hipopnea obstructiva del sueño

El Síndrome de Apnea-Hipopnea Obstructiva del Sueño (SAHOS) es un trastorno del sueño muy prevalente en la población general y con afectación de múltiples órganos. Se estima que esta patología afecta entre el 3% y 5% de la población adulta en todo el mundo y aumenta con la edad. Si bien el SAHOS es más frecuente en adultos, afecta también a niños con una prevalencia cercana al 3%. Los eventos respiratorios asociados al SAHOS durante el sueño ocurren como consecuencia de una alteración anatómico-funcional de la vía aérea superior que producen su estrechamiento parcial (hipopnea) o su bloqueo total (apnea). Para establecer el grado de severidad del SAHOS, se define el Índice de Apnea-Hipopnea. Éste índice representa el número de eventos de apnea-hipopnea por hora de sueño. El estudio de referencia para el correcto diagnóstico del SAHOS es la Polisomnografía nocturna. Dado que este tipo de estudio requiere no solo de la medición simultánea de una gran cantidad de señales fisiológicas, sino también de una infraestructura especial y de personal calificado, es de muy difícil acceso y muy costosa en términos de tiempo y dinero.En esta tesis se aborda el diseño, desarrollo, implementación y evaluación de tres métodos para el reconocimiento automático de los eventos de apnea-hipopnea a partir del análisis y procesamiento de las señales de saturación de oxígeno en sangre (SaO2). En particular, se presentan dos métodos de selección de características denominados MDAS y MDCS, los cuales se basan en representaciones ralas de señales de SaO2 para el reconocimiento de eventos de apnea-hipopnea. Además, en esta tesis se introduce una nueva medida de discriminabilidad binaria denotada por DCAF, la cual es capaz de detectar átomos discriminativos en un diccionario. Asimismo, esta medida permite cuantificar eficientemente sus correspondientes grados de discriminabilidad, lo cual resulta útil a los efectos de la clasificación. Los métodos MDAS y MDCS hacen uso de la media DCAF para detectar los átomos más discriminativos de un diccionario dado y, a partir de ellos, realizan la selección de características. En particular, el método MDCS utiliza la medida DCAF para seleccionar los átomos más discriminativos y, a partir de ellos, construir un sub-diccionario. En base a los experimentos desarrollados en esta tesis, el desempeño de la nueva medida DCAF fue comparada con el de varias otras medidas de información del estado del arte. Los resultados muestran que DCAF logró un muy buen desempeño. Por otro lado, el nuevo método MDCS fue comparado con otros tres métodos del estado de arte, superando significativamente el desempeño de todos ellos.Esta tesis introduce además una extensión del problema de clasificación binaria a uno multi-clase. En este contexto, se propone una generalización de la medida DCAF (la cual tiene en cuenta solo dos clases en los datos) a más de dos clases. En particular, la nueva medida de discriminabilidad combinada no solo tiene en cuenta la probabilidad condicional de activación de los átomos en un diccionario dada la clase y el valor de su correspondiente coeficiente de activación, sino que también incorpora el efecto que éste tiene sobre el error total de representación. Asimismo, se presenta un nuevo método iterativo llamado DAS-KSVD para el aprendizaje de diccionarios estructurados en el contexto de problemas de clasificación multi-clase, que utiliza ésta medida. El nuevo método permite detectar los átomos más discriminativos para cada una de las clases. Utilizando una base de datos de dígitos manuscritos ampliamente utilizada en la literatura, se realizó un análisis del desempeño del método DAS-KSVD obteniéndose tasas de reconocimiento superiores a las obtenidas por técnicas semejantes del estado del arte. También se utilizó el nuevo método DAS-KSVD en un problema de clasificación multi-clase asociado al SAHOS. Los resultados obtenidos muestran que éste método tiene un muy buen desempeño en la detección de la patología.Fil: Rolon, Roman Emanuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Investigación en Señales, Sistemas e Inteligencia Computacional. Universidad Nacional del Litoral. Facultad de Ingeniería y Ciencias Hídricas. Instituto de Investigación en Señales, Sistemas e Inteligencia Computacional; Argentin

Heart Diseases Diagnosis Using Artificial Neural Networks

Information technology has virtually altered every aspect of human life in the present era. The application of informatics in the health sector is rapidly gaining prominence and the benefits of this innovative paradigm are being realized across the globe. This evolution produced large number of patients’ data that can be employed by computer technologies and machine learning techniques, and turned into useful information and knowledge. This data can be used to develop expert systems to help in diagnosing some life-threating diseases such as heart diseases, with less cost, processing time and improved diagnosis accuracy. Even though, modern medicine is generating huge amount of data every day, little has been done to use this available data to solve challenges faced in the successful diagnosis of heart diseases. Highlighting the need for more research into the usage of robust data mining techniques to help health care professionals in the diagnosis of heart diseases and other debilitating disease conditions. Based on the foregoing, this thesis aims to develop a health informatics system for the classification of heart diseases using data mining techniques focusing on Radial Basis functions and emerging Neural Networks approach. The presented research involves three development stages; firstly, the development of a preliminary classification system for Coronary Artery Disease (CAD) using Radial Basis Function (RBF) neural networks. The research then deploys the deep learning approach to detect three different types of heart diseases i.e. Sleep Apnea, Arrhythmias and CAD by designing two novel classification systems; the first adopt a novel deep neural network method (with Rectified Linear unit activation) design as the second approach in this thesis and the other implements a novel multilayer kernel machine to mimic the behaviour of deep learning as the third approach. Additionally, this thesis uses a dataset obtained from patients, and employs normalization and feature extraction means to explore it in a unique way that facilitates its usage for training and validating different classification methods. This unique dataset is useful to researchers and practitioners working in heart disease treatment and diagnosis. The findings from the study reveal that the proposed models have high classification performance that is comparable, or perhaps exceed in some cases, the existing automated and manual methods of heart disease diagnosis. Besides, the proposed deep-learning models provide better performance when applied on large data sets (e.g., in the case of Sleep Apnea), with reasonable performance with smaller data sets. The proposed system for clinical diagnoses of heart diseases, contributes to the accurate detection of such disease, and could serve as an important tool in the area of clinic support system. The outcome of this study in form of implementation tool can be used by cardiologists to help them make more consistent diagnosis of heart diseases