10 research outputs found
Cardiac Arrhythmias
The most intimate mechanisms of cardiac arrhythmias are still quite unknown to scientists. Genetic studies on ionic alterations, the electrocardiographic features of cardiac rhythm and an arsenal of diagnostic tests have done more in the last five years than in all the history of cardiology. Similarly, therapy to prevent or cure such diseases is growing rapidly day by day. In this book the reader will be able to see with brighter light some of these intimate mechanisms of production, as well as cutting-edge therapies to date. Genetic studies, electrophysiological and electrocardiographyc features, ion channel alterations, heart diseases still unknown , and even the relationship between the psychic sphere and the heart have been exposed in this book. It deserves to be read
Angiographic Applications for Modern Percutaneous Coronary Intervention
This thesis sought to explore contemporary applications of invasive coronary angiography in the era of advanced percutaneous coronary intervention. Firstly, it describes the development and validation of dedicated bifurcation quantitative coronary angiography algorithms, in order to facilitate their analysis in a harmonized, reliable and reproducible manner. Then it presents the use of bifurcation quantitative coronary angiography algorithms in clinical studies, in the context of large registries and randomized trials, and discusses the clinical relevance of angiographic measures. Finally, it explores the prognostic value of angiographic scoring sys
Medical-Data-Models.org:A collection of freely available forms (September 2016)
MDM-Portal (Medical Data-Models) is a meta-data repository for creating, analysing, sharing and reusing medical forms, developed by the Institute of Medical Informatics, University of Muenster in Germany. Electronic forms for documentation of patient data are an integral part within the workflow of physicians. A huge amount of data is collected either through routine documentation forms (EHRs) for electronic health records or as case report forms (CRFs) for clinical trials. This raises major scientific challenges for health care, since different health information systems are not necessarily compatible with each other and thus information exchange of structured data is hampered. Software vendors provide a variety of individual documentation forms according to their standard contracts, which function as isolated applications. Furthermore, free availability of those forms is rarely the case. Currently less than 5 % of medical forms are freely accessible. Based on this lack of transparency harmonization of data models in health care is extremely cumbersome, thus work and know-how of completed clinical trials and routine documentation in hospitals are hard to be re-used. The MDM-Portal serves as an infrastructure for academic (non-commercial) medical research to contribute a solution to this problem. It already contains more than 4,000 system-independent forms (CDISC ODM Format, www.cdisc.org, Operational Data Model) with more than 380,000 dataelements. This enables researchers to view, discuss, download and export forms in most common technical formats such as PDF, CSV, Excel, SQL, SPSS, R, etc. A growing user community will lead to a growing database of medical forms. In this matter, we would like to encourage all medical researchers to register and add forms and discuss existing forms
Percutaneous treatment of complex lesions and complex patients
Coronary artery disease (CAD) represents a wide
spectrum of underlying anatomical disease ranging
from near normal, minor single-vessel disease (SVD),
to extensive triple-vessel disease. Its presentation is
similarly variable, from a single episode of chest pain to
acute coronary syndrome (ACS) or even death. The
aim of treatment in CAD is to relieve symptoms and
improve quality of life, reduce cardiovascular (CV)
events, and prolong survival. There have been vast
improvements in management over the years, following
a greater understanding of the underlying pathophysiology,
the identifi cation and appropriate management
of risk factors, development of new medication, and
advances in revas
New Frontiers in Percutaneous Interventions
__Abstract__
In 1977 Andreas Gruntzig introduced a catheter-based therapy for the percutaneous management
of patients with coronary artery disease. This became known as percutaneous
transluminal coronary angioplasty (PTCA). Initially there were many skeptics and pessimists.
The technology, however, evolved rapidly. With the advent of specialized catheters, guidewires,
stents, and adjuvant pharmacotherapy, the indications for PTCA have expanded to include
more urgent, comorbid cases and complex coronary disease. Furthermore, these innovations
have largely solved earlier problems related to elastic recoil, dissection and restenosis of the
treated segment. In particular, the introduction of stents with the capacity to elute drugs to the
injured arterial wall has been shown to be an effective and overall safe approach to suppress
intimal hyperplasia. The excellent results of DES in clinical trials and everyday clinical practice,
in synergy with important improvements in adjuvant drug therapy, have expanded the indications
of percutaneous coronary interventions even further. Within 10 years of its introduction,
the number of PTCA procedures
CT coronary angiography: validation and clinical implementation
Coronary heart disease is the most frequent cause of death in the Western society.1 Coronary
arteriography, a technique to visualize morphologic characteristics of the coronary arteries,
has provided an objective basic standard of diagnosis and fundamentally changed our approach
to the patient with suspected coronary artery disease
Real-time 3D echocardiography: an extra dimension in the echocardiographic diagnosis of congenital heart disease
This thesis investigates the role that real-time 3D echocardiography might play in the
analysis of structural heart disease. The 3D echocardiographic assessment of
patients with a variety of congenital heart disease is described, with specific focus on
description and measurement of intracardiac anatomy and functional assessment.
In chapter 1, the outline of the thesis is given. This thesis focuses on the feasibility
and clinical applicability of real-time 3D echocardiography in daily patient care for
congenital heart disease and whether 3D echocardiographic images give a reliable
reflection of the intracardiac anatomy in a wide variety of congenital heart defects