Depth-Dependent Physiological Modulators of the BOLD Response in the Human Motor Cortex

This dissertation proposes a set of methods for improving spatial localization of cerebral metabolic changes using functional magnetic resonance imaging (fMRI). Blood oxygen level dependent (BOLD) fMRI estabilished itself as the most frequently used technique for mapping brain activity in humans. It is non-invasive and allows to obtain information about brain oxygenation changes in a few minutes. It was discovered in 1990 and, since then, it contributed enormously to the developments in neuroscientific research. Nevertheless, the BOLD contrast suffers from inherent limitations. This comes from the fact that the observed response is the result of a complex interplay between cerebral blood flow (CBF), cerebral blood volume (CBV) and cerebral metabolic rate of oxygen consumption (CMRO2) and has a strong dependency on baseline blood volume and oxygenation. Therefore, the observed response is mislocalized from the site where the metabolic activity takes place and it is subject to high variability across experiments due to normal brain physiology. Since the peak of BOLD changes can be as much as 4 mm apart from the site of metabolic changes, the problem of spatial mislocalization is particularly constraining at submillimeter resolution. Three methods are proposed in this work in order to overcome this limitation and make data more comparable. The first method involves a modification of an estabilished model for calibration of BOLD responses (the dilution model), in order to render it applicable at higher resolutions. The second method proposes a model-free scaling of the BOLD response, based on spatial normalization by a purely vascular response pattern. The third method takes into account the hypothesis that the cortical vasculature could act as a low-pass filter for BOLD fluctuations as the blood is carried downstream, and investigates differences in frequency composition of cortical laminae. All methods are described and tested on a depth-dependent scale in the human motor cortex

MEMS Accelerometers

Micro-electro-mechanical system (MEMS) devices are widely used for inertia, pressure, and ultrasound sensing applications. Research on integrated MEMS technology has undergone extensive development driven by the requirements of a compact footprint, low cost, and increased functionality. Accelerometers are among the most widely used sensors implemented in MEMS technology. MEMS accelerometers are showing a growing presence in almost all industries ranging from automotive to medical. A traditional MEMS accelerometer employs a proof mass suspended to springs, which displaces in response to an external acceleration. A single proof mass can be used for one- or multi-axis sensing. A variety of transduction mechanisms have been used to detect the displacement. They include capacitive, piezoelectric, thermal, tunneling, and optical mechanisms. Capacitive accelerometers are widely used due to their DC measurement interface, thermal stability, reliability, and low cost. However, they are sensitive to electromagnetic field interferences and have poor performance for high-end applications (e.g., precise attitude control for the satellite). Over the past three decades, steady progress has been made in the area of optical accelerometers for high-performance and high-sensitivity applications but several challenges are still to be tackled by researchers and engineers to fully realize opto-mechanical accelerometers, such as chip-scale integration, scaling, low bandwidth, etc

ICEBEAR-3D: An Advanced Low Elevation Angle Auroral E region Imaging Radar

The Ionospheric Continuous-wave E region Bistatic Experimental Auroral Radar (ICEBEAR) is an auroral E~region radar which has operated from 7 December 2017 until the September 2019. During the first two years of operation, ICEBEAR was only capable of spatially locating E~region scatter and meteor trail targets in range and azimuth. Elevation angles were not determinable due to its East-West uniform linear receiving antenna array. Measuring elevation angles of targets when viewing from low elevation angles with radar interferometers has been a long standing problem. Past high latitude radars have attempted to obtain elevation angles of E~region targets using North-South baselines, but have always resulted in erroneous elevation angles being measured in the low elevation regime (0° to ≈30° above the horizon), leaving interesting scientific questions about scatter altitudes in the auroral E~region unanswered. The work entailed in this thesis encompasses the design of the ICEBEAR-3D system for the acquisition of these important elevation angles. The receiver antenna array was redesigned using a custom phase error minimization and stochastic antenna location perturbation technique, which produces phase tolerant receiver antenna arrays. The resulting 45-baseline sparse non-uniform coplanar T-shaped array was designed for aperture synthesis radar imaging. Conventional aperture synthesis radar imaging techniques assume point-like incoherent targets and image using a Cartesian basis over a narrow field of view. These methods are incompatible with horizon pointing E~region radars such as ICEBEAR. Instead, radar targets were imaged using the Suppressed Spherical Wave Harmonic Transform (Suppressed-SWHT) technique. This imaging method uses precalculated spherical harmonic coefficient matrices to transform the visibilities to brightness maps by direct matrix multiplication. The under sampled image domain artefacts (dirty beam) were suppressed by the products of differing harmonic order brightness maps. From the images, elevation and azimuth angles of arrival were obtained. Due to the excellent phase tolerance of ICEBEAR new light was shed on the long standing low elevation angle problem. This led to the development of the proper phase reference vertical interferometry geometry, which allowed horizon pointing radar interferometers to unambiguously measure elevation angles near the horizon. Ultimately resulting in accurate elevation angles from zenith to horizon