Jewish Studies in the Digital Age

The digitisation boom of the last two decades, and the rapid advancement of digital tools to analyse data in myriad ways, have opened up new avenues for humanities research. This volume discusses how the so-called digital turn has affected the field of Jewish Studies, explores the current state of the art and probes how digital developments can be harnessed to address the specific questions, challenges and problems in the field

Jewish Studies in the Digital Age

The digitisation boom of the last two decades, and the rapid advancement of digital tools to analyse data in myriad ways, have opened up new avenues for humanities research. This volume discusses how the so-called digital turn has affected the field of Jewish Studies, explores the current state of the art and probes how digital developments can be harnessed to address the specific questions, challenges and problems in the field

Ilo Marie Grundberg, Janice Gray v. The Upjohn Company : Brief of Appellant

Appendix to Brief of Petitioner The Upjohn Company on certified question

Ilo Marie Grundberg, Janice Gray v. The Upjohn Company : Brief of Appellant

Appendix to Brief of Petitioner The Upjohn Company on certified question

Integrative approaches to high-throughput data in lymphoid leukemias (on transcriptomes, the whole-genome mutational landscape, flow cytometry and gene copy-number alterations)

Within this thesis I developed a new approach for the analysis and integration of heterogeneous leukemic data sets applicable to any high-throughput analysis including basic research. All layers are stored in a semantic graph which facilitates modifications by just adding edges (relationships/attributes) and nodes (values/results) as well as calculating biological consensus and clinical correlation. The front-end is accessible through a GUI (graphical user interface) on a Java-based Semantic Web server. I used this framework to describe the genomic landscape of T-PLL (T-cell prolymphocytic leukemia), which is a rare (~0.6/million) mature T-cell malignancy with aggressive clinical course, notorious treatment resistance, and generally low overall survival. We have conducted gene expression and copy-number profiling as well as NGS (next-generation sequencing) analyses on a cohort comprising 94 T-PLL cases. TCL1A (T-cell leukemia/lymphoma 1A) overexpression and ATM (Ataxia Telangiectasia Mutated) impairment represent central hallmarks of T-PLL, predictive for patient survival, T-cell function and proper DNA damage responses. We identified new chromosomal lesions, including a gain of AGO2 (Argonaute 2, RISC Catalytic Component; 57.14% of cases), which is decisive for the chromosome 8q lesion. While we found significant enrichments of truncating mutations in ATM mut/no del (p=0.01365), as well as FAT (FAT Atypical Cadherin) domain mutations in ATM mut/del (p=0.01156), JAK3 (Janus Kinase 3) mut/ATM del cases may represent another tumor lineage. Using whole-transcriptome sequencing, we identified novel structural variants affecting chromosome 14 that lead to the expression of a TCL1A-TCR (T-cell receptor) fusion transcript and a likely degradated TCL1A protein. Two clustering approaches of normal T-cell subsets vs. leukemia gene expression profiles, as well as immunophenotyping-based agglomerative clustering and TCR repertoire reconstruction further revealed a restricted, memory-like T-cell phenotype. This is to date the most comprehensive, multi-level, integrative study on T-PLL and it led to an evolutionary disease model and a histone deacetylase-inhibiting / double strand break-inducing treatment that performs better than the current standard of chemoimmunotherapy in preclinical testing

Southern Accent September 2006 - April 2007

Southern Adventist University\u27s newspaper, Southern Accent, for the academic year of 2006-2007.https://knowledge.e.southern.edu/southern_accent/1084/thumbnail.jp

Antioxidant and DPPH-Scavenging Activities of Compounds and Ethanolic Extract of the Leaf and Twigs of Caesalpinia bonduc L. Roxb.

Antioxidant effects of ethanolic extract of Caesalpinia bonduc and its isolated bioactive compounds were evaluated in vitro. The compounds included two new cassanediterpenes, 1α,7α-diacetoxy-5α,6β-dihydroxyl-cass-14(15)-epoxy-16,12-olide (1)and 12α-ethoxyl-1α,14β-diacetoxy-2α,5α-dihydroxyl cass-13(15)-en-16,12-olide(2); and others, bonducellin (3), 7,4’-dihydroxy-3,11-dehydrohomoisoflavanone (4), daucosterol (5), luteolin (6), quercetin-3-methyl ether (7) and kaempferol-3-O-α-L-rhamnopyranosyl-(1Ç2)-β-D-xylopyranoside (8). The antioxidant properties of the extract and compounds were assessed by the measurement of the total phenolic content, ascorbic acid content, total antioxidant capacity and 1-1-diphenyl-2-picryl hydrazyl (DPPH) and hydrogen peroxide radicals scavenging activities.Compounds 3, 6, 7 and ethanolic extract had DPPH scavenging activities with IC50 values of 186, 75, 17 and 102 μg/ml respectively when compared to vitamin C with 15 μg/ml. On the other hand, no significant results were obtained for hydrogen peroxide radical. In addition, compound 7 has the highest phenolic content of 0.81±0.01 mg/ml of gallic acid equivalent while compound 8 showed the highest total antioxidant capacity with 254.31±3.54 and 199.82±2.78 μg/ml gallic and ascorbic acid equivalent respectively. Compound 4 and ethanolic extract showed a high ascorbic acid content of 2.26±0.01 and 6.78±0.03 mg/ml respectively.The results obtained showed the antioxidant activity of the ethanolic extract of C. bonduc and deduced that this activity was mediated by its isolated bioactive compounds