Authors' Reply to Coste et al.: "Levothyrox® New and Old Formulations: Are they Switchable for Millions of Patients?"

"Authors'Reply to Coste et al"International audienc

Antibiotic prophylaxis after total joint replacements (Authors' reply to Letters to the Editor)

Reply to Comment in Hong Kong Med J. 2010 Aug;16(4):320published_or_final_versio

Pulverized coal combustion: NOx formation mechanisms under fuel rich and staged combustion conditions

Journal ArticleA 2 Kg/h pulverized fuel one dimensional flame combustor was used to determine time resolved NO profiles under fuel rich and staged combustion conditions. Seven solid fuels, including two coal chars, were investigated. Results show that at all fuel rich conditions NO is formed rapidly and then is slowly destroyed

Tumor expression of human chorionic gonadotropin beta mRNA and prognosis of prostate cancer treated by radical prostatectomy

The beta subunit of human chorionic gonadotropin (hCG beta) is encoded by six genes (CGB) classified as type I and type II. CGB mRNA is produced in large amounts by trophoblastic tissues and in small amounts by several cancerous tissues including prostate cancer and by a few benign tissues, including the prostate. Quantitative reverse-transcription polymerase chain reaction (RT-qPCR) was used to study the expression levels of all CGB mRNAs together (total CGB mRNA) and the two types of CGB mRNA separately in non-cancerous (n = 74) and cancerous prostatic tissue obtained by radical prostatectomy (n = 193). RNA was isolated from formalin-fixed paraffin-embedded (FFPE) samples and mRNA levels of CGB were correlated with disease-specific survival. Total CGB mRNA concentrations were significantly lower (p <.0001) in cancerous than non-cancerous prostatic tissue. Separate analysis of type I CGB and type II CGB mRNA showed that both type I CGB (p <.0001) and type II CGB mRNA (p = .007) are lower in cancerous tissue than in non-cancerous tissue. Low type II CGB mRNA level in cancerous tissue was associated with shorter cancer-specific survival (p = .001) of prostate cancer patients treated by radical prostatectomy.Peer reviewe

A Restatement of Copyright Law as More Independent and Stable Treatise

This article maps the problematic consequences of over reliance by judges, lawyers and policy makers on copyright law treatises, with a particular focus on the negative effects Nimmer on Copyright has had on the evolution of various copyright law doctrines. It proposes that an ALI Restatement of Copyright Law is needed to create a reference tool that is transparently authored and edited

Delirium en el adulto mayor

Delirium in the elderly is a common complication observed in elderly patients, it can be classified into three types according to the level of alertness and physical activity of the patient, these are hyperactive, hypoactive and mixed. All patients manifested primarily by altered state of consciousness and lack of attention. To diagnose it, the diagnostic criteria of the diagnostic and statiscal manual of mental disorders are used in its fifth edition. Initial management is based on pharmacological and no pharmacological treatment.El delirium en el adulto mayor es una complicación común observada en pacientes adultos mayores. Se puede clasificar en tres tipos según el nivel de estado de alerta y actividad física del paciente, estos son hiperactivo, hipoactivo y mixto. Todos los pacientes manifiestan principalmente una alteración del estado de conciencia y falta de atención. Para diagnosticarla se utilizan los criterios diagnósticos del manual diagnóstico y estadístico de los trastornos mentales en su quinta edición. El manejo inicial se basa en tratamiento farmacológico y no farmacológico

Field effects studies in the Chernobyl Exclusion Zone: lessons to be learnt

In the initial aftermath of the 1986 Chernobyl accident there were detrimental effects recorded on wildlife, including, mass mortality of pine trees close to the reactor, reduced pine seed production, reductions in soil invertebrate abundance and diversity and likely death of small mammals. More than 30 years after the Chernobyl accident there is no consensus on the longer-term impact of the chronic exposure to radiation on wildlife in what is now referred to as the Chernobyl Exclusion Zone. Reconciling this lack of consensus is one of the main challenges for radioecology. With the inclusion of environmental protection in, for instance, the recommendations of the International Commission on Radiological Protection (ICRP), we need to be able to incorporate knowledge of the potential effects of radiation on wildlife within the regulatory process (e.g. as a basis on which to define benchmark dose rates). In this paper, we use examples of reported effects on different wildlife groups inhabiting the Chernobyl Exclusion Zone (CEZ) as a framework to discuss potential reasons for the lack of consensus, consider important factors influencing dose rates organisms receive and make some recommendations on good practice

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