3,924 research outputs found
Nature-Inspired Interconnects for Self-Assembled Large-Scale Network-on-Chip Designs
Future nano-scale electronics built up from an Avogadro number of components
needs efficient, highly scalable, and robust means of communication in order to
be competitive with traditional silicon approaches. In recent years, the
Networks-on-Chip (NoC) paradigm emerged as a promising solution to interconnect
challenges in silicon-based electronics. Current NoC architectures are either
highly regular or fully customized, both of which represent implausible
assumptions for emerging bottom-up self-assembled molecular electronics that
are generally assumed to have a high degree of irregularity and imperfection.
Here, we pragmatically and experimentally investigate important design
trade-offs and properties of an irregular, abstract, yet physically plausible
3D small-world interconnect fabric that is inspired by modern network-on-chip
paradigms. We vary the framework's key parameters, such as the connectivity,
the number of switch nodes, the distribution of long- versus short-range
connections, and measure the network's relevant communication characteristics.
We further explore the robustness against link failures and the ability and
efficiency to solve a simple toy problem, the synchronization task. The results
confirm that (1) computation in irregular assemblies is a promising and
disruptive computing paradigm for self-assembled nano-scale electronics and (2)
that 3D small-world interconnect fabrics with a power-law decaying distribution
of shortcut lengths are physically plausible and have major advantages over
local 2D and 3D regular topologies
Construction of membrane-bound artificial cells using microfluidics: a new frontier in bottom-up synthetic biology
The quest to construct artificial cells from the bottom-up using simple building blocks has received much attention over recent decades and is one of the grand challenges in synthetic biology. Cell mimics that are encapsulated by lipid membranes are a particularly powerful class of artificial cells due to their biocompatibility and the ability to reconstitute biological machinery within them. One of the key obstacles in the field centres on the following: how can membrane-based artificial cells be generated in a controlled way and in high-throughput? In particular, how can they be constructed to have precisely defined parameters including size, biomolecular composition and spatial organization? Microfluidic generation strategies have proved instrumental in addressing these questions. This article will outline some of the major principles underpinning membrane-based artificial cells and their construction using microfluidics, and will detail some recent landmarks that have been achieved
Comparison of Biomaterial-Dependent and -Independent Bioprinting Methods for Cardiovascular Medicine
There is an increasing need of human organs for transplantation, of alternatives to animal experimentation, and of better in vitro tissue models for drug testing. All these needs create unique opportunities for the development of novel and powerful tissue engineering methods, among which the 3D bioprinting is one of the most promising. However, after decades of incubation, ingenuous efforts, early success and much anticipation, biomaterial-dependent 3D bioprinting, although shows steady progress, is slow to deliver the expected clinical results. For this reason, alternative ‘scaffold-free’ 3D bioprinting methods are developing in parallel at an accelerated pace. In this opinion paper we discuss comparatively the two approaches, with specific examples drawn from the cardiovascular field. Moving the emphasis away from competition, we show that the two platforms have similar goals but evolve in complementary technological niches. We conclude that the biomaterial-dependent bioprinting is better suited for tasks requiring faster, larger, anatomically-true, cell-homogenous and matrix-rich constructs, while the scaffold-free biofabrication is more adequate for cell-heterogeneous, matrix-poor, complex and smaller constructs, but requiring longer preparation time
Soft tubular microfluidics for 2D and 3D applications
Microfluidics has been the key component for many applications, including biomedical devices, chemical processors, microactuators, and even wearable devices. This technology relies on soft lithography fabrication which requires cleanroom facilities. Although popular, this method is expensive and labor-intensive. Furthermore, current conventional microfluidic chips precludes reconfiguration, making reiterations in design very time-consuming and costly. To address these intrinsic drawbacks of microfabrication, we present an alternative solution for the rapid prototyping of microfluidic elements such as microtubes, valves, and pumps. In addition, we demonstrate how microtubes with channels of various lengths and cross-sections can be attached modularly into 2D and 3D microfluidic systems for functional applications. We introduce a facile method of fabricating elastomeric microtubes as the basic building blocks for microfluidic devices. These microtubes are transparent, biocompatible, highly deformable, and customizable to various sizes and cross-sectional geometries. By configuring the microtubes into deterministic geometry, we enable rapid, low-cost formation of microfluidic assemblies without compromising their precision and functionality. We demonstrate configurable 2D and 3D microfluidic systems for applications in different domains. These include microparticle sorting, microdroplet generation, biocatalytic micromotor, triboelectric sensor, and even wearable sensing. Our approach, termed soft tubular microfluidics, provides a simple, cheaper, and faster solution for users lacking proficiency and access to cleanroom facilities to design and rapidly construct microfluidic devices for their various applications and needs. Keywords: flexible microfluidics, elastomeric microtubes, microfluidic assemblies,
inertial focusing chip, microfluidic sensorSingapore-MIT Alliance for Research and Technology (SMART
Protein assemblies: nature-inspired and designed nanostructures
Ordered protein assemblies are attracting interest as next-generation biomaterials with a remarkable range of structural and functional properties, leading to potential applications in biocatalysis, materials templating, drug delivery and vaccine development. This Review covers ordered protein assemblies including protein nanowires/nanofibrils, nanorings, nanotubes, designed two- and three-dimensional ordered protein lattices and protein-like cages including polyhedral virus-like cage structures. The main focus is on designed ordered protein assemblies, in which the spatial organization of the proteins is controlled by tailored noncovalent interactions (including metal ion binding interactions, electrostatic interactions and ligand–receptor interactions among others) or by careful design of modified (mutant) proteins or de novo constructs. The modification of natural protein assemblies including bacterial S-layers and cage-like and rod-like viruses to impart novel function, e.g. enzymatic activity, is also considered. A diversity of structures have been created using distinct approaches, and this Review provides a summary of the state-of-the-art in the development of these systems, which have exceptional potential as advanced bionanomaterials for a diversity of applications
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