Experiences in the formalisation and verification of medical protocols

Experiences in the formalisation and verification of medical protocols / M. Balser ... - In: Artificial intelligence in medicine : 9th Conference on Artificial Intelligence in Medicine in Europe, AIME 2003, Protaras, Cyprus, October 18 - 22, 2003 ; proceedings / Michel Dojat ... (eds.). - Berlin u.a. : Springer, 2003. - S. 132-141. - (Lecture notes in computer science ; 2780 : Lecture notes in artificial intelligence

Thirty years of artificial intelligence in medicine (AIME) conferences: A review of research themes

Over the past 30 years, the international conference on Artificial Intelligence in MEdicine (AIME) has been organized at different venues across Europe every 2 years, establishing a forum for scientific exchange and creating an active research community. The Artificial Intelligence in Medicine journal has published theme issues with extended versions of selected AIME papers since 1998

Experiments with Two Approaches for Tracking Drifting Concepts

. This paper addresses the task of learning classifier from stream of labelled data. In this case we can face problem that the underling concepts can changes over time. The paper studies two mechanisms developed for dealing with changing concepts. Both are based on the time window idea. The first one forgets gradual, by assigning to the examples weight that gradually decreases over time. The second one uses a statistical test to detect changes in concept and then optimizes the size of time window, aiming to maximise the classification accuracy on the new examples. Both methods are general in nature and can be used with any learning algorithm. The objectives of the conducted experiments were to compare the mechanisms and explore whether they can combined to achieve a synergetic effect. Results from experiments with three basic learning algorithms (kNN, ID3 and NBC) using four datasets are reported and discussed

Mutual Information for Testing Gene-Environment Interaction

Despite current enthusiasm for investigation of gene-gene interactions and gene-environment interactions, the essential issue of how to define and detect gene-environment interactions remains unresolved. In this report, we define gene-environment interactions as a stochastic dependence in the context of the effects of the genetic and environmental risk factors on the cause of phenotypic variation among individuals. We use mutual information that is widely used in communication and complex system analysis to measure gene-environment interactions. We investigate how gene-environment interactions generate the large difference in the information measure of gene-environment interactions between the general population and a diseased population, which motives us to develop mutual information-based statistics for testing gene-environment interactions. We validated the null distribution and calculated the type 1 error rates for the mutual information-based statistics to test gene-environment interactions using extensive simulation studies. We found that the new test statistics were more powerful than the traditional logistic regression under several disease models. Finally, in order to further evaluate the performance of our new method, we applied the mutual information-based statistics to three real examples. Our results showed that P-values for the mutual information-based statistics were much smaller than that obtained by other approaches including logistic regression models

Detecting Irrelevant subtrees to improve probabilistic learning from tree-structured data

International audienceIn front of the large increase of the available amount of structured data (such as XML documents), many algorithms have emerged for dealing with tree-structured data. In this article, we present a probabilistic approach which aims at a posteriori pruning noisy or irrelevant subtrees in a set of trees. The originality of this approach, in comparison with classic data reduction techniques, comes from the fact that only a part of a tree (i.e. a subtree) can be deleted, rather than the whole tree itself. Our method is based on the use of confidence intervals, on a partition of subtrees, computed according to a given probability distribution. We propose an original approach to assess these intervals on tree-structured data and we experimentally show its interest in the presence of noise

Automatic production and integration of knowledge to the support of the decision and planning activities in medical-clinical diagnosis, treatment and prognosis.

El concepto de procedimiento médico se refiere al conjunto de actividades seguidas por los profesionales de la salud para solucionar o mitigar el problema de salud que afecta a un paciente. La toma de decisiones dentro del procedimiento médico ha sido, por largo tiempo, uno de las áreas más interesantes de investigación en la informática médica y el contexto de investigación de esta tesis. La motivación para desarrollar este trabajo de investigación se basa en tres aspectos fundamentales: no hay modelos de conocimiento para todas las actividades médico-clínicas que puedan ser inducidas a partir de datos médicos, no hay soluciones de aprendizaje inductivo para todas las actividades de la asistencia médica y no hay un modelo integral que formalice el concepto de procedimiento médico. Por tanto, nuestro objetivo principal es desarrollar un modelo computable basado en conocimiento que integre todas las actividades de decisión y planificación para el diagnóstico, tratamiento y pronóstico médico-clínicos. Para alcanzar el objetivo principal, en primer lugar, explicamos el problema de investigación. En segundo lugar, describimos los antecedentes del problema de investigación desde los contextos médico e informático. En tercer lugar, explicamos el desarrollo de la propuesta de investigación, basada en cuatro contribuciones principales: un nuevo modelo, basado en datos y conocimiento, para la actividad de planificación en el diagnóstico y tratamiento médico-clínicos; una novedosa metodología de aprendizaje inductivo para la actividad de planificación en el diagnóstico y tratamiento médico-clínico; una novedosa metodología de aprendizaje inductivo para la actividad de decisión en el pronóstico médico-clínico, y finalmente, un nuevo modelo computable, basado en datos y conocimiento, que integra las actividades de decisión y planificación para el diagnóstico, tratamiento y pronóstico médico-clínicos.The concept of medical procedure refers to the set of activities carried out by the health care professionals to solve or mitigate the health problems that affect a patient. Decisions making within a medical procedure has been, for a long time, one of the most interesting research areas in medical informatics and the research context of this thesis. The motivation to develop this research work is based on three main aspects: Nowadays there are not knowledge models for all the medical-clinical activities that can be induced from medical data, there are not inductive learning solutions for all the medical-clinical activities, and there is not an integral model that formalizes the concept of medical procedure. Therefore, our main objective is to develop a computable model based in knowledge that integrates all the decision and planning activities for the medical-clinical diagnosis, treatment and prognosis. To achieve this main objective: first, we explain the research problem. Second, we describe the background of the work from both the medical and the informatics contexts. Third, we explain the development of the research proposal based on four main contributions: a novel knowledge representation model, based in data, to the planning activity in medical-clinical diagnosis and treatment; a novel inductive learning methodology to the planning activity in diagnosis and medical-clinical treatment; a novel inductive learning methodology to the decision activity in medical-clinical prognosis, and finally, a novel computable model, based on data and knowledge, which integrates the decision and planning activities of medical-clinical diagnosis, treatment and prognosis

Health WARNer: An advance clinical decision support system, with knowledge discovery, integration and management features

Master'sMASTER OF SCIENC

ProCLAIM: an argument-based model for deliberating over safety critical actions

In this Thesis we present an argument-based model – ProCLAIM – intended to provide a setting for heterogeneous agents to deliberate on whether a proposed action is safe. That is, whether or not a proposed action is expected to cause some undesirable side effect that will justify not to undertake the proposed action. This is particularly relevant in safetycritical environments where the consequences ensuing from an inappropriate action may be catastrophic. For the practical realisation of the deliberations the model features a mediator agent with three main tasks: 1) guide the participating agents in what their valid argumentation moves are at each stage of the deliberation; 2) decide whether submitted arguments should be accepted on the basis of their relevance; and finally, 3) evaluate the accepted arguments in order to provide an assessment on whether the proposed action should or should not be undertaken, where the argument evaluation is based on domain consented knowledge (e.g guidelines and regulations), evidence and the decision makers’ expertise. To motivate ProCLAIM’s practical value and generality the model is applied in two scenarios: human organ transplantation and industrial wastewater. In the former scenario, ProCLAIM is used to facilitate the deliberation between two medical doctors on whether an available organ for transplantation is or is not suitable for a particular potential recipient (i.e. whether it is safe to transplant the organ). In the later scenario, a number of agents deliberate on whether an industrial discharge is environmentally safe.En esta tesis se presenta un modelo basado en la Argumentación –ProCLAIM– cuyo n es proporcionar un entorno para la deliberación sobre acciones críticas para la seguridad entre agentes heterogéneos. En particular, el propósito de la deliberación es decidir si los efectos secundario indeseables de una acción justi can no llevarla a cabo. Esto es particularmente relevante en entornos críticos para la seguridad, donde las consecuencias que se derivan de una acción inadecuada puede ser catastró cas. Para la realización práctica de las deliberaciones propuestas, el modelo cuenta con un agente mediador con tres tareas principales: 1) guiar a los agentes participantes indicando cuales son las líneas argumentación válidas en cada etapa de la deliberación; 2) decidir si los argumentos presentados deben ser aceptadas sobre la base de su relevancia y, por último, 3) evaluar los argumentos aceptados con el n de proporcionar una valoración sobre la seguridad de la acción propuesta. Esta valoración se basa en guías y regulaciones del dominio de aplicación, en evidencia y en la opinión de los expertos responsables de la decisión. Para motivar el valor práctico y la generalidad de ProCLAIM, este modelo se aplica en dos escenarios distintos: el trasplante de órganos y la gestión de aguas residuales. En el primer escenario el modelo se utiliza para facilitar la deliberación entre dos médicos sobre la viabilidad del transplante de un órgano para un receptor potencial (es decir, si el transplante es seguro). En el segundo escenario varios agentes deliberan sobre si los efectos de un vertido industrial con el propósito de minimizar su impacto medioambiental