A machine learning pipeline for supporting differentiation of glioblastomas from single brain metastases

Machine learning has provided, over the last decades, tools for knowledge extraction in complex medical domains. Most of these tools, though, are ad hoc solutions and lack the systematic approach that would be required to become mainstream in medical practice. In this brief paper, we define a machine learning-based analysis pipeline for helping in a difficult problem in the field of neuro-oncology, namely the discrimination of brain glioblastomas from single brain metastases. This pipeline involves source extraction using k-Meansinitialized Convex Non-negative Matrix Factorization and a collection of classifiers, including Logistic Regression, Linear Discriminant Analysis, AdaBoost, and Random Forests.Peer ReviewedPostprint (published version

Novel Artificial Human Optimization Field Algorithms - The Beginning

New Artificial Human Optimization (AHO) Field Algorithms can be created from scratch or by adding the concept of Artificial Humans into other existing Optimization Algorithms. Particle Swarm Optimization (PSO) has been very popular for solving complex optimization problems due to its simplicity. In this work, new Artificial Human Optimization Field Algorithms are created by modifying existing PSO algorithms with AHO Field Concepts. These Hybrid PSO Algorithms comes under PSO Field as well as AHO Field. There are Hybrid PSO research articles based on Human Behavior, Human Cognition and Human Thinking etc. But there are no Hybrid PSO articles which based on concepts like Human Disease, Human Kindness and Human Relaxation. This paper proposes new AHO Field algorithms based on these research gaps. Some existing Hybrid PSO algorithms are given a new name in this work so that it will be easy for future AHO researchers to find these novel Artificial Human Optimization Field Algorithms. A total of 6 Artificial Human Optimization Field algorithms titled "Human Safety Particle Swarm Optimization (HuSaPSO)", "Human Kindness Particle Swarm Optimization (HKPSO)", "Human Relaxation Particle Swarm Optimization (HRPSO)", "Multiple Strategy Human Particle Swarm Optimization (MSHPSO)", "Human Thinking Particle Swarm Optimization (HTPSO)" and "Human Disease Particle Swarm Optimization (HDPSO)" are tested by applying these novel algorithms on Ackley, Beale, Bohachevsky, Booth and Three-Hump Camel Benchmark Functions. Results obtained are compared with PSO algorithm.Comment: 25 pages, 41 figure

Optimization the initial weights of artificial neural networks via genetic algorithm applied to hip bone fracture prediction

This paper aims to find the optimal set of initial weights to enhance the accuracy of artificial neural networks (ANNs) by using genetic algorithms (GA). The sample in this study included 228 patients with first low-trauma hip fracture and 215 patients without hip fracture, both of them were interviewed with 78 questions. We used logistic regression to select 5 important factors (i.e., bone mineral density, experience of fracture, average hand grip strength, intake of coffee, and peak expiratory flow rate) for building artificial neural networks to predict the probabilities of hip fractures. Three-layer (one hidden layer) ANNs models with back-propagation training algorithms were adopted. The purpose in this paper is to find the optimal initial weights of neural networks via genetic algorithm to improve the predictability. Area under the ROC curve (AUC) was used to assess the performance of neural networks. The study results showed the genetic algorithm obtained an AUC of 0.858±0.00493 on modeling data and 0.802 ± 0.03318 on testing data. They were slightly better than the results of our previous study (0.868±0.00387 and 0.796±0.02559, resp.). Thus, the preliminary study for only using simple GA has been proved to be effective for improving the accuracy of artificial neural networks.This research was supported by the National Science Council (NSC) of Taiwan (Grant no. NSC98-2915-I-155-005), the Department of Education grant of Excellent Teaching Program of Yuan Ze University (Grant no. 217517) and the Center for Dynamical Biomarkers and Translational Medicine supported by National Science Council (Grant no. NSC 100- 2911-I-008-001)

The Integration of Connectionism and First-Order Knowledge Representation and Reasoning as a Challenge for Artificial Intelligence

Intelligent systems based on first-order logic on the one hand, and on artificial neural networks (also called connectionist systems) on the other, differ substantially. It would be very desirable to combine the robust neural networking machinery with symbolic knowledge representation and reasoning paradigms like logic programming in such a way that the strengths of either paradigm will be retained. Current state-of-the-art research, however, fails by far to achieve this ultimate goal. As one of the main obstacles to be overcome we perceive the question how symbolic knowledge can be encoded by means of connectionist systems: Satisfactory answers to this will naturally lead the way to knowledge extraction algorithms and to integrated neural-symbolic systems.Comment: In Proceedings of INFORMATION'2004, Tokyo, Japan, to appear. 12 page