181,942 research outputs found

    Variations on a Theme: A Bibliography on Approaches to Theorem Proving Inspired From Satchmo

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    This articles is a structured bibliography on theorem provers, approaches to theorem proving, and theorem proving applications inspired from Satchmo, the model generation theorem prover developed in the mid 80es of the 20th century at ECRC, the European Computer- Industry Research Centre. Note that the bibliography given in this article is not exhaustive

    Properties of ABA+ for Non-Monotonic Reasoning

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    We investigate properties of ABA+, a formalism that extends the well studied structured argumentation formalism Assumption-Based Argumentation (ABA) with a preference handling mechanism. In particular, we establish desirable properties that ABA+ semantics exhibit. These pave way to the satisfaction by ABA+ of some (arguably) desirable principles of preference handling in argumentation and nonmonotonic reasoning, as well as non-monotonic inference properties of ABA+ under various semantics.Comment: This is a revised version of the paper presented at the worksho

    Heuristic Refinement Method for the Derivation of Protein Solution Structures: Validation on Cytochrome B562

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    A method is described for determining the family of protein structures compatible with solution data obtained primarily from nuclear magnetic resonance (NMR) spectroscopy. Starting with all possible conformations, the method systematically excludes conformations until the remaining structures are only those compatible with the data. The apparent computational intractability of this approach is reduced by assembling the protein in pieces, by considering the protein at several levels of abstraction, by utilizing constraint satisfaction methods to consider only a few atoms at a time, and by utilizing artificial intelligence methods of heuristic control to decide which actions will exclude the most conformations. Example results are presented for simulated NMR data from the known crystal structure of cytochrome b562 (103 residues). For 10 sample backbones an average root-mean-square deviation from the crystal of 4.1 A was found for all alpha-carbon atoms and 2.8 A for helix alpha-carbons alone. The 10 backbones define the family of all structures compatible with the data and provide nearly correct starting structures for adjustment by any of the current structure determination methods
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