Hypothesis exploration with visualization of variance.

BackgroundThe Consortium for Neuropsychiatric Phenomics (CNP) at UCLA was an investigation into the biological bases of traits such as memory and response inhibition phenotypes-to explore whether they are linked to syndromes including ADHD, Bipolar disorder, and Schizophrenia. An aim of the consortium was in moving from traditional categorical approaches for psychiatric syndromes towards more quantitative approaches based on large-scale analysis of the space of human variation. It represented an application of phenomics-wide-scale, systematic study of phenotypes-to neuropsychiatry research.ResultsThis paper reports on a system for exploration of hypotheses in data obtained from the LA2K, LA3C, and LA5C studies in CNP. ViVA is a system for exploratory data analysis using novel mathematical models and methods for visualization of variance. An example of these methods is called VISOVA, a combination of visualization and analysis of variance, with the flavor of exploration associated with ANOVA in biomedical hypothesis generation. It permits visual identification of phenotype profiles-patterns of values across phenotypes-that characterize groups. Visualization enables screening and refinement of hypotheses about variance structure of sets of phenotypes.ConclusionsThe ViVA system was designed for exploration of neuropsychiatric hypotheses by interdisciplinary teams. Automated visualization in ViVA supports 'natural selection' on a pool of hypotheses, and permits deeper understanding of the statistical architecture of the data. Large-scale perspective of this kind could lead to better neuropsychiatric diagnostics

Silicon CMOS architecture for a spin-based quantum computer

Recent advances in quantum error correction (QEC) codes for fault-tolerant quantum computing \cite{Terhal2015} and physical realizations of high-fidelity qubits in a broad range of platforms \cite{Kok2007, Brown2011, Barends2014, Waldherr2014, Dolde2014, Muhonen2014, Veldhorst2014} give promise for the construction of a quantum computer based on millions of interacting qubits. However, the classical-quantum interface remains a nascent field of exploration. Here, we propose an architecture for a silicon-based quantum computer processor based entirely on complementary metal-oxide-semiconductor (CMOS) technology, which is the basis for all modern processor chips. We show how a transistor-based control circuit together with charge-storage electrodes can be used to operate a dense and scalable two-dimensional qubit system. The qubits are defined by the spin states of a single electron confined in a quantum dot, coupled via exchange interactions, controlled using a microwave cavity, and measured via gate-based dispersive readout \cite{Colless2013}. This system, based entirely on available technology and existing components, is compatible with general surface code quantum error correction \cite{Terhal2015}, enabling large-scale universal quantum computation

Enabling All-Access Mobility for Planetary Exploration Vehicles via Transformative Reconfiguration

Effective large-scale exploration of planetary surfaces requires robotic vehicles capable of mobility across chaotic terrain. Characterized by a combination of ridges, cracks and valleys, the demands of this environment can cause spacecraft to experience significant reductions in operating footprint, performance, or even result in total system loss. Significantly increasing the scientific return of an interplanetary mission is facilitated by architectures capable of real-time configuration changes that go beyond that of active suspensions while concurrently meeting system, mass, power, and cost constraints. This Phase 1 report systematically explores how in-service architecture changes can expand system capabilities and mission opportunities. A foundation for concept generation is supplied by four Martian mission profiles spanning chasms, ice fields, craters and rocky terrain. A fifth mission profile centered on Near Earth Object exploration is also introduced. Concept generation is directed using four transformation principles - a taxonomy developed by the engineering design community to explain the cause of an architecture change and existing brainstorming techniques. This allowed early conceptual sketches of architecture changes to be organized by the principle driving the greatest increase in mission performance capability

The NOAO Data Lab: Science-Driven Development

The NOAO Data Lab aims to provide infrastructure to maximize community use of the high-value survey datasets now being collected with NOAO telescopes and instruments. As a science exploration framework, the Data Lab allow users to access and search databases containing large (i.e. terabyte-scale) catalogs, visualize, analyze, and store the results of these searches, combine search results with data from other archives or facilities, and share these results with collaborators using a shared workspace and/or data publication service. In the process of implementing the needed tools and services, specific science cases are used to guide development of the system framework and tools. The result is a Year-1 capability demonstration that (fully or partially) implements each of the major architecture components in the context of a real-world science use-case. In this paper, we discuss how this model of science-driven development helped us to build a fully functional system capable of executing the chosen science case, and how we plan to scale this system to support general use in the next phase of the project

Robotic Specialization in Autonomous Robotic Structural Assembly

Robotic in-space assembly of large space structures is a long-term NASA goal to reduce launch costs and enable larger scale missions. Recently, researchers have proposed using discrete lattice building blocks and co-designed robots to build high-performance, scalable primary structure for various on-orbit and surface applications. These robots would locomote on the lattice and work in teams to build and reconfigure building-blocks into functional structure. However, the most reliable and efficient robotic system architecture, characterized by the number of different robotic 'species' and the allocation of functionality between species, is an open question. To address this problem, we decompose the robotic building-block assembly task into functional primitives and, in simulation, study the performance of the the variety of possible resulting architectures. For a set consisting of five process types (move self, move block, move friend, align bock, fasten block), we describe a method of feature space exploration and ranking based on energy and reliability cost functions. The solution space is enumerated, filtered for unique solutions, and evaluated against energy and reliability cost functions for various simulated build sizes. We find that a 2 species system, dividing the five mentioned process types between one unit cell transport robot and one fastening robot, results in the lowest energy cost system, at some cost to reliability. This system enables fastening functionality to occupy the build front while reducing the need for that functional mass to travel back and forth from a feed station. Because the details of a robot design affect the weighting and final allocation of functionality, a sensitivity analysis was conducted to evaluate the effect of changing mass allocations on architecture performance. Future systems with additional functionalities such as repair, inspection, and others may use this process to analyze and determine alternative robot architectures

Space Launch System Complex Decision-Making Process

The Space Shuttle program has ended and elements of the Constellation Program have either been cancelled or transitioned to new NASA exploration endeavors. The National Aeronautics and Space Administration (NASA) has worked diligently to select an optimum configuration for the Space Launch System (SLS), a heavy lift vehicle that will provide the foundation for future beyond low earth orbit (LEO) large-scale missions for the next several decades. From Fall 2010 until Spring 2011, an SLS decision-making framework was formulated, tested, fully documented, and applied to multiple SLS vehicle concepts at NASA from previous exploration architecture studies. This was a multistep process that involved performing figure of merit (FOM)-based assessments, creating Pass/Fail gates based on draft threshold requirements, performing a margin-based assessment with supporting statistical analyses, and performing sensitivity analysis on each. This paper focuses on the various steps and methods of this process (rather than specific data) that allowed for competing concepts to be compared across a variety of launch vehicle metrics in support of the successful completion of the SLS Mission Concept Review (MCR) milestone

The Role of SmallSats in Scientific Exploration and Commercialization of Space

Over the past decade, SmallSats have been established as having great potential for science exploration and commercialization of space. The SmallSat revolution aims to decrease the cost of space development, making space exploration accessible to students, educators, and public citizens. These efforts have focused on miniaturization of instruments and space platforms, as well as reducing their cost, mass, and needed power. In addition to enabling scientific exploration, SmallSats provide affordable means for the public to purchase remote sensing and communication products on a global scale. SmallSat mission concepts are particularly powerful when they are deployed in distributed architecture or constellations. For example, the most promising observation techniques for global science measurements of the Earth system and space weather require multi-point distributed observations of the Earth system at a feasible cost. The high cost of access to space has long been a barrier, especially with the prohibitive cost of large satellites. Affordable SmallSat constellations can be game-changers, enabling scientific exploration as well as commercial global data products. In this paper, we highlight investments made by NASA to date (specifically a study in developing and prototyping a SmallSat platform with standard interfaces), along with several example mission concept scenarios in Earth and space science (astrophysics, heliophysics, and planetary) applications that can be achieved using this platform