Design methodology for embedded computer vision systems

Computer vision has emerged as one of the most popular domains of embedded appli¬cations. Though various new powerful embedded platforms to support such applica¬tions have emerged in recent years, there is a distinct lack of efficient domain-specific synthesis techniques for optimized implementation of such systems. In this thesis, four different aspects that contribute to efficient design and synthesis of such systems are explored: (1) Graph Transformations: Dataflow modeling is widely used in digital signal processing (DSP) systems. However, support for dynamic behavior in such systems exists mainly at the modeling level and there is a lack of optimized synthesis tech¬niques for these models. New transformation techniques for efficient system-on-chip (SoC) design methods are proposed and implemented for cyclo-static dataflow and its parameterized version (parameterized cyclo-static dataflow) -- two powerful models that allow dynamic reconfigurability and phased behavior in DSP systems. (2) Design Space Exploration: The broad range of target platforms along with the complexity of applications provides a vast design space, calling for efficient tools to explore this space and produce effective design choices. A novel architectural level design methodology based on a formalism called multirate synchronization graphs is presented along with methods for performance evaluation. (3) Multiprocessor Communication Interface: Efficient code synthesis for emerg¬ing new parallel architectures is an important and sparsely-explored problem. A widely-encountered problem in this regard is efficient communication between pro¬cessors running different sub-systems. A widely used tool in the domain of general-purpose multiprocessor clusters is MPI (Message Passing Interface). However, this does not scale well for embedded DSP systems. A new, powerful and highly optimized communication interface for multiprocessor signal processing systems is presented in this work that is based on the integration of relevant properties of MPI with dataflow semantics. (4) Parameterized Design Framework for Particle Filters: Particle filter systems constitute an important class of applications used in a wide number of fields. An effi¬cient design and implementation framework for such systems has been implemented based on the observation that a large number of such applications exhibit similar prop¬erties. The key properties of such applications are identified and parameterized appro¬priately to realize different systems that represent useful trade-off points in the space of possible implementations

The feasibility of miniaturizing the versatile portable speech prosthesis: A market survey of commercial products

The feasibility of a miniature versatile portable speech prosthesis (VPSP) was analyzed and information on its potential users and on other similar devices was collected. The VPSP is a device that incorporates speech synthesis technology. The objective is to provide sufficient information to decide whether there is valuable technology to contribute to the miniaturization of the VPSP. The needs of potential users are identified, the development status of technologies similar or related to those used in the VPSP are evaluated. The VPSP, a computer based speech synthesis system fits on a wheelchair. The purpose was to produce a device that provides communication assistance in educational, vocational, and social situations to speech impaired individuals. It is expected that the VPSP can be a valuable aid for persons who are also motor impaired, which explains the placement of the system on a wheelchair

Drug development progress in duchenne muscular dystrophy

Duchenne muscular dystrophy (DMD) is a severe, progressive, and incurable X-linked disorder caused by mutations in the dystrophin gene. Patients with DMD have an absence of functional dystrophin protein, which results in chronic damage of muscle fibers during contraction, thus leading to deterioration of muscle quality and loss of muscle mass over time. Although there is currently no cure for DMD, improvements in treatment care and management could delay disease progression and improve quality of life, thereby prolonging life expectancy for these patients. Furthermore, active research efforts are ongoing to develop therapeutic strategies that target dystrophin deficiency, such as gene replacement therapies, exon skipping, and readthrough therapy, as well as strategies that target secondary pathology of DMD, such as novel anti-inflammatory compounds, myostatin inhibitors, and cardioprotective compounds. Furthermore, longitudinal modeling approaches have been used to characterize the progression of MRI and functional endpoints for predictive purposes to inform Go/No Go decisions in drug development. This review showcases approved drugs or drug candidates along their development paths and also provides information on primary endpoints and enrollment size of Ph2/3 and Ph3 trials in the DMD space