Advanced Knowledge Application in Practice

The integration and interdependency of the world economy leads towards the creation of a global market that offers more opportunities, but is also more complex and competitive than ever before. Therefore widespread research activity is necessary if one is to remain successful on the market. This book is the result of research and development activities from a number of researchers worldwide, covering concrete fields of research

Preclinical Evaluation of Lipid-Based Nanosystems

The use of lipid-based nanosystems, including lipid nanoparticles (solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC)), nanoemulsions, and liposomes, among others, is widespread. Several researchers have described the advantages of different applications of these nanosystems. For instance, they can increase the targeting and bioavailability of drugs, improving therapeutic effects. Their use in the cosmetic field is also promising, owing to their moisturizing properties and ability to protect labile cosmetic actives. Thus, it is surprising that only a few lipid-based nanosystems have reached the market. This can be explained by the strict regulatory requirements of medicines and the occurrence of unexpected in vivo failure, which highlights the need to conduct more preclinical studies.Current research is focused on testing the in vitro, ex vivo, and in vivo efficacy of lipid-based nanosystems to predict their clinical performance. However, there is a lack of method validation, which compromises the comparison between different studies.This book brings together the latest research and reviews that report on in vitro, ex vivo, and in vivo preclinical studies using lipid-based nanosystems. Readers can find up-to-date information on the most common experiments performed to predict the clinical behavior of lipid-based nanosystems. A series of 15 research articles and a review are presented, with authors from 15 different countries, which demonstrates the universality of the investigations that have been carried out in this area

Phoenix 1994

https://commons.erau.edu/phoenix-yearbooks/1027/thumbnail.jp

Strategies to Target the Bone Morphogenetic Protein Signalling Pathway in Lung Disease

Lung disease and lung injury are responsible for 20% of deaths of the Irish population every year, and the country has the 2nd highest death rate in Europe for respiratory diseases. Conditions related to the respiratory system are the second largest long term illness by young adults. Lung cancer is the largest cause of cancer related death in Europe as a whole. New and refined mechanisms of drug delivery for the prevention, cure or delayed progression of disease, represents a pathway for the delivery of novel style therapies and for the targeted delivery of different of more toxic drugs to the airways in order to increase efficiency of both the delivery mechanism and of the drug utilised. Here we looked at the use of a number of different mechanisms, which can be used as stand-alone devices/delivery agents and/or in conjunction with other devices and delivery agents to optimise targeted delivery to the lung, and to the specific areas required. We examined the use of a direct delivery mechanism, particle bombardment, for the delivery of various molecules to human and murine cells lines, and to mouse primary cell isolates, MAECs, to examine the potential of the mechanism for adaption to a clinical mechanism for delivery. An aerosol delivery system was developed to utilise a current aerosol generator for the delivery of aerosol to mice in vivo. This was done with the aim of creating a more efficacious and ergonomic mechanism for the delivery of aerosols to mice in vivo and also to investigate the effects of aerosolistation on various drug compound molecules. We also looked for BMP4 disregulation in a number of different animal models to help ascertain the role of the pathway in the progression of disease and damage in the lung. BMP4 has been shown to have a role in the induction of EMT in MAECS (E.Molloy) and to play a role in both lung cancer and allergic Rhinitis. Here we looked at its role in a number of different models. It was firstly examined in vitro in mouse cell lines and primary cell isolates and the effect of pathway stimulation and deregulation examined. The role of the pathway was then examined in both a murine Elastase model of emphysema, where it was determined to be inactive, and a murine OVA model of asthma where deregulation of the active pathway was evident. The pathway was also shown to be activated in a deregulated fashion in an Ozone/HDMA model of allergic asthma in Rhesus Macaques. In vitro models of mouse, human and primate cells lines were used to examine the role of BMP4 in more detail. Mouse cell lines and primary isolates were used both in normal culture and in an air liquid interface (ALI), stimulated with BMP4 and examined. An air liquid interface enables the culturing of cells in a system consistent with that of the in vivo environment, where the nutrition is provided through the basal surface of the cells and the dorsal surfaces of the cells are exposed to air. Murine model of OVA induced asthma in vivo was also stimulated with exogenous BMP4 and the effects monitored. Human primary cells and primate primary cell isolates were also grown in ALI and were treated with either BMP4 or EGTA and BMP4 in order to help determine more information about the cells involved in the pathway and the other pathways that are recruited by BMP activation

2018, UMaine News Press Releases

This is a catalog of press releases put out by the University of Maine Division of Marketing and Communications between March 2, 2018 and December 31, 2018

1988 Bluestone

The Bluestone is the yearbook of James Madison University.https://commons.lib.jmu.edu/allyearbooks/1081/thumbnail.jp

Life Sciences Program Tasks and Bibliography

This document includes information on all peer reviewed projects funded by the Office of Life and Microgravity Sciences and Applications, Life Sciences Division during fiscal year 1995. Additionally, this inaugural edition of the Task Book includes information for FY 1994 programs. This document will be published annually and made available to scientists in the space life sciences field both as a hard copy and as an interactive Internet web pag

The Whitworthian 1987-1988

The Whitworthian student newspaper, September 1987-May 1988.https://digitalcommons.whitworth.edu/whitworthian/1071/thumbnail.jp