516 research outputs found

    Influence maximization on social graphs: A survey

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    Environment Search Planning Subject to High Robot Localization Uncertainty

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    As robots find applications in more complex roles, ranging from search and rescue to healthcare and services, they must be robust to greater levels of localization uncertainty and uncertainty about their environments. Without consideration for such uncertainties, robots will not be able to compensate accordingly, potentially leading to mission failure or injury to bystanders. This work addresses the task of searching a 2D area while reducing localization uncertainty. Wherein, the environment provides low uncertainty pose updates from beacons with a short range, covering only part of the environment. Otherwise the robot localizes using dead reckoning, relying on wheel encoder and yaw rate information from a gyroscope. As such, outside of the regions with position updates, there will be unconstrained localization error growth over time. The work contributes a Belief Markov Decision Process formulation for solving the search problem and evaluates the performance using Partially Observable Monte Carlo Planning (POMCP). Additionally, the work contributes an approximate Markov Decision Process formulation and reduced complexity state representation. The approximate problem is evaluated using value iteration. To provide a baseline, the Google OR-Tools package is used to solve the travelling salesman problem (TSP). Results are verified by simulating a differential drive robot in the Gazebo simulation environment. POMCP results indicate planning can be tuned to prioritize constraining uncertainty at the cost of increasing path length. The MDP formulation provides consistently lower uncertainty with minimal increases in path length over the TSP solution. Both formulations show improved coverage outcomes

    Working Notes from the 1992 AAAI Spring Symposium on Practical Approaches to Scheduling and Planning

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    The symposium presented issues involved in the development of scheduling systems that can deal with resource and time limitations. To qualify, a system must be implemented and tested to some degree on non-trivial problems (ideally, on real-world problems). However, a system need not be fully deployed to qualify. Systems that schedule actions in terms of metric time constraints typically represent and reason about an external numeric clock or calendar and can be contrasted with those systems that represent time purely symbolically. The following topics are discussed: integrating planning and scheduling; integrating symbolic goals and numerical utilities; managing uncertainty; incremental rescheduling; managing limited computation time; anytime scheduling and planning algorithms, systems; dependency analysis and schedule reuse; management of schedule and plan execution; and incorporation of discrete event techniques

    Discretization approach

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    ํ•™์œ„๋…ผ๋ฌธ(๋ฐ•์‚ฌ)--์„œ์šธ๋Œ€ํ•™๊ต ๋Œ€ํ•™์› :๊ณต๊ณผ๋Œ€ํ•™ ํ™”ํ•™์ƒ๋ฌผ๊ณตํ•™๋ถ€(์—๋„ˆ์ง€ํ™˜๊ฒฝ ํ™”ํ•™์œตํ•ฉ๊ธฐ์ˆ ์ „๊ณต),2019. 8. ์ด์›๋ณด.In recent years, many researchers in chemical engineering have made great efforts to develop mathematical models on the theoretical side that are consistent with experimental results. Despite these efforts, however, establishing models for a system with complex phenomena such as multiphase flow or stirred reactors is still considered to be a challenge. In the meantime, an increase in computational efficiency and stability in various numerical methods has allowed us to correctly solve and analyze the system based on the fundamental equations. This leads to the need for a mathematical model to accurately predict the behavior of systems in which there is interdependence among the internal elements. A methodology for building a model based on equations that represent fundamental phenomena can lower technical barriers in system analysis. In this thesis, we propose three mathematical models validated from laboratory or pilot-scale experiments. First, an apparatus for vaporizing liquid natural gas is surrounded with a frost layer formed on the surface during operation, and performance of the apparatus is gradually deteriorated due to the adiabatic effect. Because the system uses ambient air as a heat sink, it is necessary to consider the phase transition and mass transfer of water vapor, and natural gas in the air in order to understand the fluctuation of system characteristics. The model predicts the experimental data of a pilot-scale vaporizer within a mean absolute error of 5.5 %. In addition, we suggest the robust design methodology and optimal design which is able to maintain the efficiency under the weather conditions for a year. Two or more data analysis techniques including discrete waveform transformation and k-means clustering are used to extract features that can represent time series data. Under the settings, the performance in the optimized desgin is improved by 22.92 percentage points compared to that in the conventional system. In the second system, the continuous tubular crystallization reactor has advantages in terms of production capacity and scale-up compared with the conventional batch reactor. However, the tubular system requires a well-designed control system to maintain its stability and durability, and thus; there is a great deal of demand for the mathematical model of this system. We were able to estimate crystal size distribution by considering the population balance model simultaneously with several heat exchanger models. The model constructed based on the first principle reaction scheme successfully predicted the results from the full-factorial experiment. The experiments were conducted with LAM (L-asparagine monohydrate) solution. In the prediction, the average crystal length and standard deviation were within 20% of the results of an experiment where the crystals were not iteratively dissolved in the liquid but maintained a low-level supersaturation. Furthermore, to confirm the controllability of the crystal size distribution in the system, we replaced the LAM solution with HEWL (Hen-egg white lysozyme) solution. Finally, we propose a multi-compartment model to predict the behavior of a high-pressure autoclave reactor for polymer production. In order to simulate a complex polymer synthesis mechanism, the rotation effect of impellers in the reactor on polymerization and the influence caused by polymerization heat were sequentially evaluated. As a result, This model turned out to be able to predict the physical properties of the polymers produced in an industrial-scale reactor within 7% accuracy. In this thesis, all three systems are distributed parameter systems which can be expressed as partial differential equations for time and space. To construct a high order model, the system was interpreted based on discretization approach under minimal assumptions. This methodology can be applied not only to the systems suggested in this thesis but also to those consisting of interpdependent variables. I hope that this thesis provides guidance for further researches of chemical engineering in nearby future.์ตœ๊ทผ์— ๋ช‡ ๋…„์— ๊ฑธ์ณ์„œ ๋งŽ์€ ์—ฐ๊ตฌ์ž๋“ค์ด ์ด๋ก ์„ ๊ธฐ๋ฐ˜์œผ๋กœ ์‹คํ—˜ ๊ฒฐ๊ณผ์™€ ์ผ์น˜ํ•˜๋Š” ์ˆ˜ํ•™ ๋ชจ๋ธ์„ ๊ฐœ๋ฐœํ•˜๊ณ ์ž ๋งŽ์€ ๋…ธ๋ ฅ์„ ๊ธฐ์šธ์—ฌ ์™”๋‹ค. ํ•˜์ง€๋งŒ ์ด๋Ÿฐ ๋…ธ๋ ฅ์—๋„ ๋ถˆ๊ตฌํ•˜๊ณ  ๋‹ค์ƒ ํ๋ฆ„ ํ˜น์€ ๊ต๋ฐ˜ ๋ฐ˜์‘๊ธฐ์™€ ๊ฐ™์€ ๋ณต์žกํ•œ ํ˜„์ƒ์„ ๋‚ดํฌํ•œ ์‹œ์Šคํ…œ์„ ์œ„ํ•œ ๋ชจ๋ธ์„ ์ˆ˜๋ฆฝํ•˜๋Š” ๊ฒƒ์€ ์—ฌ์ „ํžˆ ํ™”ํ•™ ๊ณตํ•™ ๋ถ„์•ผ์—์„œ ์‰ฝ์ง€ ์•Š์€ ์ผ๋กœ ์—ฌ๊ฒจ์ง„๋‹ค. ์ด ์™€์ค‘์— ๋‹ค์–‘ํ•œ ์ˆ˜์น˜์  ๋ฐฉ๋ฒ•์—์„œ์˜ ๊ณ„์‚ฐ ํšจ์œจ์˜ ์ฆ๊ฐ€์™€ ์•ˆ์ •์„ฑ์˜ ํ–ฅ์ƒ์€ ๊ธฐ๋ณธ๋ฐฉ์ •์‹์— ๊ธฐ์ดˆํ•œ ์‹œ์Šคํ…œ์„ ์ •ํ™•ํ•˜๊ฒŒ ํ•ด๊ฒฐํ•˜๊ณ  ๋ถ„์„ํ•  ์ˆ˜ ์žˆ๊ฒŒ ํ•ด์ฃผ์—ˆ๋‹ค. ์ด๋กœ ์ธํ•˜์—ฌ ๋‚ด๋ถ€ ์š”์†Œ๋“ค ๊ฐ„์˜ ์ƒํ˜ธ ์˜์กด์„ฑ์ด ์กด์žฌํ•˜๋Š” ์‹œ์Šคํ…œ์˜ ๊ฑฐ๋™์„ ์ •ํ™•ํ•˜๊ฒŒ ์˜ˆ์ธกํ•˜๊ธฐ ์œ„ํ•œ ์ˆ˜ํ•™์  ๋ชจ๋ธ์˜ ํ•„์š”์„ฑ์ด ๋ถ€๊ฐ๋˜์—ˆ๋‹ค. ๊ธฐ๋ณธ ํ˜„์ƒ๋“ค์„ ํ‘œํ˜„ํ•  ์ˆ˜ ์žˆ๋Š” ๋ฐฉ์ •์‹๋“ค์„ ๊ธฐ๋ฐ˜์œผ๋กœ ๋ชจ๋ธ์„ ๊ตฌ์ถ•ํ•˜๊ธฐ ์œ„ํ•œ ๋ฐฉ๋ฒ•๋ก ์€ ์‹œ์Šคํ…œ ํ•ด์„์— ์žˆ์–ด์„œ ๊ธฐ์ˆ ์  ์žฅ๋ฒฝ์„ ๋‚ฎ์ถœ ์ˆ˜ ์žˆ๋‹ค. ์ด ํ•™์œ„ ๋…ผ๋ฌธ์—์„œ ์šฐ๋ฆฌ๋Š” ์‹คํ—˜์‹ค ๋˜๋Š” ํŒŒ์ผ๋Ÿฟ ๊ทœ๋ชจ์˜ ์‹คํ—˜์œผ๋กœ๋ถ€ํ„ฐ ์ž…์ฆ๋œ ์„ธ ๊ฐ€์ง€ ์ˆ˜ํ•™์  ๋ชจ๋ธ์„ ์ œ์•ˆํ•œ๋‹ค. ์ฒซ ๋ฒˆ์งธ๋กœ, ๊ณต๊ธฐ๋ฅผ ์‚ฌ์šฉํ•˜์—ฌ ์•ก์ƒ์˜ ์ฒœ์—ฐ๊ฐ€์Šค๋ฅผ ๊ธฐํ™”์‹œํ‚ค๋Š” ์žฅ์น˜๋Š” ์šด์ „ ๋„์ค‘์— ๊ธฐํ™”๊ธฐ ํ‘œ๋ฉด์— ์„œ๋ฆฌ ์ธต์ด ํ˜•์„ฑ๋˜๊ณ  ๊ทธ๋กœ ์ธํ•œ ๋‹จ์—ด ํšจ๊ณผ๋กœ ์žฅ๋น„์˜ ์„ฑ๋Šฅ์ด ์„œ์„œํžˆ ์ €ํ•˜๋œ๋‹ค. ์‹œ์Šคํ…œ์€ ์ฃผ๋ณ€ ๊ณต๊ธฐ๋ฅผ ์—ด ํก์ˆ˜์›์œผ๋กœ ์‚ฌ์šฉํ•˜๊ธฐ ๋•Œ๋ฌธ์— ์‹œ์Šคํ…œ ํŠน์„ฑ์˜ ๋ณ€๋™์„ ํŒŒ์•…ํ•˜๊ธฐ ์œ„ํ•ด์„œ๋Š” ๊ณต๊ธฐ ์ค‘ ์ˆ˜์ฆ๊ธฐ ๋ฐ ์ฒœ์—ฐ ๊ฐ€์Šค์˜ ์ƒ์ „์ด ๋ฐ ์ „๋‹ฌ ํ˜„์ƒ์„ ๋™์‹œ์— ๊ณ ๋ คํ•˜์—ฌ์•ผ ํ•œ๋‹ค. ์ œ์‹œ๋œ ์ˆ˜ํ•™์  ๋ชจ๋ธ์— ์˜ํ•ด ์˜ˆ์ธกํ•œ ๊ฒฐ๊ณผ๋Š” ํŒŒ์ผ๋Ÿฟ ๊ทœ๋ชจ ๊ธฐํ™”๊ธฐ๋กœ๋ถ€ํ„ฐ ์–ป์€ ์‹คํ—˜ ๋ฐ์ดํ„ฐ์™€ 5.5% ํ‰๊ท  ์ ˆ๋Œ€ ์˜ค์ฐจ๋ฅผ ๋ณด์˜€๋‹ค. ์ด์— ๋”ํ•˜์—ฌ, ์•ž์—์„œ ์ œ์‹œํ•œ ๊ธฐํ™”๊ธฐ ๋ชจ๋ธ์„ ์ด์šฉํ•˜์—ฌ 1๋…„ ๋™์•ˆ์˜ ๊ธฐ์ƒ ์กฐ๊ฑด์—์„œ ์šด์ „ ํšจ์œจ์„ ์œ ์ง€ํ•˜๋ฉด์„œ ์ง€์† ์šด์ „์ด ๊ฐ€๋Šฅํ•œ ๊ธฐํ™”๊ธฐ์˜ ์„ค๊ณ„ ๋ฐฉ๋ฒ•๊ณผ ๊ฒฐ๊ณผ๋ฅผ ์ œ์•ˆํ•˜์˜€๋‹ค. ์ด์‚ฐ ํŒŒํ˜• ๋ณ€ํ™˜๊ณผ k-ํ‰๊ท  ๊ตฐ์ง‘ํ™”๋ฅผ ํฌํ•จํ•˜๋Š” ๋‘ ๊ฐ€์ง€ ์ด์ƒ์˜ ๋ฐ์ดํ„ฐ ๋ถ„์„ ๊ธฐ๋ฒ•์„ ์‚ฌ์šฉํ•˜์—ฌ ์‹œ๊ณ„์—ด ๋ฐ์ดํ„ฐ๋ฅผ ๋Œ€ํ‘œํ•  ์ˆ˜ ์žˆ๋Š” ํŠน์ง•์„ ์ถ”์ถœํ•œ๋‹ค. ์ถ”์ถœ๋œ ํŠน์ง• ์•„๋ž˜์—์„œ ์ตœ์ ํ™”๋œ ๋””์ž์ธ์€ ๊ธฐ์กด ์ œ์‹œ๋œ ์•ˆ์— ๋น„ํ•ด 22.92% ๋งŒํผ ํ–ฅ์ƒ๋œ ์„ฑ๋Šฅ์„ ๋ณด์—ฌ์ฃผ์—ˆ๋‹ค. ๋‘ ๋ฒˆ์งธ ์‹œ์Šคํ…œ์€ ์‹  ์ œ์•ฝ ๊ธฐ์ˆ  ๊ณต์ •์ธ ์—ฐ์† ๊ด€ํ˜• ๊ฒฐ์ •ํ™” ๋ฐ˜์‘๊ธฐ๋Š” ๊ธฐ์กด์— ๋„๋ฆฌ ์“ฐ์ด๋˜ ํšŒ๋ถ„์‹ ๋ฐ˜์‘๊ธฐ์— ๋น„ํ•˜์—ฌ ์ƒ์‚ฐ ์†๋„ ๋ฐ ์Šค์ผ€์ผ ์—… ์ธก๋ฉด์—์„œ ์žฅ์ ์ด ๋งŽ๋‹ค. ํ•˜์ง€๋งŒ ์ œ์–ด๊ธฐ์ˆ ์ด ๊ธฐ๋ฐ˜์ด ๋˜์–ด์•ผํ•œ๋‹ค๋Š” ์ ์— ์žˆ์–ด์„œ ๊ทธ ๋„์ž…์ด ๋Šฆ์–ด์กŒ๊ณ  ์ด์— ๋”ฐ๋ผ ์ž์—ฐ์Šค๋Ÿฝ๊ฒŒ ๊ฐœ๋ฐœ๋œ ๋ชจ๋ธ ๋˜ํ•œ ์ „๋ฌดํ•˜๋‹ค. ์šฐ๋ฆฌ๋Š” ์ด ์žฅ์น˜์—์„œ ๊ฒฐ์ • ํฌ๊ธฐ ๋ถ„ํฌ๋ฅผ ์ถ”์‚ฐํ•˜๊ธฐ ์œ„ํ•œ ์ธ๊ตฌ ๊ท ํ˜• ๋ชจ๋ธ์„ ์—ด ๊ตํ™˜ ๋ชจ๋ธ๊ณผ ๋™์‹œ์— ๊ณ ๋ คํ•˜์—ฌ ๊ฒฐ์ • ํฌ๊ธฐ ๋ถ„ํฌ๋ฅผ ์ถ”์‚ฐํ•  ์ˆ˜ ์žˆ์—ˆ๋‹ค. ์ œ 1์›๋ฆฌ ๊ฒฐ์ • ๋ฐ˜์‘์‹์„ ๊ธฐ๋ฐ˜์œผ๋กœ ๊ตฌ์ถ•๋œ ๋ชจ๋ธ์€ ์™„์ „ ์š”์ธ ๋ฐฐ์น˜๋ฒ•์„ ๊ธฐ๋ฐ˜์œผ๋กœ ์‹คํ—˜๋œ ๋ฐ์ดํ„ฐ๋ฅผ ์„ฑ๊ณต์ ์œผ๋กœ ์˜ˆ์ธกํ•˜์˜€๋‹ค. ๊ฒฐ์ •์ด ์•ก์ƒ์— ์šฉํ•ด๋˜์ง€ ์•Š์œผ๋ฉด์„œ ๋‚ฎ์€ ์ˆ˜์ค€์˜ ๊ณผํฌํ™” ์ƒํƒœ๋ฅผ ์œ ์ง€ํ•œ ์‹คํ—˜์— ๋Œ€ํ•ด์„œ๋Š” ํ‰๊ท  ๊ฒฐ์ • ๊ธธ์ด์™€ ํ‘œ์ค€ํŽธ์ฐจ๊ฐ€ ์‹คํ—˜ ๊ฒฐ๊ณผ์™€ 20% ์ด๋‚ด์˜ ์˜ค์ฐจ๋ฅผ ๋ณด์˜€๋‹ค. ์•ž์—์„œ ๋ชจ๋ธ์˜ ๊ฒ€์ฆ์— ์‚ฌ์šฉ๋œ ๋ฐ์ดํ„ฐ๊ฐ€ LAM (L-์•„์ŠคํŒŒ๋ผ๊ธด ์ผ ์ˆ˜ํ™”๋ฌผ)์šฉ์•ก์œผ๋กœ๋ถ€ํ„ฐ ์–ป์–ด์ง„ ๊ฒƒ์ด์—ˆ๋‹ค๋ฉด ์ดํ›„์—๋Š” HEWL (๋‹ฌ๊ฑ€ ํฐ์ž ๋ฆฌ์†Œ์ž์ž„)๋ฅผ ์‚ฌ์šฉํ•˜์—ฌ ์ œํ’ˆ์˜ ๊ฒฐ์ • ํฌ๊ธฐ ๋ถ„ํฌ์˜ ์กฐ์ ˆ ๊ฐ€๋Šฅ์„ฑ์„ ๋ณด์˜€๋‹ค. ๋งˆ์ง€๋ง‰์œผ๋กœ ํด๋ฆฌ๋จธ ์ƒ์‚ฐ์„ ์œ„ํ•œ ๊ณ ์•• ์˜คํ† ํด๋ ˆ์ด๋ธŒ ๋ฐ˜์‘๊ธฐ์˜ ๊ฑฐ๋™์„ ์˜ˆ์ธกํ•˜๊ธฐ ์œ„ํ•œ ๋‹ค์ค‘ ๊ตฌํš ๋ชจ๋ธ์„ ์ œ์•ˆํ•˜์˜€๋‹ค. ๋ณต์žกํ•œ ๊ณ ๋ถ„์ž ํ•ฉ์„ฑ ๋ฉ”์ปค๋‹ˆ์ฆ˜์„ ๋ชจ์‚ฌํ•˜๊ธฐ ์œ„ํ•˜์—ฌ ๋ฐ˜์‘๊ธฐ ๋‚ด ์ž„ํŽ ๋Ÿฌ์˜ ํšŒ์ „์ด ์ค‘ํ•ฉ์— ๋ฏธ์น˜๋Š” ํšจ๊ณผ์™€ ์ค‘ํ•ฉ ์—ด๋กœ ์ธํ•œ ์˜ํ–ฅ๋ ฅ์„ ์ˆœ์ฐจ์ ์œผ๋กœ ํ‰๊ฐ€ํ•˜์˜€๋‹ค. ์ œ์•ˆ๋œ ๋ชจ๋ธ์€ 3D ๊ตฌ์กฐ๋ฅผ ๊ฐ€์ง„ ์‚ฐ์—…ํ™”๋œ ๋ฐ˜์‘๊ธฐ์—์„œ ์ƒ์‚ฐ๋œ ๋‘ ๊ฐ€์ง€ ๊ณ ๋ถ„์ž์˜ ๋ฌผ์„ฑ์„ 7%์ด๋‚ด ์ •ํ™•๋„๋กœ ์˜ˆ์ธกํ•  ์ˆ˜ ์žˆ๋‹ค. ๋ณธ ํ•™์œ„๋…ผ๋ฌธ์—์„œ๋Š” ๋‹ค๋ฃจ๋Š” ์‹œ์Šคํ…œ์€ ๋ชจ๋‘ ๋ถ„ํฌ ์ •์ˆ˜๊ณ„ ์‹œ์Šคํ…œ์œผ๋กœ ์‹œ๊ฐ„๊ณผ ๊ณต๊ฐ„์— ๋Œ€ํ•˜์—ฌ ํŽธ๋ฏธ๋ถ„๋ฐฉ์ •์‹์œผ๋กœ ํ‘œํ˜„ํ•  ์ˆ˜ ์žˆ๋‹ค. ๊ณ ์ฐจ ๋ชจ๋ธ์„ ๊ตฌ์ถ•ํ•˜๊ธฐ ์œ„ํ•ด ์ด์‚ฐํ™” ์ ‘๊ทผ๋ฒ•์„ ๊ธฐ๋ฐ˜์œผ๋กœ ์ตœ์†Œํ•œ์˜ ๊ฐ€์ • ํ•˜์— ์‹œ์Šคํ…œ์„ ํ•ด์„ํ•˜์˜€๋‹ค. ์ด๋Š” ๋…ผ๋ฌธ์— ์ œ์‹œํ•œ ์‹œ์Šคํ…œ ๋ฟ๋งŒ ์•„๋‹ˆ๋ผ ์‹œ๊ณต๊ฐ„์—์„œ ์˜ˆ์ธก ์–ด๋ ค์šด ๋ถ„ํฌ๋ฅผ ๊ฐ€์ง€๋Š” ๋ณ€์ˆ˜๋ฅผ ๊ฐ€์ง„ ๋ชจ๋“  ์‹œ์Šคํ…œ์— ๋Œ€ํ•˜์—ฌ ์ ์šฉ์ด ๊ฐ€๋Šฅํ•˜๋‹ค. ์ด ๋…ผ๋ฌธ์ด ์•ž์œผ๋กœ ํ™”ํ•™ ๊ณตํ•™ ๋ถ„์•ผ์˜ ์‹œ์Šคํ…œ์„ ํ•ด์„ํ•˜๋Š” ๋ฐ ์žˆ์–ด์„œ ๋” ๋ฐœ์ „๋œ ์—ฐ๊ตฌ๋ฅผ ์œ„ํ•œ ์ง€์นจ์„œ๊ฐ€ ๋˜๊ธฐ๋ฅผ ํฌ๋งํ•œ๋‹ค.Abstract i Contents iv List of Figures viii List of Tables xii Chapter 1 1 Introduction 1 1.1 Research motivation 1 1.2 Research objective 3 1.3 Outline of the thesis 4 1.4 Associated publications 9 Chapter 2 10 Distributed parameter system 10 2.1 Introduction 10 2.2 Modeling methods 11 2.3 Conclusion 16 Chapter 3 17 Modeling and design of pilot-scale ambient air vaporizer 17 3.1 Introduction 17 3.2 Modeling and analysis of frost growth in pilot-scale ambient air vaporizer 24 3.2.1 Ambient air vaporizer 24 3.2.2 Experimental measurement 27 3.2.3 Numerical model of the vaporizer 31 3.2.4 Result and discussion 43 3.3 Robust design of ambient air vaporizer based on time-series clustering 58 3.3.1 Background 58 3.3.2 Trend of time-series weather conditions 61 3.3.3 Optimization of AAV structures under time-series weather conditions 63 3.3.4 Results and discussion 76 3.4 Conclusion 93 3.4.1 Modeling and analysis of AAV system 93 3.4.2 Robust design of AAV system 95 Chapter 4 97 Tunable protein crystal size distribution via continuous crystallization 97 4.1 Introduction 97 4.2 Mathematical modeling and experimental verification of fully automated continuous slug-flow crystallizer 101 4.2.1 Experimental methods and equipment setup 101 4.2.2 Mathematical model of crystallizer 109 4.2.3 Results and discussion 118 4.3 Continuous crystallization of a protein: hen egg white lysozyme (HEWL) 132 4.3.1 Introduction 132 4.3.2 Experimental method 135 4.3.3 Results and discussion 145 4.4 Conclusion 164 4.4.1 Mathematical model of continuous crystallizer 164 4.4.2 Tunable continuous protein crystallization process 165 Chapter 5 167 Multi-compartment model of high-pressure autoclave reactor for polymer production: combined CFD mixing model and kinetics of polymerization 167 5.1 Introduction 167 5.2 Method 170 5.2.1 EVA autoclave reactor 170 5.2.2 Multi-compartment model of the autoclave reactor 173 5.2.3 CFD simulation of mixing effects in the autoclave reactor 175 5.2.4 Region-based dividing algorithm 178 5.2.5 Polymerization kinetic model 182 5.3 Results and discussion 191 5.4 Conclusion 203 5.5 Appendix 205 Chapter 6 210 Concluding Remarks 210 6.1 Summary of contributions 210 6.2 Future work 211 Appendix 214 Acknowledgment and collaboration declaration 214 Supplementary materials 217 Reference 227 Abstract in Korean (๊ตญ๋ฌธ์ดˆ๋ก) 249Docto

    Spatio-Temporal Reasoning About Agent Behavior

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    There are many applications where we wish to reason about spatio-temporal aspects of an agent's behavior. This dissertation examines several facets of this type of reasoning. First, given a model of past agent behavior, we wish to reason about the probability that an agent takes a given action at a certain time. Previous work combining temporal and probabilistic reasoning has made either independence or Markov assumptions. This work introduces Annotated Probabilistic Temporal (APT) logic which makes neither assumption. Statements in APT logic consist of rules of the form "Formula G becomes true with a probability [L,U] within T time units after formula F becomes true'' and can be written by experts or extracted automatically. We explore the problem of entailment - finding the probability that an agent performs a given action at a certain time based on such a model. We study this problem's complexity and develop a sound, but incomplete fixpoint operator as a heuristic - implementing it and testing it on automatically generated models from several datasets. Second, agent behavior often results in "observations'' at geospatial locations that imply the existence of other, unobserved, locations we wish to find ("partners"). In this dissertation, we formalize this notion with "geospatial abduction problems" (GAPs). GAPs try to infer a set of partner locations for a set of observations and a model representing the relationship between observations and partners for a given agent. This dissertation presents exact and approximate algorithms for solving GAPs as well as an implemented software package for addressing these problems called SCARE (the Spatio-Cultural Abductive Reasoning Engine). We tested SCARE on counter-insurgency data from Iraq and obtained good results. We then provide an adversarial extension to GAPs as follows: given a fixed set of observations, if an adversary has probabilistic knowledge of how an agent were to find a corresponding set of partners, he would place the partners in locations that minimize the expected number of partners found by the agent. We examine this problem, along with its complement by studying their computational complexity, developing algorithms, and implementing approximation schemes. We also introduce a class of problems called geospatial optimization problems (GOPs). Here the agent has a set of actions that modify attributes of a geospatial region and he wishes to select a limited number of such actions (with respect to some budget and other constraints) in a manner that maximizes a benefit function. We study the complexity of this problem and develop exact methods. We then develop an approximation algorithm with a guarantee. For some real-world applications, such as epidemiology, there is an underlying diffusion process that also affects geospatial proprieties. We address this with social network optimization problems (SNOPs) where given a weighted, labeled, directed graph we seek to find a set of vertices, that if given some initial property, optimize an aggregate study with respect to such diffusion. We develop and implement a heuristic that obtains a guarantee for a large class of such problems

    Analysis of Layered Social Networks

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    Prevention of near-term terrorist attacks requires an understanding of current terrorist organizations to include their composition, the actors involved, and how they operate to achieve their objectives. To aid this understanding, operations research, sociological, and behavioral theory relevant to the study of social networks are applied, thereby providing theoretical foundations for new methodologies to analyze non-cooperative organizations, defined as those trying to hide their structure or are unwilling to provide information regarding their operations. Techniques applying information regarding multiple dimensions of interpersonal relationships, inferring from them the strengths of interpersonal ties, are explored. A layered network construct is offered that provides new analytic opportunities and insights generally unaccounted for in traditional social network analyses. These provide decision makers improved courses of action designed to impute influence upon an adversarial network, thereby achieving a desired influence, perception, or outcome to one or more actors within the target network. This knowledge may also be used to identify key individuals, relationships, and organizational practices. Subsequently, such analysis may lead to the identification of exploitable weaknesses to either eliminate the network as a whole, cause it to become operationally ineffective, or influence it to directly or indirectly support National Security Strategy

    High-Performance Modelling and Simulation for Big Data Applications

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    This open access book was prepared as a Final Publication of the COST Action IC1406 โ€œHigh-Performance Modelling and Simulation for Big Data Applications (cHiPSet)โ€œ project. Long considered important pillars of the scientific method, Modelling and Simulation have evolved from traditional discrete numerical methods to complex data-intensive continuous analytical optimisations. Resolution, scale, and accuracy have become essential to predict and analyse natural and complex systems in science and engineering. When their level of abstraction raises to have a better discernment of the domain at hand, their representation gets increasingly demanding for computational and data resources. On the other hand, High Performance Computing typically entails the effective use of parallel and distributed processing units coupled with efficient storage, communication and visualisation systems to underpin complex data-intensive applications in distinct scientific and technical domains. It is then arguably required to have a seamless interaction of High Performance Computing with Modelling and Simulation in order to store, compute, analyse, and visualise large data sets in science and engineering. Funded by the European Commission, cHiPSet has provided a dynamic trans-European forum for their members and distinguished guests to openly discuss novel perspectives and topics of interests for these two communities. This cHiPSet compendium presents a set of selected case studies related to healthcare, biological data, computational advertising, multimedia, finance, bioinformatics, and telecommunications
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