Recent Developments in Smart Healthcare

Medicine is undergoing a sector-wide transformation thanks to the advances in computing and networking technologies. Healthcare is changing from reactive and hospital-centered to preventive and personalized, from disease focused to well-being centered. In essence, the healthcare systems, as well as fundamental medicine research, are becoming smarter. We anticipate significant improvements in areas ranging from molecular genomics and proteomics to decision support for healthcare professionals through big data analytics, to support behavior changes through technology-enabled self-management, and social and motivational support. Furthermore, with smart technologies, healthcare delivery could also be made more efficient, higher quality, and lower cost. In this special issue, we received a total 45 submissions and accepted 19 outstanding papers that roughly span across several interesting topics on smart healthcare, including public health, health information technology (Health IT), and smart medicine

Optimisation for Optical Data Centre Switching and Networking with Artificial Intelligence

Cloud and cluster computing platforms have become standard across almost every domain of business, and their scale quickly approaches $\mathbf{O}(10^6)$ servers in a single warehouse. However, the tier-based opto-electronically packet switched network infrastructure that is standard across these systems gives way to several scalability bottlenecks including resource fragmentation and high energy requirements. Experimental results show that optical circuit switched networks pose a promising alternative that could avoid these. However, optimality challenges are encountered at realistic commercial scales. Where exhaustive optimisation techniques are not applicable for problems at the scale of Cloud-scale computer networks, and expert-designed heuristics are performance-limited and typically biased in their design, artificial intelligence can discover more scalable and better performing optimisation strategies. This thesis demonstrates these benefits through experimental and theoretical work spanning all of component, system and commercial optimisation problems which stand in the way of practical Cloud-scale computer network systems. Firstly, optical components are optimised to gate in $\approx 500 ps$ and are demonstrated in a proof-of-concept switching architecture for optical data centres with better wavelength and component scalability than previous demonstrations. Secondly, network-aware resource allocation schemes for optically composable data centres are learnt end-to-end with deep reinforcement learning and graph neural networks, where $3\times$ less networking resources are required to achieve the same resource efficiency compared to conventional methods. Finally, a deep reinforcement learning based method for optimising PID-control parameters is presented which generates tailored parameters for unseen devices in $\mathbf{O}(10^{-3}) s$. This method is demonstrated on a market leading optical switching product based on piezoelectric actuation, where switching speed is improved $>20\%$ with no compromise to optical loss and the manufacturing yield of actuators is improved. This method was licensed to and integrated within the manufacturing pipeline of this company. As such, crucial public and private infrastructure utilising these products will benefit from this work

Generative models of brain connectivity for population studies

Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2012.Cataloged from PDF version of thesis.Includes bibliographical references (p. 131-139).Connectivity analysis focuses on the interaction between brain regions. Such relationships inform us about patterns of neural communication and may enhance our understanding of neurological disorders. This thesis proposes a generative framework that uses anatomical and functional connectivity information to find impairments within a clinical population. Anatomical connectivity is measured via Diffusion Weighted Imaging (DWI), and functional connectivity is assessed using resting-state functional Magnetic Resonance Imaging (fMRI). We first develop a probabilistic model to merge information from DWI tractography and resting-state fMRI correlations. Our formulation captures the interaction between hidden templates of anatomical and functional connectivity within the brain. We also present an intuitive extension to population studies and demonstrate that our model learns predictive differences between a control and a schizophrenia population. Furthermore, combining the two modalities yields better results than considering each one in isolation. Although our joint model identifies widespread connectivity patterns influenced by a neurological disorder, the results are difficult to interpret and integrate with our regioncentric knowledge of the brain. To alleviate this problem, we present a novel approach to identify regions associated with the disorder based on connectivity information. Specifically, we assume that impairments of the disorder localize to a small subset of brain regions, which we call disease foci, and affect neural communication to/from these regions. This allows us to aggregate pairwise connectivity changes into a region-based representation of the disease. Once again, we use a probabilistic formulation: latent variables specify a template organization of the brain, which we indirectly observe through resting-state fMRI correlations and DWI tractography. Our inference algorithm simultaneously identifies both the afflicted regions and the network of aberrant functional connectivity. Finally, we extend the region-based model to include multiple collections of foci, which we call disease clusters. Preliminary results suggest that as the number of clusters increases, the refined model explains progressively more of the functional differences between the populations.by Archana Venkataraman.Ph.D

The Digital Humanities and Literary Studies

This book delivers an introduction and overview of developing intersections between digital methods and literary studies. The Digital Humanities and Literary Studies serves as a starting place for those who wish to learn more about the possibilities, and the limitations, of the oft-touted digital humanities in the literary space. The volume engages with the proponents of digital humanities and its detractors alike, aiming to offer a fair and balanced perspective on this controversial topic. The book combines a survey and background approach with original literary research and, therefore, straddles the divide between seasoned digital experts and interested newcomers

An Initial Framework Assessing the Safety of Complex Systems

Trabajo presentado en la Conference on Complex Systems, celebrada online del 7 al 11 de diciembre de 2020.Atmospheric blocking events, that is large-scale nearly stationary atmospheric pressure patterns, are often associated with extreme weather in the mid-latitudes, such as heat waves and cold spells which have significant consequences on ecosystems, human health and economy. The high impact of blocking events has motivated numerous studies. However, there is not yet a comprehensive theory explaining their onset, maintenance and decay and their numerical prediction remains a challenge. In recent years, a number of studies have successfully employed complex network descriptions of fluid transport to characterize dynamical patterns in geophysical flows. The aim of the current work is to investigate the potential of so called Lagrangian flow networks for the detection and perhaps forecasting of atmospheric blocking events. The network is constructed by associating nodes to regions of the atmosphere and establishing links based on the flux of material between these nodes during a given time interval. One can then use effective tools and metrics developed in the context of graph theory to explore the atmospheric flow properties. In particular, Ser-Giacomi et al. [1] showed how optimal paths in a Lagrangian flow network highlight distinctive circulation patterns associated with atmospheric blocking events. We extend these results by studying the behavior of selected network measures (such as degree, entropy and harmonic closeness centrality)at the onset of and during blocking situations, demonstrating their ability to trace the spatio-temporal characteristics of these events.This research was conducted as part of the CAFE (Climate Advanced Forecasting of sub-seasonal Extremes) Innovative Training Network which has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No. 813844

The Digital Humanities and Literary Studies

This book delivers an introduction and overview of developing intersections between digital methods and literary studies. The Digital Humanities and Literary Studies serves as a starting place for those who wish to learn more about the possibilities, and the limitations, of the oft-touted digital humanities in the literary space. The volume engages with the proponents of digital humanities and its detractors alike, aiming to offer a fair and balanced perspective on this controversial topic. The book combines a survey and background approach with original literary research and, therefore, straddles the divide between seasoned digital experts and interested newcomers

Advances in Condition Monitoring, Optimization and Control for Complex Industrial Processes

The book documents 25 papers collected from the Special Issue “Advances in Condition Monitoring, Optimization and Control for Complex Industrial Processes”, highlighting recent research trends in complex industrial processes. The book aims to stimulate the research field and be of benefit to readers from both academic institutes and industrial sectors

Reinforcement Learning

Brains rule the world, and brain-like computation is increasingly used in computers and electronic devices. Brain-like computation is about processing and interpreting data or directly putting forward and performing actions. Learning is a very important aspect. This book is on reinforcement learning which involves performing actions to achieve a goal. The first 11 chapters of this book describe and extend the scope of reinforcement learning. The remaining 11 chapters show that there is already wide usage in numerous fields. Reinforcement learning can tackle control tasks that are too complex for traditional, hand-designed, non-learning controllers. As learning computers can deal with technical complexities, the tasks of human operators remain to specify goals on increasingly higher levels. This book shows that reinforcement learning is a very dynamic area in terms of theory and applications and it shall stimulate and encourage new research in this field

Deliverable D1.1 State of the art and requirements analysis for hypervideo

This deliverable presents a state-of-art and requirements analysis report for hypervideo authored as part of the WP1 of the LinkedTV project. Initially, we present some use-case (viewers) scenarios in the LinkedTV project and through the analysis of the distinctive needs and demands of each scenario we point out the technical requirements from a user-side perspective. Subsequently we study methods for the automatic and semi-automatic decomposition of the audiovisual content in order to effectively support the annotation process. Considering that the multimedia content comprises of different types of information, i.e., visual, textual and audio, we report various methods for the analysis of these three different streams. Finally we present various annotation tools which could integrate the developed analysis results so as to effectively support users (video producers) in the semi-automatic linking of hypervideo content, and based on them we report on the initial progress in building the LinkedTV annotation tool. For each one of the different classes of techniques being discussed in the deliverable we present the evaluation results from the application of one such method of the literature to a dataset well-suited to the needs of the LinkedTV project, and we indicate the future technical requirements that should be addressed in order to achieve higher levels of performance (e.g., in terms of accuracy and time-efficiency), as necessary

Planning and Policy Improvement

MuZero is currently the most successful general reinforcement learning algorithm, achieving the state of the art on Go, chess, shogi, and Atari. We want to help MuZero to be successful in even more domains. Towards that, we do three steps: 1) We identify MuZero's problems on stochastic environments and provide ways to model enough information to support causally correct planning. 2) We develop a strong baseline agent on Atari. This agent, named Muesli, matches the state of the art on Atari, even without deep search. The conducted ablations inform us about the importance of model learning, deep search, large networks, and regularized policy optimization. 3) Because MuZero's tree search is very helpful on Go and chess, we use the principle of policy improvement to design search algorithms with even better properties. The new algorithms, named Gumbel AlphaZero and Gumbel MuZero, match the state of the art on Go, chess, and Atari, and significantly improve prior performance when planning with few simulations