Annotating patient clinical records with syntactic chunks and named entities: the Harvey corpus

The free text notes typed by physicians during patient consultations contain valuable information for the study of disease and treatment. These notes are difficult to process by existing natural language analysis tools since they are highly telegraphic (omitting many words), and contain many spelling mistakes, inconsistencies in punctuation, and non-standard word order. To support information extraction and classification tasks over such text, we describe a de-identified corpus of free text notes, a shallow syntactic and named entity annotation scheme for this kind of text, and an approach to training domain specialists with no linguistic background to annotate the text. Finally, we present a statistical chunking system for such clinical text with a stable learning rate and good accuracy, indicating that the manual annotation is consistent and that the annotation scheme is tractable for machine learning

SemClinBr -- a multi institutional and multi specialty semantically annotated corpus for Portuguese clinical NLP tasks

The high volume of research focusing on extracting patient's information from electronic health records (EHR) has led to an increase in the demand for annotated corpora, which are a very valuable resource for both the development and evaluation of natural language processing (NLP) algorithms. The absence of a multi-purpose clinical corpus outside the scope of the English language, especially in Brazilian Portuguese, is glaring and severely impacts scientific progress in the biomedical NLP field. In this study, we developed a semantically annotated corpus using clinical texts from multiple medical specialties, document types, and institutions. We present the following: (1) a survey listing common aspects and lessons learned from previous research, (2) a fine-grained annotation schema which could be replicated and guide other annotation initiatives, (3) a web-based annotation tool focusing on an annotation suggestion feature, and (4) both intrinsic and extrinsic evaluation of the annotations. The result of this work is the SemClinBr, a corpus that has 1,000 clinical notes, labeled with 65,117 entities and 11,263 relations, and can support a variety of clinical NLP tasks and boost the EHR's secondary use for the Portuguese language

Validating multilingual hybrid automatic term extraction for search engine optimisation : the use case of EBM-GUIDELINES

Tools that automatically extract terms and their equivalents in other languages from parallel corpora can contribute to multilingual professional communication in more than one way. By means of a use case with data from a medical web site with point of care evidence summaries (Ebpracticenet), we illustrate how hybrid multilingual automatic term extraction from parallel corpora works and how it can be used in a practical application such as search engine optimisation. The original aim was to use the result of the extraction to improve the recall of a search engine by allowing automated multilingual searches. Two additional possible applications were found while considering the data: searching via related forms and searching via strongly semantically related words. The second stage of this research was to find the most suitable format for the required manual validation of the raw extraction results and to compare the validation process when performed by a domain expert versus a terminologist

Structured Named Entities

The names of people, locations, and organisations play a central role in language, and named entity recognition (NER) has been widely studied, and successfully incorporated, into natural language processing (NLP) applications. The most common variant of NER involves identifying and classifying proper noun mentions of these and miscellaneous entities as linear spans in text. Unfortunately, this version of NER is no closer to a detailed treatment of named entities than chunking is to a full syntactic analysis. NER, so construed, reflects neither the syntactic nor semantic structure of NE mentions, and provides insufficient categorical distinctions to represent that structure. Representing this nested structure, where a mention may contain mention(s) of other entities, is critical for applications such as coreference resolution. The lack of this structure creates spurious ambiguity in the linear approximation. Research in NER has been shaped by the size and detail of the available annotated corpora. The existing structured named entity corpora are either small, in specialist domains, or in languages other than English. This thesis presents our Nested Named Entity (NNE) corpus of named entities and numerical and temporal expressions, taken from the WSJ portion of the Penn Treebank (PTB, Marcus et al., 1993). We use the BBN Pronoun Coreference and Entity Type Corpus (Weischedel and Brunstein, 2005a) as our basis, manually annotating it with a principled, fine-grained, nested annotation scheme and detailed annotation guidelines. The corpus comprises over 279,000 entities over 49,211 sentences (1,173,000 words), including 118,495 top-level entities. Our annotations were designed using twelve high-level principles that guided the development of the annotation scheme and difficult decisions for annotators. We also monitored the semantic grammar that was being induced during annotation, seeking to identify and reinforce common patterns to maintain consistent, parsimonious annotations. The result is a scheme of 118 hierarchical fine-grained entity types and nesting rules, covering all capitalised mentions of entities, and numerical and temporal expressions. Unlike many corpora, we have developed detailed guidelines, including extensive discussion of the edge cases, in an ongoing dialogue with our annotators which is critical for consistency and reproducibility. We annotated independently from the PTB bracketing, allowing annotators to choose spans which were inconsistent with the PTB conventions and errors, and only refer back to it to resolve genuine ambiguity consistently. We merged our NNE with the PTB, requiring some systematic and one-off changes to both annotations. This allows the NNE corpus to complement other PTB resources, such as PropBank, and inform PTB-derived corpora for other formalisms, such as CCG and HPSG. We compare this corpus against BBN. We consider several approaches to integrating the PTB and NNE annotations, which affect the sparsity of grammar rules and visibility of syntactic and NE structure. We explore their impact on parsing the NNE and merged variants using the Berkeley parser (Petrov et al., 2006), which performs surprisingly well without specialised NER features. We experiment with flattening the NNE annotations into linear NER variants with stacked categories, and explore the ability of a maximum entropy and a CRF NER system to reproduce them. The CRF performs substantially better, but is infeasible to train on the enormous stacked category sets. The flattened output of the Berkeley parser are almost competitive with the CRF. Our results demonstrate that the NNE corpus is feasible for statistical models to reproduce. We invite researchers to explore new, richer models of (joint) parsing and NER on this complex and challenging task. Our nested named entity corpus will improve a wide range of NLP tasks, such as coreference resolution and question answering, allowing automated systems to understand and exploit the true structure of named entities

GNTeam at 2018 n2c2:Feature-augmented BiLSTM-CRF for drug-related entity recognition in hospital discharge summaries

Monitoring the administration of drugs and adverse drug reactions are key parts of pharmacovigilance. In this paper, we explore the extraction of drug mentions and drug-related information (reason for taking a drug, route, frequency, dosage, strength, form, duration, and adverse events) from hospital discharge summaries through deep learning that relies on various representations for clinical named entity recognition. This work was officially part of the 2018 n2c2 shared task, and we use the data supplied as part of the task. We developed two deep learning architecture based on recurrent neural networks and pre-trained language models. We also explore the effect of augmenting word representations with semantic features for clinical named entity recognition. Our feature-augmented BiLSTM-CRF model performed with F1-score of 92.67% and ranked 4th for entity extraction sub-task among submitted systems to n2c2 challenge. The recurrent neural networks that use the pre-trained domain-specific word embeddings and a CRF layer for label optimization perform drug, adverse event and related entities extraction with micro-averaged F1-score of over 91%. The augmentation of word vectors with semantic features extracted using available clinical NLP toolkits can further improve the performance. Word embeddings that are pre-trained on a large unannotated corpus of relevant documents and further fine-tuned to the task perform rather well. However, the augmentation of word embeddings with semantic features can help improve the performance (primarily by boosting precision) of drug-related named entity recognition from electronic health records

Unsupervised Biomedical Named Entity Recognition

Named entity recognition (NER) from text is an important task for several applications, including in the biomedical domain. Supervised machine learning based systems have been the most successful on NER task, however, they require correct annotations in large quantities for training. Annotating text manually is very labor intensive and also needs domain expertise. The purpose of this research is to reduce human annotation effort and to decrease cost of annotation for building NER systems in the biomedical domain. The method developed in this work is based on leveraging the availability of resources like UMLS (Unified Medical Language System), that contain a list of biomedical entities and a large unannotated corpus to build an unsupervised NER system that does not require any manual annotations. The method that we developed in this research has two phases. In the first phase, a biomedical corpus is automatically annotated with some named entities using UMLS through unambiguous exact matching which we call weakly-labeled data. In this data, positive examples are the entities in the text that exactly match in UMLS and have only one semantic type which belongs to the desired entity class to be extracted (for example, diseases and disorders). Negative examples are the entities in the text that exactly match in UMLS but are of semantic types other than those that belong to the desired entity class. These examples are then used to train a machine learning classifier using features that represent the contexts in which they appeared in the text. The trained classifier is applied back to the text to gather more examples iteratively through the process of self-training. The trained classifier is then capable of classifying mentions in an unseen text as of the desired entity class or not from the contexts in which they appear. Although the trained named entity detector is good at detecting the presence of entities of the desired class in text, it cannot determine their correct boundaries. In the second phase of our method, called “Boundary Expansion”, the correct boundaries of the entities are determined. This method is based on a novel idea that utilizes machine learning and UMLS. Training examples for boundary expansion are gathered directly from UMLS and do not require any manual annotations. We also developed a new WordNet based approach for boundary expansion. Our developed method was evaluated on three datasets - SemEval 2014 Task 7 dataset that has diseases and disorders as the desired entity class, GENIA dataset that has proteins, DNAs, RNAs, cell types, and cell lines as the desired entity classes, and i2b2 dataset that has problems, tests, and treatments as the desired entity classes. Our method performed well and obtained performance close to supervised methods on the SemEval dataset. On the other datasets, it outperformed an existing unsupervised method on most entity classes. Availability of a list of entity names with their semantic types and a large unannotated corpus are the only requirements of our method to work well. Given these, our method generalizes across different types of entities and different types of biomedical text. Being unsupervised, the method can be easily applied to new NER tasks without needing costly annotations