3,253 research outputs found

    The implicitome: A resource for rationalizing gene-disease associations

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    High-throughput experimental methods such as medical sequencing and genome-wide association studies (GWAS) identify increasingly large numbers of potential relations between genetic variants and diseases. Both biological complexity (millions of potential gene-disease associations) and the accelerating rate of data production necessitate computational approaches to prioritize and rationalize potential gene-disease relations. Here, we use concept profile technology to expose from the biomedical literature both explicitly stated gene-disease relations (the explicitome) and a much larger set of implied gene-disease associations (the implicitome). Implicit relations are largely unknown to, or are even unintended by the original authors, but they vastly extend the reach of existing

    Augmenting applications with hyper media, functionality and meta-information

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    The Dynamic Hypermedia Engine (DHE) enhances analytical applications by adding relationships, semantics and other metadata to the application\u27s output and user interface. DHE also provides additional hypermedia navigational, structural and annotation functionality. These features allow application developers and users to add guided tours, personal links and sharable annotations, among other features, into applications. DHE runs as a middleware between the application user interface and its business logic and processes, in a n-tier architecture, supporting the extra functionalities without altering the original systems by means of application wrappers. DHE automatically generates links at run-time for each of those elements having relationships and metadata. Such elements are previously identified using a Relation Navigation Analysis. DHE also constructs more sophisticated navigation techniques not often found on the Web on top of these links. The metadata, links, navigation and annotation features supplement the application\u27s primary functionality. This research identifies element types, or classes , in the application displays. A mapping rule encodes each relationship found between two elements of interest at the class level . When the user selects a particular element, DHE instantiates the commands included in the rules with the actual instance selected and sends them to the appropriate destination system, which then dynamically generates the resulting virtual (i.e. not previously stored) page. DHE executes concurrently with these applications, providing automated link generation and other hypermedia functionality. DHE uses the extensible Markup Language (XMQ -and related World Wide Web Consortium (W3C) sets of XML recommendations, like Xlink, XML Schema, and RDF -to encode the semantic information required for the operation of the extra hypermedia features, and for the transmission of messages between the engine modules and applications. DHE is the only approach we know that provides automated linking and metadata services in a generic manner, based on the application semantics, without altering the applications. DHE will also work with non-Web systems. The results of this work could also be extended to other research areas, such as link ranking and filtering, automatic link generation as the result of a search query, metadata collection and support, virtual document management, hypermedia functionality on the Web, adaptive and collaborative hypermedia, web engineering, and the semantic Web

    Models of Interaction as a Grounding for Peer to Peer Knowledge Sharing

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    Most current attempts to achieve reliable knowledge sharing on a large scale have relied on pre-engineering of content and supply services. This, like traditional knowledge engineering, does not by itself scale to large, open, peer to peer systems because the cost of being precise about the absolute semantics of services and their knowledge rises rapidly as more services participate. We describe how to break out of this deadlock by focusing on semantics related to interaction and using this to avoid dependency on a priori semantic agreement; instead making semantic commitments incrementally at run time. Our method is based on interaction models that are mobile in the sense that they may be transferred to other components, this being a mechanism for service composition and for coalition formation. By shifting the emphasis to interaction (the details of which may be hidden from users) we can obtain knowledge sharing of sufficient quality for sustainable communities of practice without the barrier of complex meta-data provision prior to community formation

    e-Business challenges and directions: important themes from the first ICE-B workshop

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    A three-day asynchronous, interactive workshop was held at ICE-B’10 in Piraeus, Greece in July of 2010. This event captured conference themes for e-Business challenges and directions across four subject areas: a) e-Business applications and models, b) enterprise engineering, c) mobility, d) business collaboration and e-Services, and e) technology platforms. Quality Function Deployment (QFD) methods were used to gather, organize and evaluate themes and their ratings. This paper summarizes the most important themes rated by participants: a) Since technology is becoming more economic and social in nature, more agile and context-based application develop methods are needed. b) Enterprise engineering approaches are needed to support the design of systems that can evolve with changing stakeholder needs. c) The digital native groundswell requires changes to business models, operations, and systems to support Prosumers. d) Intelligence and interoperability are needed to address Prosumer activity and their highly customized product purchases. e) Technology platforms must rapidly and correctly adapt, provide widespread offerings and scale appropriately, in the context of changing situational contexts

    BlogForever D2.4: Weblog spider prototype and associated methodology

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    The purpose of this document is to present the evaluation of different solutions for capturing blogs, established methodology and to describe the developed blog spider prototype

    CHORUS Deliverable 2.2: Second report - identification of multi-disciplinary key issues for gap analysis toward EU multimedia search engines roadmap

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    After addressing the state-of-the-art during the first year of Chorus and establishing the existing landscape in multimedia search engines, we have identified and analyzed gaps within European research effort during our second year. In this period we focused on three directions, notably technological issues, user-centred issues and use-cases and socio- economic and legal aspects. These were assessed by two central studies: firstly, a concerted vision of functional breakdown of generic multimedia search engine, and secondly, a representative use-cases descriptions with the related discussion on requirement for technological challenges. Both studies have been carried out in cooperation and consultation with the community at large through EC concertation meetings (multimedia search engines cluster), several meetings with our Think-Tank, presentations in international conferences, and surveys addressed to EU projects coordinators as well as National initiatives coordinators. Based on the obtained feedback we identified two types of gaps, namely core technological gaps that involve research challenges, and “enablers”, which are not necessarily technical research challenges, but have impact on innovation progress. New socio-economic trends are presented as well as emerging legal challenges

    The genesis and emergence of Web 3.0: a study in the integration of artificial intelligence and the semantic web in knowledge creation

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    The web as we know it has evolved rapidly over the last decade. We have gone from a phase of rapid growth as seen with the dot.com boom where business was king to the current web 2.0 phase where social networking, Wiki’s, Blogs and other related tools flood the bandwidth of the world wide web. The empowerment of the web user with web 2.0 technologies has led to the exponential growth of data, information and knowledge on the web. With this rapid change, there is a need to logically categorise this information and knowledge so it can be fully utilised by all. It can be argued that the power of the knowledge held on the web is not fully exposed under its current structure and to improve this we need to explore the foundations of the web. This dissertation will explore the evolution of the web from its early days to the present day. It will examine the way web content is stored and discuss the new semantic technologies now available to represent this content. The research aims to demonstrate the possibilities of efficient knowledge extraction from a knowledge portal such as a Wiki or SharePoint portal using these semantic technologies. This generation of dynamic knowledge content within a limited domain will attempt to demonstrate the benefits of semantic web to the knowledge age
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