10,596 research outputs found

    The Metaverse: Survey, Trends, Novel Pipeline Ecosystem & Future Directions

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    The Metaverse offers a second world beyond reality, where boundaries are non-existent, and possibilities are endless through engagement and immersive experiences using the virtual reality (VR) technology. Many disciplines can benefit from the advancement of the Metaverse when accurately developed, including the fields of technology, gaming, education, art, and culture. Nevertheless, developing the Metaverse environment to its full potential is an ambiguous task that needs proper guidance and directions. Existing surveys on the Metaverse focus only on a specific aspect and discipline of the Metaverse and lack a holistic view of the entire process. To this end, a more holistic, multi-disciplinary, in-depth, and academic and industry-oriented review is required to provide a thorough study of the Metaverse development pipeline. To address these issues, we present in this survey a novel multi-layered pipeline ecosystem composed of (1) the Metaverse computing, networking, communications and hardware infrastructure, (2) environment digitization, and (3) user interactions. For every layer, we discuss the components that detail the steps of its development. Also, for each of these components, we examine the impact of a set of enabling technologies and empowering domains (e.g., Artificial Intelligence, Security & Privacy, Blockchain, Business, Ethics, and Social) on its advancement. In addition, we explain the importance of these technologies to support decentralization, interoperability, user experiences, interactions, and monetization. Our presented study highlights the existing challenges for each component, followed by research directions and potential solutions. To the best of our knowledge, this survey is the most comprehensive and allows users, scholars, and entrepreneurs to get an in-depth understanding of the Metaverse ecosystem to find their opportunities and potentials for contribution

    Experiments with active and driven synthetic colloids in complex fluids

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    In this review, we focus on recent experimental research involving active colloidal particles of non-biological origin evolving in non-Newtonian fluids. This includes self-propelling active particles and particles driven by external fields. We present different propulsion strategies that are either enabled, or strongly modified, by the presence of a complex medium. This paves the way for novel mechanisms of active transport in biofluids or in other non-Newnotian fluids. When considering the medium, we differentiate between disordered complex fluids, such as diluted polymer solutions, and liquid crystals. While the latter are also viscoelastic fluids, the ability to control their molecular orientation results in distinct colloidal driving and steering mechanisms, and enables new types of active soft matter in the form of active quasi-particles

    Management controls, government regulations, customer involvement: Evidence from a Chinese family-owned business

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    This research reports on a case study of a family-owned elevator manufacturing company in China, where management control was sandwiched between the state policies and global customer production requirements. By analysing the role of government and customer, this thesis aimed to illustrate how management control operated in a family-owned business and to see how and why they do management control differently. In particular, it focused on how international production standards and existing Chinese industry policies translated into a set of the management control practices through a local network within the family-owned business I studied. Based on an ethnographic approach to research, I spent six months in the field, conducted over 30 interviews, several conservations, and reviewed relevant internal documents to understand how management control (MC) techniques with humans cooperated in the company. I also understood how two layers of pressure have shaped company behaviour, and how a company located in a developing country is connecting with global network. I also found there is considerable tension among key actors and investigated how the company responded and managed it. Drawing on Actor Network Theory (ANT), I analysed the interviews from key actors, examined the role of government regulations and customer requirements to see how management control being managed under two layers of pressure, i.e., the government regulations (e.g., labour, tax, environment control) and customer requirement (e.g., quality and production control). Management controls were an obligatory passage point (OPP), and transformation of those elements of Western production requirements and government requirements arrived at the Chinese local factory and influenced management control and budgeting. The findings suggest that management control systems are not only a set of technical procedures, but it is also about managing tensions. This understanding shows a linear perspective on MC practices rather than a social perspective. However, when we use ANT as a theoretical perspective, we see those actors who, being obliged and sandwiched, and controlled by external forces for them to follow. Consequently, human actors must work in an unavoidable OPP. This is the tension they face which constructed mundane practices of MC. Hence, MCs are managing such tensions. This study contributes to management control research by analysing management controls in terms of OPP, extends our understanding by illustrating the role of the government and customers, and our understanding of family-owned business from a management controls perspective in a developing country

    Water and Wastewater Digital Surveillance 1 for Monitoring and Early Detection of 2 the COVID-19 Hotspot: Industry 4.0

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    Abstract: There are a high number of COVID-19 cases per capita in the world that goes undetected including clinical diseases compatible with COVID-19. While the presence of the COVID-19 in untreated drinking water is possible, it is yet to be detected in the drinking-water supplies. COVID-19 viral fragments have been found in excrete, this call for wastewater monitoring and analysis (wastewater surveillance) of the potential health risk. This raises concern about the potential of the SARS-CoV-2 transmission via the water systems. The economic limits on the medical screening for the SARS-CoV-2 or COVID-19 worldwide are turning to wastewater-based epidemiology as great potential tools for assessing and management of the COVID-19 pandemic. Surveillance and tracking of the pathogens in the wastewater are key to the early warning system and public health strategy monitoring of the COVID-19. Currently, RT-qPCR assays is been developed for SARS-CoV-2 RNA specimen clinical testing and detection in the water system. Convectional wastewater treatment methods and disinfection are expected to eradicate the SAR-CoV-2. Chlorine, UV radiation, ozone, chloramine is been used to inactivate and disinfect the water treatment system against the SARS-CoV-2. Water management and design of the water infrastructure require major changes to accommodate climate change, water cycle, reimaging of digitalization, infrastructure and privacy protection. The water digital revolution, biosensors and nanoscale, contact tracing, knowledge management can accelerate with disruption of the COVID-19 outbreak (water-health-digital nexus)

    Antibody Targeting of HIV-1 Env: A Structural Perspective

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    A key component of contemporary efforts toward a human immunodeficiency virus 1 (HIV-1) vaccine is the use of structural biology to understand the structural characteristics of antibodies elicited both from human patients and animals immunized with engineered 'immunogens,' or early vaccine candidates. This thesis will report on projects characterizing both types of antibodies against HIV-1. Chapter 1 will introduce relevant topics, including the reasons HIV-1 is particularly capable of evading the immune system in natural infection and after vaccination, the 20+ year history of unsuccessful HIV-1 vaccine large-scale efficacy trials, an introduction to broadly neutralizing antibodies (bNAbs), and a review of common strategies utilized in HIV-1 immunogen design today. Chapter 2 describes the isolation, high-resolution structural characterization, and in vitro resistance profile of a new bNAb, 1-18, that is both very broad and potent, as well as able to restrict HIV-1 escape in vivo. Chapter 3 reports the results of an epitope-focusing immunogen design and immunization experiment carried out in wild type mice, rabbits, and non-human primates where it was shown that B cells targeting the desired epitope were expanded after a single prime immunization with immunogen RC1 or a variant, RC1-4fill. Chapter 4 describes Ab1245, an off-target non-neutralizing monoclonal antibody isolated in a macaque that had been immunized with a series of sequential immunogens after the prime immunization reported in Chapter 3. The antibody structure describes a specific type of distracting response as it binds in a way that causes a large structural change in Env, resulting in the destruction of the neutralizing fusion peptide epitope. Chapter 5 is adapted from a review about how antibodies differentially recognize the viruses HIV-1, SARS-CoV-2, and Zika virus. This review serves as an introduction to the virus SARS-CoV-2, which is the topic of the final chapter, Chapter 6. In this chapter, structures of many neutralizing antibodies isolated from SARS-CoV-2 patients were used to define potentially therapeutic classes of neutralizing receptor-binding domain (RBD) antibodies based on their epitopes and binding profiles

    Expanding the scope of single-molecule energy transfer with gold nanoparticles and graphene

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    Förster resonance energy transfer (FRET) is a common tool to measure the distances between a donor and an acceptor fluorophore and is employed as a spectroscopic ruler. This non-radiative energy transfer is utilized to not only measure distances but also to observe dynamics in the field of biophysics and medicine. However, main limitations of FRET are the limited time resolution and working range between donor and acceptor molecules of 10 nm. To increase the application of FRET, this limitation can be circumvented by the introduction of different ma-terials in the close proximity. For characterization of the altered distance dependence, a precise distance control between the dyes and the applied material is required, which here is provided by the DNA origami technique. In DNA origami, DNA self-assembles into programmable, complex, and robust structures, which can be easily modified with dyes and other entities with nanometric control. DNA origami nanoantennas constructed of a pair of gold nanoparticles have recently been introduced to substantially increase the obtainable fluorescence signal that yields a higher time resolution in biophysical single-molecule FRET experiments. In this context, it is crucial to understand the influence of the gold nanoparticles on the FRET process itself. In this work, gold nanoparticles are placed next to FRET pairs using the DNA origami technique (see publication I). A measurement procedure to accurately determine energy transfer efficiencies is estab-lished and reveals that in the intermediate coupling regime, the energy transfer efficiency drops in the presence of nanoparticles whereas the energy transfer rate constant from the donor to the acceptor is not significantly altered. Next, graphene is introduced to increase the range of energy transfer. Graphene is a 2D carbon lattice, which can also be employed as an unbleachable broadband acceptor without labeling. To understand the principles of the energy transfer between a fluorophore and the graphene surface, the distance dependence of the energy transfer from a fluorophore to graphene is investigated (see publication II). As such experiments require high quality graphene surfac-es, a cleaning and transferring procedure to generate reproducible graphene-on-glass-coverslips is established (see publication III) and characterized by different spectroscopic methods. Finally, the full potential of graphene-on-glass coverslips as microscopy platforms are highlighted by adopting graphene in the fields of biosensing, biophysics and super-resolution microscopy (see publication IV). The designed biosensors are capable to detect a DNA target, a viscosity change, or the binding of a biomolecule. In addition, FRET between two dyes is expanded by additional graphene energy transfer (GET) that reveals the relative orientation of the FRET pairs to the graphene surface. Finally, GET is used in super-resolution experiments to reach isotopic nanometric 3D-resolution and track a single fluorophore that undergoes 6-nm jumps. The developed techniques and assays have the potential to become the basis for numerous new applications in single-molecule sensing, biophysics, and super-resolution microscopy

    Excess foundry sand characterization and experimental investigation in controlled low-strength material and hot-mixing asphalt

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    This report provides technical data regarding the reuse of excess foundry sand. The report addresses three topics: a statistically sound evaluation of the characterization of foundry sand, a laboratory investigation to qualify excess foundry sand as a major component in controlled low-strength material (CLSM), and the identification of the best methods for using foundry sand as a replacement for natural aggregates for construction purposes, specifically in asphalt paving materials. The survival analysis statistical technique was used to characterize foundry sand over a full spectrum of general chemical parameters, metallic elements, and organic compounds regarding bulk analysis and leachate characterization. Not limited to characterization and environmental impact, foundry sand was evaluated by factor analyses, which contributes to proper selection of factor and maximization of the reuse marketplace for foundry sand. Regarding the integration of foundry sand into CLSM, excavatable CLSM and structural CLSM containing different types of excess foundry sands were investigated through laboratory experiments. Foundry sand was approved to constitute a major component in CLSM. Regarding the integration of foundry sand into asphalt paving materials, the optimum asphalt content was determined for each mixture, as well as the bulk density, maximum density, asphalt absorption, and air voids at Nini, Ndes, and Nmax. It was found that foundry sands can be used as an aggregate in hot-mix asphalt production, but each sand should be evaluated individually. Foundry sands tend to lower the strength of mixtures and also may make them more susceptible to moisture damage. Finally, traditional anti-stripping additives may decrease the moisture sensitivity of a mixture containing foundry sand, but not to the level allowed by most highway agencies.Structural Engineerin
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