8,322 research outputs found
Schizophrenia classification using machine learning on resting state EEG signal
Schizophrenia is a severe mental disorder associated with a wide spectrum of cognitive and neurophysiological
dysfunctions. Early diagnosis is still difficult and based on the manifestation of the disorder. In this study, we
have evaluated whether machine learning techniques can help in the diagnosis of schizophrenia, and proposed a
processing pipeline in order to obtain machine learning classifiers of schizophrenia based on resting state EEG
data. We have computed well-known linear and non-linear measures on sliding windows of the EEG data,
selected those measures which better differentiate between patients and healthy controls, and combined them
through principal component analysis. These components were finally used as features in five standard machine
learning algorithms: k-nearest neighbours (kNN), logistic regression (LR), decision trees (DT), random forest (RF)
and support vector machines (SVM). Complexity measures showed a high level of ability in differentiating
schizophrenia patients from healthy controls. These differences between groups were mainly located in a
delimited zone of the right brain hemisphere, corresponding to the opercular area and the temporal pole. Based
on the area under the curve parameter in receiver operating characteristic curve analysis, we obtained high
classification power in almost all of the machine learning algorithms tested: SVM (0.89), RF (0.87), LR (0.86),
kNN (0.86) and DT (0.68). Our results suggest that the proposed processing pipeline on resting state EEG data is
able to easily compute and select a set of features which allow standard machine learning algorithms to perform
very efficiently in differentiating schizophrenia patients from healthy subjects.Spanish Government
European Commission PID2019-105145RB-I00
MCIN/AEI/10.13039/50110001103
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The role of HG in the analysis of temporal iteration and interaural correlation
Analysis of cross-correlations in electroencephalogram signals as an approach to proactive diagnosis of schizophrenia
We apply flicker-noise spectroscopy (FNS), a time series analysis method
operating on structure functions and power spectrum estimates, to study the
clinical electroencephalogram (EEG) signals recorded in children/adolescents
(11 to 14 years of age) with diagnosed schizophrenia-spectrum symptoms at the
National Center for Psychiatric Health (NCPH) of the Russian Academy of Medical
Sciences. The EEG signals for these subjects were compared with the signals for
a control sample of chronically depressed children/adolescents. The purpose of
the study is to look for diagnostic signs of subjects' susceptibility to
schizophrenia in the FNS parameters for specific electrodes and
cross-correlations between the signals simultaneously measured at different
points on the scalp. Our analysis of EEG signals from scalp-mounted electrodes
at locations F3 and F4, which are symmetrically positioned in the left and
right frontal areas of cerebral cortex, respectively, demonstrates an essential
role of frequency-phase synchronization, a phenomenon representing specific
correlations between the characteristic frequencies and phases of excitations
in the brain. We introduce quantitative measures of frequency-phase
synchronization and systematize the values of FNS parameters for the EEG data.
The comparison of our results with the medical diagnoses for 84 subjects
performed at NCPH makes it possible to group the EEG signals into 4 categories
corresponding to different risk levels of subjects' susceptibility to
schizophrenia. We suggest that the introduced quantitative characteristics and
classification of cross-correlations may be used for the diagnosis of
schizophrenia at the early stages of its development.Comment: 36 pages, 6 figures, 2 tables; to be published in "Physica A
High-frequency neural oscillations and visual processing deficits in schizophrenia
Visual information is fundamental to how we understand our environment, make predictions, and interact with others. Recent research has underscored the importance of visuo-perceptual dysfunctions for cognitive deficits and pathophysiological processes in schizophrenia. In the current paper, we review evidence for the relevance of high frequency (beta/gamma) oscillations towards visuo-perceptual dysfunctions in schizophrenia. In the first part of the paper, we examine the relationship between beta/gamma band oscillations and visual processing during normal brain functioning. We then summarize EEG/MEG-studies which demonstrate reduced amplitude and synchrony of high-frequency activity during visual stimulation in schizophrenia. In the final part of the paper, we identify neurobiological correlates as well as offer perspectives for future research to stimulate further inquiry into the role of high-frequency oscillations in visual processing impairments in the disorder
Magnetoencephalography as a tool in psychiatric research: current status and perspective
The application of neuroimaging to provide mechanistic insights into circuit dysfunctions in major psychiatric conditions and the development of biomarkers are core challenges in current psychiatric research. In this review, we propose that recent technological and analytic advances in Magnetoencephalography (MEG), a technique which allows the measurement of neuronal events directly and non-invasively with millisecond resolution, provides novel opportunities to address these fundamental questions. Because of its potential in delineating normal and abnormal brain dynamics, we propose that MEG provides a crucial tool to advance our understanding of pathophysiological mechanisms of major neuropsychiatric conditions, such as Schizophrenia, Autism Spectrum Disorders, and the dementias. In our paper, we summarize the mechanisms underlying the generation of MEG signals and the tools available to reconstruct generators and underlying networks using advanced source-reconstruction techniques. We then survey recent studies that have utilized MEG to examine aberrant rhythmic activity in neuropsychiatric disorders. This is followed by links with preclinical research, which have highlighted possible neurobiological mechanisms, such as disturbances in excitation/inhibition parameters, which could account for measured changes in neural oscillations. In the final section of the paper, challenges as well as novel methodological developments are discussed which could pave the way for a widespread application of MEG in translational research with the aim of developing biomarkers for early detection and diagnosis
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Aberrant activity in conceptual networks underlies N400 deficits and unusual thoughts in schizophrenia.
BackgroundThe N400 event-related potential (ERP) is triggered by meaningful stimuli that are incongruous, or unmatched, with their semantic context. Functional magnetic resonance imaging (fMRI) studies have identified brain regions activated by semantic incongruity, but their precise links to the N400 ERP are unclear. In schizophrenia (SZ), N400 amplitude reduction is thought to reflect overly broad associations in semantic networks, but the abnormalities in brain networks underlying deficient N400 remain unknown. We utilized joint independent component analysis (JICA) to link temporal patterns in ERPs to neuroanatomical patterns from fMRI and investigate relationships between N400 amplitude and neuroanatomical activation in SZ patients and healthy controls (HC).MethodsSZ patients (n = 24) and HC participants (n = 25) performed a picture-word matching task, in which words were either matched (APPLE→apple) by preceding pictures, or were unmatched by semantically related (in-category; IC, APPLE→lemon) or unrelated (out of category; OC, APPLE→cow) pictures, in separate ERP and fMRI sessions. A JICA "data fusion" analysis was conducted to identify the fMRI brain regions specifically associated with the ERP N400 component. SZ and HC loading weights were compared and correlations with clinical symptoms were assessed.ResultsJICA identified an ERP-fMRI "fused" component that captured the N400, with loading weights that were reduced in SZ. The JICA map for the IC condition showed peaks of activation in the cingulate, precuneus, bilateral temporal poles and cerebellum, whereas the JICA map from the OC condition was linked primarily to visual cortical activation and the left temporal pole. Among SZ patients, fMRI activity from the IC condition was inversely correlated with unusual thought content.ConclusionsThe neural networks associated with the N400 ERP response to semantic violations depends on conceptual relatedness. These findings are consistent with a distributed network underlying neural responses to semantic incongruity including unimodal visual areas as well as integrative, transmodal areas. Unusual thoughts in SZ may reflect impaired processing in transmodal hub regions such as the precuneus, leading to overly broad semantic associations
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