64 research outputs found

    Time-frequency investigation of heart rate variability and cardiovascular system modeling of normal and chronic obstructive pulmonary disease (COPD) subjects

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    A study has been designed to add insight to some questions that have not been fully investigated in the heart rate variability field and the cardiovascular regulation system in normal and Chronic Obstructive Pulmonary Disease (COPD) subjects. It explores the correlations between heart rate variability and cardiovascular regulation, which interact through complex multiple feedback and control loops. This work examines the coupling between heart rate (HR), respiration (RESP), and blood pressure (BP) via closed-loop system identification techniques in order to noninvasively assess the underlying physiology. In the first part of the study, the applications of five different bilinear time-frequency representations are evaluated on modeled HRV test signals, actual electrocardiograms (ECG), BP and RESP signals. Each distribution: the short time Fourier transform (STFT), the smoothed pseudo Wigner-Ville (SPWVD), the ChoiWilliams (CWD), the Bom-Jordan-Cohen (BJC) and wavelet distribution (WL), has unique characteristics which is shown to affect the amount of smoothing and the generation of cross-terms. The CWD and the WL are chosen for further application because of overcoming the drawbacks of other distributions by providing higher resolution in time and frequency while suppressing interferences between the signal components. In the second part of the study, the Morlet, Meyer, Daubechies 4, Mexican Hat and Haar wavelets are used to investigate the heart rate and blood pressure variability from both COPD and normal subjects. The results of wavelet analysis give much more useful information than the Cohen\u27s class representations. Here we are able to quantitatively assess the parasympathetic (HF) and sympatho-vagal balance (LF:HF) changes as a function of time. As a result, COPD subjects breathe faster, have higher blood pressure variability and lower HRV. In the third part of the study, a special class of the exogenous autoregressive (ARX) model is developed as an analytical tool for uncovering the hidden autonomic control processes. Non-parametric relationships between the input and outputs of the ARX model resulting in transfer function estimations of the noise filters and the input filter were used as mechanistic cardiovascular models that have shown to have predictive capabilities for the underlying autonomic nervous system activity of COPD patients. Transfer functions of COPD cardiovascular models have similar DC gains but show a larger lag in phase as compared to the models of normal subjects. Finally, a method of severity classification is presented. This method combines the techniques of principal component analysis (PCA) and cluster analysis (CA) and has been shown to separate the COPD from the normal population with 100% accuracy. It can also classify the COPD population into at risk , mild , moderate and severe stages with 100%, 90%, 88% and 100% accuracy respectively. As a result, cluster and principal component analysis can be used to separate COPD and normal subjects and can be used successfully in COPD severity classification

    Bilinear time-frequency representations of heart rate variability and respiration during stress

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    Recently, joint time-frequency signal representation has received considerable attention as a powerful tool for analyzing a variety of signals and systems. In particular, if the frequency content is time varying as in signals of biological origin which often do not comply with the stationarity assumptions, then this approach is quite attractive. In this dissertation, we explore the possibility of better representation of two particular biological signals, namely heart rate variability (HRV) and respiration. We propose the use of time-frequency analysis as a new and innovative approach to examine the physical and mental exertion attributed to exercise. Two studies are used for the main investigation, the preliminary and anticipation protocols. In the first phase of this work, the application of five different bilinear representations on modeled HRV test signals and experimental HRV and respiration signals of the preliminary protocol is evaluated. Each distribution: the short time Fourier transform (STFT), the pseudo Wigner-Ville (WVD), the smoothed pseudo Wigner-Ville (SPWVD), The Choi-Williams (CWD), and the Born-Jordan-Cohen (RID) has unique characteristics which is shown to affect the amount of smoothing and the generation of cross-terms differently . The CWD and the SPWVD are chosen for further application because of overcoming the drawbacks of the other distributions by providing higher resolution in time arid frequency while suppressing interferences between the signal components. In the second phase of this research, the SPWVD and CWD are used to investigate the presence of an anticipatory component due to the stressful exercise condition as reflected in the HRV signal from a change in behavior in the autonomic nervous system. By expanding the concept of spectral analysis of heart rate variability (HRV) into time-frequency analysis, we are able to quantitatively assess the parasympathetic (HF) and sympatho-vagal balance (LF:HF) changes as a function of time. As a result, the assessment of the autonomic nervous system during rapid changes is made. A new methodology is also proposed that adaptively uncovers the region of parasympathetic activity. It is well known that parasympathetic activity is highly correlated with the respiration frequency. This technique traces the respiration frequency and extracts the corresponding parasympathetic activity from the heart rate variability signal by adaptive filtering

    On time-frequency analysis of heart rate variability

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    On time-frequency analysis of heart rate variability

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    Fixed and data adaptive kernels in Cohen's class of time-frequency distributions

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    Estimating the spectra of non-stationary signals represents a difficult challenge. Classical techniques employing the Fourier transform and local stationarity have been employed with limited success. A more promising approach is the use of time-frequency distributions. The majority of useful distributions have been unified under Cohen's class of distributions, a bilinear transformation with an arbitrary, fixed kernel function. The properties of several popular distributions developed from Cohen's class of distribution are examined. the ability of the kernel to suppress spurious cross-terms resulting from the bilinear nature of these distributions is examined along with their characteristics. Distributions employing a fixed kernel usually give good results only for a small class of signals. A data adaptive kernel is also examined which promises to give superior results for a broad class of signals. Results are shown for several test cases employing synthetic, analytic signals.http://archive.org/details/fixeddataadaptiv00parkLieutenant, United States NavyApproved for public release; distribution is unlimited

    Spectral Analysis for Signal Detection and Classification : Reducing Variance and Extracting Features

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    Spectral analysis encompasses several powerful signal processing methods. The papers in this thesis present methods for finding good spectral representations, and methods both for stationary and non-stationary signals are considered. Stationary methods can be used for real-time evaluation, analysing shorter segments of an incoming signal, while non-stationary methods can be used to analyse the instantaneous frequencies of fully recorded signals. All the presented methods aim to produce spectral representations that have high resolution and are easy to interpret. Such representations allow for detection of individual signal components in multi-component signals, as well as separation of close signal components. This makes feature extraction in the spectral representation possible, relevant features include the frequency or instantaneous frequency of components, the number of components in the signal, and the time duration of the components. Two methods that extract some of these features automatically for two types of signals are presented in this thesis. One adapted to signals with two longer duration frequency modulated components that detects the instantaneous frequencies and cross-terms in the Wigner-Ville distribution, the other for signals with an unknown number of short duration oscillations that detects the instantaneous frequencies in a reassigned spectrogram. This thesis also presents two multitaper methods that reduce the influence of noise on the spectral representations. One is designed for stationary signals and the other for non-stationary signals with multiple short duration oscillations. Applications for the methods presented in this thesis include several within medicine, e.g. diagnosis from analysis of heart rate variability, improved ultrasound resolution, and interpretation of brain activity from the electroencephalogram

    On time-frequence analysis of heart rate variability

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    The aim of this research is to develop a time-frequency method suitable to study HRV in greater detail. The following approach was used: • two known time-frequency representations were applied to HRV to understand its advantages and disadvantages in describing HRV in frequency and in amplitude, over time; • a new method was developed that describes the time-varying fluctuations in the characteristic frequency bands of HRV by means of the instantaneous frequency and the instantaneous amplitude with an optimal time-resolution; • an index was developed to separate the oscillatory from the irregular periods in the instantaneous frequency; • from the instantaneous amplitude and frequency, we derived summarizing parameters which we applied to describe the changes in the instantaneous amplitude and frequency over time for the oscillatory and irregular periods separatel
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