182 research outputs found

    Media construction of Korean transnational sporting masculinities

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    This study examined discursively produced transnational masculinities through mediated Korean-born sport celebrities playing in the major league baseball. Considering that studies of men and masculinity are more likely to offer richer, more in-depth analyses when they recognize the intersections of class, race, gender, sexuality, and nationality, this research explored diverse and plural conflations of contemporary masculinities in transnational contexts. In the process, I took into account a variety of theoretical approaches including post-colonial feminist theory, queer theory, critical race theory, new manism theory, and hegemonic theory in order to find a more appropriate theoretical framework for the analysis of transnational subjectivities. Linking theoretical frames with feminist critical discourse analysis and Fairclough's three dimensions of critical discourse analysis, I investigated multiple media sport texts including online newspapers and reader comments in US and South Korean contexts. Based on a total number of 108 media texts in online newspapers, six distinguishing thematic discourses were analyzed: athletic masculinities, heterosexual patriarchal masculinities, militarized masculinities, trans/nationalist masculinities, Korean Confucian masculinities, and color solidarity. Through analyzing a total number of 83 media texts in reader comments, also, four dominant discourse categories were identified: othering masculinities, regulating bodies, commodified transnational masculinities, and multifaceted androcentric nationalism. The results illustrate that diversely conflated transnational relationships and the intersectional factors including race, class, gender, sexuality, and nationality have an influence on shaping the hybridity of Korean sporting masculinities. Resisting a dominant dichotomous perception that the western males and masculinities are standardized as a norm but Asian/Korean males and masculinities are merely effeminate, the results of this study effectively illuminate newly racialized transnational subjects and the masculinities under the power of new imperialism

    On the dynamics of interdomain routing in the Internet

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    The routes used in the Internet's interdomain routing system are a rich information source that could be exploited to answer a wide range of questions.  However, analyzing routes is difficult, because the fundamental object of study is a set of paths. In this dissertation, we present new analysis tools -- metrics and methods -- for analyzing paths, and apply them to study interdomain routing in the Internet over long periods of time. Our contributions are threefold. First, we build on an existing metric (Routing State Distance) to define a new metric that allows us to measure the similarity between two prefixes with respect to the state of the global routing system. Applying this metric over time yields a measure of how the set of paths to each prefix varies at a given timescale. Second, we present PathMiner, a system to extract large scale routing events from background noise and identify the AS (Autonomous System) or AS-link most likely responsible for the event. PathMiner is distinguished from previous work in its ability to identify and analyze large-scale events that may re-occur many times over long timescales. We show that it is scalable, being able to extract significant events from multiple years of routing data at a daily granularity. Finally, we equip Routing State Distance with a new set of tools for identifying and characterizing unusually-routed ASes. At the micro level, we use our tools to identify clusters of ASes that have the most unusual routing at each time. We also show that analysis of individual ASes can expose business and engineering strategies of the organizations owning the ASes.  These strategies are often related to content delivery or service replication. At the macro level, we show that the set of ASes with the most unusual routing defines discernible and interpretable phases of the Internet's evolution. Furthermore, we show that our tools can be used to provide a quantitative measure of the "flattening" of the Internet

    The rhythm that unites: an empirical investigation into synchrony, ritual, and hierarchy

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    Synchrony, or rhythmic bodily unison activities such as drumming or cadence marching, has attracted growing scholarly interest. Among laboratory subjects, synchrony elicits prosocial responses, including altruism and empathy. In light of such findings, researchers in social psychology and the bio-cultural study of religion have suggested that synchrony played a role in humanity’s evolutionary history by engendering collectivistic commitments and social cohesion. These models propose that synchrony enhances cohesion by making people feel united. However, such models overlook the importance of differentiated social relations, such as hierarchies. This dissertation builds on this insight by drawing on neuroscience, coordination dynamics, social psychology, anthropology, and ritual studies to generate a complex model of synchrony, ritual, and social hierarchy, which is then tested in an experimental study. In the hypothesized model, shared motor unison suppresses the brain’s ability to distinguish cognitively between self-caused and exogenous motor acts, resulting in subjective self-other overlap. During synchrony each participant is dynamically entrained to a group mean rhythm; this “immanent authority” prevents any one participant from unilaterally dictating the rhythm, flattening relative hierarchy. As a ritualized behavior, synchrony therefore paradigmatically evokes shared ideals of equality and unity. However, when lab participants were assigned to either a synchrony or asynchrony manipulation and given a collaborative task requiring complex coordination, synchrony predicted a marginally lower degree of collaboration and significantly lower interpersonal satisfaction. These findings imply that unity and equality can undercut group cohesion if the collective agenda is a shared goal that requires interpersonal coordination. My results emphasize that, despite the inevitable tensions associated with social hierarchy, complementary roles and hierarchy are vital for certain aspects of social cohesion. Ritual and convention institute social boundaries that can be adroitly negotiated, even as egalitarian effervescence such as communitas (in the sense of Victor Turner) facilitates social unity and inspires affective commitments. These findings corroborate theories in ritual studies and sociology that caution both against excessive emphasis on inner emotive states (such as empathy) and against excessively rigid conventions or roles. An organic balance between unity and functional differentiation is vital for genuinely robust, long-term social cohesion.2018-06-21T00:00:00

    Unmet goals of tracking: within-track heterogeneity of students' expectations for

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    Educational systems are often characterized by some form(s) of ability grouping, like tracking. Although substantial variation in the implementation of these practices exists, it is always the aim to improve teaching efficiency by creating homogeneous groups of students in terms of capabilities and performances as well as expected pathways. If students’ expected pathways (university, graduate school, or working) are in line with the goals of tracking, one might presume that these expectations are rather homogeneous within tracks and heterogeneous between tracks. In Flanders (the northern region of Belgium), the educational system consists of four tracks. Many students start out in the most prestigious, academic track. If they fail to gain the necessary credentials, they move to the less esteemed technical and vocational tracks. Therefore, the educational system has been called a 'cascade system'. We presume that this cascade system creates homogeneous expectations in the academic track, though heterogeneous expectations in the technical and vocational tracks. We use data from the International Study of City Youth (ISCY), gathered during the 2013-2014 school year from 2354 pupils of the tenth grade across 30 secondary schools in the city of Ghent, Flanders. Preliminary results suggest that the technical and vocational tracks show more heterogeneity in student’s expectations than the academic track. If tracking does not fulfill the desired goals in some tracks, tracking practices should be questioned as tracking occurs along social and ethnic lines, causing social inequality

    Elements of Applied Linguistics

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    Documento PDF, 104 páginasGuía de estudio para el curso Elements of Applied Linguistics, código 5189, de la cátedra de Lengua y Cultura que imparte la UNEDUniversidad Estatal a Distancia de Costa Ric

    Software curating : the politics of curating in/as (an) Open System(s)

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    The thesis examines how Information technologies have changed the practice of curating. It proposes an Interdisciplinary approach that directly links curating (often understood as an activity of artistic programming), computing (the activity of computer programming) and a relatively recent Interest In software art (in which programming Is understood as artistic practice). Although there Is much contemporary critical work and practice that Is described as art-oriented programming or software art, the thesis aims to explore a perceived gap In discussions around software curating. Curators working with online technologies are presented with the challenge of how to respond to new artistic forms that Involve programming: for Instance program-objects that display dynamic and transformative properties, and that are distributed over socio-technological networks. Although there are many examples of social platforms and highly relevant examples of online 'art platforms', these still largely operate In display mode replicating more conventional models of curating and the operations of art Institutions In general. The tendency Is for these curatorial online systems to concentrate on the display of executed code and pay less attention to source code. New sensibilities are required that simultaneously reflect the significance of source code as art, and software not as a production tool or a display platform but as cultural practice that Is analogous to curating. What Is distinctive about the thesis Is that It speculates on a curatorial model that emphasises the analogy to programming. Consequently, the thesis argues for online software systems that display properties of curating but reprocess established definitions by deliberately collapsing firm distinctions between the fields of programming, artistic practice and curatorial practice. To consider these Issues, the thesis brings together a number of Inter-related fields of critical Inquiry and situates curating In the context of theories of immateriality, a critical discourse around software art practice, and an understanding of open systems. The key Issue for the thesis becomes how power relations, control and agency are expressed In new curatorial forms that Involve programming and networks; In other words, the thesis Is concerned with the politics of curating In/as (an) open system(s). Indeed, curating Itself can be described In terms of open systems, Implying a state In which there Is continuous Interaction with the soclo-technological environment. The system Is opened up to communicative processes that Involve producers/users and to divergent exchanges that take place and that disrupt established social relations of production and distribution. Thus, and Importantly for an understanding of the power relations Involved, software opens up curating to dynamic possibilities and transformations beyond the usual Institutional model (analogous to the model of production associated with the industrial factory) Into the context of networks (and what Is referred to by the Autonomists as the 'social factory'). The suggestion Is that the curatorial process Is now closely Integrated with the dynamic soclo-technological networks and with software that Is not simply used to curate but demonstrates the activity of curatIng In Itself Consequently, the thesis offers an expanded description of curating with respect to software In which agency Is reconstituted to Include alternative dynamics of networks. The curatorial model Is not only theorlsed but also deployed In the production of experimental software for curating source code (kurator) that forms the practical part of the doctoral research. in addition to a written thesis and software, two further projects produced during the registration period 2002-2008 are Included in support of the overall thesis: a conference CuratIng, Immaterlafity, Systems (CIS) (Tate Modern, London 2005) and an edited book Curating immateriality: The Work of The Curator In the Age of Network Systems (CI) (Autonomedia, New York 2006). The kurator software Is a further development of the conference and subsequent book, and offers an online, user-moderated curatorial system for further public modification. In so doing, the argument Is that the curatorial process Is demonstrably a collective and distributed executable that displays machinic agency. This Is what Is referred to in the thesis as software curating.Faculty of Technology and Faculty of Arts, University of Plymouth

    Differential Privacy - A Balancing Act

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    Data privacy is an ever important aspect of data analyses. Historically, a plethora of privacy techniques have been introduced to protect data, but few have stood the test of time. From investigating the overlap between big data research, and security and privacy research, I have found that differential privacy presents itself as a promising defender of data privacy.Differential privacy is a rigorous, mathematical notion of privacy. Nevertheless, privacy comes at a cost. In order to achieve differential privacy, we need to introduce some form of inaccuracy (i.e. error) to our analyses. Hence, practitioners need to engage in a balancing act between accuracy and privacy when adopting differential privacy. As a consequence, understanding this accuracy/privacy trade-off is vital to being able to use differential privacy in real data analyses.In this thesis, I aim to bridge the gap between differential privacy in theory, and differential privacy in practice. Most notably, I aim to convey a better understanding of the accuracy/privacy trade-off, by 1) implementing tools to tweak accuracy/privacy in a real use case, 2) presenting a methodology for empirically predicting error, and 3) systematizing and analyzing known accuracy improvement techniques for differentially private algorithms. Additionally, I also put differential privacy into context by investigating how it can be applied in the automotive domain. Using the automotive domain as an example, I introduce the main challenges that constitutes the balancing act, and provide advice for moving forward

    The Data Science Design Manual

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    Development and validation of in silico tools for efficient library design and data analysis in high throughput screening campaigns

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    My PhD project findings have their major application in the early phase of the drug discovery process, in particular we have developed and validated two computational tools (Molecular Assembles and LiGen) to support the hit finding and the hit to lead phases. I have reported here novel methods to first design chemical libraries optimized for HTS and then profile them for a specific target receptor or enzyme. I also analyzed the generated bio-chemical data in order to obtain robust SARs and to select the most promising hits for the follow up. The described methods support the iterative process of validated hit series optimization up to the identification of a lead. In chapter 3, Ligand generator (LiGen), a de novo tool for structure based virtual screening, is presented. The development of LiGen is a project based on a collaboration among Dompé Farmaceutici SpA, CINECA and the University of Parma. In this multidisciplinary group, the integration of different skills has allowed the development, from scratch, of a virtual screening tool, able to compete in terms of performance with long standing, well-established molecular docking tools such as Glide, Autodock and PLANTS. LiGen, using a novel docking algorithm, is able to perform ligand flexible docking without performing a conformational sampling. LiGen also has other distinctive features with respect to other molecular docking programs: • LiGen uses the inverse pharmacophore derived from the binding site to identify the putative bioactive conformation of the molecules, thus avoiding the evaluation of molecular conformations which do not match the key features of the binding site. • LiGen implemenst a de novo molecule builder based on the accurate definition of chemical rules taking account of building block (reagents) reactivity. • LiGen is natively a multi-platform C++ portable code designed for HPC applications and optimized for the most recent hardware architectures like the Xeon Phi Accelerators. Chapter 3 also reports the further development and optimization of the software starting from the results obtained in the first optimization step performed to validate the software and to derive the default parameters. In chapter 4, the application of LiGen in the discovery and optimization of novel inhibitors of the complement factor 5 receptor (C5aR) is reported. Briefly, the C5a anaphylatoxin acting on its cognate G protein-coupled receptor C5aR is a potent pronociceptive mediator in several models of inflammatory and neuropathic pain. Although there has long been interest in the identification of C5aR inhibitors, their development has been complicated, as is the case with many peptidomimetic drugs, mostly due to the poor drug-like properties of these molecules. Herein, we report the de novo design of a potent and selective C5aR noncompetitive allosteric inhibitor, DF2593A. DF2593A design was guided by the hypothesis that an allosteric site, the “minor pocket”, previously characterized in CXCR1 and CXCR2, could be functionally conserved in the GPCR class.DF2593A potently inhibited C5a-induced migration of human and rodent neutrophils in vitro. Moreover, oral administration of DF2593A effectively reduced mechanical hyperalgesia in several models of acute and chronic inflammatory and neuropathic pain in vivo, without any apparent side effects. Chapter 5 describes another tool: Molecular Assemblies (MA), a novel metrics based on a hierarchical representation of the molecule based on different representations of the scaffold of the molecule and pruning rules. The algorithm used by MA, defining a priori a metrics (a set of rules), creates a representation of the chemical structure through hierarchical decomposition of the scaffold in fragments, in a pathway invariant way (this feature is novel with respect to the other algorithms reported in literature). Such structure decomposition is applied to nine hierarchical representation of the scaffold of the reference molecule, differing for the content of structural information: atom typing and bond order (this feature is novel with respect to the other algorithms reported in literature) The algorithm (metrics) generates a multi-dimensional hierarchical representation of the molecule. This descriptor applied to a library of compounds is able to extract structural (molecule having the same scaffold, wireframe or framework) and sub structural (molecule having the same fragments in common) relations among all the molecules. At least, this method generates relations among molecules based on identities (scaffolds or fragments). Such an approach produces a unique representation of the reference chemical space not biased by the threshold used to define the similarity cut-off between two molecules. This is in contrast to other methods which generate representations based in similarities. MA procedure, retrieving all scaffold representation, fragments and fragmentation’s patterns (according to the predefined rules) from a molecule, creates a molecular descriptor useful for several cheminformatics applications: • Visualization of the chemical space. The scaffold relations (Figure 7) and the fragmentation patterns can be plotted using a network representation. The obtained graphs are useful depictions of the chemical space highlighting the relations that occur among the molecule in a two dimensional space. • Clustering of the chemical space. The relations among the molecules are based on identities. This means that the scaffold representations and their fragments can be used as a hierarchical clustering method. This descriptor produces clusters that are independent from the number and similarity among closest neighbors because belonging to a cluster is a property of the single molecule (Figure 8). This intrinsic feature makes the scaffold based clustering much faster than other methods in producing “stable” clusters in fact, adding and removing molecules increases and decreases the number of clusters while adding or removing relations among the clusters. However these changes do not affect the cluster number and the relation of the other molecules in dataset. • Generate scaffold-based fingerprints. The descriptor can be used as a fingerprint of the molecule and to generate a similarity index able to compare single molecules or also to compare the diversity of two libraries as a whole. Chapter 6 reports an application of MA in the design of a diverse drug-like scaffold based library optimized for HTS campaigns. A well designed, sizeable and properly organized chemical library is a fundamental prerequisite for any HTS project. To build a collection of chemical compounds with high chemical diversity was the aim of the Italian Drug Discovery Network (IDDN) initiative. A structurally diverse collection of about 200,000 chemical molecules was designed and built taking into account practical aspects related to experimental HTS procedures. Algorithms and procedures were developed and implemented to address compound filtering, selection, clusterization and plating. Chapter 7 collects concluding remarks and plans for the further development of the tools

    Listening to ab(pre)scence: a derridean approach to the analysis of sound-image relations in early cinema

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    My thesis is an investigation into the period of history surrounding the introduction of synchronised sound to film. The intention is in part to redress the current position that sound practice and theory holds in film today, but also to discover a method for understanding film as an audiovisual medium; ontologically necessitating an interplay between sound and image. Prioritising sound is not the intention of this thesis, as to do so would negate the ability to understand film as both sound and image. Theoretical concepts from the deconstructionist philosopher, Jacques Derrida, are appropriated to create a new model that can be used for film analysis. This model attempts to treat film as audiovisual, and uncover specifically, a way in which sound and image can be understood and examined together, resulting in a proliferation of available readings and meanings from the film text. Two ‘transitional’ films from 1927, The Jazz Singer, and Sunrise, along with synchronised sound tests from the 1890s onwards, are used as case studies to which the deconstructionist model of analysis is applied. Once the films are removed from their technological and historical positions in film history, the analysis uncovers new meanings and readings. Archival magazines and journals are reviewed to provide additional insights into the period of transition to synchronised sound. The knowledge uncovered here helps to contribute to a greater understanding of the period and, combined with a Derridean analysis, the research also offers insight that is valuable to the understanding of film today
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