Correlation Between High-sensitivity C Reactive Protein and Local Arterial Stiffness Measured by Radio Frequency Echotracking System in Type 2 Diabetic Patients

Aim: to identify the correlation between hsCRP and arterial stiffness in type-2 diabetic patients. Methods: a cross-sectional study was conducted to assess the plasma levels of hsCRP and carotid arterial stiffness in 40 patients with type-2 diabetes mellitus. The common carotid artery stiffness was evaluated using radio frequency echo-tracking system to determine the local carotid pulse wave velocity (carotid-PWV). Results: median value of hsCRP in this study was 4.5 (0.2 to 18.9) mg/L and the average value of local carotid stiffness was 8.8±1.7 m/sec. High sensitive CRP showed a strong correlation with carotid-PWV (r=0.503, P=0.001). hsCRP level was independently associated with carotid-PWV after adjustment for age, body mass index, and mean arterial pressure (r=0.450, P=0.005). Conclusion: hs-CRP has moderate positive correlation with arterial stiffness in patients with type-2 diabets mellitus. Key words: arterial stiffness, C-reactive protei

An exploration of the rhythm of Malay

In recent years there has been a surge of interest in speech rhythm. However we still lack a clear understanding of the nature of rhythm and rhythmic differences across languages. Various metrics have been proposed as means for measuring rhythm on the phonetic level and making typological comparisons between languages (Ramus et al, 1999; Grabe & Low, 2002; Dellwo, 2006) but the debate is ongoing on the extent to which these metrics capture the rhythmic basis of speech (Arvaniti, 2009; Fletcher, in press). Furthermore, cross linguistic studies of rhythm have covered a relatively small number of languages and research on previously unclassified languages is necessary to fully develop the typology of rhythm. This study examines the rhythmic features of Malay, for which, to date, relatively little work has been carried out on aspects rhythm and timing. The material for the analysis comprised 10 sentences produced by 20 speakers of standard Malay (10 males and 10 females). The recordings were first analysed using rhythm metrics proposed by Ramus et. al (1999) and Grabe & Low (2002). These metrics (∆C, %V, rPVI, nPVI) are based on durational measurements of vocalic and consonantal intervals. The results indicated that Malay clustered with other so-called syllable-timed languages like French and Spanish on the basis of all metrics. However, underlying the overall findings for these metrics there was a large degree of variability in values across speakers and sentences, with some speakers having values in the range typical of stressed-timed languages like English. Further analysis has been carried out in light of Fletcher’s (in press) argument that measurements based on duration do not wholly reflect speech rhythm as there are many other factors that can influence values of consonantal and vocalic intervals, and Arvaniti’s (2009) suggestion that other features of speech should also be considered in description of rhythm to discover what contributes to listeners’ perception of regularity. Spectrographic analysis of the Malay recordings brought to light two parameters that displayed consistency and regularity for all speakers and sentences: the duration of individual vowels and the duration of intervals between intensity minima. This poster presents the results of these investigations and points to connections between the features which seem to be consistently regulated in the timing of Malay connected speech and aspects of Malay phonology. The results are discussed in light of current debate on the descriptions of rhythm

Rhotics.New Data and Perspectives

This book provides an insight into the patterns of variation and change of rhotics in different languages and from a variety of perspectives. It sheds light on the phonetics, the phonology, the socio-linguistics and the acquisition of /r/-sounds in languages as diverse as Dutch, English, French, German, Greek, Hebrew, Italian, Kuikuro, Malayalam, Romanian, Slovak, Tyrolean and Washili Shingazidja thus contributing to the discussion on the unity and uniqueness of this group of sounds

Effects of consonantal constrictions on voice quality

A speech production experiment with electroglottography investigated how voicing is affected by consonants of differing degrees of constriction. Measures of glottal contact [closed quotient (CQ)] and strength of voicing [strength of excitation (SoE)] were used in conditional inference tree analyses. Broadly, the results show that as the degree of constriction increases, both CQ and SoE values decrease, indicating breathier and weaker voicing. Similar changes in voicing quality are observed throughout the course of the production of a given segment. Implications of these results for a greater understanding of source-tract interactions and for the phonological notion of sonority are discussed

Ultra-high-speed imaging of bubbles interacting with cells and tissue

Ultrasound contrast microbubbles are exploited in molecular imaging, where bubbles are directed to target cells and where their high-scattering cross section to ultrasound allows for the detection of pathologies at a molecular level. In therapeutic applications vibrating bubbles close to cells may alter the permeability of cell membranes, and these systems are therefore highly interesting for drug and gene delivery applications using ultrasound. In a more extreme regime bubbles are driven through shock waves to sonoporate or kill cells through intense stresses or jets following inertial bubble collapse. Here, we elucidate some of the underlying mechanisms using the 25-Mfps camera Brandaris128, resolving the bubble dynamics and its interactions with cells. We quantify acoustic microstreaming around oscillating bubbles close to rigid walls and evaluate the shear stresses on nonadherent cells. In a study on the fluid dynamical interaction of cavitation bubbles with adherent cells, we find that the nonspherical collapse of bubbles is responsible for cell detachment. We also visualized the dynamics of vibrating microbubbles in contact with endothelial cells followed by fluorescent imaging of the transport of propidium iodide, used as a membrane integrity probe, into these cells showing a direct correlation between cell deformation and cell membrane permeability