Analysis of signalling pathways using the prism model checker

We describe a new modelling and analysis approach for signal transduction networks in the presence of incomplete data. We illustrate the approach with an example, the RKIP inhibited ERK pathway [1]. Our models are based on high level descriptions of continuous time Markov chains: reactions are modelled as synchronous processes and concentrations are modelled by discrete, abstract quantities. The main advantage of our approach is that using a (continuous time) stochastic logic and the PRISM model checker, we can perform quantitative analysis of queries such as if a concentration reaches a certain level, will it remain at that level thereafter? We also perform standard simulations and compare our results with a traditional ordinary differential equation model. An interesting result is that for the example pathway, only a small number of discrete data values is required to render the simulations practically indistinguishable

Perfect simulation, monotonicity and finite queueing networks

International audienceTutorial on perfect sampling with applications to queueing network

On Correctness, Precision, and Performance in Quantitative Verification: QComp 2020 Competition Report

Quantitative verification tools compute probabilities, expected rewards, or steady-state values for formal models of stochastic and timed systems. Exact results often cannot be obtained efficiently, so most tools use floating-point arithmetic in iterative algorithms that approximate the quantity of interest. Correctness is thus defined by the desired precision and determines performance. In this paper, we report on the experimental evaluation of these trade-offs performed in QComp 2020: the second friendly competition of tools for the analysis of quantitative formal models. We survey the precision guarantees - ranging from exact rational results to statistical confidence statements - offered by the nine participating tools. They gave rise to a performance evaluation using five tracks with varying correctness criteria, of which we present the results

XBorne 2016: A Brief Introduction

International audienceWe present the new version of XBorne a software tool for the probabilistic modeling with Markov chains. The tool which has been developed initially as a testbed for the algorithmic stochastic comparisons of stochastic matrices and Markov chains, is now a general purpose framework which can be used for the Markovian modelling in education and research

A modest approach to Markov automata

A duplicate of https://zenodo.org/record/5758839. Reason: The submitter forgot to indicate the DOI before publishing, so it got another one assigned automatically, which is unchangeable