A survey of molecular communication in cell biology : establishing a new hierarchy for interdisciplinary applications

Molecular communication (MC) engineering is inspired by the use of chemical signals as information carriers in cell biology. The biological nature of chemical signaling makes MC a promising methodology for interdisciplinary applications requiring communication between cells and other microscale devices. However, since the life sciences and communications engineering fields have distinct approaches to formulating and solving research problems, the mismatch between them can hinder the translation of research results and impede the development and implementation of interdisciplinary solutions. To bridge this gap, this survey proposes a novel communication hierarchy for MC signaling in cell biology and maps phenomena, contributions, and problems to the hierarchy. The hierarchy includes: 1) the physical propagation of cell signaling at the Physical Signal Propagation level; 2) the generation, reception, and biochemical pathways of molecular signals at the Physical and Chemical Signal Interaction level; 3) the quantification of physical signals, including macroscale observation and control methods, and conversion of signals to information at the Signal-Data Interface level; 4) the interpretation of information in cell signals and the realization of synthetic systems to store, process, and communicate molecular signals at the Local Data Abstraction level; and 5) applications relying on communication with MC signals at the Application level. To further demonstrate the proposed hierarchy, it is applied to case studies on quorum sensing, neuronal signaling, and communication via DNA. Finally, several open problems are identified for each level and the integration of multiple levels. The proposed hierarchy provides language for communication engineers to study and interface with biological systems, and also helps biologists to understand how communications engineering concepts can be exploited to interpret, control, and manipulate signaling in cell biology

Mechatronic Systems

Mechatronics, the synergistic blend of mechanics, electronics, and computer science, has evolved over the past twenty five years, leading to a novel stage of engineering design. By integrating the best design practices with the most advanced technologies, mechatronics aims at realizing high-quality products, guaranteeing at the same time a substantial reduction of time and costs of manufacturing. Mechatronic systems are manifold and range from machine components, motion generators, and power producing machines to more complex devices, such as robotic systems and transportation vehicles. With its twenty chapters, which collect contributions from many researchers worldwide, this book provides an excellent survey of recent work in the field of mechatronics with applications in various fields, like robotics, medical and assistive technology, human-machine interaction, unmanned vehicles, manufacturing, and education. We would like to thank all the authors who have invested a great deal of time to write such interesting chapters, which we are sure will be valuable to the readers. Chapters 1 to 6 deal with applications of mechatronics for the development of robotic systems. Medical and assistive technologies and human-machine interaction systems are the topic of chapters 7 to 13.Chapters 14 and 15 concern mechatronic systems for autonomous vehicles. Chapters 16-19 deal with mechatronics in manufacturing contexts. Chapter 20 concludes the book, describing a method for the installation of mechatronics education in schools

Resource-aware plan recognition in instrumented environments

This thesis addresses the problem of plan recognition in instrumented environments, which is to infer an agent';s plans by observing its behavior. In instrumented environments such observations are made by physical sensors. This introduces specific challenges, of which the following two are considered in this thesis: - Physical sensors often observe state information instead of actions. As classical plan recognition approaches usually can only deal with action observations, this requires a cumbersome and error-prone inference of executed actions from observed states. - Due to limited physical resources of the environment it is often not possible to run all sensors at the same time, thus sensor selection techniques have to be applied. Current plan recognition approaches are not able to support the environment in selecting relevant subsets of sensors. This thesis proposes a two-stage approach to solve the problems described above. Firstly, a DBN-based plan recognition approach is presented which allows for the explicit representation and consideration of state knowledge. Secondly, a POMDP-based utility model for observation sources is presented which can be used with generic utility-based sensor selection algorithms. Further contributions include the presentation of a software toolkit that realizes plan recognition and sensor selection in instrumented environments, and an empirical evaluation of the validity and performance of the proposed models.Diese Arbeit behandelt das Problem der Planerkennung in instrumentierten Umgebungen. Ziel ist dabei das Erschließen der Pläne des Nutzers anhand der Beobachtung seiner Handlungen. In instrumentierten Umgebungen erfolgt diese Beobachtung über physische Sensoren. Dies wirft spezifische Probleme auf, von denen zwei in dieser Arbeit näher betrachtet werden: - Physische Sensoren beobachten in der Regel Zustände anstelle direkter Nutzeraktionen. Klassische Planerkennungsverfahren basieren jedoch auf der Beobachtung von Aktionen, was bisher eine aufwendige und fehlerträchtige Ableitung von Aktionen aus Zustandsbeobachtungen notwendig macht. - Aufgrund beschränkter Resourcen der Umgebung ist es oft nicht möglich alle Sensoren gleichzeitig zu aktivieren. Aktuelle Planerkennungsverfahren bieten keine Möglichkeit, die Umgebung bei der Auswahl einer relevanten Teilmenge von Sensoren zu unterstützen. Diese Arbeit beschreibt einen zweistufigen Ansatz zur Lösung der genannten Probleme. Zunächst wird ein DBN-basiertes Planerkennungsverfahren vorgestellt, das Zustandswissen explizit repräsentiert und in Schlussfolgerungen berücksichtigt. Dieses Verfahren bildet die Basis für ein POMDP-basiertes Nutzenmodell für Beobachtungsquellen, das für den Zweck der Sensorauswahl genutzt werden kann. Des Weiteren wird ein Toolkit zur Realisierung von Planerkennungs- und Sensorauswahlfunktionen vorgestellt sowie die Gültigkeit und Performanz der vorgestellten Modelle in einer empirischen Studie evaluiert

Closed-loop approaches for innovative neuroprostheses

The goal of this thesis is to study new ways to interact with the nervous system in case of damage or pathology. In particular, I focused my effort towards the development of innovative, closed-loop stimulation protocols in various scenarios: in vitro, ex vivo, in vivo

Recent Advances in Multi Robot Systems

To design a team of robots which is able to perform given tasks is a great concern of many members of robotics community. There are many problems left to be solved in order to have the fully functional robot team. Robotics community is trying hard to solve such problems (navigation, task allocation, communication, adaptation, control, ...). This book represents the contributions of the top researchers in this field and will serve as a valuable tool for professionals in this interdisciplinary field. It is focused on the challenging issues of team architectures, vehicle learning and adaptation, heterogeneous group control and cooperation, task selection, dynamic autonomy, mixed initiative, and human and robot team interaction. The book consists of 16 chapters introducing both basic research and advanced developments. Topics covered include kinematics, dynamic analysis, accuracy, optimization design, modelling, simulation and control of multi robot systems

Proceedings of the NASA Conference on Space Telerobotics, volume 2

These proceedings contain papers presented at the NASA Conference on Space Telerobotics held in Pasadena, January 31 to February 2, 1989. The theme of the Conference was man-machine collaboration in space. The Conference provided a forum for researchers and engineers to exchange ideas on the research and development required for application of telerobotics technology to the space systems planned for the 1990s and beyond. The Conference: (1) provided a view of current NASA telerobotic research and development; (2) stimulated technical exchange on man-machine systems, manipulator control, machine sensing, machine intelligence, concurrent computation, and system architectures; and (3) identified important unsolved problems of current interest which can be dealt with by future research