Computerized Analysis of Magnetic Resonance Images to Study Cerebral Anatomy in Developing Neonates

The study of cerebral anatomy in developing neonates is of great importance for the understanding of brain development during the early period of life. This dissertation therefore focuses on three challenges in the modelling of cerebral anatomy in neonates during brain development. The methods that have been developed all use Magnetic Resonance Images (MRI) as source data. To facilitate study of vascular development in the neonatal period, a set of image analysis algorithms are developed to automatically extract and model cerebral vessel trees. The whole process consists of cerebral vessel tracking from automatically placed seed points, vessel tree generation, and vasculature registration and matching. These algorithms have been tested on clinical Time-of- Flight (TOF) MR angiographic datasets. To facilitate study of the neonatal cortex a complete cerebral cortex segmentation and reconstruction pipeline has been developed. Segmentation of the neonatal cortex is not effectively done by existing algorithms designed for the adult brain because the contrast between grey and white matter is reversed. This causes pixels containing tissue mixtures to be incorrectly labelled by conventional methods. The neonatal cortical segmentation method that has been developed is based on a novel expectation-maximization (EM) method with explicit correction for mislabelled partial volume voxels. Based on the resulting cortical segmentation, an implicit surface evolution technique is adopted for the reconstruction of the cortex in neonates. The performance of the method is investigated by performing a detailed landmark study. To facilitate study of cortical development, a cortical surface registration algorithm for aligning the cortical surface is developed. The method first inflates extracted cortical surfaces and then performs a non-rigid surface registration using free-form deformations (FFDs) to remove residual alignment. Validation experiments using data labelled by an expert observer demonstrate that the method can capture local changes and follow the growth of specific sulcus

Human gesture classification by brute-force machine learning for exergaming in physiotherapy

In this paper, a novel approach for human gesture classification on skeletal data is proposed for the application of exergaming in physiotherapy. Unlike existing methods, we propose to use a general classifier like Random Forests to recognize dynamic gestures. The temporal dimension is handled afterwards by majority voting in a sliding window over the consecutive predictions of the classifier. The gestures can have partially similar postures, such that the classifier will decide on the dissimilar postures. This brute-force classification strategy is permitted, because dynamic human gestures show sufficient dissimilar postures. Online continuous human gesture recognition can classify dynamic gestures in an early stage, which is a crucial advantage when controlling a game by automatic gesture recognition. Also, ground truth can be easily obtained, since all postures in a gesture get the same label, without any discretization into consecutive postures. This way, new gestures can be easily added, which is advantageous in adaptive game development. We evaluate our strategy by a leave-one-subject-out cross-validation on a self-captured stealth game gesture dataset and the publicly available Microsoft Research Cambridge-12 Kinect (MSRC-12) dataset. On the first dataset we achieve an excellent accuracy rate of 96.72%. Furthermore, we show that Random Forests perform better than Support Vector Machines. On the second dataset we achieve an accuracy rate of 98.37%, which is on average 3.57% better then existing methods

Online learning and detection of faces with low human supervision

The final publication is available at link.springer.comWe present an efficient,online,and interactive approach for computing a classifier, called Wild Lady Ferns (WiLFs), for face learning and detection using small human supervision. More precisely, on the one hand, WiLFs combine online boosting and extremely randomized trees (Random Ferns) to compute progressively an efficient and discriminative classifier. On the other hand, WiLFs use an interactive human-machine approach that combines two complementary learning strategies to reduce considerably the degree of human supervision during learning. While the first strategy corresponds to query-by-boosting active learning, that requests human assistance over difficult samples in function of the classifier confidence, the second strategy refers to a memory-based learning which uses ¿ Exemplar-based Nearest Neighbors (¿ENN) to assist automatically the classifier. A pre-trained Convolutional Neural Network (CNN) is used to perform ¿ENN with high-level feature descriptors. The proposed approach is therefore fast (WilFs run in 1 FPS using a code not fully optimized), accurate (we obtain detection rates over 82% in complex datasets), and labor-saving (human assistance percentages of less than 20%). As a byproduct, we demonstrate that WiLFs also perform semi-automatic annotation during learning, as while the classifier is being computed, WiLFs are discovering faces instances in input images which are used subsequently for training online the classifier. The advantages of our approach are demonstrated in synthetic and publicly available databases, showing comparable detection rates as offline approaches that require larger amounts of handmade training data.Peer ReviewedPostprint (author's final draft

Hierarchical Subquery Evaluation for Active Learning on a Graph

To train good supervised and semi-supervised object classifiers, it is critical that we not waste the time of the human experts who are providing the training labels. Existing active learning strategies can have uneven performance, being efficient on some datasets but wasteful on others, or inconsistent just between runs on the same dataset. We propose perplexity based graph construction and a new hierarchical subquery evaluation algorithm to combat this variability, and to release the potential of Expected Error Reduction. Under some specific circumstances, Expected Error Reduction has been one of the strongest-performing informativeness criteria for active learning. Until now, it has also been prohibitively costly to compute for sizeable datasets. We demonstrate our highly practical algorithm, comparing it to other active learning measures on classification datasets that vary in sparsity, dimensionality, and size. Our algorithm is consistent over multiple runs and achieves high accuracy, while querying the human expert for labels at a frequency that matches their desired time budget.Comment: CVPR 201