Updates of Wearing Devices (WDs) In Healthcare, And Disease Monitoring

 With the rising pervasiveness of growing populace, aging and chronic illnesses consistently rising medical services costs, the health care system is going through a crucial change from the conventional hospital focused system to an individual-focused system. Since the twentieth century, wearable sensors are becoming widespread in medical care and biomedical monitoring systems, engaging consistent estimation of biomarkers for checking of the diseased condition and wellbeing, clinical diagnostics and assessment in biological fluids like saliva, blood, and sweat. Recently, the improvements have been centered around electrochemical and optical biosensors, alongside advances with the non-invasive monitoring of biomarkers, bacteria and hormones, etc. Wearable devices have created with a mix of multiplexed biosensing, microfluidic testing and transport frameworks incorporated with flexible materials and body connections for additional created wear ability and effortlessness. These wearables hold guarantee and are fit for a higher understanding of the relationships between analyte focuses inside the blood or non-invasive biofluids and feedback to the patient, which is fundamentally significant in ideal finding, therapy, and control of diseases. In any case, cohort validation studies and execution assessment of wearable biosensors are expected to support their clinical acceptance. In the current review, we discussed the significance, highlights, types of wearables, difficulties and utilizations of wearable devices for biological fluids for the prevention of diseased conditions and real time monitoring of human wellbeing. In this, we sum up the different wearable devices that are developed for health care monitoring and their future potential has been discussed in detail

Emerging and Disruptive Next-Generation Technologies for POC: Sensors, Chemistry and Microfluidics for Diagnostics

Recently, the attention paid to self-care tests and the easy and large screening of a high number of people has dramatically increased. Indeed, easy and affordable tools for the safe management of biological fluids together with self-diagnosis have emerged as compulsory requirements in this time of the COVID-19 pandemic, to lighten the pressure on public healthcare institutions and thus limiting the diffusion of infections. Obviously, other kinds of pathologies (cancer or other degenerative diseases) also continue to require attention, with progressively earlier and more widespread diagnoses. The contribution to the development of this research field comes from the areas of innovative plastic and 3D microfluidics, smart chemistry and the integration of miniaturized sensors, going in the direction of improving the performances of in vitro diagnostic (IVD) devices. In our Special Issue, we include papers describing easy strategies to identify diseases at the point-of-care and near-the-bed levels, but also dealing with innovative biomarkers, sample treatments, and chemistry processes which, in perspective, represent promising tools to be applied in the field

Digital fabrication of custom interactive objects with rich materials

As ubiquitous computing is becoming reality, people interact with an increasing number of computer interfaces embedded in physical objects. Today, interaction with those objects largely relies on integrated touchscreens. In contrast, humans are capable of rich interaction with physical objects and their materials through sensory feedback and dexterous manipulation skills. However, developing physical user interfaces that offer versatile interaction and leverage these capabilities is challenging. It requires novel technologies for prototyping interfaces with custom interactivity that support rich materials of everyday objects. Moreover, such technologies need to be accessible to empower a wide audience of researchers, makers, and users. This thesis investigates digital fabrication as a key technology to address these challenges. It contributes four novel design and fabrication approaches for interactive objects with rich materials. The contributions enable easy, accessible, and versatile design and fabrication of interactive objects with custom stretchability, input and output on complex geometries and diverse materials, tactile output on 3D-object geometries, and capabilities of changing their shape and material properties. Together, the contributions of this thesis advance the fields of digital fabrication, rapid prototyping, and ubiquitous computing towards the bigger goal of exploring interactive objects with rich materials as a new generation of physical interfaces.Computer werden zunehmend in Geräten integriert, mit welchen Menschen im Alltag interagieren. Heutzutage basiert diese Interaktion weitgehend auf Touchscreens. Im Kontrast dazu steht die reichhaltige Interaktion mit physischen Objekten und Materialien durch sensorisches Feedback und geschickte Manipulation. Interfaces zu entwerfen, die diese Fähigkeiten nutzen, ist allerdings problematisch. Hierfür sind Technologien zum Prototyping neuer Interfaces mit benutzerdefinierter Interaktivität und Kompatibilität mit vielfältigen Materialien erforderlich. Zudem sollten solche Technologien zugänglich sein, um ein breites Publikum zu erreichen. Diese Dissertation erforscht die digitale Fabrikation als Schlüsseltechnologie, um diese Probleme zu adressieren. Sie trägt vier neue Design- und Fabrikationsansätze für das Prototyping interaktiver Objekte mit reichhaltigen Materialien bei. Diese ermöglichen einfaches, zugängliches und vielseitiges Design und Fabrikation von interaktiven Objekten mit individueller Dehnbarkeit, Ein- und Ausgabe auf komplexen Geometrien und vielfältigen Materialien, taktiler Ausgabe auf 3D-Objektgeometrien und der Fähigkeit ihre Form und Materialeigenschaften zu ändern. Insgesamt trägt diese Dissertation zum Fortschritt der Bereiche der digitalen Fabrikation, des Rapid Prototyping und des Ubiquitous Computing in Richtung des größeren Ziels, der Exploration interaktiver Objekte mit reichhaltigen Materialien als eine neue Generation von physischen Interfaces, bei

Correlating the Effect of Dynamic Variability in the Sensor Environment on Sensor Design

This dissertation studies the effect of biofluid dynamics on the electrochemical response of a wearable sensor for monitoring of chronic wounds. The research investigates various dynamic in vivo parameters and correlates them with experimentally measured behavior with wound monitoring as a use case. Wearable electrochemical biosensors suffer from several unaddressed challenges, like stability and sensitivity, that need to be resolved for obtaining accurate data. One of the major challenges in the use of these sensors is continuous variation in biofluid composition. Wound healing is a dynamic process with wound composition changing continuously. This dissertation investigates the effects of several in vivo biochemical and environmental parameters on the sensor response to establish actionable correlations. Real-time assessment of wound healing was carried out through longitudinal monitoring of uric acid and other wound fluid characteristics. A textile sensor was designed using a simple fabrication approach combining conductive inks with a polymeric substrate, for conformal contact with the wound bed. A −1 cm−2, establishing the applicability of the sensor for measurements in the physiologically relevant range. The sensor was also found to be stable for a period of 3 days when subjected to physiological and elevated temperatures (37oC and 40oC) confirming its relevance for long-term monitoring. A direct correlation between sensor response and the dynamic parameters was seen, with the results showing a ~20% deviation from the accurate UA reading. The results confirmed that as a consequence of these parameters temporally changing in the wound environment, the sensor response will be altered. The work develops mathematical models correlating this effect on sensor response to allow for real-time sensor calibration. The clinical validation studies established the feasibility of UA measurement by the developed electrochemical sensor and derive correlations between the wound chronicity and UA levels. The protocols developed in this work for the design, fabrication, and calibration of the sensor to correct for the dynamic in vivo behavior can be extended to any wearable sensor for improved accuracy

Analysis of Wireless Body-Centric Medical Sensors for Remote Healthcare

Aquesta tesi aborda el problema de trobar solucions confortables, de baixa potència i sense fils per aplicacions mèdiques. La tesi tracta els avantatges i les limitacions de tres tecnologies de comunicació diferents per la mesura de paràmetres del cos i mètodes per redissenyar sensors per avaluacions òptimes centrades en el cos. La tecnologia RFID es considera una de les solucions més influents per superar el problema del consum d'energia limitat, a causa de la presència de molts sensors connectats. També s'ha estudiat la tecnologia Bluetooth de baixa energia per resoldre els problemes de seguretat i la distància de lectura que, en general, representen el coll d'ampolla de RFID pels sensors de cos. Els dispositius analògics poden reduir dràsticament les necessitats d'energia a causa dels sensors i les comunicacions, considerant pocs elements i un mètode de transmissió simple. S'estudia un mètode de comunicació completament passiu, basat en FSS, que permet una distància de lectura raonable amb capacitats de detecció precises i confiables, que s'ha discutit en aquesta tesi. L'objectiu d'aquesta tesi és investigar múltiples tecnologies sense fils per dispositius portàtils per identificar solucions adequades per aplicacions particulars en el camp mèdic. El primer objectiu és demostrar la facilitat d'ús de les tecnologies econòmiques sense bateria com un indicador útil de paràmetres fisiopatològics mitjançant la investigació de les propietats de les etiquetes RFID. A més a més, s'ha abordat un aspecte més complex respecte a l'ús de petits components passius com sensors sense fils per trastorns del son. Per últim, un altre objectiu de la tesi és el desenvolupament d'un sistema completament autònom que utilitzi tecnologia BLE per obtenir propietats avançades mantenint baix tant el consum com el preuEsta tesis aborda el problema de encontrar soluciones confortables, inalámbricas y de baja potencia para aplicaciones médicas. La tesis discute las ventajas y limitaciones de tres tecnologías de comunicación diferentes para la medición en el cuerpo y los métodos para elegir y remodelar los sensores para evaluaciones óptimas centradas en el cuerpo. La tecnología RFID se considera una de las soluciones más influyentes para superar el consumo de energía limitado debido a la presencia de muchos sensores conectados. Además, la baja energía de Bluetooth se ha estudiado se ha estudiado la tecnologia Bluetooth de baja energia para resolver los problemas de seguridad y la distancia de lectura que, en general, representan el cuello de botella de la RFID para los sensores de cuerpo. Los dispositivos analógicos pueden reducir drásticamente las necesidades de energía debido a los sensores y las comunicaciones, considerando pocos elementos y un método de transmisión simple. Se estudia un método de comunicación completamente pasivo, basado en FSS, que permite una distancia de lectura razonable con capacidades de detección precisas y confiables, que se ha discutido en esta tesis. El objetivo de esta tesis es investigar múltiples tecnologías inalámbricas para dispositivos portátiles para identificar soluciones adecuadas para aplicaciones particulares en campos médicos. El primer objetivo es demostrar la facilidad de uso de las tecnologías económicas sin batería como un indicador útil de dichos parámetros fisiopatológicos mediante la investigación de las propiedades de las etiquetas RFID. Además, se ha abordado un aspecto más complejo con respecto al uso de pequeños componentes pasivos como sensores inalámbricos para enfermedades del sueño. Por último, un resultado de la tesis es desarrollar un sistema completamente autónomo que utilice la tecnología BLE para obtener propiedades avanzadas que mantengan la baja potencia y un precio bajo.This thesis addresses the problem of comfortable, low powered and, wireless solutions for specific body-worn sensing. The thesis discusses advantages and limitations of three different communication technologies for on body measurement and investigate methods to reshape sensors for optimum body-centric assessments. The RFID technology is considered one of the most influential solutions to overcome the limitated power consumption due to the presence of many sensors connected. Further, the Bluetooth low energy has been studied to solve security problems and reading distance that overall represent the bottleneck of the RFID for the body-worn sensors. Analog devices can drastically reduce the energy needs due to the sensors and the communications, considering few elements and a simple transmitting method. An entirely passive communication method, based on FSS is studied, enabling a reasonable reading distance with precise and reliable sensing capabilities, which has been discussed in this thesis. The objective of this thesis is to investigate multiple wireless technologies for wearable devices to identify suitable solutions for particular applications in medical fields. The first objective is to demonstrate the usability of the inexpensive battery-less technologies as a useful indicator of such a physio-pathological parameters by investigating the properties of the RFID tags. Furthermore, a more complex aspect regards the use of small passive components as wireless sensors for sleep diseases has been addressed. Lastly, an outcome of the thesis is to develop an entirely autonomous system using the BLE technology to obtain advanced properties keeping low power and a low price

Security Aspects of Printed Electronics Applications

Gedruckte Elektronik (Printed Electronics (PE)) ist eine neu aufkommende Technologie welche komplementär zu konventioneller Elektronik eingesetzt wird. Dessen einzigartigen Merkmale führten zu einen starken Anstieg von Marktanteilen, welche 2010 \$6 Milliarden betrugen, \$41 Milliarden in 2019 und in 2027 geschätzt \$153 Milliarden. Gedruckte Elektronik kombiniert additive Technologien mit funktionalen Tinten um elektronische Komponenten aus verschiedenen Materialien direkt am Verwendungsort, kosteneffizient und umweltfreundlich herzustellen. Die dabei verwendeten Substrate können flexibel, leicht, transparent, großflächig oder implantierbar sein. Dadurch können mit gedruckter Elektronik (noch) visionäre Anwendungen wie Smart-Packaging, elektronische Einmalprodukte, Smart Labels oder digitale Haut realisiert werden. Um den Fortschritt von gedruckten Elektronik-Technologien voranzutreiben, basierten die meisten Optimierungen hauptsächlich auf der Erhöhung von Produktionsausbeute, Reliabilität und Performance. Jedoch wurde auch die Bedeutung von Sicherheitsaspekten von Hardware-Plattformen in den letzten Jahren immer mehr in den Vordergrund gerückt. Da realisierte Anwendungen in gedruckter Elektronik vitale Funktionalitäten bereitstellen können, die sensible Nutzerdaten beinhalten, wie zum Beispiel in implantierten Geräten und intelligenten Pflastern zur Gesundheitsüberwachung, führen Sicherheitsmängel und fehlendes Produktvertrauen in der Herstellungskette zu teils ernsten und schwerwiegenden Problemen. Des Weiteren, wegen den charakteristischen Merkmalen von gedruckter Elektronik, wie zum Beispiel additive Herstellungsverfahren, hohe Strukturgröße, wenige Schichten und begrenzten Produktionsschritten, ist gedruckte Hardware schon per se anfällig für hardware-basierte Attacken wie Reverse-Engineering, Produktfälschung und Hardware-Trojanern. Darüber hinaus ist die Adoption von Gegenmaßnahmen aus konventionellen Technologien unpassend und ineffizient, da solche zu extremen Mehraufwänden in der kostengünstigen Fertigung von gedruckter Elektronik führen würden. Aus diesem Grund liefert diese Arbeit eine Technologie-spezifische Bewertung von Bedrohungen auf der Hardware-Ebene und dessen Gegenmaßnahmen in der Form von Ressourcen-beschränkten Hardware-Primitiven, um die Produktionskette und Funktionalitäten von gedruckter Elektronik-Anwendungen zu schützen. Der erste Beitrag dieser Dissertation ist ein vorgeschlagener Ansatz um gedruckte Physical Unclonable Functions (pPUF) zu entwerfen, welche Sicherheitsschlüssel bereitstellen um mehrere sicherheitsrelevante Gegenmaßnahmen wie Authentifizierung und Fingerabdrücke zu ermöglichen. Zusätzlich optimieren wir die multi-bit pPUF-Designs um den Flächenbedarf eines 16-bit-Schlüssels-Generators um 31\% zu verringern. Außerdem entwickeln wir ein Analyse-Framework basierend auf Monte Carlo-Simulationen für pPUFs, mit welchem wir Simulationen und Herstellungs-basierte Analysen durchführen können. Unsere Ergebnisse haben gezeigt, dass die pPUFs die notwendigen Eigenschaften besitzen um erfolgreich als Sicherheitsanwendung eingesetzt zu werden, wie Einzigartigkeit der Signatur und ausreichende Robustheit. Der Betrieb der gedruckten pPUFs war möglich bis zu sehr geringen Betriebsspannungen von nur 0.5 V. Im zweiten Beitrag dieser Arbeit stellen wir einen kompakten Entwurf eines gedruckten physikalischen Zufallsgenerator vor (True Random Number Generator (pTRNG)), welcher unvorhersehbare Schlüssel für kryptographische Funktionen und zufälligen "Authentication Challenges" generieren kann. Der pTRNG Entwurf verbessert Prozess-Variationen unter Verwendung von einer Anpassungsmethode von gedruckten Widerständen, ermöglicht durch die individuelle Konfigurierbarkeit von gedruckten Schaltungen, um die generierten Bits nur von Zufallsrauschen abhängig zu machen, und damit ein echtes Zufallsverhalten zu erhalten. Die Simulationsergebnisse legen nahe, dass die gesamten Prozessvariationen des TRNGs um das 110-fache verbessert werden, und der zufallsgenerierte Bitstream der TRNGs die "National Institute of Standards and Technology Statistical Test Suit"-Tests bestanden hat. Auch hier können wir nachweisen, dass die Betriebsspannungen der TRNGs von mehreren Volt zu nur 0.5 V lagen, wie unsere Charakterisierungsergebnisse der hergestellten TRNGs aufgezeigt haben. Der dritte Beitrag dieser Dissertation ist die Beschreibung der einzigartigen Merkmale von Schaltungsentwurf und Herstellung von gedruckter Elektronik, welche sehr verschieden zu konventionellen Technologien ist, und dadurch eine neuartige Reverse-Engineering (RE)-Methode notwendig macht. Hierfür stellen wir eine robuste RE-Methode vor, welche auf Supervised-Learning-Algorithmen für gedruckte Schaltungen basiert, um die Vulnerabilität gegenüber RE-Attacken zu demonstrieren. Die RE-Ergebnisse zeigen, dass die vorgestellte RE-Methode auf zahlreiche gedruckte Schaltungen ohne viel Komplexität oder teure Werkzeuge angewandt werden kann. Der letzte Beitrag dieser Arbeit ist ein vorgeschlagenes Konzept für eine "one-time programmable" gedruckte Look-up Table (pLUT), welche beliebige digitale Funktionen realisieren kann und Gegenmaßnahmen unterstützt wie Camouflaging, Split-Manufacturing und Watermarking um Attacken auf der Hardware-Ebene zu verhindern. Ein Vergleich des vorgeschlagenen pLUT-Konzepts mit existierenden Lösungen hat gezeigt, dass die pLUT weniger Flächen-bedarf, geringere worst-case Verzögerungszeiten und Leistungsverbrauch hat. Um die Konfigurierbarkeit der vorgestellten pLUT zu verifizieren, wurde es simuliert, hergestellt und programmiert mittels Tintenstrahl-gedruckter elektrisch leitfähiger Tinte um erfolgreich Logik-Gatter wie XNOR, XOR und AND zu realisieren. Die Simulation und Charakterisierungsergebnisse haben die erfolgreiche Funktionalität der pLUT bei Betriebsspannungen von nur 1 V belegt

DEVELOPMENT OF FUNCTIONAL NANOCOMPOSITE MATERIALS TOWARDS BIODEGRADABLE SOFT ROBOTICS AND FLEXIBLE ELECTRONICS

World population is continuously growing, as well as the influence we have on the ecosystem\u2019s natural equilibrium. Moreover, such growth is not homogeneous and it results in an overall increase of older people. Humanity\u2019s activity, growth and aging leads to many challenging issues to address: among them, there are the spread of suddenly and/or chronic diseases, malnutrition, resource pressure and environmental pollution. Research in the novel field of biodegradable soft robotics and electronics can help dealing with these issues. In fact, to face the aging of the population, it is necessary an improvement in rehabilitation technologies, physiological and continuous monitoring, as well as personalized care and therapy. Also in the agricultural sector, an accurate and efficient direct measure of the plants health conditions would be of help especially in the less-developed countries. But since living beings, such as humans and plants, are constituted by soft tissues that continuously change their size and shapes, today\u2019s traditional technologies, based on rigid materials, may not be able to provide an efficient interaction necessary to satisfy these needs: the mechanical mismatch is too prohibitive. Instead, soft robotic systems and devices can be designed to combine active functionalities with soft mechanical properties that can allow them to efficiently and safely interact with soft living tissues. Soft implantable biomedical devices, smart rehabilitation devices and compliant sensors for plants are all applications that can be achieved with soft technologies. The development of sophisticated autonomous soft systems needs the integration on a unique soft body or platform of many functionalities (such as mechanical actuation, energy harvesting, storage and delivery, sensing capabilities). A great research interest is recently arising on this topic, but yet not so many groups are focusing their efforts in the use of natural-derived and biodegradable raw materials. In fact, resource pressure and environmental pollution are becoming more and more critical problems. It should be completely avoided the use of in exhaustion, pollutant, toxic and non-degradable resources, such as lithium, petroleum derivatives, halogenated compounds and organic solvents. So-obtained biodegradable soft systems and devices could then be manufactured in high number and deployed in the environment to fulfil their duties without the need to recover them, since they can safely degrade in the environment. The aim of the current Ph.D. project is the use of natural-derived and biodegradable polymers and substances as building blocks for the development of smart composite materials that could operate as functional elements in a soft robotic system or device. Soft mechanical properties and electronic/ionic conductive properties are here combined together within smart nanocomposite materials. The use of supersonic cluster beam deposition (SCBD) technique enabled the fabrication of cluster-assembled Au electrodes that can partially penetrate into the surface of soft materials, providing an efficient solution to the challenge of coupling conductive metallic layers and soft deformable polymeric substrates. In this work, cellulose derivatives and poly(3-hydroxybutyrate) bioplastic are used as building blocks for the development of both underwater and in-air soft electromechanical actuators that are characterized and tested. A cellulosic matrix is blended with natural-derived ionic liquids to design and manufacture completely biodegradable supercapacitors, extremely interesting energy storage devices. Lastly, ultrathin Au electrodes are here deposited on biodegradable cellulose acetate sheets, in order to develop transparent flexible electronics as well as bidirectional resistive-type strain sensors. The results obtained in this work can be regarded as a preliminary study towards the realization of full natural-derived and biodegradable soft robotic and electronic systems and devices

Solid-Liquid Composites for Soft Multifunctional Materials

Soft materials with a liquid component are an emerging paradigm in materials design. The incorporation of a liquid phase, such as water, liquid metals, or complex fluids, into solid materials imparts unique properties and characteristics that emerge as a result of the dramatically different properties of the liquid and solid. Especially in recent years, this has led to the development and study of a range of novel materials with new functional responses, with applications in topics including soft electronics, soft robotics, 3D printing, wet granular systems and even in cell biology. Here we provide a review of solid-liquid composites, broadly defined as a material system with at least one, phase-separated liquid component, and discuss their morphology and fabrication approaches, their emergent mechanical properties and functional response, and the broad range of their applications

Sensors Based on Bio and Biomimetic Receptors in Medical Diagnostic, Environment, and Food Analysis

Analytical chemistry is now developing mainly in two areas: automation and the creation of complexes that allow, on the one hand, for simultaneously analyzing a large number of samples without the participation of an operator, and on the other, the development of portable miniature devices for personalized medicine and the monitoring of a human habitat. The sensor devices, the great majority of which are biosensors and chemical sensors, perform the role of the latter. That last line is considered in the proposed review. Attention is paid to transducers, receptors, techniques of immobilization of the receptor layer on the transducer surface, processes of signal generation and detection, and methods for increasing sensitivity and accuracy. The features of sensors based on synthetic receptors and additional components (aptamers, molecular imprinted polymers, biomimetics) are discussed. Examples of bio- and chemical sensors’ application are given. Miniaturization paths, new power supply means, and wearable and printed sensors are described. Progress in this area opens a revolutionary era in the development of methods of on-site and in-situ monitoring, that is, paving the way from the “test-tube to the smartphone”