Efficient range alignment algorithm for real-time range-Doppler algorithm

When deriving a range-Doppler image or a time-frequency image of a fast-maneuvering target at long range, existing range alignment methods yield poor results due to the large numbers of range profiles (RPs) and range bins that are required for this task. This paper proposes a three-step range alignment method to overcome the problems of these existing methods and to yield focused images: (1) coarse alignment using the interpolated center of mass of each RP, (2) fine alignment with an integer step using an entropy cost function, and (3) fine-tuning using particle swarm optimization. Compared to existing methods, the proposed method is computationally more efficient and provides better image focus. © 2017, Electromagnetics Academy. All rights reserved.11Yscopu

Moving Target Analysis in ISAR Image Sequences with a Multiframe Marked Point Process Model

In this paper we propose a Multiframe Marked Point Process model of line segments and point groups for automatic target structure extraction and tracking in Inverse Synthetic Aperture Radar (ISAR) image sequences. For the purpose of dealing with scatterer scintillations and high speckle noise in the ISAR frames, we obtain the resulting target sequence by an iterative optimization process, which simultaneously considers the observed image data and various prior geometric interaction constraints between the target appearances in the consecutive frames. A detailed quantitative evaluation is performed on 8 real ISAR image sequences of different carrier ship and airplane targets, using a test database containing 545 manually annotated frames

Anti-jamming of Inverse Synthetic Aperture Radar based on Slope-varying Linear Frequency Modulation Signal

Deceptive jamming technology against inverse synthetic aperture radar is matured now, which is meaningful in military application. But the research on anti-jamming technology for inverse synthetic aperture radar (ISAR) is still not a mature technology. Through the analysis on the theory of deceptive jamming technology against ISAR, a new method for anti-jamming against ISAR based on linear frequency modulation signals frequency slope-varying is presented. The false target echo energy is suppressed due to frequency modulation slope mis-matching. Doppler domain averaging is adopted for improving the quality of the ISAR image, which helps automatic target recognition. Simulation result based on simulating data shows the validity of the new algorithm.Defence Science Journal, 2009, 59(5), pp.537-544, DOI:http://dx.doi.org/10.14429/dsj.59.155

Two-Dimensional Imaging Algorithm Based on Linear Prognosis for Space Target in Bistatic ISAR System

In bistatic inverse synthetic aperture radar (Bi-ISAR) system, its image resolution is lower than monostatic ISAR system. In order to solve this problem, the linear prognosis algorithm is adopted in the imaging process and the imaging algorithm based on linear prognosis is proposed. Space target Bi-ISAR imaging is taken as example in the research. The one-dimensional range profile is created through pulse compression method. Before the azimuth compression, burg entropy maximum algorithm in Levions recursive method is used to estimate the prognosis coefficients and the azimuth echo data. Then Fourier transformation is used to compress the azimuth data in order to get the high resolution azimuth image. This imaging method can obtain the two-dimensional image with the resolution equal to the monostatic ISAR or even higher than it. Simulation experiments have verified the effectiveness and availability of the algorithm

Cross-species network and transcript transfer

Metabolic processes, signal transduction, gene regulation, as well as gene and protein expression are largely controlled by biological networks. High-throughput experiments allow the measurement of a wide range of cellular states and interactions. However, networks are often not known in detail for specific biological systems and conditions. Gene and protein annotations are often transferred from model organisms to the species of interest. Therefore, the question arises whether biological networks can be transferred between species or whether they are specific for individual contexts. In this thesis, the following aspects are investigated: (i) the conservation and (ii) the cross-species transfer of eukaryotic protein-interaction and gene regulatory (transcription factor- target) networks, as well as (iii) the conservation of alternatively spliced variants. In the simplest case, interactions can be transferred between species, based solely on the sequence similarity of the orthologous genes. However, such a transfer often results either in the transfer of only a few interactions (medium/high sequence similarity threshold) or in the transfer of many speculative interactions (low sequence similarity threshold). Thus, advanced network transfer approaches also consider the annotations of orthologous genes involved in the interaction transfer, as well as features derived from the network structure, in order to enable a reliable interaction transfer, even between phylogenetically very distant species. In this work, such an approach for the transfer of protein interactions is presented (COIN). COIN uses a sophisticated machine-learning model in order to label transferred interactions as either correctly transferred (conserved) or as incorrectly transferred (not conserved). The comparison and the cross-species transfer of regulatory networks is more difficult than the transfer of protein interaction networks, as a huge fraction of the known regulations is only described in the (not machine-readable) scientific literature. In addition, compared to protein interactions, only a few conserved regulations are known, and regulatory elements appear to be strongly context-specific. In this work, the cross-species analysis of regulatory interaction networks is enabled with software tools and databases for global (ConReg) and thousands of context-specific (CroCo) regulatory interactions that are derived and integrated from the scientific literature, binding site predictions and experimental data. Genes and their protein products are the main players in biological networks. However, to date, the aspect is neglected that a gene can encode different proteins. These alternative proteins can differ strongly from each other with respect to their molecular structure, function and their role in networks. The identification of conserved and species-specific splice variants and the integration of variants in network models will allow a more complete cross-species transfer and comparison of biological networks. With ISAR we support the cross-species transfer and comparison of alternative variants by introducing a gene-structure aware (i.e. exon-intron structure aware) multiple sequence alignment approach for variants from orthologous and paralogous genes. The methods presented here and the appropriate databases allow the cross-species transfer of biological networks, the comparison of thousands of context-specific networks, and the cross-species comparison of alternatively spliced variants. Thus, they can be used as a starting point for the understanding of regulatory and signaling mechanisms in many biological systems.In biologischen Systemen werden Stoffwechselprozesse, Signalübertragungen sowie die Regulation von Gen- und Proteinexpression maßgeblich durch biologische Netzwerke gesteuert. Hochdurchsatz-Experimente ermöglichen die Messung einer Vielzahl von zellulären Zuständen und Wechselwirkungen. Allerdings sind für die meisten Systeme und Kontexte biologische Netzwerke nach wie vor unbekannt. Gen- und Proteinannotationen werden häufig von Modellorganismen übernommen. Demnach stellt sich die Frage, ob auch biologische Netzwerke und damit die systemischen Eigenschaften ähnlich sind und übertragen werden können. In dieser Arbeit wird: (i) Die Konservierung und (ii) die artenübergreifende Übertragung von eukaryotischen Protein-Interaktions- und regulatorischen (Transkriptionsfaktor-Zielgen) Netzwerken, sowie (iii) die Konservierung von Spleißvarianten untersucht. Interaktionen können im einfachsten Fall nur auf Basis der Sequenzähnlichkeit zwischen orthologen Genen übertragen werden. Allerdings führt eine solche Übertragung oft dazu, dass nur sehr wenige Interaktionen übertragen werden können (hoher bis mittlerer Sequenzschwellwert) oder dass ein Großteil der übertragenden Interaktionen sehr spekulativ ist (niedriger Sequenzschwellwert). Verbesserte Methoden berücksichtigen deswegen zusätzlich noch die Annotationen der Orthologen, Eigenschaften der Interaktionspartner sowie die Netzwerkstruktur und können somit auch Interaktionen auf phylogenetisch weit entfernte Arten (zuverlässig) übertragen. In dieser Arbeit wird ein solcher Ansatz für die Übertragung von Protein-Interaktionen vorgestellt (COIN). COIN verwendet Verfahren des maschinellen Lernens, um Interaktionen als richtig (konserviert) oder als falsch übertragend (nicht konserviert) zu klassifizieren. Der Vergleich und die artenübergreifende Übertragung von regulatorischen Interaktionen ist im Vergleich zu Protein-Interaktionen schwieriger, da ein Großteil der bekannten Regulationen nur in der (nicht maschinenlesbaren) wissenschaftlichen Literatur beschrieben ist. Zudem sind im Vergleich zu Protein-Interaktionen nur wenige konservierte Regulationen bekannt und regulatorische Elemente scheinen stark kontextabhängig zu sein. In dieser Arbeit wird die artenübergreifende Analyse von regulatorischen Netzwerken mit Softwarewerkzeugen und Datenbanken für globale (ConReg) und kontextspezifische (CroCo) regulatorische Interaktionen ermöglicht. Regulationen wurden dafür aus Vorhersagen, experimentellen Daten und aus der wissenschaftlichen Literatur abgeleitet und integriert. Grundbaustein für viele biologische Netzwerke sind Gene und deren Proteinprodukte. Bisherige Netzwerkmodelle vernachlässigen allerdings meist den Aspekt, dass ein Gen verschiedene Proteine kodieren kann, die sich von der Funktion, der Proteinstruktur und der Rolle in Netzwerken stark voneinander unterscheiden können. Die Identifizierung von konservierten und artspezifischen Proteinprodukten und deren Integration in Netzwerkmodelle würde einen vollständigeren Übertrag und Vergleich von Netzwerken ermöglichen. In dieser Arbeit wird der artenübergreifende Vergleich von Proteinprodukten mit einem multiplen Sequenzalignmentverfahren für alternative Varianten von paralogen und orthologen Genen unterstützt, unter Berücksichtigung der bekannten Exon-Intron-Grenzen (ISAR). Die in dieser Arbeit vorgestellten Verfahren, Datenbanken und Softwarewerkzeuge ermöglichen die Übertragung von biologischen Netzwerken, den Vergleich von tausenden kontextspezifischen Netzwerken und den artenübergreifenden Vergleich von alternativen Varianten. Sie können damit die Ausgangsbasis für ein Verständnis von Kommunikations- und Regulationsmechanismen in vielen biologischen Systemen bilden

ISAR Autofocus Imaging Algorithm for Maneuvering Targets Based on Phase Retrieval and Gabor Wavelet Transform

The imaging issue of a rotating maneuvering target with a large angle and a high translational speed has been a challenging problem in the area of inverse synthetic aperture radar (ISAR) autofocus imaging, in particular when the target has both radial and angular accelerations. In this paper, on the basis of the phase retrieval algorithm and the Gabor wavelet transform (GWT), we propose a new method for phase error correction. The approach first performs the range compression on ISAR raw data to obtain range profiles, and then carries out the GWT transform as the time-frequency analysis tool for the rotational motion compensation (RMC) requirement. The time-varying terms, caused by rotational motion in the Doppler frequency shift, are able to be eliminated at the selected time frame. Furthermore, the processed backscattered signal is transformed to the one in the frequency domain while applying the phase retrieval to run the translational motion compensation (TMC). Phase retrieval plays an important role in range tracking, because the ISAR echo module is not affected by both radial velocity and the acceleration of the target. Finally, after the removal of both the rotational and translational motion errors, the time-invariant Doppler shift is generated, and radar returned signals from the same scatterer are always kept in the same range cell. Therefore, the unwanted motion effects can be removed by applying this approach to have an autofocused ISAR image of the maneuvering target. Furthermore, the method does not need to estimate any motion parameters of the maneuvering target, which has proven to be very effective for an ideal range–Doppler processing. Experimental and simulation results verify the feasibility of this approach