2,493 research outputs found

    UMSL Bulletin 2023-2024

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    The 2023-2024 Bulletin and Course Catalog for the University of Missouri St. Louis.https://irl.umsl.edu/bulletin/1088/thumbnail.jp

    UMSL Bulletin 2022-2023

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    The 2022-2023 Bulletin and Course Catalog for the University of Missouri St. Louis.https://irl.umsl.edu/bulletin/1087/thumbnail.jp

    Tradition and Innovation in Construction Project Management

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    This book is a reprint of the Special Issue 'Tradition and Innovation in Construction Project Management' that was published in the journal Buildings

    Modern meat: the next generation of meat from cells

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    Modern Meat is the first textbook on cultivated meat, with contributions from over 100 experts within the cultivated meat community. The Sections of Modern Meat comprise 5 broad categories of cultivated meat: Context, Impact, Science, Society, and World. The 19 chapters of Modern Meat, spread across these 5 sections, provide detailed entries on cultivated meat. They extensively tour a range of topics including the impact of cultivated meat on humans and animals, the bioprocess of cultivated meat production, how cultivated meat may become a food option in Space and on Mars, and how cultivated meat may impact the economy, culture, and tradition of Asia

    Identifying therapeutic targets against viral hepatitis and liver cancer

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    Characterising novel genetic causes of growth failure

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    To identify novel genetic causes of growth failure, I developed a unique, targeted whole gene panel for rapid and accurate genetic testing of patients with short stature and features of Growth Hormone Insensitivity (GHI) or unexplained short stature. This included 64 genes of interest, including those in the GH-IGF1 pathway and genes linked to conditions with overlapping features. In parallel, I also assessed these patients for copy number variants. Using custom bioinformatic pipelines to filter these data sets and a variety of in silico prediction programs, I identified interesting novel genetic defects in both known and candidate growth genes. I then performed functional analysis of these defects to determine if they affected gene structure/function and could explain the patient phenotype. I identified several novel splicing mutations in the Growth Hormone Receptor (GHR) causing a spectrum of GHI. These include a novel mutation deep within intron 6 GHR that leads to mis-splicing and pseudoexon inclusion. Pseudoexon inclusion leads to frameshift of the GHR and thus causes a non-functional Growth Hormone Receptor and severe GHI. I discovered two novel heterozygous GHR mutations in patients with milder GHI phenotypes. These mutations both led to mis-splicing of exon 9 of the GHR and act in a dominant negative effect on the GHR, reducing the efficacy of signalling and explaining their milder phenotypes. I identified a rare novel heterozygous IGF1 variant that I hypothesised would impair IGF-1 cleavage causing functional IGF-1 deficiency. Our patient cohort was enriched for low frequency CNVs, particularly in patients with subtle features of Silver Russell Syndrome. This is the first study to assess CNVs in patients with GHI. From my CNV analysis, I identified CHD1L and HMGA2 as key candidate growth genes and functionally assessed several patient variants identified within our cohort

    Procedural Constraint-based Generation for Game Development

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    Behavior quantification as the missing link between fields: Tools for digital psychiatry and their role in the future of neurobiology

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    The great behavioral heterogeneity observed between individuals with the same psychiatric disorder and even within one individual over time complicates both clinical practice and biomedical research. However, modern technologies are an exciting opportunity to improve behavioral characterization. Existing psychiatry methods that are qualitative or unscalable, such as patient surveys or clinical interviews, can now be collected at a greater capacity and analyzed to produce new quantitative measures. Furthermore, recent capabilities for continuous collection of passive sensor streams, such as phone GPS or smartwatch accelerometer, open avenues of novel questioning that were previously entirely unrealistic. Their temporally dense nature enables a cohesive study of real-time neural and behavioral signals. To develop comprehensive neurobiological models of psychiatric disease, it will be critical to first develop strong methods for behavioral quantification. There is huge potential in what can theoretically be captured by current technologies, but this in itself presents a large computational challenge -- one that will necessitate new data processing tools, new machine learning techniques, and ultimately a shift in how interdisciplinary work is conducted. In my thesis, I detail research projects that take different perspectives on digital psychiatry, subsequently tying ideas together with a concluding discussion on the future of the field. I also provide software infrastructure where relevant, with extensive documentation. Major contributions include scientific arguments and proof of concept results for daily free-form audio journals as an underappreciated psychiatry research datatype, as well as novel stability theorems and pilot empirical success for a proposed multi-area recurrent neural network architecture.Comment: PhD thesis cop

    Ciguatoxins

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    Ciguatoxins (CTXs), which are responsible for Ciguatera fish poisoning (CFP), are liposoluble toxins produced by microalgae of the genera Gambierdiscus and Fukuyoa. This book presents 18 scientific papers that offer new information and scientific evidence on: (i) CTX occurrence in aquatic environments, with an emphasis on edible aquatic organisms; (ii) analysis methods for the determination of CTXs; (iii) advances in research on CTX-producing organisms; (iv) environmental factors involved in the presence of CTXs; and (v) the assessment of public health risks related to the presence of CTXs, as well as risk management and mitigation strategies
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