Statistical region based active contour using a fractional entropy descriptor: Application to nuclei cell segmentation in confocal microscopy images

We propose an unsupervised statistical region based active contour approach integrating an original fractional entropy measure for image segmentation with a particular application to single channel actin tagged fluorescence confocal microscopy image segmentation. Following description of statistical based active contour segmentation and the mathematical definition of the proposed fractional entropy descriptor, we demonstrate comparative segmentation results between the proposed approach and standard Shannon’s entropy on synthetic and natural images. We also show that the proposed unsupervised statistical based approach, integrating the fractional entropy measure, leads to very satisfactory segmentation of the cell nuclei from which shape characterization can be calculated

Fractional Entropy Based Active Contour Segmentation of Cell Nuclei in Actin-Tagged Confocal Microscopy Images

In the framework of cell structure characterization for predictive oncology, we propose in this paper an unsupervised statistical region based active contour approach integrating an original fractional entropy measure for single channel actin tagged fluorescence confocal microscopy image segmentation. Following description of statistical based active contour segmentation and the mathematical definition of the proposed fractional entropy descriptor, we demonstrate comparative segmentation results between the proposed approach and standard Shannon’s entropy obtained for nuclei segmentation. We show that the unsupervised proposed statistical based approach integrating the fractional entropy measure leads to very satisfactory segmentation of the cell nuclei from which shape characterization can be subsequently used for the therapy progress assessment

Vlasov-Poisson in 1D for initially cold systems: post-collapse Lagrangian perturbation theory

We study analytically the collapse of an initially smooth, cold, self-gravitating collisionless system in one dimension. The system is described as a central "S" shape in phase-space surrounded by a nearly stationary halo acting locally like a harmonic background on the S. To resolve the dynamics of the S under its self-gravity and under the influence of the halo, we introduce a novel approach using post-collapse Lagrangian perturbation theory. This approach allows us to follow the evolution of the system between successive crossing times and to describe in an iterative way the interplay between the central S and the halo. Our theoretical predictions are checked against measurements in entropy conserving numerical simulations based on the waterbag method. While our post-collapse Lagrangian approach does not allow us to compute rigorously the long term behavior of the system, i.e. after many crossing times, it explains the close to power-law behavior of the projected density observed in numerical simulations. Pushing the model at late time suggests that the system could build at some point a very small flat core, but this is very speculative. This analysis shows that understanding the dynamics of initially cold systems requires a fine grained approach for a correct description of their very central part. The analyses performed here can certainly be extended to spherical symmetry.Comment: 20 pages, 9 figures, accepted for publication in MNRA

Quantum Chaos and Thermalization in Isolated Systems of Interacting Particles

This review is devoted to the problem of thermalization in a small isolated conglomerate of interacting constituents. A variety of physically important systems of intensive current interest belong to this category: complex atoms, molecules (including biological molecules), nuclei, small devices of condensed matter and quantum optics on nano- and micro-scale, cold atoms in optical lattices, ion traps. Physical implementations of quantum computers, where there are many interacting qubits, also fall into this group. Statistical regularities come into play through inter-particle interactions, which have two fundamental components: mean field, that along with external conditions, forms the regular component of the dynamics, and residual interactions responsible for the complex structure of the actual stationary states. At sufficiently high level density, the stationary states become exceedingly complicated superpositions of simple quasiparticle excitations. At this stage, regularities typical of quantum chaos emerge and bring in signatures of thermalization. We describe all the stages and the results of the processes leading to thermalization, using analytical and massive numerical examples for realistic atomic, nuclear, and spin systems, as well as for models with random parameters. The structure of stationary states, strength functions of simple configurations, and concepts of entropy and temperature in application to isolated mesoscopic systems are discussed in detail. We conclude with a schematic discussion of the time evolution of such systems to equilibrium.Comment: 69 pages, 31 figure

Statistical Theory of Finite Fermi-Systems Based on the Structure of Chaotic Eigenstates

The approach is developed for the description of isolated Fermi-systems with finite number of particles, such as complex atoms, nuclei, atomic clusters etc. It is based on statistical properties of chaotic excited states which are formed by the interaction between particles. New type of ``microcanonical'' partition function is introduced and expressed in terms of the average shape of eigenstates $F(E_k,E)$ where $E$ is the total energy of the system. This partition function plays the same role as the canonical expression $exp(-E^{(i)}/T)$ for open systems in thermal bath. The approach allows to calculate mean values and non-diagonal matrix elements of different operators. In particular, the following problems have been considered: distribution of occupation numbers and its relevance to the canonical and Fermi-Dirac distributions; criteria of equilibrium and thermalization; thermodynamical equation of state and the meaning of temperature, entropy and heat capacity, increase of effective temperature due to the interaction. The problems of spreading widths and shape of the eigenstates are also studied.Comment: 17 pages in RevTex and 5 Postscript figures. Changes are RevTex format (instead of plain LaTeX), minor misprint corrections plus additional references. To appear in Phys. Rev.