Synthesis and Optimization of Reversible Circuits - A Survey

Reversible logic circuits have been historically motivated by theoretical research in low-power electronics as well as practical improvement of bit-manipulation transforms in cryptography and computer graphics. Recently, reversible circuits have attracted interest as components of quantum algorithms, as well as in photonic and nano-computing technologies where some switching devices offer no signal gain. Research in generating reversible logic distinguishes between circuit synthesis, post-synthesis optimization, and technology mapping. In this survey, we review algorithmic paradigms --- search-based, cycle-based, transformation-based, and BDD-based --- as well as specific algorithms for reversible synthesis, both exact and heuristic. We conclude the survey by outlining key open challenges in synthesis of reversible and quantum logic, as well as most common misconceptions.Comment: 34 pages, 15 figures, 2 table

A study of smart device-based mobile imaging and implementation for engineering applications

Title from PDF of title page, viewed on June 12, 2013Thesis advisor: ZhiQiang ChenVitaIncludes bibliographic references (pages 76-82)Thesis (M.S.)--School of Computing and Engineering. University of Missouri--Kansas City, 2013Mobile imaging has become a very active research topic in recent years thanks to the rapid development of computing and sensing capabilities of mobile devices. This area features multi-disciplinary studies of mobile hardware, imaging sensors, imaging and vision algorithms, wireless network and human-machine interface problems. Due to the limitation of computing capacity that early mobile devices have, researchers proposed client-server module, which push the data to more powerful computing platforms through wireless network, and let the cloud or standalone servers carry out all the computing and processing work. This thesis reviewed the development of mobile hardware and software platform, and the related research done on mobile imaging for the past 20 years. There are several researches on mobile imaging, but few people aim at building a framework which helps engineers solving problems by using mobile imaging. With higher-resolution imaging and high-performance computing power built into smart mobile devices, more and more imaging processing tasks can be achieved on the device rather than the client-server module. Based on this fact, a framework of collaborative mobile imaging is introduced for civil infrastructure condition assessment to help engineers solving technical challenges. Another contribution in this thesis is applying mobile imaging application into home automation. E-SAVE is a research project focusing on extensive use of automation in conserving and using energy wisely in home automation. Mobile users can view critical information such as energy data of the appliances with the help of mobile imaging. OpenCV is an image processing and computer vision library. The applications in this thesis use functions in OpenCV including camera calibration, template matching, image stitching and Canny edge detection. The application aims to help field engineers is interactive crack detection. The other one uses template matching to recognize appliances in the home automation system.Introduction -- Background and related work -- Basic imaging processing methods for mobile applications -- Collaborative and interactive mobile imaging -- Mobile imaging for smart energy -- Conclusion and recommendation

Design of a High-Speed Architecture for Stabilization of Video Captured Under Non-Uniform Lighting Conditions

Video captured in shaky conditions may lead to vibrations. A robust algorithm to immobilize the video by compensating for the vibrations from physical settings of the camera is presented in this dissertation. A very high performance hardware architecture on Field Programmable Gate Array (FPGA) technology is also developed for the implementation of the stabilization system. Stabilization of video sequences captured under non-uniform lighting conditions begins with a nonlinear enhancement process. This improves the visibility of the scene captured from physical sensing devices which have limited dynamic range. This physical limitation causes the saturated region of the image to shadow out the rest of the scene. It is therefore desirable to bring back a more uniform scene which eliminates the shadows to a certain extent. Stabilization of video requires the estimation of global motion parameters. By obtaining reliable background motion, the video can be spatially transformed to the reference sequence thereby eliminating the unintended motion of the camera. A reflectance-illuminance model for video enhancement is used in this research work to improve the visibility and quality of the scene. With fast color space conversion, the computational complexity is reduced to a minimum. The basic video stabilization model is formulated and configured for hardware implementation. Such a model involves evaluation of reliable features for tracking, motion estimation, and affine transformation to map the display coordinates of a stabilized sequence. The multiplications, divisions and exponentiations are replaced by simple arithmetic and logic operations using improved log-domain computations in the hardware modules. On Xilinx\u27s Virtex II 2V8000-5 FPGA platform, the prototype system consumes 59% logic slices, 30% flip-flops, 34% lookup tables, 35% embedded RAMs and two ZBT frame buffers. The system is capable of rendering 180.9 million pixels per second (mpps) and consumes approximately 30.6 watts of power at 1.5 volts. With a 1024×1024 frame, the throughput is equivalent to 172 frames per second (fps). Future work will optimize the performance-resource trade-off to meet the specific needs of the applications. It further extends the model for extraction and tracking of moving objects as our model inherently encapsulates the attributes of spatial distortion and motion prediction to reduce complexity. With these parameters to narrow down the processing range, it is possible to achieve a minimum of 20 fps on desktop computers with Intel Core 2 Duo or Quad Core CPUs and 2GB DDR2 memory without a dedicated hardware

Split and Shift Methodology: Overcoming Hardware Limitations on Cellular Processor Arrays for Image Processing

Na era multimedia, o procesado de imaxe converteuse nun elemento de singular importancia nos dispositivos electrónicos. Dende as comunicacións (p.e. telemedicina), a seguranza (p.e. recoñecemento retiniano) ou control de calidade e de procesos industriais (p.e. orientación de brazos articulados, detección de defectos do produto), pasando pola investigación (p.e. seguimento de partículas elementais) e diagnose médica (p.e. detección de células estrañas, identificaciónn de veas retinianas), hai un sinfín de aplicacións onde o tratamento e interpretación automáticas de imaxe e fundamental. O obxectivo último será o deseño de sistemas de visión con capacidade de decisión. As tendencias actuais requiren, ademais, a combinación destas capacidades en dispositivos pequenos e portátiles con resposta en tempo real. Isto propón novos desafíos tanto no deseño hardware como software para o procesado de imaxe, buscando novas estruturas ou arquitecturas coa menor area e consumo de enerxía posibles sen comprometer a funcionalidade e o rendemento

High-performance hardware accelerators for image processing in space applications

Mars is a hard place to reach. While there have been many notable success stories in getting probes to the Red Planet, the historical record is full of bad news. The success rate for actually landing on the Martian surface is even worse, roughly 30%. This low success rate must be mainly credited to the Mars environment characteristics. In the Mars atmosphere strong winds frequently breath. This phenomena usually modifies the lander descending trajectory diverging it from the target one. Moreover, the Mars surface is not the best place where performing a safe land. It is pitched by many and close craters and huge stones, and characterized by huge mountains and hills (e.g., Olympus Mons is 648 km in diameter and 27 km tall). For these reasons a mission failure due to a landing in huge craters, on big stones or on part of the surface characterized by a high slope is highly probable. In the last years, all space agencies have increased their research efforts in order to enhance the success rate of Mars missions. In particular, the two hottest research topics are: the active debris removal and the guided landing on Mars. The former aims at finding new methods to remove space debris exploiting unmanned spacecrafts. These must be able to autonomously: detect a debris, analyses it, in order to extract its characteristics in terms of weight, speed and dimension, and, eventually, rendezvous with it. In order to perform these tasks, the spacecraft must have high vision capabilities. In other words, it must be able to take pictures and process them with very complex image processing algorithms in order to detect, track and analyse the debris. The latter aims at increasing the landing point precision (i.e., landing ellipse) on Mars. Future space-missions will increasingly adopt Video Based Navigation systems to assist the entry, descent and landing (EDL) phase of space modules (e.g., spacecrafts), enhancing the precision of automatic EDL navigation systems. For instance, recent space exploration missions, e.g., Spirity, Oppurtunity, and Curiosity, made use of an EDL procedure aiming at following a fixed and precomputed descending trajectory to reach a precise landing point. This approach guarantees a maximum landing point precision of 20 km. By comparing this data with the Mars environment characteristics, it is possible to understand how the mission failure probability still remains really high. A very challenging problem is to design an autonomous-guided EDL system able to even more reduce the landing ellipse, guaranteeing to avoid the landing in dangerous area of Mars surface (e.g., huge craters or big stones) that could lead to the mission failure. The autonomous behaviour of the system is mandatory since a manual driven approach is not feasible due to the distance between Earth and Mars. Since this distance varies from 56 to 100 million of km approximately due to the orbit eccentricity, even if a signal transmission at the light speed could be possible, in the best case the transmission time would be around 31 minutes, exceeding so the overall duration of the EDL phase. In both applications, algorithms must guarantee self-adaptability to the environmental conditions. Since the Mars (and in general the space) harsh conditions are difficult to be predicted at design time, these algorithms must be able to automatically tune the internal parameters depending on the current conditions. Moreover, real-time performances are another key factor. Since a software implementation of these computational intensive tasks cannot reach the required performances, these algorithms must be accelerated via hardware. For this reasons, this thesis presents my research work done on advanced image processing algorithms for space applications and the associated hardware accelerators. My research activity has been focused on both the algorithm and their hardware implementations. Concerning the first aspect, I mainly focused my research effort to integrate self-adaptability features in the existing algorithms. While concerning the second, I studied and validated a methodology to efficiently develop, verify and validate hardware components aimed at accelerating video-based applications. This approach allowed me to develop and test high performance hardware accelerators that strongly overcome the performances of the actual state-of-the-art implementations. The thesis is organized in four main chapters. Chapter 2 starts with a brief introduction about the story of digital image processing. The main content of this chapter is the description of space missions in which digital image processing has a key role. A major effort has been spent on the missions in which my research activity has a substantial impact. In particular, for these missions, this chapter deeply analizes and evaluates the state-of-the-art approaches and algorithms. Chapter 3 analyzes and compares the two technologies used to implement high performances hardware accelerators, i.e., Application Specific Integrated Circuits (ASICs) and Field Programmable Gate Arrays (FPGAs). Thanks to this information the reader may understand the main reasons behind the decision of space agencies to exploit FPGAs instead of ASICs for high-performance hardware accelerators in space missions, even if FPGAs are more sensible to Single Event Upsets (i.e., transient error induced on hardware component by alpha particles and solar radiation in space). Moreover, this chapter deeply describes the three available space-grade FPGA technologies (i.e., One-time Programmable, Flash-based, and SRAM-based), and the main fault-mitigation techniques against SEUs that are mandatory for employing space-grade FPGAs in actual missions. Chapter 4 describes one of the main contribution of my research work: a library of high-performance hardware accelerators for image processing in space applications. The basic idea behind this library is to offer to designers a set of validated hardware components able to strongly speed up the basic image processing operations commonly used in an image processing chain. In other words, these components can be directly used as elementary building blocks to easily create a complex image processing system, without wasting time in the debug and validation phase. This library groups the proposed hardware accelerators in IP-core families. The components contained in a same family share the same provided functionality and input/output interface. This harmonization in the I/O interface enables to substitute, inside a complex image processing system, components of the same family without requiring modifications to the system communication infrastructure. In addition to the analysis of the internal architecture of the proposed components, another important aspect of this chapter is the methodology used to develop, verify and validate the proposed high performance image processing hardware accelerators. This methodology involves the usage of different programming and hardware description languages in order to support the designer from the algorithm modelling up to the hardware implementation and validation. Chapter 5 presents the proposed complex image processing systems. In particular, it exploits a set of actual case studies, associated with the most recent space agency needs, to show how the hardware accelerator components can be assembled to build a complex image processing system. In addition to the hardware accelerators contained in the library, the described complex system embeds innovative ad-hoc hardware components and software routines able to provide high performance and self-adaptable image processing functionalities. To prove the benefits of the proposed methodology, each case study is concluded with a comparison with the current state-of-the-art implementations, highlighting the benefits in terms of performances and self-adaptability to the environmental conditions

Solid State Circuits Technologies

The evolution of solid-state circuit technology has a long history within a relatively short period of time. This technology has lead to the modern information society that connects us and tools, a large market, and many types of products and applications. The solid-state circuit technology continuously evolves via breakthroughs and improvements every year. This book is devoted to review and present novel approaches for some of the main issues involved in this exciting and vigorous technology. The book is composed of 22 chapters, written by authors coming from 30 different institutions located in 12 different countries throughout the Americas, Asia and Europe. Thus, reflecting the wide international contribution to the book. The broad range of subjects presented in the book offers a general overview of the main issues in modern solid-state circuit technology. Furthermore, the book offers an in depth analysis on specific subjects for specialists. We believe the book is of great scientific and educational value for many readers. I am profoundly indebted to the support provided by all of those involved in the work. First and foremost I would like to acknowledge and thank the authors who worked hard and generously agreed to share their results and knowledge. Second I would like to express my gratitude to the Intech team that invited me to edit the book and give me their full support and a fruitful experience while working together to combine this book

A computationally efficient stereo vision algorithm for adaptive cruise control

Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 1997.Includes bibliographical references (p. 55-56).by Jason Robert Bergendahl.M.S

Acquisition systems and decoding algorithms of peripheral neural signals for prosthetic applications

During the years, neuroprosthetic applications have obtained a great deal of attention by the international research, especially in the bioengineering field, thanks to the huge investments on several proposed projects funded by the political institutions which consider the treatment of this particular disease of fundamental importance for the global community. The aim of these projects is to find a possible solution to restore the functionalities lost by a patient subjected to an upper limb amputation trying to develop, according to physiological considerations, a communication link between the brain in which the significant signals are generated and a motor prosthesis device able to perform the desired action. Moreover, the designed system must be able to give back to the brain a sensory feedback about the surrounding world in terms of pressure or temperature acquired by tactile biosensors placed at the surface of the cybernetic hand. It in fact allows to execute involuntarymovements when for example the armcomes in contact with hot objects. The development of such a closed-loop architecture involves the need to address some critical issues which depend on the chosen approach. Several solutions have been proposed by the researches of the field, each one differing with respect to where the neural signals are acquired, either at the central nervous systemor at the peripheral one,most of themfollowing the former even that the latter is always considered by the amputees amore natural way to handle the artificial limb. This research work is based on the use of intrafascicular electrodes directly implanted in the residual peripheral nerves of the stump which represents a good compromise choice in terms of invasiveness and selectivity extracting electroneurographic (ENG) signals from which it is possible to identify the significant activity of a quite limited number of neuronal cells. In the perspective of the hardware implementation of the resulting solution which can work autonomously without any intervention by the amputee in an adaptive way according to the current characteristics of the processed signal and by using batteries as power source allowing portability, it is necessary to fulfill the tight constraints imposed by the application under consideration involved in each of the various phases which compose the considered closed-loop system. Regarding to the recording phase, the implementation must be able to remove the unwanted interferences mainly due to the electro-stimulations of themuscles placed near the electrodes featured by an order of magnitude much greater in comparison to that of the signals of interest amplifying the frequency components belonging to the significant bandwidth, and to convert them with a high resolution in order to obtain good performance at the next processing phases. To this aim, a recording module for peripheral neural signals will be presented, based on the use of a sigma-delta architecture which is composed by two main parts: an analog front-end stage for neural signal acquisition, pre-filtering and sigma-delta modulation and a digital unit for sigma-delta decimation and system configuration. Hardware/software cosimulations exploiting the Xilinx System Generator tool in Matlab Simulink environment and then transistor-level simulations confirmed that the system is capable of recording neural signals in the order of magnitude of tens of μV rejecting the huge low-frequency noise due to electromyographic interferences. The same architecture has been then exploited to implement a prototype of an 8-channel implantable electronic bi-directional interface between the peripheral nervous system and the neuro-controlled hand prosthesis. The solution includes a custom designed Integrated Circuit (0.35μm CMOS technology), responsible of the signal pre-filtering and sigma-delta modulation for each channel and the neural stimuli generation (in the opposite path) based on the directives sent by a digital control systemmapped on a low-cost Xilinx FPGA Spartan-3E 1600 development board which also involves the multi-channel sigma-delta decimation with a high-order band-pass filter as first stage in order to totally remove the unwanted interferences. In this way, the analog chip can be implanted near the electrodes thanks to its limited size avoiding to add a huge noise to theweak neural signals due to longwires connections and to cause heat-related infections, shifting the complexity to the digital part which can be hosted on a separated device in the stump of the amputeewithout using complex laboratory instrumentations. The system has been successfully tested from the electrical point of view and with in-vivo experiments exposing good results in terms of output resolution and noise rejection even in case of critical conditions. The various output channels at the Nyquist sampling frequency coming from the acquisition system must be processed in order to decode the intentions of movements of the amputee, applying the correspondent electro-mechanical stimulation in input to the cybernetic hand in order to perform the desired motor action. Different decoding approaches have been presented in the past, the majority of them were conceived starting from the relative implementation and performance evaluation of their off-line version. At the end of the research, it is necessary to develop these solutions on embedded systems performing an online processing of the peripheral neural signals. However, it is often possible only by using complex hardware platforms clocked at very high operating frequencies which are not be compliant with the low-power requirements needed to allow portability for the prosthetic device. At present, in fact, the important aspect of the real-time implementation of sophisticated signal processing algorithms on embedded systems has been often overlooked, notwithstanding the impact that limited resources of the former may have on the efficiency/effectiveness of any given algorithm. In this research work it has been addressed the optimization of a state-of-the-art algorithmfor PNS signals decoding that is a step forward for its real-time, full implementation onto a floating-point Digital Signal Processor (DSP). Beyond low-level optimizations, different solutions have been proposed at an high level in order to find the best trade-off in terms of effectiveness/efficiency. A latency model, obtained through cycle accurate profiling of the different code sections, has been drawn in order to perform a fair performance assessment. The proposed optimized real-time algorithmachieves up to 96% of correct classification on real PNS signals acquired through tf-LIFE electrodes on animals, and performs as the best off-line algorithmfor spike clustering on a synthetic cortical dataset characterized by a reasonable dissimilarity between the spikemorphologies of different neurons. When the real-time requirements are joined to the fulfilment of area and power minimization for implantable/portable applications, such as for the target neuroprosthetic devices, only custom VLSI implementations can be adopted. In this case, every part of the algorithmshould be carefully tuned. To this aim, the first preprocessing stage of the decoding algorithmbased on the use of aWavelet Denoising solution able to remove also the in-band noise sources has been deeply analysed in order to obtain an optimal hardware implementation. In particular, the usually overlooked part related to threshold estimation has been evaluated in terms of required hardware resources and functionality, exploiting the commercial Xilinx System Generator tool for the design of the architecture and the co-simulation. The analysis has revealed how the widely used Median Absolute Deviation (MAD) could lead o hardware implementations highly inefficient compared to other dispersion estimators demonstrating better scalability, relatively to the specific application. Finally, two different hardware implementations of the reference decoding algorithm have been presented highlighting pros and cons of each one of them. Firstly, a novel approach based on high-level dataflow description and automatic hardware generation is presented and evaluated on the on-line template-matching spike sorting algorithmwhich represents the most complex processing stage. It starts from the identification of the single kernels with the greater computational complexity and using their dataflow description to generate the HDL implementation of a coarse-grained reconfigurable global kernel characterized by theminimumresources in order to reduce the area and the energy dissipation for the fulfilment of the low-power requirements imposed by the application. Results in the best case have revealed a 71%of area saving compared tomore traditional solutions,without any accuracy penalty. With respect to single kernels execution, better latency performance are achievable stillminimizing the number of adopted resources. The performance in terms of latency can also be improved by tuning the implemented parallelismin the light of a defined number of channels and real-time constraints, by using more than one reconfigurable global kernel in order that they can be exploited to perform the same or different kernels at the same time in a parallel way, due to the fact that each one can execute the relative processing only in a sequential way. For this reason, a second FPGA-based prototype has been proposed based on the use of aMulti-Processor System-on-Chip (MPSoC) embedded architecture. This prototype is capable of respecting the real-time constraints posed by the application when clocked at less than 50 MHz, in comparison to 300 MHz of the previous DSP implementation. Considering that the application workload is extremely data dependent and unpredictable due to the sparsity of the neural signals, the architecture has to be dimensioned taking into account critical worst-case operating conditions in order to always ensure the correct functionality. To compensate the resulting overprovisioning of the system architecture, a software-controllable power management based on the use of clock gating techniques has been integrated in order tominimize the dynamic power consumption of the resulting solution. Summarizing, this research work can be considered a sort of proof-of-concept for the proposed techniques considering all the design issues which characterize each stage of the closed-loop system in the perspective of a portable low-power real-time hardware implementation of the neuro-controlled prosthetic device

Acquisition systems and decoding algorithms of peripheral neural signals for prosthetic applications

During the years, neuroprosthetic applications have obtained a great deal of attention by the international research, especially in the bioengineering field, thanks to the huge investments on several proposed projects funded by the political institutions which consider the treatment of this particular disease of fundamental importance for the global community. The aim of these projects is to find a possible solution to restore the functionalities lost by a patient subjected to an upper limb amputation trying to develop, according to physiological considerations, a communication link between the brain in which the significant signals are generated and a motor prosthesis device able to perform the desired action. Moreover, the designed system must be able to give back to the brain a sensory feedback about the surrounding world in terms of pressure or temperature acquired by tactile biosensors placed at the surface of the cybernetic hand. It in fact allows to execute involuntarymovements when for example the armcomes in contact with hot objects. The development of such a closed-loop architecture involves the need to address some critical issues which depend on the chosen approach. Several solutions have been proposed by the researches of the field, each one differing with respect to where the neural signals are acquired, either at the central nervous systemor at the peripheral one,most of themfollowing the former even that the latter is always considered by the amputees amore natural way to handle the artificial limb. This research work is based on the use of intrafascicular electrodes directly implanted in the residual peripheral nerves of the stump which represents a good compromise choice in terms of invasiveness and selectivity extracting electroneurographic (ENG) signals from which it is possible to identify the significant activity of a quite limited number of neuronal cells. In the perspective of the hardware implementation of the resulting solution which can work autonomously without any intervention by the amputee in an adaptive way according to the current characteristics of the processed signal and by using batteries as power source allowing portability, it is necessary to fulfill the tight constraints imposed by the application under consideration involved in each of the various phases which compose the considered closed-loop system. Regarding to the recording phase, the implementation must be able to remove the unwanted interferences mainly due to the electro-stimulations of themuscles placed near the electrodes featured by an order of magnitude much greater in comparison to that of the signals of interest amplifying the frequency components belonging to the significant bandwidth, and to convert them with a high resolution in order to obtain good performance at the next processing phases. To this aim, a recording module for peripheral neural signals will be presented, based on the use of a sigma-delta architecture which is composed by two main parts: an analog front-end stage for neural signal acquisition, pre-filtering and sigma-delta modulation and a digital unit for sigma-delta decimation and system configuration. Hardware/software cosimulations exploiting the Xilinx System Generator tool in Matlab Simulink environment and then transistor-level simulations confirmed that the system is capable of recording neural signals in the order of magnitude of tens of μV rejecting the huge low-frequency noise due to electromyographic interferences. The same architecture has been then exploited to implement a prototype of an 8-channel implantable electronic bi-directional interface between the peripheral nervous system and the neuro-controlled hand prosthesis. The solution includes a custom designed Integrated Circuit (0.35μm CMOS technology), responsible of the signal pre-filtering and sigma-delta modulation for each channel and the neural stimuli generation (in the opposite path) based on the directives sent by a digital control systemmapped on a low-cost Xilinx FPGA Spartan-3E 1600 development board which also involves the multi-channel sigma-delta decimation with a high-order band-pass filter as first stage in order to totally remove the unwanted interferences. In this way, the analog chip can be implanted near the electrodes thanks to its limited size avoiding to add a huge noise to theweak neural signals due to longwires connections and to cause heat-related infections, shifting the complexity to the digital part which can be hosted on a separated device in the stump of the amputeewithout using complex laboratory instrumentations. The system has been successfully tested from the electrical point of view and with in-vivo experiments exposing good results in terms of output resolution and noise rejection even in case of critical conditions. The various output channels at the Nyquist sampling frequency coming from the acquisition system must be processed in order to decode the intentions of movements of the amputee, applying the correspondent electro-mechanical stimulation in input to the cybernetic hand in order to perform the desired motor action. Different decoding approaches have been presented in the past, the majority of them were conceived starting from the relative implementation and performance evaluation of their off-line version. At the end of the research, it is necessary to develop these solutions on embedded systems performing an online processing of the peripheral neural signals. However, it is often possible only by using complex hardware platforms clocked at very high operating frequencies which are not be compliant with the low-power requirements needed to allow portability for the prosthetic device. At present, in fact, the important aspect of the real-time implementation of sophisticated signal processing algorithms on embedded systems has been often overlooked, notwithstanding the impact that limited resources of the former may have on the efficiency/effectiveness of any given algorithm. In this research work it has been addressed the optimization of a state-of-the-art algorithmfor PNS signals decoding that is a step forward for its real-time, full implementation onto a floating-point Digital Signal Processor (DSP). Beyond low-level optimizations, different solutions have been proposed at an high level in order to find the best trade-off in terms of effectiveness/efficiency. A latency model, obtained through cycle accurate profiling of the different code sections, has been drawn in order to perform a fair performance assessment. The proposed optimized real-time algorithmachieves up to 96% of correct classification on real PNS signals acquired through tf-LIFE electrodes on animals, and performs as the best off-line algorithmfor spike clustering on a synthetic cortical dataset characterized by a reasonable dissimilarity between the spikemorphologies of different neurons. When the real-time requirements are joined to the fulfilment of area and power minimization for implantable/portable applications, such as for the target neuroprosthetic devices, only custom VLSI implementations can be adopted. In this case, every part of the algorithmshould be carefully tuned. To this aim, the first preprocessing stage of the decoding algorithmbased on the use of aWavelet Denoising solution able to remove also the in-band noise sources has been deeply analysed in order to obtain an optimal hardware implementation. In particular, the usually overlooked part related to threshold estimation has been evaluated in terms of required hardware resources and functionality, exploiting the commercial Xilinx System Generator tool for the design of the architecture and the co-simulation. The analysis has revealed how the widely used Median Absolute Deviation (MAD) could lead o hardware implementations highly inefficient compared to other dispersion estimators demonstrating better scalability, relatively to the specific application. Finally, two different hardware implementations of the reference decoding algorithm have been presented highlighting pros and cons of each one of them. Firstly, a novel approach based on high-level dataflow description and automatic hardware generation is presented and evaluated on the on-line template-matching spike sorting algorithmwhich represents the most complex processing stage. It starts from the identification of the single kernels with the greater computational complexity and using their dataflow description to generate the HDL implementation of a coarse-grained reconfigurable global kernel characterized by theminimumresources in order to reduce the area and the energy dissipation for the fulfilment of the low-power requirements imposed by the application. Results in the best case have revealed a 71%of area saving compared tomore traditional solutions,without any accuracy penalty. With respect to single kernels execution, better latency performance are achievable stillminimizing the number of adopted resources. The performance in terms of latency can also be improved by tuning the implemented parallelismin the light of a defined number of channels and real-time constraints, by using more than one reconfigurable global kernel in order that they can be exploited to perform the same or different kernels at the same time in a parallel way, due to the fact that each one can execute the relative processing only in a sequential way. For this reason, a second FPGA-based prototype has been proposed based on the use of aMulti-Processor System-on-Chip (MPSoC) embedded architecture. This prototype is capable of respecting the real-time constraints posed by the application when clocked at less than 50 MHz, in comparison to 300 MHz of the previous DSP implementation. Considering that the application workload is extremely data dependent and unpredictable due to the sparsity of the neural signals, the architecture has to be dimensioned taking into account critical worst-case operating conditions in order to always ensure the correct functionality. To compensate the resulting overprovisioning of the system architecture, a software-controllable power management based on the use of clock gating techniques has been integrated in order tominimize the dynamic power consumption of the resulting solution. Summarizing, this research work can be considered a sort of proof-of-concept for the proposed techniques considering all the design issues which characterize each stage of the closed-loop system in the perspective of a portable low-power real-time hardware implementation of the neuro-controlled prosthetic device