Optimization of a hardware/software coprocessing platform for EEG eyeblink detection and removal

The feasibility of implementing a real-time system for removing eyeblink artifacts from electroencephalogram (EEG) recordings utilizing a hardware/software coprocessing platform was investigated. A software based wavelet and independent component analysis (ICA) eyeblink detection and removal process was extended to enable variation in its processing parameters. Exploiting the efficiency of hardware and the reconfigurability of software, it was ported to a field programmable gate array (FPGA) development platform which was found to be capable of implementing the revised algorithm, although not in real-time. The implemented hardware and software solution was applied to a collection of both simulated and clinically acquired EEG data with known artifact and waveform characteristics to assess its speed and accuracy. Configured for optimal accuracy in terms of minimal false positives and negatives as well as maintaining the integrity of the underlying EEG, especially when encountering EEG waveform patterns with an appearance similar to eyeblink artifacts, the system was capable of processing a 10 second EEG epoch in an average of 123 seconds. Configured for efficiency, but with diminished accuracy, the system required an average of 34 seconds. Varying the ICA contrast function showed that the gaussian nonlinearity provided the best combination of reliability and accuracy, albeit with a long execution time. The cubic nonlinearity was fast, but unreliable, while the hyperbolic tangent contrast function frequently diverged. It is believed that the utilization of programmable logic with increased logic capacity and processing speed may enable this approach to achieve the objective of real-time operation

Design and Implementation of Complexity Reduced Digital Signal Processors for Low Power Biomedical Applications

Wearable health monitoring systems can provide remote care with supervised, inde-pendent living which are capable of signal sensing, acquisition, local processing and transmission. A generic biopotential signal (such as Electrocardiogram (ECG), and Electroencephalogram (EEG)) processing platform consists of four main functional components. The signals acquired by the electrodes are amplified and preconditioned by the (1) Analog-Front-End (AFE) which are then digitized via the (2) Analog-to-Digital Converter (ADC) for further processing. The local digital signal processing is usually handled by a custom designed (3) Digital Signal Processor (DSP) which is responsible for either anyone or combination of signal processing algorithms such as noise detection, noise/artefact removal, feature extraction, classification and compres-sion. The digitally processed data is then transmitted via the (4) transmitter which is renown as the most power hungry block in the complete platform. All the afore-mentioned components of the wearable systems are required to be designed and fitted into an integrated system where the area and the power requirements are stringent. Therefore, hardware complexity and power dissipation of each functional component are crucial aspects while designing and implementing a wearable monitoring platform. The work undertaken focuses on reducing the hardware complexity of a biosignal DSP and presents low hardware complexity solutions that can be employed in the aforemen-tioned wearable platforms. A typical state-of-the-art system utilizes Sigma Delta (Σ∆) ADCs incorporating a Σ∆ modulator and a decimation filter whereas the state-of-the-art decimation filters employ linear phase Finite-Impulse-Response (FIR) filters with high orders that in-crease the hardware complexity [1–5]. In this thesis, the novel use of minimum phase Infinite-Impulse-Response (IIR) decimators is proposed where the hardware complexity is massively reduced compared to the conventional FIR decimators. In addition, the non-linear phase effects of these filters are also investigated since phase non-linearity may distort the time domain representation of the signal being filtered which is un-desirable effect for biopotential signals especially when the fiducial characteristics carry diagnostic importance. In the case of ECG monitoring systems the effect of the IIR filter phase non-linearity is minimal which does not affect the diagnostic accuracy of the signals. The work undertaken also proposes two methods for reducing the hardware complexity of the popular biosignal processing tool, Discrete Wavelet Transform (DWT). General purpose multipliers are known to be hardware and power hungry in terms of the number of addition operations or their underlying building blocks like full adders or half adders required. Higher number of adders leads to an increase in the power consumption which is directly proportional to the clock frequency, supply voltage, switching activity and the resources utilized. A typical Field-Programmable-Gate-Array’s (FPGA) resources are Look-up Tables (LUTs) whereas a custom Digital Signal Processor’s (DSP) are gate-level cells of standard cell libraries that are used to build adders [6]. One of the proposed methods is the replacement of the hardware and power hungry general pur-pose multipliers and the coefficient memories with reconfigurable multiplier blocks that are composed of simple shift-add networks and multiplexers. This method substantially reduces the resource utilization as well as the power consumption of the system. The second proposed method is the design and implementation of the DWT filter banks using IIR filters which employ less number of arithmetic operations compared to the state-of-the-art FIR wavelets. This reduces the hardware complexity of the analysis filter bank of the DWT and can be employed in applications where the reconstruction is not required. However, the synthesis filter bank for the IIR wavelet transform has a higher computational complexity compared to the conventional FIR wavelet synthesis filter banks since re-indexing of the filtered data sequence is required that can only be achieved via the use of extra registers. Therefore, this led to the proposal of a novel design which replaces the complex IIR based synthesis filter banks with FIR fil-ters which are the approximations of the associated IIR filters. Finally, a comparative study is presented where the hybrid IIR/FIR and FIR/FIR wavelet filter banks are de-ployed in a typical noise reduction scenario using the wavelet thresholding techniques. It is concluded that the proposed hybrid IIR/FIR wavelet filter banks provide better denoising performance, reduced computational complexity and power consumption in comparison to their IIR/IIR and FIR/FIR counterparts

Survey of FPGA applications in the period 2000 – 2015 (Technical Report)

Romoth J, Porrmann M, Rückert U. Survey of FPGA applications in the period 2000 – 2015 (Technical Report).; 2017.Since their introduction, FPGAs can be seen in more and more different fields of applications. The key advantage is the combination of software-like flexibility with the performance otherwise common to hardware. Nevertheless, every application field introduces special requirements to the used computational architecture. This paper provides an overview of the different topics FPGAs have been used for in the last 15 years of research and why they have been chosen over other processing units like e.g. CPUs

Design of hardware architectures for HMM–based signal processing systems with applications to advanced human-machine interfaces

In questa tesi viene proposto un nuovo approccio per lo sviluppo di interfacce uomo–macchina. In particolare si tratta il caso di sistemi di pattern recognition che fanno uso di Hidden Markov Models per la classificazione. Il progetto di ricerca è partito dall’ideazione di nuove tecniche per la realizzazione di sistemi di riconoscimento vocale per parlato spontaneo. Gli HMM sono stati scelti come lo strumento algoritmico di base per la realizzazione del sistema. Dopo una fase di studio preliminare gli obiettivi sono stati estesi alla realizzazione di una architettura hardware in grado di fornire uno strumento riconfigurabile che possa essere utilizzato non solo per il riconoscimento vocale, ma in qualsiasi tipo di classificatore basato su HMM. Il lavoro si concentra quindi sullo sviluppo di architetture hardware dedicate, ma nuovi risultati sono stati ottenuti anche a livello di applicazione per quanto riguarda la classificazione di segnali elettroencefalografici attraverso gli HMM. Innanzitutto state sviluppata una architettura a livello di sistema applicabile a qualsiasi sistema di pattern recognition che faccia usi di HMM. L’architettura stata concepita in modo tale da essere utilizzabile come un sistema stand–alone. Definita l’architettura, un processore hardware per HMM, completamente riconfigurabile, stato decritto in linguaggio VHDL e simulato con successo. Un array parallelo di questi processori costituisce di fatto il nucleo di processamento dell’architettura sviluppata. Sulla base del progetto in VHDL, due piattaforme di prototipaggio rapido basate su FPGA sono state selezionate per dei test di implementazione. Diverse configurazioni costituite da array paralleli di processori HMM sono state implementate su FPGA. Le soluzioni che offrivano un miglior compromesso tra prestazioni e quantità di risorse hardware utilizzate sono state selezionate per ulteriori analisi. Un sistema software per il pattern recognition basato su HMM stato scelto come sistema di riferimento per verificare la corretta funzionalità delle architetture implementate. Diversi test sono stati progettati per validare che il funzionamento del sistema corrispondesse alle specifiche iniziali. Le versioni implementate del sistema sono state confrontate con il software di riferimento sulla base dei risultati forniti dai test. Dal confronto è stato possibile appurare che le architetture sviluppate hanno un comportamento corrispondente a quello richiesto. Infine le implementazioni dell’array parallelo di processori HMM `e sono state applicate a due applicazioni reali: un riconoscitore vocale, ed un classificatore per interfacce basate su segnali elettroencefalografici. In entrambi i casi l’architettura si è dimostrata in grado di gestire l’applicazione senza alcun problema. L’uso del processamento hardware per il riconoscimento vocale apre di fatto la strada a nuovi sviluppi nel campo grazie al notevole incremento di prestazioni ottenibili in termini di tempo di esecuzione. L’applicazione al processamento dell’EEG, invece, introduce di fatto un approccio completamente nuovo alla classificazione di questo tipo di segnali, e mostra come in futuro potrebbe essere possibile lo sviluppo di interfacce basate sulla classificazione dei segnali generati dal pensiero spontaneo. I possibili sviluppi del lavoro iniziato con questa tesi sono molteplici. Una direzione possibile è quella dell’implementazione completa dell’architettura proposta come un sistema stand–alone riconfigurabile per l’accelerazione di sistemi per pattern recognition di qualsiasi natura purchè basati su HMM. Le potenzialità di tale sistema renderebbero possibile la realizzazione di classificatiori in tempo reale con un alto grado di complessità, e quindi allo sviluppo di interfacce realmente multimodali, con una vasta gamma di applicazioni, dai sistemi di per lo spazio a quelli di supporto per persone disabili.In this thesis a new approach is described for the development of human–computer interfaces. In particular the case of pattern recognition systems based on Hidden Markov Models have been taken into account. The research started from he development of techniques for the realization of natural language speech recognition systems. The Hidden Markov Model (HMM) was chosen as the main algorithmic tool to be used to build the system. After the early work the goal was extended to the development of an hardware architecture that provided a reconfigurable tool to be used in any pattern recognition task, and not only in speech recognition. The whole work is thus focused on the development of dedicated hardware architectures, but also some new results have been obtained on the classification of electroencephalographic signals through the use of HMMs. Firstly a system–level architecture has been developed to be used in HMM based pattern recognition systems. The architecture has been conceived in order to be able to work as a stand–alone system. Then a VHDL description has been made of a flexible and completely reconfigurable hardware HMM processor and the design was successfully simulated. A parallel array of these processors is actually the core processing block of the developed architecture. Then two suitable FPGA based, fast prototyping platforms have been identified to be the targets for the implementation tests. Different configurations of parallel HMM processor arrays have been set up and mapped on the target FPGAs. Some solutions have been selected to be the best in terms of balance between performance and resources utilization. Furthermore a software HMM based pattern recognition system has been chosen to be the reference system for the functionality of the implemented subsystems. A set of tests have been developed with the aim to test the correct functionality of the hardware. The implemented system was compared to the reference system on the basis of the tests’ results, and it was found that the behavior was the one expected and the required functionality was correctly achieved. Finally the implementation of the parallel HMM array was tested through its application to two real–world applications: a speech recognition task and a brain–computer interface task. In both cases the architecture showed to be functionally suitable and powerful enough to handle the task without problems. The application of the hardware processing to speech recognition opens new perspectives in the design of this kind of systems because of the dramatic increment in performance. The application to brain–computer interface is really interesting because of a new approach in the classification of EEG that shows how could be possible a future development of interfaces based on the classification of spontaneous thought. The possible evolution directions of the work started with this thesis are many. Effort could be spent of the implementation of the developed architecture as a stand–alone reconfigurable system suitable for any kind of HMM–based pattern recognition task. The potential performance of such a system could open the way to extremely complex real–time pattern recognition systems, and thus to the realization of truly multimodal interfaces, with a variety of applications, from space to aid systems for the impaired

Computationally efficient algorithms and implementations of adaptive deep brain stimulation systems for Parkinson's disease

Clinical deep brain stimulation (DBS) is a tool used to mitigate pharmacologically intractable neurodegenerative diseases such as Parkinson's disease (PD), tremor and dystonia. Present implementations of DBS use continuous, high frequency voltage or current pulses so as to mitigate PD. This results in some limitations, among which there is stimulation induced side effects and shortening of pacemaker battery life. Adaptive DBS (aDBS) can be used to overcome a number of these limitations. Adaptive DBS is intended to deliver stimulation precisely only when needed. This thesis presents work undertaken to investigate, propose and develop novel algorithms and implementations of systems for adapting DBS. This thesis proposes four system implementations that could facilitate DBS adaptation either in the form of closed-loop DBS or spatial adaptation. The first method involved the use of dynamic detection to track changes in local field potentials (LFP) which can be indicative of PD symptoms. The work on dynamic detection included the synthesis of validation dataset using mainly autoregressive moving average (ARMA) models to enable the evaluation of a subset of PD detection algorithms for accuracy and complexity trade-offs. The subset of algorithms consisted of feature extraction (FE), dimensionality reduction (DR) and dynamic pattern classification stages. The combination with the best trade-off in terms of accuracy and complexity consisted of discrete wavelet transform (DWT) for FE, maximum ratio method (MRM) for DR and k-nearest neighbours (k-NN) for classification. The MRM is a novel DR method inspired by Fisher's separability criterion. The best combination achieved accuracy measures: F1-score of 97.9%, choice probability of 99.86% and classification accuracy of 99.29%. Regarding complexity, it had an estimated microchip area of 0.84 mm² for estimates in 90 nm CMOS process. The second implementation developed the first known PD detection and monitoring processor. This was achieved using complementary detection, which presents a hardware-efficient method of implementing a PD detection processor for monitoring PD progression in Parkinsonian patients. Complementary detection is achieved by using a combination of weak classifiers to produce a classifier with a higher consistency and confidence level than the individual classifiers in the configuration. The PD detection processor using the same processing stages as the first implementation was validated on an FPGA platform. By mapping the implemented design on a 45 nm CMOS process, the most optimal implementation achieved a dynamic power per channel of 2.26 μW and an area per channel of 0.2384 mm². It also achieved mean accuracy measures: Mathews correlation coefficient (MCC) of 0.6162, an F1-score of 91.38%, and mean classification accuracy of 91.91%. The third implementation proposed a framework for adapting DBS based on a critic-actor control approach. This models the relationship between a trained clinician (critic) and a neuro-modulation system (actor) for modulating DBS. The critic was implemented and validated using machine learning models, and the actor was implemented using a fuzzy controller. Therapy is modulated based on state estimates obtained through the machine learning models. PD suppression was achieved in seven out of nine test cases. The final implementation introduces spatial adaptation for aDBS. Spatial adaptation adjusts to variation in lead position and/or stimulation focus, as poor stimulation focus has been reported to affect therapeutic benefits of DBS. The implementation proposes dynamic current steering systems as a power-efficient implementation for multi-polar multisite current steering, with a particular focus on the output stage of the dynamic current steering system. The output stage uses dynamic current sources in implementing push-pull current sources that are interfaced to 16 electrodes so as to enable current steering. The performance of the output stage was demonstrated using a supply of 3.3 V to drive biphasic current pulses of up to 0.5 mA through its electrodes. The preliminary design of the circuit was implemented in 0.18 μm CMOS technology

An Energy Efficient non-volatile FPGA Digital Processor for Brain Neuromodulation

PhD ThesisBrain stimulation technologies have the potential to provide considerable clinical benefits for people with a range of neurological disorders. Recent neuroscience studies have shown that considerable information of brain states is contained in the low frequency local field potential (If-LFP; below 5Hz) recordings with application in real-time closed-loop neurostimulation for treating neurological disorders. Given these signals can be sampled at low sampling rate and hence provide sparse data streams, there is an opportunity to design implantable neuroprosthesis with long battery lifecycles which enables enough processing power to implement long-term, real-time closed loop control algorithms. In this thesis, a closed-loop embedded digital processor has been created for use in rodent neuroscience experiments. The first contribution of this work is to develop a mathematical analytical design approach of feedback controller for suppressing high-amplitude epileptic activity in the neuron mass model to form a better understanding of how to perform a better closed-loop stimulation to control seizures. The second contribution and the third contribution are combined to present an exploratory energy-efficient digital processor architecture built with commercial off-the-shelf non-volatile FPGAs and microcontroller for sparse data processing of brain neuromodulation. A digital hardware design of an exemplar PID control algorithm has been implemented on this proposed digital architecture. A new power computing diagram of this time-driven approach significantly reduced the power consumption which suggests that a digital combined control system of non-volatile FPGAs and microcontroller outweighs a digital control system of microcontroller with microcontroller regarding computing time cost and energy consumption supposing one microcontroller is always required. Taken together, this digital energy-efficient processor architecture gives important insights and viewpoints for the further advancements of neuroprosthesis for brain neurostimulation to achieve lower power consumption for sparse sampling data rate

Advanced Interfaces for HMI in Hand Gesture Recognition

The present thesis investigates techniques and technologies for high quality Human Machine Interfaces (HMI) in biomedical applications. Starting from a literature review and considering market SoA in this field, the thesis explores advanced sensor interfaces, wearable computing and machine learning techniques for embedded resource-constrained systems. The research starts from the design and implementation of a real-time control system for a multifinger hand prosthesis based on pattern recognition algorithms. This system is capable to control an artificial hand using a natural gesture interface, considering the challenges related to the trade-off between responsiveness, accuracy and light computation. Furthermore, the thesis addresses the challenges related to the design of a scalable and versatile system for gesture recognition with the integration of a novel sensor interface for wearable medical and consumer application

Enhancement and optimization of a multi-command-based brain-computer interface

Brain-computer interfaces (BCI) assist disabled person to control many appliances without any physically interaction (e.g., pressing a button). SSVEP is brain activities elicited by evoked signals that are observed by visual stimuli paradigm. In this dissertation were addressed the problems which are oblige more usability of BCI-system by optimizing and enhancing the performance using particular design. Main contribution of this work is improving brain reaction response depending on focal approaches

Design of hardware architectures for HMM–based signal processing systems with applications to advanced human-machine interfaces

In questa tesi viene proposto un nuovo approccio per lo sviluppo di interfacce uomo–macchina. In particolare si tratta il caso di sistemi di pattern recognition che fanno uso di Hidden Markov Models per la classificazione. Il progetto di ricerca è partito dall’ideazione di nuove tecniche per la realizzazione di sistemi di riconoscimento vocale per parlato spontaneo. Gli HMM sono stati scelti come lo strumento algoritmico di base per la realizzazione del sistema. Dopo una fase di studio preliminare gli obiettivi sono stati estesi alla realizzazione di una architettura hardware in grado di fornire uno strumento riconfigurabile che possa essere utilizzato non solo per il riconoscimento vocale, ma in qualsiasi tipo di classificatore basato su HMM. Il lavoro si concentra quindi sullo sviluppo di architetture hardware dedicate, ma nuovi risultati sono stati ottenuti anche a livello di applicazione per quanto riguarda la classificazione di segnali elettroencefalografici attraverso gli HMM. Innanzitutto state sviluppata una architettura a livello di sistema applicabile a qualsiasi sistema di pattern recognition che faccia usi di HMM. L’architettura stata concepita in modo tale da essere utilizzabile come un sistema stand–alone. Definita l’architettura, un processore hardware per HMM, completamente riconfigurabile, stato decritto in linguaggio VHDL e simulato con successo. Un array parallelo di questi processori costituisce di fatto il nucleo di processamento dell’architettura sviluppata. Sulla base del progetto in VHDL, due piattaforme di prototipaggio rapido basate su FPGA sono state selezionate per dei test di implementazione. Diverse configurazioni costituite da array paralleli di processori HMM sono state implementate su FPGA. Le soluzioni che offrivano un miglior compromesso tra prestazioni e quantità di risorse hardware utilizzate sono state selezionate per ulteriori analisi. Un sistema software per il pattern recognition basato su HMM stato scelto come sistema di riferimento per verificare la corretta funzionalità delle architetture implementate. Diversi test sono stati progettati per validare che il funzionamento del sistema corrispondesse alle specifiche iniziali. Le versioni implementate del sistema sono state confrontate con il software di riferimento sulla base dei risultati forniti dai test. Dal confronto è stato possibile appurare che le architetture sviluppate hanno un comportamento corrispondente a quello richiesto. Infine le implementazioni dell’array parallelo di processori HMM `e sono state applicate a due applicazioni reali: un riconoscitore vocale, ed un classificatore per interfacce basate su segnali elettroencefalografici. In entrambi i casi l’architettura si è dimostrata in grado di gestire l’applicazione senza alcun problema. L’uso del processamento hardware per il riconoscimento vocale apre di fatto la strada a nuovi sviluppi nel campo grazie al notevole incremento di prestazioni ottenibili in termini di tempo di esecuzione. L’applicazione al processamento dell’EEG, invece, introduce di fatto un approccio completamente nuovo alla classificazione di questo tipo di segnali, e mostra come in futuro potrebbe essere possibile lo sviluppo di interfacce basate sulla classificazione dei segnali generati dal pensiero spontaneo. I possibili sviluppi del lavoro iniziato con questa tesi sono molteplici. Una direzione possibile è quella dell’implementazione completa dell’architettura proposta come un sistema stand–alone riconfigurabile per l’accelerazione di sistemi per pattern recognition di qualsiasi natura purchè basati su HMM. Le potenzialità di tale sistema renderebbero possibile la realizzazione di classificatiori in tempo reale con un alto grado di complessità, e quindi allo sviluppo di interfacce realmente multimodali, con una vasta gamma di applicazioni, dai sistemi di per lo spazio a quelli di supporto per persone disabili.In this thesis a new approach is described for the development of human–computer interfaces. In particular the case of pattern recognition systems based on Hidden Markov Models have been taken into account. The research started from he development of techniques for the realization of natural language speech recognition systems. The Hidden Markov Model (HMM) was chosen as the main algorithmic tool to be used to build the system. After the early work the goal was extended to the development of an hardware architecture that provided a reconfigurable tool to be used in any pattern recognition task, and not only in speech recognition. The whole work is thus focused on the development of dedicated hardware architectures, but also some new results have been obtained on the classification of electroencephalographic signals through the use of HMMs. Firstly a system–level architecture has been developed to be used in HMM based pattern recognition systems. The architecture has been conceived in order to be able to work as a stand–alone system. Then a VHDL description has been made of a flexible and completely reconfigurable hardware HMM processor and the design was successfully simulated. A parallel array of these processors is actually the core processing block of the developed architecture. Then two suitable FPGA based, fast prototyping platforms have been identified to be the targets for the implementation tests. Different configurations of parallel HMM processor arrays have been set up and mapped on the target FPGAs. Some solutions have been selected to be the best in terms of balance between performance and resources utilization. Furthermore a software HMM based pattern recognition system has been chosen to be the reference system for the functionality of the implemented subsystems. A set of tests have been developed with the aim to test the correct functionality of the hardware. The implemented system was compared to the reference system on the basis of the tests’ results, and it was found that the behavior was the one expected and the required functionality was correctly achieved. Finally the implementation of the parallel HMM array was tested through its application to two real–world applications: a speech recognition task and a brain–computer interface task. In both cases the architecture showed to be functionally suitable and powerful enough to handle the task without problems. The application of the hardware processing to speech recognition opens new perspectives in the design of this kind of systems because of the dramatic increment in performance. The application to brain–computer interface is really interesting because of a new approach in the classification of EEG that shows how could be possible a future development of interfaces based on the classification of spontaneous thought. The possible evolution directions of the work started with this thesis are many. Effort could be spent of the implementation of the developed architecture as a stand–alone reconfigurable system suitable for any kind of HMM–based pattern recognition task. The potential performance of such a system could open the way to extremely complex real–time pattern recognition systems, and thus to the realization of truly multimodal interfaces, with a variety of applications, from space to aid systems for the impaired

Real-time neural signal processing and low-power hardware co-design for wireless implantable brain machine interfaces

Intracortical Brain-Machine Interfaces (iBMIs) have advanced significantly over the past two decades, demonstrating their utility in various aspects, including neuroprosthetic control and communication. To increase the information transfer rate and improve the devices’ robustness and longevity, iBMI technology aims to increase channel counts to access more neural data while reducing invasiveness through miniaturisation and avoiding percutaneous connectors (wired implants). However, as the number of channels increases, the raw data bandwidth required for wireless transmission also increases becoming prohibitive, requiring efficient on-implant processing to reduce the amount of data through data compression or feature extraction. The fundamental aim of this research is to develop methods for high-performance neural spike processing co-designed within low-power hardware that is scaleable for real-time wireless BMI applications. The specific original contributions include the following: Firstly, a new method has been developed for hardware-efficient spike detection, which achieves state-of-the-art spike detection performance and significantly reduces the hardware complexity. Secondly, a novel thresholding mechanism for spike detection has been introduced. By incorporating firing rate information as a key determinant in establishing the spike detection threshold, we have improved the adaptiveness of spike detection. This eventually allows the spike detection to overcome the signal degradation that arises due to scar tissue growth around the recording site, thereby ensuring enduringly stable spike detection results. The long-term decoding performance, as a consequence, has also been improved notably. Thirdly, the relationship between spike detection performance and neural decoding accuracy has been investigated to be nonlinear, offering new opportunities for further reducing transmission bandwidth by at least 30% with minor decoding performance degradation. In summary, this thesis presents a journey toward designing ultra-hardware-efficient spike detection algorithms and applying them to reduce the data bandwidth and improve neural decoding performance. The software-hardware co-design approach is essential for the next generation of wireless brain-machine interfaces with increased channel counts and a highly constrained hardware budget. The fundamental aim of this research is to develop methods for high-performance neural spike processing co-designed within low-power hardware that is scaleable for real-time wireless BMI applications. The specific original contributions include the following: Firstly, a new method has been developed for hardware-efficient spike detection, which achieves state-of-the-art spike detection performance and significantly reduces the hardware complexity. Secondly, a novel thresholding mechanism for spike detection has been introduced. By incorporating firing rate information as a key determinant in establishing the spike detection threshold, we have improved the adaptiveness of spike detection. This eventually allows the spike detection to overcome the signal degradation that arises due to scar tissue growth around the recording site, thereby ensuring enduringly stable spike detection results. The long-term decoding performance, as a consequence, has also been improved notably. Thirdly, the relationship between spike detection performance and neural decoding accuracy has been investigated to be nonlinear, offering new opportunities for further reducing transmission bandwidth by at least 30\% with only minor decoding performance degradation. In summary, this thesis presents a journey toward designing ultra-hardware-efficient spike detection algorithms and applying them to reduce the data bandwidth and improve neural decoding performance. The software-hardware co-design approach is essential for the next generation of wireless brain-machine interfaces with increased channel counts and a highly constrained hardware budget.Open Acces