advligorts: The Advanced LIGO Real-Time Digital Control and Data Acquisition System

The Advanced LIGO detectors are sophisticated opto-mechanical devices. At the core of their operation is feedback control. The Advanced LIGO project developed a custom digital control and data acquisition system to handle the unique needs of this new breed of astronomical detector. The advligorts is the software component of this system. This highly modular and extensible system has enabled the unprecedented performance of the LIGO instruments, and has been a vital component in the direct detection of gravitational waves

Regulon organization of Arabidopsis

<p>Abstract</p> <p>Background</p> <p>Despite the mounting research on Arabidopsis transcriptome and the powerful tools to explore biology of this model plant, the organization of expression of Arabidopsis genome is only partially understood. Here, we create a coexpression network from a 22,746 Affymetrix probes dataset derived from 963 microarray chips that query the transcriptome in response to a wide variety of environmentally, genetically, and developmentally induced perturbations.</p> <p>Results</p> <p>Markov chain graph clustering of the coexpression network delineates 998 regulons ranging from one to 1623 genes in size. To assess the significance of the clustering results, the statistical over-representation of GO terms is averaged over this set of regulons and compared to the analogous values for 100 randomly-generated sets of clusters. The set of regulons derived from the experimental data scores significantly better than any of the randomly-generated sets. Most regulons correspond to identifiable biological processes and include a combination of genes encoding related developmental, metabolic pathway, and regulatory functions. In addition, nearly 3000 genes of unknown molecular function or process are assigned to a regulon. Only five regulons contain plastomic genes; four of these are exclusively plastomic. In contrast, expression of the mitochondrial genome is highly integrated with that of nuclear genes; each of the seven regulons containing mitochondrial genes also incorporates nuclear genes. The network of regulons reveals a higher-level organization, with dense local neighborhoods articulated for photosynthetic function, genetic information processing, and stress response.</p> <p>Conclusion</p> <p>This analysis creates a framework for generation of experimentally testable hypotheses, gives insight into the concerted functions of Arabidopsis at the transcript level, and provides a test bed for comparative systems analysis.</p

Novel PET Systems and Image Reconstruction with Actively Controlled Geometry

Positron Emission Tomography (PET) provides in vivo measurement of imaging ligands that are labeled with positron emitting radionuclide. Since its invention, most PET scanners have been designed to have a group of gamma ray detectors arranged in a ring geometry, accommodating the whole patient body. Virtual Pinhole PET incorporates higher resolution detectors being placed close to the Region-of-Interest (ROI) within the imaging Field-of-View (FOV) of the whole-body scanner, providing better image resolution and contrast recover. To further adapt this technology to a wider range of diseases, we proposed a second generation of virtual pinhole PET using actively controlled high resolution detectors integrated on a robotic arm. When the whole system is integrated to a commercial PET scanner, we achieved positioning repeatability within 0.5 mm. Monte Carlo simulation shows that by focusing the high-resolution detectors to a specific organ of interest, we can achieve better resolution, sensitivity and contrast recovery. In another direction, we proposed a portable, versatile and low cost PET imaging system for Point-of-Care (POC) applications. It consists of one or more movable detectors in coincidence with a detector array behind a patient. The movable detectors make it possible for the operator to control the scanning trajectory freely to achieve optimal coverage and sensitivity for patient specific imaging tasks. Since this system does not require a conventional full ring geometry, it can be built portable and low cost for bed-side or intraoperative use. We developed a proof-of-principle prototype that consists of a compact high resolution silicon photomultiplier detector mounted on a hand-held probe and a half ring of conventional detectors. The probe is attached to a MicroScribe device, which tracks the location and orientation of the probe as it moves. We also performed Monte Carlo simulations for two POC PET geometries with Time-of-Flight (TOF) capability. To support the development of such PET systems with unconventional geometries, a fully 3D image reconstruction framework has been developed for PET systems with arbitrary geometry. For POC PET and the second generation robotic Virtual Pinhole PET, new challenges emerge and our targeted applications require more efficiently image reconstruction that provides imaging results in near real time. Inspired by the previous work, we developed a list mode GPU-based image reconstruction framework with the capability to model dynamically changing geometry. Ordered-Subset MAP-EM algorithm is implemented on multi-GPU platform to achieve fast reconstruction in the order of seconds per iteration, under practical data rate. We tested this using both experimental and simulation data, for whole body PET scanner and unconventional PET scanners. Future application of adaptive imaging requires near real time performance for large statistics, which requires additional acceleration of this framework

Bin-picking de precisão usando um sensor 3D e um sensor laser 1D

The technique that is being used by a robot to grab objects that are randomly placed inside a box or on a pallet is called bin-picking. This process is of great interest in an industrial environment as it provides enhanced automation, increased production and cost reduction. Bin-picking has evolved greatly over the years due to tremendous strides empowered by advanced vision technology, software, and gripping solutions which are in constant development. However, the creation of a versatile system, capable of collecting any type of object without deforming it, regardless of the disordered environment around it, remains a challenge. To this goal, the use of 3D perception is unavoidable. Still, the information acquired by some lower cost 3D sensors is not very precise; therefore, the combination of this information with the one of other devices is an approach already in study. The main goal of this work is to develop a solution for the execution of a precise bin-picking process capable of grasping small and fragile objects without breaking or deforming them. This may be done by combining the information provided by two sensors: one 3D sensor (Kinect) used to analyse the workspace and identify the object, and a 1D laser sensor to determine the exact distance to the object when approaching it. Additionally, the developed system may be placed at the end of a manipulator in order to become an active perception unit. Once the global system of sensors, their controllers and the robotic manipulator are integrated into a ROS (Robot Operating System) infrastructure, the data provided by the sensors can be analysed and combined to provide a bin-picking solution. Finally, the testing phase demonstrated the viability and the reliability of the developed bin-picking process.À tecnologia usada por um robô para agarrar objetos que estão dispostos de forma aleatória dentro de uma caixa ou sobre uma palete chama-se binpicking. Este processo é de grande interesse para a industria uma vez que oferece maior autonomia, aumento de produção e redução de custos. O binpicking tem evoluido de forma significativa ao longo dos anos graças aos avanços possibilitados pelo desenvolvimento tecnológico na área da visão, software e soluções de diferentes garras que estão em constante evolução. Contudo, a criação de um sistema versátil, capaz de agarrar qualquer tipo de objeto sem o deformar, independentemente do ambiente desordenado à sua volta, continua a ser o principal objetivo. Para esse fim, o recurso à perceção 3D é imprescindível. Ainda assim, a informação adquirida por sensores 3D não é muito precisa e, por isso, a combinação deste com a de outros dispositivos é uma abordagem ainda em estudo. O objetivo principal deste trabalho é então desenvolver uma solução para a execução de um processo de bin-picking capaz de agarrar objetos pequenos e frágeis sem os partir ou deformar. Isto poderá ser feito através da combinação entre a informação proveniente de dois sensores: um sensor 3D (Kinect) usado para analisar o espaço de trabalho e identificar o objeto, e um sensor laser 1D usado para determinar a sua distância exata e assim se poder aproximar. Adicionalmente, o sistema desenvolvido pode ser acoplado a um manipulador de forma a criar uma unidade de perceção ativa. Uma vez tendo um sistema global de sensores, os seus controladores e o manipulador robótico integrados numa infraestrutura ROS (Robot Operating System), os dados fornecidos pelos sensores podem ser analisados e combinados, e uma solução de bin-picking pode ser desenvolvida. Por último, a fase de testes demonstrou, depois de alguns ajustes nas medidas do sensor laser, a viabilidade e fiabilidade do processo de bin-picking desenvolvido.Mestrado em Engenharia Mecânic

Bibliometric analysis on Hand Gesture Controlled Robot

This paper discusses about the survey and bibliometric analysis of hand gesture-controlled robot using Scopus database in analyzing the research by area, influential authors, countries, institutions, and funding agencies. The 293 documents are extracted from the year 2016 till 6th March 2021 from the database. Bibliometric analysis is the statistical analysis of the research published as articles, conference papers, and reviews, which helps in understanding the impact of publication in the research domain globally. The visualization analysis is done with open-source tools namely GPS Visualizer, Gephi, VOS viewer, and ScienceScape. The visualization aids in a quick and clear understanding of the different perspective as mentioned above in a particular research domain search

INDUSTRIAL DEVICE INTEGRATION AND VIRTUALIZATION FOR SMART FACTORIES

Given the constant industry growth and modernization, several technologies have been introduced in the shop floor, in particular regarding industrial devices. Each device brand and model usually requires different interfaces and communication protocols, a technological diversity which renders the automatic interconnection with production management software extremely challenging. However, combining key technologies such as machine monitoring, digital twin and virtual commissioning, along with a complete communication protocol like OPC UA, it is possible to contribute towards industrial device integration on a Smart Factory environment. To achieve this goal, several methodologies and a set of tools were defined. This set of tools, as well as facilitating the integration tasks, should also be part of a virtual engineering environment, sharing the same virtual model, the digital twin, through the complete lifecycle of the industrial device, namely the project, simulation, implementation and execution/monitoring/supervision and, eventually, decommissioning phases. A key result of this work is the development of a set of virtual engineering tools and methodologies based on OPC UA communication, with the digital twin implemented using RobotStudio, in order to accomplish the complete lifecycle support of an industrial device, from the project and simulation phases, to monitoring and supervision, suitable for integration in Industry 4.0 factories. To evaluate the operation of the developed set of tools, experiments were performed for a test scenario with different devices. Other relevant result is related with the integration of a specific industrial device – CNC machining equipment. Given the variety of monitoring systems and communication protocols, an approach where various solutions available on the market are combined on a single system is followed. These kinds of all-in-one solutions would give production managers access to the information necessary for a continuous monitoring and improvement of the entire production process

High Resolution Analysis of Meiotic Chromosome Structure and Behaviour in Barley (Hordeum vulgare L.)

Reciprocal crossing over and independent assortment of chromosomes during meiosis generate most of the genetic variation in sexually reproducing organisms. In barley, crossovers are confined primarily to distal regions of the chromosomes, which means that a substantial proportion of the genes of this crop rarely, if ever, engage in recombination events. There is potentially much to be gained by redistributing crossovers to more proximal regions, but our ability to achieve this is dependent upon a far better understanding of meiosis in this species. This study explores the meiotic process by describing with unprecedented resolution the early behaviour of chromosomal domains, the progression of synapsis and the structure of the synaptonemal complex (SC). Using a combination of molecular cytogenetics and advanced fluorescence imaging, we show for the first time in this species that non-homologous centromeres are coupled prior to synapsis. We demonstrate that at early meiotic prophase the loading of the SC-associated structural protein ASY1, the cluster of telomeres, and distal synaptic initiation sites occupy the same polarised region of the nucleus. Through the use of advanced 3D image analysis, we show that synapsis is driven predominantly from the telomeres, and that new synaptic initiation sites arise during zygotene. In addition, we identified two different SC configurations through the use of super-resolution 3D structured illumination microscopy (3D-SIM)

A Model-based Approach for Designing Cyber-Physical Production Systems

The most recent development trend related to manufacturing is called "Industry 4.0". It proposes to transition from "blind" mechatronics systems to Cyber-Physical Production Systems (CPPSs). Such systems are capable of communicating with each other, acquiring and transmitting real-time production data. Their management and control require a structured software architecture, which is tipically referred to as the "Automation Pyramid". The design of both the software architecture and the components (i.e., the CPPSs) is a complex task, where the complexity is induced by the heterogeneity of the required functionalities. In such a context, the target of this thesis is to propose a model-based framework for the analysis and the design of production lines, compliant with the Industry 4.0 paradigm. In particular, this framework exploits the Systems Modeling Language (SysML) as a unified representation for the different viewpoints of a manufacturing system. At the components level, the structural and behavioral diagrams provided by SysML are used to produce a set of logical propositions about the system and components under design. Such an approach is specifically tailored towards constructing Assume-Guarantee contracts. By exploiting reactive synthesis techniques, contracts are used to prototype portions of components' behaviors and to verify whether implementations are consistent with the requirements. At the software level, the framework proposes a particular architecture based on the concept of "service". Such an architecture facilitates the reconfiguration of components and integrates an advanced scheduling technique, taking advantage of the production recipe SysML model. The proposed framework has been built coupled with the construction of the ICE Laboratory, a research facility consisting of a full-fledged production line. Such an approach has been adopted to construct models of the laboratory, to virtual prototype parts of the system and to manage the physical system through the proposed software architecture

Bibliometric Studies and Worldwide Research Trends on Global Health

Global health, conceived as a discipline, aims to train, research and respond to problems of a transboundary nature, in order to improve health and health equity at the global level. The current worldwide situation is ruled by globalization, and therefore the concept of global health involves not only health-related issues, but also those related to the environment and climate change. Therefore, in this Special Issue, the problems related to global health have been addressed from a bibliometric approach in four main areas: environmental issues, diseases, health, education and society