Computer Aided ECG Analysis - State of the Art and Upcoming Challenges

In this paper we present current achievements in computer aided ECG analysis and their applicability in real world medical diagnosis process. Most of the current work is covering problems of removing noise, detecting heartbeats and rhythm-based analysis. There are some advancements in particular ECG segments detection and beat classifications but with limited evaluations and without clinical approvals. This paper presents state of the art advancements in those areas till present day. Besides this short computer science and signal processing literature review, paper covers future challenges regarding the ECG signal morphology analysis deriving from the medical literature review. Paper is concluded with identified gaps in current advancements and testing, upcoming challenges for future research and a bullseye test is suggested for morphology analysis evaluation.Comment: 7 pages, 3 figures, IEEE EUROCON 2013 International conference on computer as a tool, 1-4 July 2013, Zagreb, Croati

Region-based representations of image and video: segmentation tools for multimedia services

This paper discusses region-based representations of image and video that are useful for multimedia services such as those supported by the MPEG-4 and MPEG-7 standards. Classical tools related to the generation of the region-based representations are discussed. After a description of the main processing steps and the corresponding choices in terms of feature spaces, decision spaces, and decision algorithms, the state of the art in segmentation is reviewed. Mainly tools useful in the context of the MPEG-4 and MPEG-7 standards are discussed. The review is structured around the strategies used by the algorithms (transition based or homogeneity based) and the decision spaces (spatial, spatio-temporal, and temporal). The second part of this paper proposes a partition tree representation of images and introduces a processing strategy that involves a similarity estimation step followed by a partition creation step. This strategy tries to find a compromise between what can be done in a systematic and universal way and what has to be application dependent. It is shown in particular how a single partition tree created with an extremely simple similarity feature can support a large number of segmentation applications: spatial segmentation, motion estimation, region-based coding, semantic object extraction, and region-based retrieval.Peer ReviewedPostprint (published version

Understanding Epileptiform After-Discharges as Rhythmic Oscillatory Transients

Electro-cortical activity in patients with epilepsy may show abnormal rhythmic transients in response to stimulation. Even when using the same stimulation parameters in the same patient, wide variability in the duration of transient response has been reported. These transients have long been considered important for the mapping of the excitability levels in the epileptic brain but their dynamic mechanism is still not well understood. To understand the occurrence of abnormal transients dynamically, we use a thalamo-cortical neural population model of epileptic spike-wave activity and study the interaction between slow and fast subsystems. In a reduced version of the thalamo-cortical model, slow wave oscillations arise from a fold of cycles (FoC) bifurcation. This marks the onset of a region of bistability between a high amplitude oscillatory rhythm and the background state. In vicinity of the bistability in parameter space, the model has excitable dynamics, showing prolonged rhythmic transients in response to suprathreshold pulse stimulation. We analyse the state space geometry of the bistable and excitable states, and find that the rhythmic transient arises when the impending FoC bifurcation deforms the state space and creates an area of locally reduced attraction to the fixed point. This area essentially allows trajectories to dwell there before escaping to the stable steady state, thus creating rhythmic transients. In the full thalamo-cortical model, we find a similar FoC bifurcation structure. Based on the analysis, we propose an explanation of why stimulation induced epileptiform activity may vary between trials, and predict how the variability could be related to ongoing oscillatory background activity.Comment: http://journal.frontiersin.org/article/10.3389/fncom.2017.00025/ful

Deconstructing the glass transition through critical experiments on colloids

The glass transition is the most enduring grand-challenge problem in contemporary condensed matter physics. Here, we review the contribution of colloid experiments to our understanding of this problem. First, we briefly outline the success of colloidal systems in yielding microscopic insights into a wide range of condensed matter phenomena. In the context of the glass transition, we demonstrate their utility in revealing the nature of spatial and temporal dynamical heterogeneity. We then discuss the evidence from colloid experiments in favor of various theories of glass formation that has accumulated over the last two decades. In the next section, we expound on the recent paradigm shift in colloid experiments from an exploratory approach to a critical one aimed at distinguishing between predictions of competing frameworks. We demonstrate how this critical approach is aided by the discovery of novel dynamical crossovers within the range accessible to colloid experiments. We also highlight the impact of alternate routes to glass formation such as random pinning, trajectory space phase transitions and replica coupling on current and future research on the glass transition. We conclude our review by listing some key open challenges in glass physics such as the comparison of growing static lengthscales and the preparation of ultrastable glasses, that can be addressed using colloid experiments.Comment: 137 pages, 45 figure

Automatic Test Methods for Image and Video Verification

In this thesis four methods for automatic verification of images and video on mobile platforms are developed. Both the case of recording images and video and the case of viewing images and video on the mobile lcd screen are considered. The first method is used to test the zoom function of the camera. It uses SURF decriptors along with clustering and histograms to determine which of six discrete zoom levels the current frame belongs to. The second method identifies color effects and color anomalies using histograms. The third method determines if the autofocus works correctly by measuring the average length of edges in the image. The fourth method is an artifact detection scheme using a non-reference implementation of the SSIM metric, used in conjunction with a for this purpose specially designed test setup. Together these methods form a tool kit for detecting the mnost common errors to occur in images and video during the development stage of mobile platforms

A Minimal Mechanosensing Model Predicts Keratocyte Evolution on Flexible Substrates

A mathematical model is proposed for shape evolution and locomotion of fish epidermal keratocytes on elastic substrates. The model is based on mechanosensing concepts: cells apply contractile forces onto the elastic substrate, while cell shape evolution depends locally on the substrate stress generated by themselves or external mechanical stimuli acting on the substrate. We use the level set method to study the behaviour of the model numerically, and predict a number of distinct phenomena observed in experiments, such as (i) symmetry breaking from the stationary centrosymmetric to the well-known steadily propagating crescent shape, (ii) asymmetric bipedal oscillations and travelling waves in the lamellipodium leading edge, (iii) response to remote mechanical stress externally applied to the substrate (tensotaxis) and (iv) changing direction of motion towards an interface with a rigid substrate (durotaxis)