Complementary Roles of Hippocampus and Medial Entorhinal Cortex in Episodic Memory

Spatial mapping and navigation are figured prominently in the extant literature that describes hippocampal function. The medial entorhinal cortex is likewise attracting increasing interest, insofar as evidence accumulates that this area also contributes to spatial information processing. Here, we discuss recent electrophysiological findings that offer an alternate view of hippocampal and medial entorhinal function. These findings suggest complementary contributions of the hippocampus and medial entorhinal cortex in support of episodic memory, wherein hippocampal networks encode sequences of events that compose temporally and spatially extended episodes, whereas medial entorhinal networks disambiguate overlapping episodes by binding sequential events into distinct memories.National Institute of Mental Health Grants (MH51570, MH071702); National Science Foundation (Science of Learning Center grant SBE-0354378

Any Data, Any Time, Anywhere: Global Data Access for Science

Data access is key to science driven by distributed high-throughput computing (DHTC), an essential technology for many major research projects such as High Energy Physics (HEP) experiments. However, achieving efficient data access becomes quite difficult when many independent storage sites are involved because users are burdened with learning the intricacies of accessing each system and keeping careful track of data location. We present an alternate approach: the Any Data, Any Time, Anywhere infrastructure. Combining several existing software products, AAA presents a global, unified view of storage systems - a "data federation," a global filesystem for software delivery, and a workflow management system. We present how one HEP experiment, the Compact Muon Solenoid (CMS), is utilizing the AAA infrastructure and some simple performance metrics.Comment: 9 pages, 6 figures, submitted to 2nd IEEE/ACM International Symposium on Big Data Computing (BDC) 201

On the Representability of Line Graphs

A graph G=(V,E) is representable if there exists a word W over the alphabet V such that letters x and y alternate in W if and only if (x,y) is in E for each x not equal to y. The motivation to study representable graphs came from algebra, but this subject is interesting from graph theoretical, computer science, and combinatorics on words points of view. In this paper, we prove that for n greater than 3, the line graph of an n-wheel is non-representable. This not only provides a new construction of non-representable graphs, but also answers an open question on representability of the line graph of the 5-wheel, the minimal non-representable graph. Moreover, we show that for n greater than 4, the line graph of the complete graph is also non-representable. We then use these facts to prove that given a graph G which is not a cycle, a path or a claw graph, the graph obtained by taking the line graph of G k-times is guaranteed to be non-representable for k greater than 3.Comment: 10 pages, 5 figure

Role of regional policies in promoting networking and innovation activity of firms

The success of firms and regions is increasingly defined by their innovation and learning capabilities. It has been emphasized in several studies that a local operational environment may have a positive impact on innovation activity of firms. From policy point of view, the relationship between firms and their local environment is an important research topic. The purpose of this paper is to explore whether there is a demand for regional policy makers in promoting innovative and networking activity of firms, and what are the appropriate strategies in this regard. The concept of innovative milieu provides a theoretical base for this study. The data used is based on personal interviews representing 30 high tech firms located in Jyväskylä Science Park in Finland. The results show that the firms appreciate an individual-level approach by policy makers which enables them to take the real needs of firms into consideration. A developed service structure, that is planned to meet the demand of new and established firms as well as possible, is an essential part of the well functioning operational environment. Supporting contacts with service providers and experts from different fields and organizing collective meetings for firms are important targets for the policy makers. In the innovation process, a commercial view of external part is considered very crucial. The small advances which alternate between the development of the innovation process and networks among firms and their interest groups could form a favourable path towards an operational environment with efficient innovative networks.

Citizen Preferences for Marine Environmental Policy

The growing global population, combined with increased land use, has emphasized the demand for sustainable ocean management strategies. Among suggestions for these strategies is a closer examination of the visual impact that aquaculture sites may have on coastal homes, as well as perception and preferences on coastal issues including coastal hazards, impacts of development, and marine debris. Maine’s unique and extensive history, as well as geographic location makes it an ideal setting to study these vital coastal issues, as well as to assist decision makers with informed options for management and policy. This research explores various coastal usages and issues to determine what role visual impacts and perceptions may play on coastal communities in Maine. Empirical methods utilized include 1) viewshed analysis and semi-log hedonic pricing framework in order to capture information regarding impact that view of marine aquaculture may have on coastal home prices; and 2) various survey instruments such as frequencies, cross tabulation, factor analysis, and logistic regression to explore perceptions concerning ocean and coastal priority areas; to determine what housing, demographic, and social characteristics may be associated with different levels of awareness of policy-relevant knowledge; and to investigate the relationship between perception of and preference for Maine coastal and ocean issues. Results from our spatially fixed semi-log hedonic pricing model suggest that visibility of aquaculture may have mixed impacts on coastal housing markets depending on geographic region, as well as how view of aquaculture enters our models. For Casco Bay, visibility of aquaculture shows no statistically significant impacts in our base model and alternate model 2 and positive impacts in alternate model 1 (entering the model as an aquaculture view dummy indicator). Damariscotta also shows no statistically significant effects in base model and alternate model 2, while conveying positive effects on housing prices in alternate model 1. View of aquaculture conveys no statistically significant effects in Penobscot Bay in base model or alternate model 1, but conveys positive and significant effects in alternate model 2. Additionally, we find that omission of visibility may lead to omitted variable bias. These results also suggest that we may be missing additional indicators associated with aquaculture (noise, smell, etc.). The research completed from our models is a critical step towards the end objective to inform policy makers and stakeholders of social costs related to future site selection for sustainable marine aquaculture. Results from our survey data suggest that participating Maine coastal citizens who agreed or strongly agreed with the perceived statements regarding current ocean and coastal conditions prioritized these areas as outlined in the Maine Coastal Program. Additionally, certain situational factors such as trust in science, belief in climate change, and perception of ocean health may be important predictors of knowledge and preferences. Overall, we find that participants who have an awareness in the situational factors listed above are more likely to support coastal zone priority areas enacted by the Maine Coastal Plan that promote effective marine planning and protection

Incorporating video into Google MSV

Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2010.Cataloged from PDF version of thesis.Includes bibliographical references (p. 52).Mobile Street View is a compelling application but suffers from significant latency problems, especially in limited bandwidth circumstances. Currently, the application uses static images to display street level information. Utilizing video in addition to images has the potential to improve the Street View user experience. In this paper, we examine the design and performance of mobile Street View and consider how to use video to reduce user visible latency. Video also allows for alternate navigation methods which could improve the application's ease of use. We created a prototype on Android to examine the plausibility of incorporating video into mobile Street View. Comparing the performance of our video prototype to the traditional step-by-step Street View approach, we found a 4x increase in the speed of viewing an entire street. For the video prototype I also found significant improvement in both user visible latencies and useful screen time. Additionally, I found that the time to fetch video chunks was less than the time to display them.by Christina Wright.M.Eng

Feasibility Meets Implementation Science: Narrowing the Research-To-Practice Gap for Exercise Activity in Multiple Sclerosis

Background: There is a need to identify why multiple sclerosis exercise research is not translating into real-world participation. To lay the foundations of strong clinical research, considering the translational element of implementation science at the feasibility phase of a trial is vital. Methods: Document analysis was used to examine document sources on exercise activity interventions designed for people living with multiple sclerosis. Document sources focused on multiple sclerosis research that incorporated exercise pre scription elements and behaviour change and were feasibility studies incorporating aspects of implementation science. Results: Implementation science should come much earlier than the efficacy or effectiveness research pipeline. An alternate view is outlined where feasibility and implementation science should meet based on case examples that have not yet shown strong efficacy or effectiveness. Findings from our key themes indicate a need for a cyclical iterative approach to the translational process. Multiple aspects of feasibility and how it can be assessed using an implementation science lens to support more successful interventions are provided. The determination of feasibility in behaviour change should involve implementation science as feasibility is drawn on for theory development, optimising the intervention design and quality of implementation strategies, and identifying those delivering the intervention before conducting efficacy and effectiveness research. Conclusions: Document analysis methodology is underused in qualitative research and was appropriate to use as it was a very resource, time-efficient and an unobtrusive process that could track change and development to explore the integration of implementation science at the feasibility phase, with the findings indicating the earlier implementation science is introduced into multiple sclerosis exercise interventions the better

Feasibility meets implementation science: Narrowing the research-to-practice gap for exercise activity in multiple sclerosis

Background: There is a need to identify why multiple sclerosis exercise research is not translating into real-world participation. To lay the foundations of strong clinical research, considering the translational element of implementation science at the feasibility phase of a trial is vital. Methods: Document analysis was used to examine document sources on exercise activity interventions designed for people living with multiple sclerosis. Document sources focused on multiple sclerosis research that incorporated exercise prescription elements and behaviour change and were feasibility studies incorporating aspects of implementation science. Results: Implementation science should come much earlier than the efficacy or effectiveness research pipeline. An alternate view is outlined where feasibility and implementation science should meet based on case examples that have not yet shown strong efficacy or effectiveness. Findings from our key themes indicate a need for a cyclical iterative approach to the translational process. Multiple aspects of feasibility and how it can be assessed using an implementation science lens to support more successful interventions are provided. The determination of feasibility in behaviour change should involve implementation science as feasibility is drawn on for theory development, optimising the intervention design and quality of implementation strategies, and identifying those delivering the intervention before conducting efficacy and effectiveness research. Conclusions: Document analysis methodology is underused in qualitative research and was appropriate to use as it was a very resource, time-efficient and an unobtrusive process that could track change and development to explore the integration of implementation science at the feasibility phase, with the findings indicating the earlier implementation science is introduced into multiple sclerosis exercise interventions the better

DANP-Evaluation of AHP-DSS

The analytic hierarchy process (AHP) and the analytic network process (ANP) are important multi-criteria decision-making (MCDM) methods for solving strategic decision problems. In the field of the research and teaching projects of a university’s Management Science Department, the use of adequate decision support systems (DSS) enables an appropriate application and acceptance of these methods. By reason of the great variety of AHP-DSS, the aim of this paper is the selection of AHP-supporting software. Owing to the interdependencies of the software quality criteria, these influences can be evaluated appropriately by the ANP. As for the various requirements of the different department members, the ANP procedure is linked with the DEMATEL approach. Within such a combined framework (DANP), the alternate software products and their quality selection criteria are transparently analysed and evaluated from a multi-personal point of view. The described procedure is an object of reference to solve such structuring and evaluation problems by support of parallel and/or distributed computing architecture

Das Anthropozän - Die Erde in unserer Hand

The Anthropocene concept is a comprehensive conceptual "toolbox" for systemic analysis, interdisciplinary monitoring and a new understanding of the gigantic current impact of human activities on the Earth system. At the same time, it neither implies a fatalistic acceptance of an apocalypse, nor does it promote a simplistic "everything will be fine" positivism, but rather allows differentiated observations from different perspectives. Precisely because of its systemic and interdisciplinary approach, the concept does not narrow possible pathways for the development, propagation and application of future options. On the contrary, the Earth system sciences, social sciences, cultural studies and the humanities together and very clearly express that in order to achieve global development goals such as justice, food security, health, peace and other goals for sustainable development (SDGs) (UNSDGs 2015), we keep on needing "assessable" and predictable conditions of an Anthropocene Earth system (Steffen et al. 2016). In order not to completely switch from the relative stability of the Holocene to incalculable risks, but rather to transform the Anthropocene Earth System into a different, but permanently habitable Anthropocene, it is necessary not to exceed planetary boundaries (sensu Rockström et al. 2009, Steffen et al. 2015b) and to see the SDGs as a compass. For this purpose, continuous monitoring of the state of the Anthropocene Earth system is indispensable. Only then both safe shelter spaces and a creative leeway for shaping the Anthropocene remain guaranteed. Within this framework, and depending on the region, the culture, the social requirements and the sociopolitical goals, it should be possible to negotiate very freely where the future journey should go. Necessary for that is a generally more holistic, systemic view of the integration of humankind into planetary processes, which means an integration of all societal groups, i.e. politics, science, business, administration, civil society groups and individuals. Another prerequisite is the improvement of future literacy via education in schools, universities, companies etc., with the goal to develop skills for better imagining alternate futures, depicting desirable futures, and designing solution portfolios for them. (excerpt from the conclusions of the paper