Ontology-Based Queries over Cancer Data

The ever-increasing amount of data in biomedical research, and in cancer research in particular, needs to be managed to support efficient data access, exchange and integration. Existing software infrastructures, such as caGrid, support access to distributed information annotated with a domain ontology. However, caGrid's current querying functionality depends on the structure of individual data resources without exploiting the semantic annotations. In this paper, we present the design and development of an ontology-based querying functionality that consists of: the generation of OWL2 ontologies from the underlying data resources’ metadata and a query rewriting and translation process based on reasoning, which converts a query at the domain ontology level into queries at the software infrastructure level. We present a detailed analysis of our approach as well as an extensive performance evaluation. While the implementation and evaluation was performed for the caGrid infrastructure, the approach could be applicable to other model and metadata-driven environments for data sharing

Translating semantic web service based business process models

We describe a model-driven translation approach between Semantic Web Service based business process models in the context of the SUPER project. In SUPER we provide a set of business process ontologies for enabling access to the business process space inside the organisation at the semantic level. One major task in this context is to handle the translations between the provided ontologies in order to navigate from different views at the business level to the IT view at the execution level. In this paper we present the results of our translation approach, which transforms instances of BPMO to instances of sBPEL

PowerAqua: fishing the semantic web

The Semantic Web (SW) offers an opportunity to develop novel, sophisticated forms of question answering (QA). Specifically, the availability of distributed semantic markup on a large scale opens the way to QA systems which can make use of such semantic information to provide precise, formally derived answers to questions. At the same time the distributed, heterogeneous, large-scale nature of the semantic information introduces significant challenges. In this paper we describe the design of a QA system, PowerAqua, designed to exploit semantic markup on the web to provide answers to questions posed in natural language. PowerAqua does not assume that the user has any prior information about the semantic resources. The system takes as input a natural language query, translates it into a set of logical queries, which are then answered by consulting and aggregating information derived from multiple heterogeneous semantic sources

Automated syntactic mediation for Web service integration

As the Web Services and Grid community adopt Semantic Web technology, we observe a shift towards higher-level workflow composition and service discovery practices. While this provides excellent functionality to non-expert users, more sophisticated middleware is required to hide the details of service invocation and service integration. An investigation of a common Bioinformatics use case reveals that the execution of high-level workflow designs requires additional processing to harmonise syntactically incompatible service interfaces. In this paper, we present an architecture to support the automatic reconciliation of data formats in such Web Service worklflows. The mediation of data is driven by ontologies that encapsulate the information contained in heterogeneous data structures supplying a common, conceptual data representation. Data conversion is carried out by a Configurable Mediator component, consuming mappings between \xml schemas and \owl ontologies. We describe our system and give examples of our mapping language against the background of a Bioinformatics use case

PlanetOnto: from news publishing to integrated knowledge management support

Given a scenario in which members of an academic community collaboratively construct and share an archive of news items, several knowledge management challenges arise. The authors' integrated suite of tools, called PlanetOnto, supports a speedy but high quality publishing process, allows ontology-driven document formalization and augments standard browsing and search facilities with deductive knowledge retrieva

Cloud service localisation

The essence of cloud computing is the provision of software and hardware services to a range of users in dierent locations. The aim of cloud service localisation is to facilitate the internationalisation and localisation of cloud services by allowing their adaption to dierent locales. We address the lingual localisation by providing service-level language translation techniques to adopt services to dierent languages and regulatory localisation by providing standards-based mappings to achieve regulatory compliance with regionally varying laws, standards and regulations. The aim is to support and enforce the explicit modelling of aspects particularly relevant to localisation and runtime support consisting of tools and middleware services to automating the deployment based on models of locales, driven by the two localisation dimensions. We focus here on an ontology-based conceptual information model that integrates locale specication in a coherent way

An ontology of agile aspect oriented software development

Both agile methods and aspect oriented programming (AOP) have emerged in recent years as new paradigms in software development. Both promise to free the process of building software systems from some of the constraints of more traditional approaches. As a software engineering approach on the one hand, and a software development tool on the other, there is the potential for them to be used in conjunction. However, thus far, there has been little interplay between the two. Nevertheless, there is some evidence that there may be untapped synergies that may be exploited, if the appropriate approach is taken to integrating AOP with agile methods. This paper takes an ontological approach to supporting this integration, proposing ontology enabled development based on an analysis of existing ontologies of aspect oriented programming, a proposed ontology of agile methods, and a derived ontology of agile aspect oriented development

Ontology-based patterns for the integration of business processes and enterprise application architectures

Increasingly, enterprises are using Service-Oriented Architecture (SOA) as an approach to Enterprise Application Integration (EAI). SOA has the potential to bridge the gap between business and technology and to improve the reuse of existing applications and the interoperability with new ones. In addition to service architecture descriptions, architecture abstractions like patterns and styles capture design knowledge and allow the reuse of successfully applied designs, thus improving the quality of software. Knowledge gained from integration projects can be captured to build a repository of semantically enriched, experience-based solutions. Business patterns identify the interaction and structure between users, business processes, and data. Specific integration and composition patterns at a more technical level address enterprise application integration and capture reliable architecture solutions. We use an ontology-based approach to capture architecture and process patterns. Ontology techniques for pattern definition, extension and composition are developed and their applicability in business process-driven application integration is demonstrated

An Ontology Based Method to Solve Query Identifier Heterogeneity in Post-Genomic Clinical Trials

The increasing amount of information available for biomedical research has led to issues related to knowledge discovery in large collections of data. Moreover, Information Retrieval techniques must consider heterogeneities present in databases, initially belonging to different domains—e.g. clinical and genetic data. One of the goals, among others, of the ACGT European is to provide seamless and homogeneous access to integrated databases. In this work, we describe an approach to overcome heterogeneities in identifiers inside queries. We present an ontology classifying the most common identifier semantic heterogeneities, and a service that makes use of it to cope with the problem using the described approach. Finally, we illustrate the solution by analysing a set of real queries