16,373 research outputs found
The Requirements for Ontologies in Medical Data Integration: A Case Study
Evidence-based medicine is critically dependent on three sources of
information: a medical knowledge base, the patients medical record and
knowledge of available resources, including where appropriate, clinical
protocols. Patient data is often scattered in a variety of databases and may,
in a distributed model, be held across several disparate repositories.
Consequently addressing the needs of an evidence-based medicine community
presents issues of biomedical data integration, clinical interpretation and
knowledge management. This paper outlines how the Health-e-Child project has
approached the challenge of requirements specification for (bio-) medical data
integration, from the level of cellular data, through disease to that of
patient and population. The approach is illuminated through the requirements
elicitation and analysis of Juvenile Idiopathic Arthritis (JIA), one of three
diseases being studied in the EC-funded Health-e-Child project.Comment: 6 pages, 1 figure. Presented at the 11th International Database
Engineering & Applications Symposium (Ideas2007). Banff, Canada September
200
Ontology-assisted database integration to support natural language processing and biomedical data-mining
Successful biomedical data mining and information extraction require a complete picture of biological phenomena such as genes, biological processes, and diseases; as these exist on different levels of granularity. To realize this goal, several freely available heterogeneous databases as well as proprietary structured datasets have to be integrated into a single global customizable scheme. We will present a tool to integrate different biological data sources by mapping them to a proprietary biomedical ontology that has been developed for the purposes of making computers understand medical natural language
Creating a new Ontology: a Modular Approach
Creating a new Ontology: a Modular ApproachComment: in Adrian Paschke, Albert Burger, Andrea Splendiani, M. Scott
Marshall, Paolo Romano: Proceedings of the 3rd International Workshop on
Semantic Web Applications and Tools for the Life Sciences, Berlin,Germany,
December 8-10, 201
Applications of the ACGT Master Ontology on Cancer
In this paper we present applications of the ACGT Master Ontology (MO) which is a new terminology resource for a transnational network providing data exchange in oncology, emphasizing the integration of both clinical and molecular data. The development of a new ontology was necessary due to problems with existing biomedical ontologies in oncology. The ACGT MO is a test case for the application of best practices in ontology development. This paper provides an overview of the application of the ontology within the ACGT project thus far
Knowledge Organization Systems (KOS) in the Semantic Web: A Multi-Dimensional Review
Since the Simple Knowledge Organization System (SKOS) specification and its
SKOS eXtension for Labels (SKOS-XL) became formal W3C recommendations in 2009 a
significant number of conventional knowledge organization systems (KOS)
(including thesauri, classification schemes, name authorities, and lists of
codes and terms, produced before the arrival of the ontology-wave) have made
their journeys to join the Semantic Web mainstream. This paper uses "LOD KOS"
as an umbrella term to refer to all of the value vocabularies and lightweight
ontologies within the Semantic Web framework. The paper provides an overview of
what the LOD KOS movement has brought to various communities and users. These
are not limited to the colonies of the value vocabulary constructors and
providers, nor the catalogers and indexers who have a long history of applying
the vocabularies to their products. The LOD dataset producers and LOD service
providers, the information architects and interface designers, and researchers
in sciences and humanities, are also direct beneficiaries of LOD KOS. The paper
examines a set of the collected cases (experimental or in real applications)
and aims to find the usages of LOD KOS in order to share the practices and
ideas among communities and users. Through the viewpoints of a number of
different user groups, the functions of LOD KOS are examined from multiple
dimensions. This paper focuses on the LOD dataset producers, vocabulary
producers, and researchers (as end-users of KOS).Comment: 31 pages, 12 figures, accepted paper in International Journal on
Digital Librarie
The OBO Foundry: Coordinated Evolution of Ontologies to Support Biomedical Data Integration
The value of any kind of data is greatly enhanced when it exists in a form that allows it to be integrated with other data. One approach to integration is through the annotation of multiple bodies of data using common controlled vocabularies or âontologiesâ. Unfortunately, the very success of this approach has led to a proliferation of ontologies, which itself creates obstacles to integration. The Open Biomedical Ontologies (OBO) consortium has set in train a strategy to overcome this problem. Existing OBO ontologies, including the Gene Ontology, are undergoing a process of coordinated reform, and new ontologies being created, on the basis of an evolving set of shared principles governing ontology development. The result is an expanding family of ontologies designed to be interoperable, logically well-formed, and to incorporate accurate representations of biological reality. We describe the OBO Foundry initiative, and provide guidelines for those who might wish to become involved in the future
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