Physiological-based Driver Monitoring Systems: A Scoping Review

A physiological-based driver monitoring system (DMS) has attracted research interest and has great potential for providing more accurate and reliable monitoring of the driver’s state during a driving experience. Many driving monitoring systems are driver behavior-based or vehicle-based. When these non-physiological based DMS are coupled with physiological-based data analysis from electroencephalography (EEG), electrooculography (EOG), electrocardiography (ECG), and electromyography (EMG), the physical and emotional state of the driver may also be assessed. Drivers’ wellness can also be monitored, and hence, traffic collisions can be avoided. This paper highlights work that has been published in the past five years related to physiological-based DMS. Specifically, we focused on the physiological indicators applied in DMS design and development. Work utilizing key physiological indicators related to driver identification, driver alertness, driver drowsiness, driver fatigue, and drunk driver is identified and described based on the PRISMA Extension for Scoping Reviews (PRISMA-Sc) Framework. The relationship between selected papers is visualized using keyword co-occurrence. Findings were presented using a narrative review approach based on classifications of DMS. Finally, the challenges of physiological-based DMS are highlighted in the conclusion. Doi: 10.28991/CEJ-2022-08-12-020 Full Text: PD

Rating organ failure via adverse events using data mining in the intensive care unit

The main intensive care unit (ICU) goal is to avoid or reverse the organ failure process by adopting a timely intervention. Within this context, early identification of organ impairment is a key issue. The sequential organ failure assessment (SOFA) is an expert-driven score that is widely used in European ICUs to quantify organ disorder. This work proposes a complementary data-driven approach based on adverse events, defined from commonly monitored biometrics. The aim is to 8. study the impact of these events when predicting the risk of ICU organ failure.FRICEBIOMED - projecto BMH4-CT96-0817, EURICUS IIFundação para a Ciência ea Tecnologia (FCT) - projecto PTDC/EIA/72819/2006

Event Extraction: A Survey

Extracting the reported events from text is one of the key research themes in natural language processing. This process includes several tasks such as event detection, argument extraction, role labeling. As one of the most important topics in natural language processing and natural language understanding, the applications of event extraction spans across a wide range of domains such as newswire, biomedical domain, history and humanity, and cyber security. This report presents a comprehensive survey for event detection from textual documents. In this report, we provide the task definition, the evaluation method, as well as the benchmark datasets and a taxonomy of methodologies for event extraction. We also present our vision of future research direction in event detection.Comment: 20 page

Use of deep learning to develop continuous-risk models for adverse event prediction from electronic health records

Early prediction of patient outcomes is important for targeting preventive care. This protocol describes a practical workflow for developing deep-learning risk models that can predict various clinical and operational outcomes from structured electronic health record (EHR) data. The protocol comprises five main stages: formal problem definition, data pre-processing, architecture selection, calibration and uncertainty, and generalizability evaluation. We have applied the workflow to four endpoints (acute kidney injury, mortality, length of stay and 30-day hospital readmission). The workflow can enable continuous (e.g., triggered every 6 h) and static (e.g., triggered at 24 h after admission) predictions. We also provide an open-source codebase that illustrates some key principles in EHR modeling. This protocol can be used by interdisciplinary teams with programming and clinical expertise to build deep-learning prediction models with alternate data sources and prediction tasks

Performance Evaluation of Smart Decision Support Systems on Healthcare

Medical activity requires responsibility not only from clinical knowledge and skill but also on the management of an enormous amount of information related to patient care. It is through proper treatment of information that experts can consistently build a healthy wellness policy. The primary objective for the development of decision support systems (DSSs) is to provide information to specialists when and where they are needed. These systems provide information, models, and data manipulation tools to help experts make better decisions in a variety of situations. Most of the challenges that smart DSSs face come from the great difficulty of dealing with large volumes of information, which is continuously generated by the most diverse types of devices and equipment, requiring high computational resources. This situation makes this type of system susceptible to not recovering information quickly for the decision making. As a result of this adversity, the information quality and the provision of an infrastructure capable of promoting the integration and articulation among different health information systems (HIS) become promising research topics in the field of electronic health (e-health) and that, for this same reason, are addressed in this research. The work described in this thesis is motivated by the need to propose novel approaches to deal with problems inherent to the acquisition, cleaning, integration, and aggregation of data obtained from different sources in e-health environments, as well as their analysis. To ensure the success of data integration and analysis in e-health environments, it is essential that machine-learning (ML) algorithms ensure system reliability. However, in this type of environment, it is not possible to guarantee a reliable scenario. This scenario makes intelligent SAD susceptible to predictive failures, which severely compromise overall system performance. On the other hand, systems can have their performance compromised due to the overload of information they can support. To solve some of these problems, this thesis presents several proposals and studies on the impact of ML algorithms in the monitoring and management of hypertensive disorders related to pregnancy of risk. The primary goals of the proposals presented in this thesis are to improve the overall performance of health information systems. In particular, ML-based methods are exploited to improve the prediction accuracy and optimize the use of monitoring device resources. It was demonstrated that the use of this type of strategy and methodology contributes to a significant increase in the performance of smart DSSs, not only concerning precision but also in the computational cost reduction used in the classification process. The observed results seek to contribute to the advance of state of the art in methods and strategies based on AI that aim to surpass some challenges that emerge from the integration and performance of the smart DSSs. With the use of algorithms based on AI, it is possible to quickly and automatically analyze a larger volume of complex data and focus on more accurate results, providing high-value predictions for a better decision making in real time and without human intervention.A atividade médica requer responsabilidade não apenas com base no conhecimento e na habilidade clínica, mas também na gestão de uma enorme quantidade de informações relacionadas ao atendimento ao paciente. É através do tratamento adequado das informações que os especialistas podem consistentemente construir uma política saudável de bem-estar. O principal objetivo para o desenvolvimento de sistemas de apoio à decisão (SAD) é fornecer informações aos especialistas onde e quando são necessárias. Esses sistemas fornecem informações, modelos e ferramentas de manipulação de dados para ajudar os especialistas a tomar melhores decisões em diversas situações. A maioria dos desafios que os SAD inteligentes enfrentam advêm da grande dificuldade de lidar com grandes volumes de dados, que é gerada constantemente pelos mais diversos tipos de dispositivos e equipamentos, exigindo elevados recursos computacionais. Essa situação torna este tipo de sistemas suscetível a não recuperar a informação rapidamente para a tomada de decisão. Como resultado dessa adversidade, a qualidade da informação e a provisão de uma infraestrutura capaz de promover a integração e a articulação entre diferentes sistemas de informação em saúde (SIS) tornam-se promissores tópicos de pesquisa no campo da saúde eletrônica (e-saúde) e que, por essa mesma razão, são abordadas nesta investigação. O trabalho descrito nesta tese é motivado pela necessidade de propor novas abordagens para lidar com os problemas inerentes à aquisição, limpeza, integração e agregação de dados obtidos de diferentes fontes em ambientes de e-saúde, bem como sua análise. Para garantir o sucesso da integração e análise de dados em ambientes e-saúde é importante que os algoritmos baseados em aprendizagem de máquina (AM) garantam a confiabilidade do sistema. No entanto, neste tipo de ambiente, não é possível garantir um cenário totalmente confiável. Esse cenário torna os SAD inteligentes suscetíveis à presença de falhas de predição que comprometem seriamente o desempenho geral do sistema. Por outro lado, os sistemas podem ter seu desempenho comprometido devido à sobrecarga de informações que podem suportar. Para tentar resolver alguns destes problemas, esta tese apresenta várias propostas e estudos sobre o impacto de algoritmos de AM na monitoria e gestão de transtornos hipertensivos relacionados com a gravidez (gestação) de risco. O objetivo das propostas apresentadas nesta tese é melhorar o desempenho global de sistemas de informação em saúde. Em particular, os métodos baseados em AM são explorados para melhorar a precisão da predição e otimizar o uso dos recursos dos dispositivos de monitorização. Ficou demonstrado que o uso deste tipo de estratégia e metodologia contribui para um aumento significativo do desempenho dos SAD inteligentes, não só em termos de precisão, mas também na diminuição do custo computacional utilizado no processo de classificação. Os resultados observados buscam contribuir para o avanço do estado da arte em métodos e estratégias baseadas em inteligência artificial que visam ultrapassar alguns desafios que advêm da integração e desempenho dos SAD inteligentes. Como o uso de algoritmos baseados em inteligência artificial é possível analisar de forma rápida e automática um volume maior de dados complexos e focar em resultados mais precisos, fornecendo previsões de alto valor para uma melhor tomada de decisão em tempo real e sem intervenção humana

Deep learning methods for knowledge base population

Knowledge bases store structured information about entities or concepts of the world and can be used in various applications, such as information retrieval or question answering. A major drawback of existing knowledge bases is their incompleteness. In this thesis, we explore deep learning methods for automatically populating them from text, addressing the following tasks: slot filling, uncertainty detection and type-aware relation extraction. Slot filling aims at extracting information about entities from a large text corpus. The Text Analysis Conference yearly provides new evaluation data in the context of an international shared task. We develop a modular system to address this challenge. It was one of the top-ranked systems in the shared task evaluations in 2015. For its slot filler classification module, we propose contextCNN, a convolutional neural network based on context splitting. It improves the performance of the slot filling system by 5.0% micro and 2.9% macro F1. To train our binary and multiclass classification models, we create a dataset using distant supervision and reduce the number of noisy labels with a self-training strategy. For model optimization and evaluation, we automatically extract a labeled benchmark for slot filler classification from the manual shared task assessments from 2012-2014. We show that results on this benchmark are correlated with slot filling pipeline results with a Pearson's correlation coefficient of 0.89 (0.82) on data from 2013 (2014). The combination of patterns, support vector machines and contextCNN achieves the best results on the benchmark with a micro (macro) F1 of 51% (53%) on test. Finally, we analyze the results of the slot filling pipeline and the impact of its components. For knowledge base population, it is essential to assess the factuality of the statements extracted from text. From the sentence "Obama was rumored to be born in Kenya", a system should not conclude that Kenya is the place of birth of Obama. Therefore, we address uncertainty detection in the second part of this thesis. We investigate attention-based models and make a first attempt to systematize the attention design space. Moreover, we propose novel attention variants: External attention, which incorporates an external knowledge source, k-max average attention, which only considers the vectors with the k maximum attention weights, and sequence-preserving attention, which allows to maintain order information. Our convolutional neural network with external k-max average attention sets the new state of the art on a Wikipedia benchmark dataset with an F1 score of 68%. To the best of our knowledge, we are the first to integrate an uncertainty detection component into a slot filling pipeline. It improves precision by 1.4% and micro F1 by 0.4%. In the last part of the thesis, we investigate type-aware relation extraction with neural networks. We compare different models for joint entity and relation classification: pipeline models, jointly trained models and globally normalized models based on structured prediction. First, we show that using entity class prediction scores instead of binary decisions helps relation classification. Second, joint training clearly outperforms pipeline models on a large-scale distantly supervised dataset with fine-grained entity classes. It improves the area under the precision-recall curve from 0.53 to 0.66. Third, we propose a model with a structured prediction output layer, which globally normalizes the score of a triple consisting of the classes of two entities and the relation between them. It improves relation extraction results by 4.4% F1 on a manually labeled benchmark dataset. Our analysis shows that the model learns correct correlations between entity and relation classes. Finally, we are the first to use neural networks for joint entity and relation classification in a slot filling pipeline. The jointly trained model achieves the best micro F1 score with a score of 22% while the neural structured prediction model performs best in terms of macro F1 with a score of 25%

Automation of Patient Trajectory Management: A deep-learning system for critical care outreach

The application of machine learning models to big data has become ubiquitous, however their successful translation into clinical practice is currently mostly limited to the field of imaging. Despite much interest and promise, there are many complex and interrelated barriers that exist in clinical settings, which must be addressed systematically in advance of wide-spread adoption of these technologies. There is limited evidence of comprehensive efforts to consider not only their raw performance metrics, but also their effective deployment, particularly in terms of the ways in which they are perceived, used and accepted by clinicians. The critical care outreach team at St Vincent’s Public Hospital want to automatically prioritise their workload by predicting in-patient deterioration risk, presented as a watch-list application. This work proposes that the proactive management of in-patients at risk of serious deterioration provides a comprehensive case-study in which to understand clinician readiness to adopt deep-learning technology due to the significant known limitations of existing manual processes. Herein is described the development of a proof of concept application uses as its input the subset of real-time clinical data available in the EMR. This data set has the noteworthy challenge of not including any electronically recorded vital signs data. Despite this, the system meets or exceeds similar benchmark models for predicting in-patient death and unplanned ICU admission, using a recurrent neural network architecture, extended with a novel data-augmentation strategy. This augmentation method has been re-implemented in the public MIMIC-III data set to confirm its generalisability. The method is notable for its applicability to discrete time-series data. Furthermore, it is rooted in knowledge of how data entry is performed within the clinical record and is therefore not restricted in applicability to a single clinical domain, instead having the potential for wide-ranging impact. The system was presented to likely end-users to understand their readiness to adopt it into their workflow, using the Technology Adoption Model. In addition to confirming feasibility of predicting risk from this limited data set, this study investigates clinician readiness to adopt artificial intelligence in the critical care setting. This is done with a two-pronged strategy, addressing technical and clinically-focused research questions in parallel