Tools for Assessment of Occupational Health Risks of some Engineered Nanoparticles and Carbon Materials Used in Semiconductor Applications

Engineered nanomaterials (ENM) are used in a wide variety of applications: from cosmetics and paints to sportswear and semiconductor chips. While for chemicals there are established regulatory frameworks dealing with the risk for the consumers, workers, and the environment, this is not the case for nanomaterials. This is precisely why ENMs are used—the properties of matter change at the nanoscale and become dependent on the particle morphology and size. Our understanding on how such nano-systems react with biological matter, such as cells and tissues, is far from complete, and this brings about an increasing level of uncertainty in the research and development process. This chapter will give an overview of several materials, which are either used or have potential applications in nanoelectronics. While silicon dioxide and metal oxide nanoparticles are used in semiconductor processing in standard polishing steps, applications of carbon materials may be more disruptive. As promising materials with broad applications, we focus on carbon nanotubes and graphene. So-identified materials are used to illustrate the use of different risk assessment tools in the occupational setting of nanoelectronics. The application of such tools in itself is also a growing area of research efforts supported by international stakeholders, such as the European Commission

Potential Harm of IQOS Smoke to Rat Liver

The Food and Drug Administration has recently classified the IQOS electronic cigarette as a modified-risk tobacco product. However, IQOS cigarettes still release various harmful constituents typical of conventional cigarettes (CCs), although the concentrations are markedly lower. Here, we investigated the damaging effects of IQOS smoking on the liver. Male Sprague Dawley rats were exposed, whole body, 5 days/week for 4 weeks to IQOS smoke (4 sticks/day), and hepatic xenobiotic metabolism, redox homeostasis and lipidomic profile were investigated. IQOS boosted reactive radicals and generated oxidative stress. Exposure decreased cellular reserves of total glutathione (GSH) but not GSH-dependent antioxidant enzymes. Catalase and xanthine oxidase were greater in the exposed group, as were various hepatic CYP-dependent monooxygenases (CYP2B1/2, CYP1A1, CYP2A1, CYP2E1-linked). Respiratory chain activity was unaltered, while the number of liver mitochondria was increased. IQOS exposure had an impact on the hepatic lipid profile. With regard to the expression of some MAP kinases commonly activated by CC smoking, IQOS increased the p-p38/p38 ratio, while erythroid nuclear transcription factor 2 (Nrf2) was negatively affected. Our data suggest that IQOS significantly impairs liver function, supporting the precautionary stance taken by the WHO toward the use of these devices, especially by young people and pregnant women

Evaluation and Management of Patients with Methomyl Poisoning – A Case Report

The Apulian Poison Centre (PC) of Foggia, Italy, annually manages numerous consultations concerning certain or suspected poisonings from pesticides, starting at the same time a careful activity related to the risk assessment phase. The management of the exposure to pesticides and to other chemicals, and the alerting of the “National center for chemicals, cosmetics and consumer protection” at the Istituto Superiore di Sanità (ISS), actively contributes to the improvement of products quality and safety. Thus, leading to a reduction in the number of intoxications - and therefore of the accesses to the emergency services - allows greater protection for workers, bystanders, residents and consumers. The reported case of methomyl poisoning has been of fundamental importance both from the medical point of view and for the management of the intoxicated patient, both for the risk assessment actions, and for cooperation with the competent authorities, generating discussion points on the regulations in force between PCs and National Competent Authority. It follows that the feedback of intoxication in an emergency can lead to improvements in the management and risk mitigation measures in order to reach a greater protection of human, animal, and environmental health. In addition, the regulatory feedback deriving from these reports is an input to the increase product quality improvement (mixtures, labels, packaging, and risk communication) leading to a greater protection of potential exposed subjects. The importance of creating an information and management network that allows the optimization of the flow of information deriving from PCs arises. The actions taken are therefore described, both relating to the management of the emergency, and relating to the subsequent information flow and to the measures for containing the consequent risks

Environmental Effects on Health: Ignorance and Undone Science

Considerable research has been completed showing that environmental exposures can have significant effects on people’s health, especially in terms of autoimmune conditions, cancers, and neurological and psychological conditions. Health effects are possible at exposure levels far below those generally considered safe by orthodox health authorities. A prime example is multiple chemical sensitivity (MCS), where sufferers themselves have made clear, short-term associations between health effects and low-level environmental exposures. The condition of MCS is not clearly definable and significantly overlaps with other, largely unrecognised health conditions including fibromyalgia (FMS), chronic fatigue syndrome (CFS), electro hypersensitivity syndrome (EHS) and chronic inflammatory response syndrome (CIRS). The orthodox medical diagnostic process is implicated in the production of ignorance on such health conditions. Despite the large amount of research showing health effects from low level environmental exposures, there remains much “undone science” in the field - research that could be done but isn’t. The reasons for undone science and the consequent societal ignorance are generally due to society’s ingrained desire for technological improvements. Industry, responsible for technological developments the use of chemical products or radiation devices, is not interested in possible health effects, so expensive scientific research into them is left undone. When subsequent research or firsthand experiences of health effects start to be realised there is ample evidence that the industries responsible for environmental exposures then become active in generating ignorance. Due to close ties with industry, medical and health systems become complicit in industry’s strategy, and knowledge is manipulated by the industry funding of scientific studies, which then influences the conclusions of the research. The support of industry products by institutions, including regulatory agencies, due to conflicts of interest also contributes to knowledge manipulation. Common industry strategies of generating ignorance also include using doubt, blame, power, industry shills, astroturfing, smear campaigns, media manipulation and fact checking services. Future generations of children who inherit contaminants from their conception will be most affected by the gross neglect of their effect on health. The carry-through of health effects and their magnification in subsequent generations is a tragedy in the making

Information Economics and Chemical Toxicity: Designing Laws to Produce and Use Data

Just as laws may create entitlements to the use of information, they may also be written to distribute information and to encourage information production. This Article discusses the ways in which law affects the generation and distribution of information related to chemical exposure and toxicity. It describes the economic impact of recently enacted right-to-know laws and proposes that better and more abundant data could be produced if the law paid greater attention to basic economic principles that influence research and information systems

Under the influence? Considering the role of alcohol and sexual assault in social contexts

This paper reviews research around alcohol use in sexual assaults that are perpetrated in circumstances of socialising and sexual interactions. Introduction Alcohol is a common feature in many sexual assaults, particularly those committed in a social context. Although there is extensive research on the link between alcohol and sexual assault, there is a lack of clarity about the exact role that alcohol plays. In the ACSSA research report Insights Into Sexual Assault Perpetration: Giving Voice to Victim/Survivors\u27 Knowledge, alcohol was seen as a tool, commonly used by perpetrators. The report will be referred to throughout this paper as Giving Voice. The findings from Giving Voice identified a variety of ways in which alcohol was used by perpetrators in social interactions and settings in order to perpetrate sexual assault. These included: taking advantage of the social use of alcohol to enable and facilitate the assaults; as a method of increasing perpetrator confidence; excusing their perpetrating behaviour after the assault; and enabling manipulation of the effects of alcohol for the purposes of reinterpreting the assault or women\u27s memories of it - alcohol has the effect of creating a barrier to the reporting of sexual assault as women often see their own intoxication or drinking behaviour as contributing to the assault. This Issues paper aims to review research around alcohol use in sexual assaults that are perpetrated in circumstances of socialising and sexual interactions. It will highlight key points from the literature that provide relevant information for prevention. This paper also discusses 14 transcripts from interviews with victims of sexual assault in which alcohol was present. These interviews were originally undertaken as part of the Giving Voice report. The report was originally conceived as a step towards enhancing understanding about sexual assault perpetration. This Issues paper builds on one aspect of the findings from that report - namely that alcohol is often present when sexual assault is perpetrated. The aim of drawing on the Giving Voice transcripts that highlighted the presence of alcohol was to gain some insight into alcohol\u27s role in sexual assault facilitation and seeing whether this insight accords with the wider literature on alcohol