Spatial Organization and Molecular Correlation of Tumor-Infiltrating Lymphocytes Using Deep Learning on Pathology Images

Beyond sample curation and basic pathologic characterization, the digitized H&E-stained images of TCGA samples remain underutilized. To highlight this resource, we present mappings of tumorinfiltrating lymphocytes (TILs) based on H&E images from 13 TCGA tumor types. These TIL maps are derived through computational staining using a convolutional neural network trained to classify patches of images. Affinity propagation revealed local spatial structure in TIL patterns and correlation with overall survival. TIL map structural patterns were grouped using standard histopathological parameters. These patterns are enriched in particular T cell subpopulations derived from molecular measures. TIL densities and spatial structure were differentially enriched among tumor types, immune subtypes, and tumor molecular subtypes, implying that spatial infiltrate state could reflect particular tumor cell aberration states. Obtaining spatial lymphocytic patterns linked to the rich genomic characterization of TCGA samples demonstrates one use for the TCGA image archives with insights into the tumor-immune microenvironment

ANTIDS: Self-Organized Ant-based Clustering Model for Intrusion Detection System

Security of computers and the networks that connect them is increasingly becoming of great significance. Computer security is defined as the protection of computing systems against threats to confidentiality, integrity, and availability. There are two types of intruders: the external intruders who are unauthorized users of the machines they attack, and internal intruders, who have permission to access the system with some restrictions. Due to the fact that it is more and more improbable to a system administrator to recognize and manually intervene to stop an attack, there is an increasing recognition that ID systems should have a lot to earn on following its basic principles on the behavior of complex natural systems, namely in what refers to self-organization, allowing for a real distributed and collective perception of this phenomena. With that aim in mind, the present work presents a self-organized ant colony based intrusion detection system (ANTIDS) to detect intrusions in a network infrastructure. The performance is compared among conventional soft computing paradigms like Decision Trees, Support Vector Machines and Linear Genetic Programming to model fast, online and efficient intrusion detection systems.Comment: 13 pages, 3 figures, Swarm Intelligence and Patterns (SIP)- special track at WSTST 2005, Muroran, JAPA

Exploratory study to explore the role of ICT in the process of knowledge management in an Indian business environment

In the 21st century and the emergence of a digital economy, knowledge and the knowledge base economy are rapidly growing. To effectively be able to understand the processes involved in the creating, managing and sharing of knowledge management in the business environment is critical to the success of an organization. This study builds on the previous research of the authors on the enablers of knowledge management by identifying the relationship between the enablers of knowledge management and the role played by information communication technologies (ICT) and ICT infrastructure in a business setting. This paper provides the findings of a survey collected from the four major Indian cities (Chennai, Coimbatore, Madurai and Villupuram) regarding their views and opinions about the enablers of knowledge management in business setting. A total of 80 organizations participated in the study with 100 participants in each city. The results show that ICT and ICT infrastructure can play a critical role in the creating, managing and sharing of knowledge in an Indian business environment

Incremental document map formation: multi-stage approach

The paper presents methodology for the incremental map formation in a multi-stage process of a search engine with the map based user interface1. The architecture of the experimental system allows for comparative evaluation of different constituent technologies for various stages of the process. The quality of the map generation process has been investigated based on a number of clustering and classification measures. Some conclusions concerning the impact of various technological solutions on map quality are presented