Multichannel FPGA based MVT system for high precision time (20~ps~RMS) and charge measurement

In this article it is presented an FPGA based $M$ulti-$V$oltage $T$hreshold (MVT) system which allows of sampling fast signals ($1-2$ ns rising and falling edge) in both voltage and time domain. It is possible to achieve a precision of time measurement of $20$ ps RMS and reconstruct charge of signals, using a simple approach, with deviation from real value smaller than 10$\%$. Utilization of the differential inputs of an FPGA chip as comparators together with an implementation of a TDC inside an FPGA allowed us to achieve a compact multi-channel system characterized by low power consumption and low production costs. This paper describes realization and functioning of the system comprising 192-channel TDC board and a four mezzanine cards which split incoming signals and discriminate them. The boards have been used to validate a newly developed Time-of-Flight Positron Emission Tomography system based on plastic scintillators. The achieved full system time resolution of $\sigma$(TOF) $\approx 68$ ps is by factor of two better with respect to the current TOF-PET systems.Comment: Accepted for publication in JINST, 10 pages, 8 figure

FPGA를 이용한 시간 기반 고집적 PET 데이터 수집 장치

학위논문(박사)--서울대학교 대학원 :의과대학 의과학과,2019. 8. 이재성.Positron emission tomography (PET) is a widely used functional imaging device for diagnosing cancer and neurodegenerative diseases. PET instrumentation studies focus on improving both spatial resolution and sensitivity to improve the lesion detectability while reducing radiation exposure to patients. The silicon photomultiplier (SiPM) is a photosensor suitable for high-performance PET scanners owing to its compact size and fast response. However, the SiPM-based PET scanners require a large number of readout channels owing to a high level of granularity. For example, the typical whole-body PET scanners require more than 40,000 SiPM channels. Therefore, the highly integrated data acquisition (DAQ) system that can digitize a large number of SiPM signal with preserving its fast temporal response is required to develop the high-performance SiPM-based PET scanners. Time-based signal digitization is a promising method to develop highly integrated DAQ systems owing to its simple circuitry and fast temporal response. In this thesis, studies on developing highly integrated DAQ systems using a field-programmable gate array (FPGA) were presented. Firstly, a 10-ps time-to-digital converter (TDC) implemented within the FPGA was developed. The FPGA-TDCs suffer from the non-linearity, because FPGAs are not originally designed to implement TDC. We proposed the dual-phase sampling architecture considering the FPGA clock distribution network to mitigate the TDC non-linearity. In addition, we developed the on-the-fly calibrator that compensated the innate bin width variations without introducing the dead time. Secondly, the time-based SiPM multiplexing and readout method was developed using the principle of the global positioning system (GPS). The signal traces connecting every SiPM to four timing channels were used to encode the position information. The position information was obtained using the innate transit time differences measured by four FPGA-TDCs. In addition, the minimal signal distortion by multiplexing circuit allowed to use a time-over-threshold (ToT) method for energy measurement after multiplexing. Thirdly, we proposed a new FPGA-only digitizer. The programmable FPGA input/output (I/O) port was configured with stub-series terminated logic (SSTL) input receiver, and each FPGA I/O port functioned as a high-performance voltage comparator with a fast temporal response. We demonstrated that the FPGA can be used as a high-performance DAQ system by directly digitizing the time-of-flight (TOF) PET detector signals using the FPGA without any front-end electronics. Lastly, we developed comparator-less charge-to-time converter (QTC) DAQ systems to collect data from a prototype high-resolution brain PET scanner. The energy channel consisted of a QTC combined with the SSTL input receiver of the FPGA. The timing channel was a TDC implemented within the same FPGA. The detailed structure of brain phantom was well-resolved using the developed high-resolution brain PET scanner and the highly-integrated time-based DAQ systems.양전자방출단층촬영 (Positron Emission Tomography; PET) 장치는 암과 신경퇴행성 질환을 영상화하는 데 널리 쓰이는 기능 영상장치이다. 최근 PET 스캐너 연구는 공간 분해능과 장비 민감도를 높여 병변의 진단을 쉽게 하면서 환자의 방사선 피폭을 줄이는 방법에 초점을 맞추고 있다. 실리콘 관증배기 (silicon photomultiplier; SiPM)은 크기가 작고 반응속도가 빠르기 때문에 고성능 PET 스캐너에 적합한 광검출소자이다. 하지만 SiPM 기반 PET 스캐너는 개별 SiPM의 크기가 작기 때문에 수많은 데이터 수집 채널이 필요하다. 예를 들어, 전신 PET 스캐너를 SiPM으로 구성할 경우 40,000개 이상의 SiPM 소자가 필요하다. 따라서, SiPM의 성능을 유지하면서 다채널 신호 디지털화가 가능한 고집적 데이터 수집장치 (data acquisition; DAQ)가 고성능 SiPM PET 스캐너 개발에 필요하다. 시간 기반 신호 디지털 방법은 단순한 회로와 빠른 반응속도 덕분에 고집적 DAQ 시스템을 구현하는 유망한 방법이다. 본 학위논문에서는 프로그램 가능 게이트 배열 (field-programmable gate array; FPGA)을 이용하여 고집적 DAQ 시스템을 개발하는 연구내용을 다룬다. 첫째로, 10 ps 의 분해능을 갖는 FPGA 기반 시간-디지털 변환기 (time-to-digital converter; TDC)를 개발하였다. FPGA는 TDC 구현을 위한 집적소자가 아니므로 FPGA에 구현된 TDC는 일반적으로 비선형성 문제를 가진다. 이를 해결하기 위해 비선형성 문제를 야기하는 FPGA의 클락 신호 분배 구조를 고려하여 이중 위상 샘플링 방법을 제안하였다. 또한, FPGA TDC 고유의 불균일한 분해능을 측정하고 보상하기 위하여 실시간 보정기술을 개발하였다. 둘째로, GPS 원리를 사용한 시간 기반 신호 부호화 (multiplexing) 및 수집 방법을 개발하였다. 부호화 회로는 SiPM을 네 개의 시간 수집 채널로 연결한 도선으로 구성되고 위치정보는 각 SiPM으로부터 네 개의 시간 수집 채널까지의 고유한 도파시간 차이를 계산해서 수집할 수 있다. 또한, 기존 전하 분배 부호화 회로와 달리 신호가 왜곡되지 않기 때문에 문턱 전압 방법 (time-over-threshold; ToT) 방식으로 에너지를 수집하는 것이 가능하였다. 셋째로, FPGA만으로 아날로그 신호를 디지털화 하는 새로운 방법을 개발하였다. FPGA의 프로그램 가능 입출력포트를 stub-series terminated logic (SSTL) 수신기로 프로그램하면, 각각의 FPGA 입출력포트가 빠른 시간 반응성을 가진 고성능 전압비교기로 동작한다. 비정시간 (time-of-flight; TOF) 측정 가능 PET 검출기의 신호를 전단회로 없이 FPGA만으로 디지털화하여 FPGA를 고성능 DAQ 장치로 사용할 수 있음을 입증하였다. 마지막으로, 공간분해능이 뛰어난 뇌전용 스캐너로부터 데이터를 수집하기 위해 전압비교기를 사용하지 않는 시간 기반 DAQ 장치를 개발하였다. 에너지 측정 채널은 시간-전하 변환기 (charge-to-time converter; QTC)와 FPGA의 SSTL 수신기로 구성하였다. 시각 측정 채널은 FPGA 기반 TDC로 구성하였다. 개발한 뇌전용 스캐너와 고집적 시간 기반 DAQ 장치로 획득한 뇌모양 팬텀의 자세한 구조들은 잘 구분되었다.Chapter 1. Introduction 1 1.1. Background 1 1.1.1. Positron Emission Tomography 1 1.1.2. Silicon Photomultiplier 1 1.1.3. Data Acquisition System 2 1.1.4. Time-based Signal Digitization Method 3 1.2. Purpose of Research 6 Chapter 2. FPGA-based Time-to-Digital Converter 8 2.1. Background 8 2.2. Materials and Methods 9 2.2.1. Tapped-Delay-Line TDC 9 2.2.2. FPGA 11 2.2.3. Dual-Phase TDL TDC with On-the-Fly Calibrator 11 2.2.3.1. FPGA Clock Distribution Network 11 2.2.3.2. The Principle of Dual-Phase TDL TDC 14 2.2.3.3. The Principle of Pipelined On-the-Fly Calibrator 16 2.2.3.4. Implementation of Dual-Phase TDL TDC with On-the-Fly Calibrator 18 2.2.4. Experimental Setups and Data Processing 20 2.2.4.1. TDC Characteristics 21 2.2.4.2. Arrival Time Difference Measurements 22 2.3. Results 24 2.3.1. TDC Characteristics 24 2.3.2. Arrival Time Difference Measurements 25 2.4. Discussion 28 Chapter 3. Time-based Multiplexing Method 29 3.1. Background 29 3.2. Materials and Methods 30 3.2.1. Delay Grid Multiplexing 30 3.2.2. Detector for Concept Verification 32 3.2.3. Front-end Electronics 34 3.2.4. Experimental Setups 35 3.2.4.1. Data Acquisition Using the Waveform Digitizer 37 3.2.4.2. Data Acquisition Using the FPGA-TDC 37 3.2.5. Data Processing and Analysis 38 3.2.5.1. Waveform Digitizer 38 3.2.5.2. FPGA-TDC 41 3.3. Results 44 3.3.1. Waveform Digitizer 44 3.3.1.1. Waveform, Rise Time, and Decay Time 44 3.3.1.2. Flood Map 46 3.3.1.3. Energy 48 3.3.1.4. CTR 49 3.3.2. FPGA-TDC 50 3.3.2.1. ToT and Energy 50 3.3.2.2. Flood Map 51 3.3.2.3. CTR 52 3.4. Discussion 53 Chapter 4. FPGA-Only Signal Digitization Method 54 4.1. Background 54 4.2. Materials and Methods 56 4.2.1. Single-ended Memory Interface Input Receiver 56 4.2.2. SeMI Digitizer 56 4.2.3. Experimental Setup for Intrinsic Performance Characterization 59 4.2.3.1. ToT 59 4.2.3.2. Timing 60 4.2.4. Experimental Setup for Individual Signal Digitization 60 4.2.4.1. TOF PET Detector 60 4.2.4.2. Data Acquisition Using the Waveform Digitizer 61 4.2.4.3. Data Acquisition Using the SeMI Digitizer 63 4.2.4.4. Data Analysis 63 4.3. Results 64 4.3.1. Results of Intrinsic Performance Characterization 64 4.3.1.1. ToT 64 4.3.1.2. Timing 65 4.3.2. Results of Individual Signal Digitization 66 4.3.2.1. Energy 66 4.3.2.2. CTR 67 4.4. Discussion 68 Chapter 5. Comparator-less QTC DAQ Systems for High-Resolution Brain PET Scanners 70 5.1. Background 70 5.2. Materials and Methods 72 5.2.1. Brain PET Scanner 72 5.2.1.1. Block Detector 72 5.2.1.2. Sector 73 5.2.1.3. Scanner Geometry 74 5.2.2. Comparator-less QTC DAQ System 75 5.2.3. Data Acquisition Chain of Brain PET Scanner 79 5.2.4. Experimental Setups and Data Processing 79 5.2.4.1. Energy Linearity 79 5.2.4.2. Performance Evaluation of Block Detector 80 5.2.4.3. Phantom Studies 82 5.3. Results 83 5.3.1. Energy Linearity 83 5.3.2. Performance Evaluation of Block Detector 83 5.3.3. Phantom Studies 85 5.4. Discussion 87 Chapter 6. Conclusions 89 Bibliography 90 Abstract in Korean (국문 초록) 94Docto

Evaluation of Single-Chip, Real-Time Tomographic Data Processing on FPGA - SoC Devices

A novel approach to tomographic data processing has been developed and evaluated using the Jagiellonian PET (J-PET) scanner as an example. We propose a system in which there is no need for powerful, local to the scanner processing facility, capable to reconstruct images on the fly. Instead we introduce a Field Programmable Gate Array (FPGA) System-on-Chip (SoC) platform connected directly to data streams coming from the scanner, which can perform event building, filtering, coincidence search and Region-Of-Response (ROR) reconstruction by the programmable logic and visualization by the integrated processors. The platform significantly reduces data volume converting raw data to a list-mode representation, while generating visualization on the fly.Comment: IEEE Transactions on Medical Imaging, 17 May 201

Application of the Compress Sensing Theory for Improvement of the TOF Resolution in a Novel J-PET Instrument

Nowadays, in Positron Emission Tomography (PET) systems, a Time of Flight information is used to improve the image reconstruction process. In Time of Flight PET (TOF-PET), fast detectors are able to measure the difference in the arrival time of the two gamma rays, with the precision enabling to shorten significantly a range along the line-of-response (LOR) where the annihilation occurred. In the new concept, called J-PET scanner, gamma rays are detected in plastic scintillators. In a single strip of J-PET system, time values are obtained by probing signals in the amplitude domain. Owing to Compress Sensing theory, information about the shape and amplitude of the signals is recovered. In this paper we demonstrate that based on the acquired signals parameters, a better signal normalization may be provided in order to improve the TOF resolution. The procedure was tested using large sample of data registered by a dedicated detection setup enabling sampling of signals with 50 ps intervals. Experimental setup provided irradiation of a chosen position in the plastic scintillator strip with annihilation gamma quanta

Evaluation of a Modular PET System Architecture with Synchronization over Data Links

A DAQ architecture for a PET system is presented that focuses on modularity, scalability and reusability. The system defines two basic building blocks: data acquisitors and concentra- tors, which can be replicated in order to build a complete DAQ of variable size. Acquisition modules contain a scintillating crystal and either a position-sensitive photomultiplier (PSPMT) or an array of silicon photomultipliers (SiPM). The detector signals are processed by AMIC, an integrated analog front-end that generates programmable analog outputs which contain the first few statistical moments of the light distribution in the scintillator. These signals are digitized at 156.25 Msamples/s with free-run- ning ADCs and sent to an FPGA which detects single gamma events, extracts position and time information online using digital algorithms, and submits these data to a concentrator module. Concentrator modules collect single events from acquisition modules and perform coincidence detection and data aggregation. A synchronization scheme over data links is implemented that calibrates each link s latency independently, ensuring that there are no limitations on module mobility, and that the architecture is arbitrarily scalable. Prototype boards with both acquisition and concentration functionality have been built for evaluation pur- poses. The performance of a small PET system with two detectors based on continuous scintillators is presented. A synchronization error below 50 ps rms is measured, and energy resolutions of 19% and 24% and timing resolutions of 2.0 ns and 4.7 ns FWHM are obtained for PMT and SiPM photodetectors, respectively.Manuscript received June 25, 2013; revised November 06, 2013; accepted January 03, 2014. Date of publication January 29, 2014; date of current version February 06, 2014. This work was supported in part by the Spanish Ministry of Science and Innovation under CICYT Grant FIS2010-21216-C02-02.Aliaga Varea, RJ.; Herrero Bosch, V.; Monzó Ferrer, JM.; Ros García, A.; Gadea Gironés, R.; Colom Palero, RJ. (2014). Evaluation of a Modular PET System Architecture with Synchronization over Data Links. IEEE Transactions on Nuclear Science. 61(1):88-98. https://doi.org/10.1109/TNS.2014.2298399S889861

MATRIX16: A 16-Channel Low-Power TDC ASIC with 8 ps Time Resolution

This paper presents a highly configurable 16-channel TDC ASIC designed in a commercial 180 nm technology with the following features: time-of-flight and time-over-threshold measurements, 8.6 ps LSB, 7.7 ps jitter, 5.6 ps linearity error, up to 5 MHz of sustained input rate per channel, 9.1 mW of power consumption per channel, and an area of 4.57 mm2 . The main contributions of this work are the novel design of the clock interpolation circuitry based on a resistive interpolation mesh circuit and the capability to operate at different supply voltages and operating frequencies, thus providing a compromise between TDC resolution and power consumption. Keywords: TDC; time-to-digital converter; fast timing; PET; VLSI; ASIC; ToF; ToT; low power; frontend electronic